The Biology Of Alzheimer Disease
DOWNLOAD
Download The Biology Of Alzheimer Disease PDF/ePub or read online books in Mobi eBooks. Click Download or Read Online button to get The Biology Of Alzheimer Disease book now. This website allows unlimited access to, at the time of writing, more than 1.5 million titles, including hundreds of thousands of titles in various foreign languages. If the content not found or just blank you must refresh this page
The Biology Of Alzheimer Disease
DOWNLOAD
Author : Dennis J. Selkoe
language : en
Publisher: Cold Spring Harbor Perspective
Release Date : 2012
The Biology Of Alzheimer Disease written by Dennis J. Selkoe and has been published by Cold Spring Harbor Perspective this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with Medical categories.
Alzheimer disease causes the gradual deterioration of cognitive function, including severe memory loss and impairments in abstraction and reasoning. Understanding the complex changes that occur in the brain as the disease progressesincluding the accumulation of amyloid plaques and neurofibrillary tanglesis critical for the development of successful therapeutic approaches. Written and edited by leading experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine includes contributions covering all aspects of Alzheimer disease, from our current molecular understanding to therapeutic agents that could be used to treat and, ultimately, prevent it. Contributors discuss the biochemistry and cell biology of amyloid -protein precursor (APP), tau, presenilin, -secretase, and apolipoprotein E and their involvement in Alzheimer disease. They also review the clinical, neuropathological, imaging, and biomarker phenotypes of the disease; genetic alterations associated with the disorder; and epidemiological insights into its causation and pathogenesis. This comprehensive volume, which includes discussions of therapeutic strategies that are currently used or under development, is a vital reference for neurobiologists, cell biologists, pathologists, and other scientists pursuing the biological basis of Alzheimer disease, as well as investigators, clinicians, and students interested in its pathogenesis, treatment, and prevention.
Molecular Biology Of Alzheimer S Disease
DOWNLOAD
Author : Christian Haass
language : en
Publisher: CRC Press
Release Date : 2003-09-02
Molecular Biology Of Alzheimer S Disease written by Christian Haass and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-09-02 with Science categories.
Highlighting the latest and the most timely aspects of Alzheimer's disease research, this text will enable scientists in related research fields, as well as physicians working with Alzheimer's disease patients, to obtain a quick and complete overview of the current state of the art in one of the most exciting fields in neuroscience research. Leading scientists have contributed articles focusing on key developments in this field. This includes an overview about the pathology, the genetics of familial Alzheimer's disease, proteolytic generation and aggregation of amyloid -peptide, presenilins, risk factors such as ApoE, and transgenic animal models. Some of the latest developments in Alzheimer's disease research, including the effect of presenilin knock outs on amyloid -peptide generation, are also included.
Alzheimer S Disease Biology Biophysics And Computational Models
DOWNLOAD
Author : Don Kulasiri
language : en
Publisher: World Scientific
Release Date : 2022-01-06
Alzheimer S Disease Biology Biophysics And Computational Models written by Don Kulasiri and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-01-06 with Medical categories.
Alzheimer's disease (AD) is the leading cause of dementia and, unfortunately, remains incurable. The social, emotional and financial implications of AD are immeasurable, and about 47 million people worldwide are affected by AD or other forms of dementia. As lifespans are improved by healthcare systems worldwide, age-associated neurodegenerative diseases are imposing an increasing challenge to science. It is becoming imperative for us to understand the causes of these diseases, AD in particular, at molecular and cellular levels. Starting with the broader picture from a biological perspective, this book takes the reader through fascinating dynamics within and outside of neurons in the brain.Alzheimer's Disease: Biology, Biophysics and Computational Models helps the reader to understand AD from mechanistic and biochemical perspectives at intra- and inter-cellular levels. It focuses on biochemical pathways and modeling associated with AD. Some of the recent research on biophysics and computational models related to AD are explained using context-driven computational and mathematical modeling and essential biology is discussed to understand the modeling research.
Alzheimer Disease
DOWNLOAD
Author : Robert Becker
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Alzheimer Disease written by Robert Becker and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Alzheimer S Disease
DOWNLOAD
Author : Sangram S. Sisodia
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-02-16
Alzheimer S Disease written by Sangram S. Sisodia and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-02-16 with Medical categories.
This book examines every major aspect of Alzheimer disease at a time when there has been no scholarly research volume on the subject published in the last 3-5 years. This edition includes expanded coverage of the cellular-level exploration of related dementing disorders, with in-depth presentation of prion diseases, Pick's disease, fronto-temporal disorders, transgenic models, and biochemistry of presenilins.
Alzheimer S Disease Lessons From Cell Biology
DOWNLOAD
Author : Ken S. Kosik
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Alzheimer S Disease Lessons From Cell Biology written by Ken S. Kosik and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
Like the unflinching gaze of Captain Ahab walking the deck of the Pequod, Alzheimer researchers have had their sights fixed firmly on the disease for many years. Now, as this volume amply demonstrates, accomplished researchers from other fields, who have thought deeply about cell biological problems are applying their insights to Alzheimer's disease. The contri butions here represent the text versions of the proceedings from the tenth "Colloque medecine et recherche" of the Fondation IPSEN devoted to research on Alzheimer's disease. The symposium, entitled "Alzheimer's Disease: Lessons from Cell Biology" was held in Paris on April 25, 1994. As is apparent from the varied backgrounds of the contributors, the scientific pursuit of Alzheimer's disease has begun to meld with more basic disciplines, particularly cell biology. While on the one hand, new areas of specialization are continuously emerging, the boundaries of older disciplines are increas ingly blurred. Perhaps for most of the years since the first descriptions of the disease in 1907, the science of Alzheimer's disease was descriptive, and lay in the province of pathologists. This time period, during which a great deal was learned about the topography of senile plaques and neurofibrillary tangles, culminated with an ultrastructural description of these hallmark structures. The modern era of Alzheimer's disease research opened with the iden tification of the component proteins in plaques and tangles.
Systems Biology Of Alzheimer S Disease
DOWNLOAD
Author : Juan I. Castrillo
language : en
Publisher: Humana
Release Date : 2016-10-15
Systems Biology Of Alzheimer S Disease written by Juan I. Castrillo and has been published by Humana this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-10-15 with Medical categories.
Alzheimer’s disease (AD) and many other neurodegenerative disorders are multifactorial in nature, involving a combination of genomic, epigenomic, network dynamic and environmental factors. A proper investigation requires new integrative Systems Biology approaches, at both the experimental and computational level. The interplay of disease mechanisms and homeostatic networks will underlie the time of onset and rate of progression of the disease. This book addresses such an integrated approach to AD. It aims to present Systems Biology, including both experimental and computational approaches, as a new strategy for the study of AD and other multifactorial diseases, with the hope that the results will translate into more effective diagnosis and treatment, as well as improved public health policies. Written for the highly successful Methods in Molecular Biology series, practical and cutting-edge, Systems Biology of Alzheimer’s Disease is intended for post-graduate students, post-doctoral researchers and experts in different fields with an interest in comprehensive Systems Biology strategies applicable to AD and other complex multifactorial diseases (including other neurodegenerative diseases and cancers). This book aims to complement other excellent volumes and monographs on AD that cover fundamental, physiological or medical aspects of the disease.
Molecular Pathology Of Alzheimer S Disease
DOWNLOAD
Author : Rudy Castellani
language : en
Publisher: Biota Publishing
Release Date : 2013-10-01
Molecular Pathology Of Alzheimer S Disease written by Rudy Castellani and has been published by Biota Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-10-01 with Health & Fitness categories.
Alzheimer’s Disease is characterized pathologically by two principal hallmark lesions: the senile plaque and the neurofibrillary tangle. Since the identification of each over 100 years ago, the major protein components have been elucidated. This has led in turn to the elaboration of metabolic cascades involving amyloid-β production in the case of the senile plaque, and phosphorylated-tau protein in the case of the neurofibrillary tangle. The pathogenesis and histogenesis of each have been the source of extensive investigation and some controversy in recent years, as both cascades have been implicated in the pathogenesis of Alzheimer’s Disease, relied upon in the diagnostic criteria for Alzheimer’s Disease at autopsy, and targeted for therapeutic intervention. With the accumulation of data and expansion of knowledge of the molecular biology of Alzheimer’s Disease, it appears that the enthusiasm for successful intervention has been premature. In this book, we detail the discovery and characterization of the major pathological lesions, their associated molecular biology, their relationship to clinical disease, and potential fundamental errors in understanding that may be leading scientific investigators in unintended directions.
Biological Diagnostic And Therapeutic Advances In Alzheimer S Disease
DOWNLOAD
Author : Ghulam Md Ashraf
language : en
Publisher: Springer Nature
Release Date : 2019-10-11
Biological Diagnostic And Therapeutic Advances In Alzheimer S Disease written by Ghulam Md Ashraf and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-10-11 with Medical categories.
This book discusses the latest research into the highly prevalent neurodevelopmental disease most commonly associated with aging: Alzheimer’s disease (AD). Even after years of research, Alzheimer’s disease is still far from being cured. It presents a range of common symptoms in the form of behavioral and cognitive impairments. This book describes the symptoms and the biology behind them. The contents covers latest findings on the genetics involved and various factors and pathways influencing disease development. It also covers various non-pharmacological therapies like immunotherapy, use of natural products, and employing nanotechnology in both the detection and treatment of AD. This book also highlights the role of diet and nutrition in healthy aging. Given its scope, it offers a valuable asset for researchers and clinicians alike.
Concepts Of Alzheimer Disease
DOWNLOAD
Author : Peter J. Whitehouse
language : en
Publisher: JHU Press
Release Date : 2003-05-27
Concepts Of Alzheimer Disease written by Peter J. Whitehouse and has been published by JHU Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-05-27 with Health & Fitness categories.
As the essays in this volume show, conceptualizing dementia has always been a complex process. With contributions from noted professionals in psychiatry, neurology, molecular biology, sociology, history, ethics, and health policy, Concepts of Alzheimer Disease looks at the ways in which Alzheimer disease has been defined in various historical and cultural contexts. The book covers every major development in the field, from the first case described by Alois Alzheimer in 1907 through groundbreaking work on the genetics of the disease. Essays examine not only the prominent role that biomedical and clinical researchers have played in defining Alzheimer disease, but also the ways in which the perspectives of patients, their caregivers, and the broader public have shaped concepts.