The Experimental Animal In Biomedical Research
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The Experimental Animal In Biomedical Research
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Author : Bernard E. Rollin
language : en
Publisher: CRC Press
Release Date : 1990-08-27
The Experimental Animal In Biomedical Research written by Bernard E. Rollin and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1990-08-27 with Medical categories.
The Experimental Animal in Biomedical Research provides a concise, useful survey of knowledge regarding laboratory animal care. Volume I addresses researchers who use animals and focuses on how to maximize the welfare of animals used in research.
The Experimental Animal In Biomedical Research
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Author : Bernard E. Rollin
language : en
Publisher: CRC Press
Release Date : 1995-03-13
The Experimental Animal In Biomedical Research written by Bernard E. Rollin and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995-03-13 with Medical categories.
This volume focuses on considerations that maximize both scientific benefit and animal well-being for major species of animals used in biomedical research. Each species is discussed in terms of uses in research; basic biology; husbandry requirements; proper handling; disease control; anesthesia, analgesia, and stress control; natural behavior, behavioral needs, psychological needs, and social needs; and ideal environment for the animals. This book is a must for anyone working with experimental animals.
Use Of Laboratory Animals In Biomedical And Behavioral Research
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Author : National Research Council
language : en
Publisher: National Academies Press
Release Date : 1988-02-01
Use Of Laboratory Animals In Biomedical And Behavioral Research written by National Research Council and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1988-02-01 with Science categories.
Scientific experiments using animals have contributed significantly to the improvement of human health. Animal experiments were crucial to the conquest of polio, for example, and they will undoubtedly be one of the keystones in AIDS research. However, some persons believe that the cost to the animals is often high. Authored by a committee of experts from various fields, this book discusses the benefits that have resulted from animal research, the scope of animal research today, the concerns of advocates of animal welfare, and the prospects for finding alternatives to animal use. The authors conclude with specific recommendations for more consistent government action.
The Design Of Animal Experiments
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Author : Michael Festing
language : en
Publisher: SAGE Publications Limited
Release Date : 2016-12-14
The Design Of Animal Experiments written by Michael Festing and has been published by SAGE Publications Limited this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-12-14 with Science categories.
Where there is no alternative to the use of animals in biomedical research, it is important that experiments are well designed and correctly analysed in order to minimise pain and maximize the chance of getting scientifically valid results. Experiments that use too few animals may fail to pick up biologically important effects, while those who use them incorrectly or wastefully may get invalid results while subjecting the animals to unnecessary pain, distress or lasting harm. The Design of Animal Experiments is intended for all research scientists who use laboratory animals, with the aim of helping them to design their own experiments more effectively and/or to improve their ability to communicate with professional statisticians when necessary. It covers all randomised controlled experimental designs likely to be needed in laboratory animal research, with worked examples showing how they can be statistically analysed. It suggests the more widespread use of randomised block designs and shows how both males and females can be included in an experiment without the need to increase the total number of animals by using factorial designs. It also includes guidance on the choice of experimental animals. The book covers the learning outcomes of Module 10 and part (ii) of Module 11 of education and training under Directive 2010/63/EU.
Using Animal Models In Biomedical Research
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Author : Pierce K. H. Chow
language : en
Publisher: World Scientific
Release Date : 2008
Using Animal Models In Biomedical Research written by Pierce K. H. Chow and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with Medical categories.
Ch. 1. Scientific considerations and choice of species. ch. 1.1. The rationale for the use of animal models in biomedical research / Pierce Chow. ch. 1.2. Experimental animal models in biomedical resarch / Robert Ng. ch. 1.3. Nonhuman primates as models in biomedical research / Jason Vilano and Bryan Ogden -- ch. 2. Regulatory considerations in the use of animal models. ch. 2.1. Laws, regulations and guidelines for biomedical research in Singapore / Boon Theng Kuah. ch. 2.2. The functions of the institutional animal care and use committee / Pierce Chow. ch. 2.3. Responsibilities of principal investigators and research protocol evaluation / Hock Soo Ong. ch. 2.4. The 3R's, research variables and the use of alternatives / Hock Soo Ong. ch. 2.5. Use of statistics as determinant for number of animals used / Huihua Li. ch. 2.6. The advantages of accreditation with AAALAC / Bryan Ogden -- ch. 3. Animal handling and surgical procedures. ch. 3.1. General handling, restraint, oral dosing/gavage and injections in laboratory animals / Bryan Ogden. ch. 3.2. Blood collection from laboratory animals / Jason Villano. ch. 3.3. Antibiotic coverage and therapy / Darvi Sergio. ch. 3.4. Animal preparation and transport / Robert Ng. ch. 3.5. Preparation and implementation of animal surgery / Robert Ng. ch. 3.6. Animal intubation / Robert Ng. ch. 3.7. Anaesthesia and maintenance of homeostasis / Robert Ng. ch. 3.8. Animal euthanasia / Darvi Sergio. ch. 3.9. Rodent sentinel programme / Peik Khin Tan -- ch. 4. Basic animal investigative methods. ch. 4.1. Bioimaging in animals / David Ng [und weitere]. ch. 4.2. Histology sampling and techniques / In Chin Song. ch. 4.3. Animal tissue perfusion and preservation / Robert Ng. ch. 4.4. Animal cell culture / Kai Zhang and Peggy Yong. ch. 4.5. Application of microsurgical techniques in animal research / Bien Keem Tan [und weitere] -- ch. 5. Animal welfare considerations. ch. 5.1. Species specific caging configuration and design / Cindy Phua. ch. 5.2. Postoperative care and pain management / Jason Villano. ch. 5.3. Animal feeds and nutritional requirements / Peik Khin Tan -- ch. 6. Safety management of an animal facility. ch. 6.1. Occupational health and safety programme / Angela Goh. ch. 6.2. New employee and external users orientation / Inria Kurniawan Then. ch. 6.3. Radiation safety awareness in animal research / S. Somanesan. ch. 6.4. Emergency crisis management / Irene Kee. ch. 6.5. Zoonoses and laboratory animal allergies / Jason Villano -- ch. 7. Supporting facilities design. ch. 7.1. Clinical skills laboratory / Robert Ng. ch. 7.2. Animal research supporting laboratories / Robert Ng. ch. 7.3. Animal research and housing facilities / Robert Ng -- ch. 8. The development of comprehensive animal facilities in Singapore. ch. 8.1. History of the Department of Experimental Surgery as a reflection of translational research development in Singapore / Robert Ng
Fundamentals Of Laboratory Animal Science
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Author : Enqi Liu
language : en
Publisher: CRC Press
Release Date : 2017-07-28
Fundamentals Of Laboratory Animal Science written by Enqi Liu and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-07-28 with Medical categories.
Laboratory animals are becoming increasingly important for biomedical research. It is said that approximately 70% of biomedical research is associated with the use of experimental animals. Laboratory animal research not only expands our knowledge of science, but also greatly improves human and animal health. The field of laboratory animal science is ever-growing and changing as new experimental techniques are developed and new animal models are created. It is essential to know not only the biological features of each laboratory animal but also how to use and care for them responsibly in order to perform high-quality experiments. Courses in beginning Laboratory Animal Science are starting to be offered in many universities throughout the world. However, a practical introductory textbook that contains state-of-the-art techniques is still lacking. Fundamentals of Laboratory Animal Science provides comprehensive information on the principles and practices of using laboratory animals for biomedical research. Each individual chapter focuses on a key sub-discipline of laboratory animal science: animal welfare and best humane care practices in the laboratory; the quality control of laboratory animals; the anatomy, physiology, and husbandry of commonly used species; the principles of creating and using animal models for studying human diseases; practical techniques used for laboratory animal experiments; experimental design; and animal experimentation management. Knowledge of this broad spectrum of concepts and skills will ensure research goes smoothly while greatly reducing animal pain and distress. Well-illustrated and thoroughly referenced, this book will serve not only as a standard textbook but also as a handy guide for veterinarians, researchers, animal care staff, administrators, and other professionals who are involved in laboratory animal science.
The Importance Of Animal Experimentation For Safety And Biomedical Research
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Author : S. Garattini
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
The Importance Of Animal Experimentation For Safety And Biomedical Research written by S. Garattini and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Scientists are coming under increasing pressure from activist groups to stop animal experimentation, branded as cruel and unnecessary for improving human health. This attitude, however, stems from an unrealistic evaluation of the situation and distorted information about present scientific knowledge. There is no question that most medical progress - perhaps all, in fac- has been attained through knowledge derived initially from experiments in various animal species. There is practically no way of replacing animals in these investigations and so-called 'alternative methods' are in reality merely complementary. Tissue cultures, cell, microorganisms, enzymes, membranes, mathematical models - all are useful for preliminary screening tests and for testing hypotheses, but the complexity of a living organism is such that in vivo studies are essential before any test can responsibly be made in man. This book presents the proceedings of an international symposium organized in Strasbourg (October 24-25, 1988), with the aim of assessing present-day requirements as regards animal experimentation in research related to major medical and toxicological problems still awaiting solutions.
Why Animal Experimentation Matters
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Author : Ellen Frankel Paul
language : en
Publisher: Transaction Publishers
Release Date :
Why Animal Experimentation Matters written by Ellen Frankel Paul and has been published by Transaction Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on with Nature categories.
Animal experimentation has made a crucial contribution to many of the most important advances in modern medicine. The development of vaccines for deadly viruses like rabies and yellow fever depended upon animal research, and much of our basic knowledge about human health and physiology was discovered through the use of animals as well. Inspite of these gains, animal rights activists have been zealous in communicating to the public and policymakers their view that the use of animals in medical research is morally wrong and should be severely curtailed or eliminated. The activists' arguments draw upon a range of disciplines and focus on both practical and ethical aspects of animal experimentation. Advocates of animal experimentation have been slow to respond to these arguments. Given that the worldwide toll of communicable diseases is still immense--and that deadly new pathogens may emerge at any time in the future to menace human health--failing to defend animal experimentation from the arguments of its opponents has disastrous implications. A quick response to an unanticipated threat on the order of the AIDS epidemic is unimaginable absent a vigorous research establishment, which in turn is dependent on animal proxies. Why Animal Experimentation Matters is a first attempt by research scientists and moral philosophers to mount a convincing defense against animal rights enthusiasts. Because opponents of animal experimentation come from a variety of intellectual backgrounds, this defense is necessarily interdisciplinary as well. In this collection of eight essays, the authors scrutinize how animal experimentation actually functions in the laboratory, the vital role that it plays in palliating and eradicating human and animal diseases, and the moral justification for sacrificing animals for the betterment of human life. The subjects covered in the essays include the moral status of animals and persons, the importance of animals for advancing scientific knowledge, the history of animal experimentation (and of its detractors), differing theoretical approaches of American and European animal-experimentation regulations, the heavily restrictive legislation promoted by animal rights activists, and the threats posed to research and researchers by violent animal rights zealots. Contributors include Baruch Brody, H. Tristram Englehardt, Jr., R. G. Frey, Kenneth F. Kiple and Kriemhild Cone Ornelas, Adrian R. Morrison, Charles S. Nicoll and Sharon M. Russell, Jerrold Tannenbaum, and Stuart M. Zola. This important anthology will be of interest to scientists, philosophers, individuals suffering from heritable or communicable diseases, relatives of afflicted individuals, and policymakers. Ellen Frankel Paul is deputy director of the Social Philosophy and Policy Center, professor of political science and philosophy at Bowling Green State University, and editor-in-chief of the journal Social Philosophy & Policy. Fred D. Miller, Jr., and Jeffrey Paul are, respectively, the executive director and associate director of the Social Philosophy and Policy Center; both are professors of philosophy at Bowling Green State University.
Science Medicine And Animals
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Author : National Research Council
language : en
Publisher: National Academies Press
Release Date : 2004-11-21
Science Medicine And Animals written by National Research Council and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-11-21 with Science categories.
Science, Medicine, and Animals explains the role that animals play in biomedical research and the ways in which scientists, governments, and citizens have tried to balance the experimental use of animals with a concern for all living creatures. An accompanying Teacher's Guide is available to help teachers of middle and high school students use Science, Medicine, and Animals in the classroom. As students examine the issues in Science, Medicine, and Animals, they will gain a greater understanding of the goals of biomedical research and the real-world practice of the scientific method in general. Science, Medicine, and Animals and the Teacher's Guide were written by the Institute for Laboratory Animal Research and published by the National Research Council of the National Academies. The report was reviewed by a committee made up of experts and scholars with diverse perspectives, including members of the U.S. Department of Agriculture, National Institutes of Health, the Humane Society of the United States, and the American Society for the Prevention of Cruelty to Animals. The Teacher's Guide was reviewed by members of the National Academies' Teacher Associates Network. Science, Medicine, and Animals is recommended by the National Science Teacher's Association.
The Importance Of Laboratory Animal Genetics Health And The Environment In Biomedical Research
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Author : Edward C. Jr. Melby
language : en
Publisher: Elsevier
Release Date : 2012-12-02
The Importance Of Laboratory Animal Genetics Health And The Environment In Biomedical Research written by Edward C. Jr. Melby and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-02 with Medical categories.
The Importance of Laboratory Animal Genetics, Health, and the Environment in Biomedical Research documents the proceedings of the Fifth Charles River International Symposium on Laboratory Animals, in Heidelberg, Federal Republic of Germany, March 14-16, 1983. These papers examine how the health and genetic monitoring of laboratory animals, coupled with environmental influences, affect the investigations of oncologists, toxicologists, or pharmacologists. The book is organized into four parts. Part I focuses on the health monitoring of laboratory animals for biomedical research. It includes studies on the effects of health and health monitoring in toxicology studies, oncology studies, and pharmacologic studies. Part II deals with the genetic monitoring of laboratory animals. It examines the causes of genetic alternation in laboratory animals and ways to prevent them. Part III considers the environmental monitoring that is necessary for research on laboratory animals. Part IV on new research frontiers includes studies on the production of monoclonal antibodies for the experimental and therapeutic modulation of laboratory animals, and the quality control aspects of animal experimentation.