The Molecular Genetics Of Aging
DOWNLOAD
Download The Molecular Genetics Of Aging PDF/ePub or read online books in Mobi eBooks. Click Download or Read Online button to get The Molecular Genetics Of Aging book now. This website allows unlimited access to, at the time of writing, more than 1.5 million titles, including hundreds of thousands of titles in various foreign languages. If the content not found or just blank you must refresh this page
The Molecular Genetics Of Aging
DOWNLOAD
Author : Siegfried Hekimi
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
The Molecular Genetics Of Aging written by Siegfried Hekimi and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
The molecular genetics of aging or life-span determination is an expanding field. One reason is because many people would consider it desirable if hu man life span could be extended. Indeed, it is difficult not to be fascinated by tales of the life and death of people who have succeeded in living a very long life. Because of this, we have placed at the head of this book the chapter by Perls et al. on Centenerians and the Genetics of Longevity. Perls and his coauthors convincingly argue that, while the average life expectancy might be mostly determined by environmental factors because the average person has an average genotype, extremely long life spans are genetically determined. Of course, studying humans to uncover the genetics of aging is not ideal, not so much because one cannot easily perform experiments as because they live such a long time. This is why most of this book describes the current state of research with model organisms such as yeast, worms, flies, and mice. J aswinski focuses on yeast and how metabolic activity and stress resistance affect the longevity of Saccharomyces cerevisiae. In the process, he discusses the concept of aging as applied to a unicellular organism such as yeast and the importance of metabolism and stress resistance for aging in all organisms.
Molecular Biology Of Aging
DOWNLOAD
Author : Leonard Guarente
language : en
Publisher: CSHL Press
Release Date : 2008
Molecular Biology Of Aging written by Leonard Guarente and has been published by CSHL Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with Aging categories.
This volume covers the major threads in the molecular genetics of aging, including genes that regulate aging, causes of aging, evolutionary theories of aging, and the relationship between diet and aging. Among specific topics covered are calorie restriction, mitochondria, sirtuins, telomeres, stem cells, and cancer.
Molecular Genetic Mechanisms In Development And Aging
DOWNLOAD
Author : Morris Rockstein
language : en
Publisher: Elsevier
Release Date : 2012-12-02
Molecular Genetic Mechanisms In Development And Aging written by Morris Rockstein and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-02 with Nature categories.
Molecular Genetic Mechanisms in Development and Aging discusses the mechanisms of aging at the level of the genome. This book explores the fundamental knowledge concerning the regulation and expression of gene, which is derived from investigations on microbial organisms. Organized into nine chapters, this book starts with an overview of the molecular genetic basis for the processes of aging. This text then explores the highly complex multicellular members of the class Insecta, which provide the researcher with many distinct and unique advantages for aging studies. Other chapters discuss the mechanisms of genetic control and organization during the development and aging of eukaryotes, which pose some challenging problems in cellular and developmental biology. The final chapter deals with the limitations of previous studies, including the lack of comparability due to differences in techniques, the measuring of free amino acid titers in hemolyph only, and differing diet and environmental variations. Biologists and students interested in developmental and molecular genetics will find this book useful.
The Genetics Of Aging
DOWNLOAD
Author : Edward Schneider
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-11-11
The Genetics Of Aging written by Edward Schneider and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-11 with Psychology categories.
The Genetics of Aging is divided into several sections in an attempt to provide a logical progression from the level of the genome to the realm of human genetics. The relationship between the genetic material and aging will be thoroughly explored in the initial chapters. These chapters discuss in depth the various theories that have been proposed for the mechanisms of aging at the molecular level and present data which either support or contradict these hypotheses. Subsequent chapters will deal with the genetics of aging in organisms ranging from paramecium to mammals. The largest section of this volume will be devoted to several important areas in human genetics: human genetic disorders which feature premature aging, the effect of human parental aging on the production of genetically abnor mal offspring, the genetics of human longevity, and a review of studies on aging human twins. Over the last few decades genetic technology has provided enormous insight into a number of disciplines. Therefore, in the last few chapters, several genetic approaches to the study of aging are discussed: somatic cell genetics, immunogenetics, and behavioral genetics. As the goal of this volume is to present a comprehensive examination of the genetics of aging, most chapters are oriented toward general review of their respective areas. It is my hope that this volume will encourage clinical, biological, and behavioral investigators to turn their attention to the genetic aspects of aging as well as to employ genetic technology to obtain further insight into aging processes.
Molecular Basis Of Aging
DOWNLOAD
Author : A Roy
language : en
Publisher: Elsevier
Release Date : 2012-12-02
Molecular Basis Of Aging written by A Roy and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-02 with Science categories.
Molecular Basis of Aging is a collection of papers that discuss the molecular aspects of aging in the light of molecular biology, biochemical gerontology, and genetics. Each chapter of the book contains a different study about the topic, which includes the effects of aging on DNA synthesis; the amplification of extrachromosomal circular copies and mitochondrial DNA during aging; and the altered actions of hormones and neurotransmitters during aging. The book also encompasses the loss of responsiveness to growth factors in cell senescence; the integration of cellular-molecular and neuroendocrine concepts of aging; changes and inactivation of enzymes during aging; and the relationship of aging with free radicals. The text is recommended for molecular biologists, biochemists, and gerontologists who wish to study further the effects of aging on the body on a molecular level.
Genes And Aging
DOWNLOAD
Author : M. S. Kanungo
language : en
Publisher: Cambridge University Press
Release Date : 1994-03-25
Genes And Aging written by M. S. Kanungo and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994-03-25 with Science categories.
This book reviews the molecular biology of the gene in relation to aging. The author presents basic information on eukaryotic genes and follows this with details of the changes that occur in their structure and function during aging. He reviews the latest studies being carried out in various laboratories, outlines the gaps and deficiencies in our present knowledge, and suggests the most profitable future areas of research.
Aging At The Molecular Level
DOWNLOAD
Author : Thomas von Zglinicki
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-06-29
Aging At The Molecular Level written by Thomas von Zglinicki and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-29 with Science categories.
During the last 40 years, the study of the biological basis of aging has progressed tremendously, and it has now become an independent and respectable field of study and research. The essential cause of aging is molecular damage that slowly overwhelms cellular and organismic defense, repair and maintenance systems. In recent years, a wealth of highly sophisticated research has transformed this idea from a credible hypothesis not only to a major theory, but essentially to accepted knowledge. Aging at the Molecular Level examines the key elements in this transformation. Bringing together contributions from an international team of authors, this volume will be of interest to graduates and postgraduates in the fields of medicine and nursing, researchers of different aspects of biogerontology and those in the pharmaceutical, cosmeceutical, nutraceutical and health-care industry.
Genetics And Evolution Of Aging
DOWNLOAD
Author : Michael R. Rose
language : en
Publisher: Springer
Release Date : 1994-09-30
Genetics And Evolution Of Aging written by Michael R. Rose and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994-09-30 with Family & Relationships categories.
The study of aging has recently been transformed by the application of tools and ideas from genetics and evolution. This development began in 1980, and has since been gathering momentum. The present volume collects most of the principles contributing to this new direction in aging research. Additionally the book incorporates elements from both molecular genetics and evolutionary genetics, uniting two divergent strategies in the study of aging. Some of the book's articles are more molecular, and some are more evolutionary in their orientation, some contributions combine both approaches in a way that has rarely been seen. The book will thus be of broad interest through all `levels' of biology, from molecular biology to evolutionary biology. The phylogenetic diversity covered by the articles is also fairly great: from yeast to plants, nematodes to Drosophila, and rodents to man. Nonetheless, there is a unity to the treatment, with questions like mutation-accumulation, number of loci, and the possibility of postponing aging arising repeatedly throughout the discussions of particular taxonomic groups. There are few better starting places for graduate students interested in biological aging research than this volume. It is also a convenient collection for research workers in the area, who may need to track down an important idea or result. Finally, the book as a whole provides a bracing overview of biological aging.
Abstracts Of Papers Presented At The 2008 Meeting On Molecular Genetics Of Aging September 24 28 2008
DOWNLOAD
Author :
language : en
Publisher: Cold Spring Harbor Laboratory Press
Release Date : 2008
Abstracts Of Papers Presented At The 2008 Meeting On Molecular Genetics Of Aging September 24 28 2008 written by and has been published by Cold Spring Harbor Laboratory Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with Medical categories.
Biology Of Aging
DOWNLOAD
Author : Alvaro Macieira-Coelho
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Biology Of Aging written by Alvaro Macieira-Coelho and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
The survival of the human species has improved significantly in modern times. During the last century, the mean survival of human populations in developed countries has increased more than during the preceding 5000 years. This improvement in survival was accompanied by an increase in the number of active years. In other words, the increase in mean life span was accompanied by an increase in health span. This is now accentuated by progress in medicine reducing the impact of physiologic events such as menopause and of patho logical processes such as atherosclerosis. Up to now,research on aging, whether theoretical or experimental, has not contributed to improvement in human survival. Actually, there is a striking contrast between these significant modifications in survival and the present knowledge of the mechanisms of human aging. Revealed by this state of affairs are the profound disagreements between gerontologists in regard to the way oflooking at the aging process. The definition of aging itself is difficult to begin with because of the variability of how it occurs in different organisms.