The Genetics Of Aging
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The Genetics Of Aging
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Author : Edward Schneider
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-11-11
The Genetics Of Aging written by Edward Schneider and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-11 with Psychology categories.
The Genetics of Aging is divided into several sections in an attempt to provide a logical progression from the level of the genome to the realm of human genetics. The relationship between the genetic material and aging will be thoroughly explored in the initial chapters. These chapters discuss in depth the various theories that have been proposed for the mechanisms of aging at the molecular level and present data which either support or contradict these hypotheses. Subsequent chapters will deal with the genetics of aging in organisms ranging from paramecium to mammals. The largest section of this volume will be devoted to several important areas in human genetics: human genetic disorders which feature premature aging, the effect of human parental aging on the production of genetically abnor mal offspring, the genetics of human longevity, and a review of studies on aging human twins. Over the last few decades genetic technology has provided enormous insight into a number of disciplines. Therefore, in the last few chapters, several genetic approaches to the study of aging are discussed: somatic cell genetics, immunogenetics, and behavioral genetics. As the goal of this volume is to present a comprehensive examination of the genetics of aging, most chapters are oriented toward general review of their respective areas. It is my hope that this volume will encourage clinical, biological, and behavioral investigators to turn their attention to the genetic aspects of aging as well as to employ genetic technology to obtain further insight into aging processes.
The Molecular Genetics Of Aging
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Author : Siegfried Hekimi
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
The Molecular Genetics Of Aging written by Siegfried Hekimi and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
The molecular genetics of aging or life-span determination is an expanding field. One reason is because many people would consider it desirable if hu man life span could be extended. Indeed, it is difficult not to be fascinated by tales of the life and death of people who have succeeded in living a very long life. Because of this, we have placed at the head of this book the chapter by Perls et al. on Centenerians and the Genetics of Longevity. Perls and his coauthors convincingly argue that, while the average life expectancy might be mostly determined by environmental factors because the average person has an average genotype, extremely long life spans are genetically determined. Of course, studying humans to uncover the genetics of aging is not ideal, not so much because one cannot easily perform experiments as because they live such a long time. This is why most of this book describes the current state of research with model organisms such as yeast, worms, flies, and mice. J aswinski focuses on yeast and how metabolic activity and stress resistance affect the longevity of Saccharomyces cerevisiae. In the process, he discusses the concept of aging as applied to a unicellular organism such as yeast and the importance of metabolism and stress resistance for aging in all organisms.
Handbook Of The Biology Of Aging
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Author : Nicolas Musi
language : en
Publisher: Academic Press
Release Date : 2015-08-20
Handbook Of The Biology Of Aging written by Nicolas Musi and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-08-20 with Medical categories.
Handbook of the Biology of Aging, Eighth Edition, provides readers with an update on the rapid progress in the research of aging. It is a comprehensive synthesis and review of the latest and most important advances and themes in modern biogerontology, and focuses on the trend of 'big data' approaches in the biological sciences, presenting new strategies to analyze, interpret, and understand the enormous amounts of information being generated through DNA sequencing, transcriptomic, proteomic, and the metabolomics methodologies applied to aging related problems. The book includes discussions on longevity pathways and interventions that modulate aging, innovative new tools that facilitate systems-level approaches to aging research, the mTOR pathway and its importance in age-related phenotypes, new strategies to pharmacologically modulate the mTOR pathway to delay aging, the importance of sirtuins and the hypoxic response in aging, and how various pathways interact within the context of aging as a complex genetic trait, amongst others. - Covers the key areas in biological gerontology research in one volume, with an 80% update from the previous edition - Edited by Matt Kaeberlein and George Martin, highly respected voices and researchers within the biology of aging discipline - Assists basic researchers in keeping abreast of research and clinical findings outside their subdiscipline - Presents information that will help medical, behavioral, and social gerontologists in understanding what basic scientists and clinicians are discovering - New chapters on genetics, evolutionary biology, bone aging, and epigenetic control - Provides a close examination of the diverse research being conducted today in the study of the biology of aging, detailing recent breakthroughs and potential new directions
Epigenetics Of Aging
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Author : Trygve O. Tollefsbol
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-11-11
Epigenetics Of Aging written by Trygve O. Tollefsbol and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-11-11 with Medical categories.
Recent studies have indicated that epigenetic processes may play a major role in both cellular and organismal aging. These epigenetic processes include not only DNA methylation and histone modifications, but also extend to many other epigenetic mediators such as the polycomb group proteins, chromosomal position effects, and noncoding RNA. The topics of this book range from fundamental changes in DNA methylation in aging to the most recent research on intervention into epigenetic modifications to modulate the aging process. The major topics of epigenetics and aging covered in this book are: 1) DNA methylation and histone modifications in aging; 2) Other epigenetic processes and aging; 3) Impact of epigenetics on aging; 4) Epigenetics of age-related diseases; 5) Epigenetic interventions and aging: and 6) Future directions in epigenetic aging research. The most studied of epigenetic processes, DNA methylation, has been associated with cellular aging and aging of organisms for many years. It is now apparent that both global and gene-specific alterations occur not only in DNA methylation during aging, but also in several histone alterations. Many epigenetic alterations can have an impact on aging processes such as stem cell aging, control of telomerase, modifications of telomeres, and epigenetic drift can impact the aging process as evident in the recent studies of aging monozygotic twins. Numerous age-related diseases are affected by epigenetic mechanisms. For example, recent studies have shown that DNA methylation is altered in Alzheimer’s disease and autoimmunity. Other prevalent diseases that have been associated with age-related epigenetic changes include cancer and diabetes. Paternal age and epigenetic changes appear to have an effect on schizophrenia and epigenetic silencing has been associated with several of the progeroid syndromes of premature aging. Moreover, the impact of dietary or drug intervention into epigenetic processes as they affect normal aging or age-related diseases is becoming increasingly feasible.
An Introduction To Gerontology
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Author : Ian Stuart-Hamilton
language : en
Publisher: Cambridge University Press
Release Date : 2011-03-31
An Introduction To Gerontology written by Ian Stuart-Hamilton and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-03-31 with Psychology categories.
With the world's population getting increasingly older, there has never been a more pressing need for the study of old age and ageing. An Introduction to Gerontology provides a wide-ranging introduction to this important topic. By assuming no prior expert knowledge and avoiding jargon, this book will guide students through all the main subjects in gerontology, covering both traditional areas, such as biological and social ageing, and more contemporary areas, such as technology, the arts and sexuality. An Introduction to Gerontology is written by a team of international authors with multidisciplinary backgrounds who draw evidence from a variety of different perspectives and traditions.
Aging At The Molecular Level
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Author : Thomas von Zglinicki
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-06-29
Aging At The Molecular Level written by Thomas von Zglinicki and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-29 with Science categories.
During the last 40 years, the study of the biological basis of aging has progressed tremendously, and it has now become an independent and respectable field of study and research. The essential cause of aging is molecular damage that slowly overwhelms cellular and organismic defense, repair and maintenance systems. In recent years, a wealth of highly sophisticated research has transformed this idea from a credible hypothesis not only to a major theory, but essentially to accepted knowledge. Aging at the Molecular Level examines the key elements in this transformation. Bringing together contributions from an international team of authors, this volume will be of interest to graduates and postgraduates in the fields of medicine and nursing, researchers of different aspects of biogerontology and those in the pharmaceutical, cosmeceutical, nutraceutical and health-care industry.
Lifespan
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Author : David A. Sinclair
language : en
Publisher: Simon and Schuster
Release Date : 2019-09-10
Lifespan written by David A. Sinclair and has been published by Simon and Schuster this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-09-10 with Science categories.
A NEW YORK TIMES BESTSELLER “Brilliant and enthralling.” —The Wall Street Journal A paradigm-shifting book from an acclaimed Harvard Medical School scientist and one of Time’s most influential people. It’s a seemingly undeniable truth that aging is inevitable. But what if everything we’ve been taught to believe about aging is wrong? What if we could choose our lifespan? In this groundbreaking book, Dr. David Sinclair, leading world authority on genetics and longevity, reveals a bold new theory for why we age. As he writes: “Aging is a disease, and that disease is treatable.” This eye-opening and provocative work takes us to the frontlines of research that is pushing the boundaries on our perceived scientific limitations, revealing incredible breakthroughs—many from Dr. David Sinclair’s own lab at Harvard—that demonstrate how we can slow down, or even reverse, aging. The key is activating newly discovered vitality genes, the descendants of an ancient genetic survival circuit that is both the cause of aging and the key to reversing it. Recent experiments in genetic reprogramming suggest that in the near future we may not just be able to feel younger, but actually become younger. Through a page-turning narrative, Dr. Sinclair invites you into the process of scientific discovery and reveals the emerging technologies and simple lifestyle changes—such as intermittent fasting, cold exposure, exercising with the right intensity, and eating less meat—that have been shown to help us live younger and healthier for longer. At once a roadmap for taking charge of our own health destiny and a bold new vision for the future of humankind, Lifespan will forever change the way we think about why we age and what we can do about it.
The Epidemiology Of Aging
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Author : Anne Newman
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-12
The Epidemiology Of Aging written by Anne Newman and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-12 with Medical categories.
The average age of the world’s population is increasing at an unprecedented rate and this increase is changing the world. This “Silver tsunami” emphasizes the need to provide advanced training in epidemiology and increase the cadre of experts in the study of aging. This book is designed to summarize unique methodological issues relevant to the study of aging, biomarkers of aging and the biology/physiology of aging and in-depth discussions of the etiology and epidemiology of common geriatric syndromes and diseases. Contributing authors in the book represent many disciplines, not only epidemiology and clinical geriatrics, but also demography, health services, research, cardiovascular disease, diabetes, psychiatry, neurology, social services, musculoskeletal diseases and cancer. The aim of the book is to provide a broad multidisciplinary background for any student/researcher interested in aging. The material in the book is organized and comprehensive. It represents the most up-to-date information on the scientific issues in aging research written by academics who specialize in research and training in the broad field of aging. The structure and organization of the book reflects our course series in the Epidemiology of Aging starting with the broad issues of demography and methodology, and then addressing specific health conditions and geriatric conditions common to older persons.
Between Zeus And The Salmon
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Author : Caleb E. Finch
language : en
Publisher:
Release Date : 1997-10-29
Between Zeus And The Salmon written by Caleb E. Finch and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997-10-29 with Health & Fitness categories.
Demographers and public health specialists have been surprised by the rapid increases in life expectancy, especially at the oldest ages, that have occurred since the early 1960s. Some scientists are calling into question the idea of a fixed upper limit for the human life span. There is new evidence about the genetic bases for both humans and other species. There are also new theories and models of the role of mutations accumulating over the life span and the possible evolutionary advantages of survival after the reproductive years. This volume deals with such diverse topics as the role of the elderly in other species and among human societies past and present, the contribution of evolutionary theory to our understanding of human longevity and intergenerational transfers, mathematical models for survival, and the potential for collecting genetic material in household surveys. It will be particularly valuable for promoting communication between the social and life sciences.
Human Aging
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Author : Calogero Caruso
language : en
Publisher: Elsevier
Release Date : 2021-05-13
Human Aging written by Calogero Caruso and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-05-13 with Medical categories.
Intro -- Human Aging: From Cellular Mechanisms to Therapeutic Strategies -- Copyright -- Contents -- Contributors -- About the editors -- Preface -- Chapter 1: Aging and longevity: An evolutionary approach -- 1.1. Introduction -- 1.2. Why does aging occur? -- 1.3. Mechanisms of aging -- 1.4. Causality and chance in aging and longevity -- 1.5. Conclusions and future perspectives -- References -- Chapter 2: Demographic aspects of aging -- 2.1. Introduction -- 2.2. Understanding the process: Browsing around the demographic transition theories -- 2.3. Aging inequalities -- 2.3.1. Differences by gender, education, and cause of death -- 2.3.2. Does having a longer life also mean having a better life? -- 2.3.3. Economics of population aging -- 2.4. Conclusions and perspectives -- References -- Chapter 3: Pathobiology of aging: An introduction to age-related diseases -- 3.1. Introduction -- 3.2. Complexity -- 3.3. Hallmarks of aging -- 3.4. Genomic instability -- 3.5. Epigenetic alteration -- 3.6. Deregulated nutrient sensing pathways -- 3.6.1. FOXO3 -- 3.6.2. Insulin/IGF-1 pathway -- 3.6.3. mTOR pathway -- 3.6.4. Sirtuin pathway -- 3.6.5. Autophagy -- 3.7. Loss of proteostasis -- 3.8. Mitochondrial dysfunction -- 3.9. Telomere attrition -- 3.10. Cellular senescence -- 3.11. Stem cell exhaustion -- 3.12. Altered intercellular communication -- 3.13. Cancer and aging -- 3.14. Conclusion and future perspectives -- References -- Chapter 4: Cellular senescence and senescence-associated secretory phenotype (SASP) in aging process -- 4.1. Introduction -- 4.2. Signaling pathway stimulating the appearance of SASP -- 4.3. SASP components -- 4.4. MiRNA and extracellular vesicles as new regulators and components of SASP -- 4.5. SASP profile in different cell types -- 4.6. Cellular senescence, SASP, and aging -- 4.7. Conclusions and future perspectives -- References.