The Interleukin Revolution

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The Interleukin Revolution

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Author : Kendall Smith
language : en
Publisher:
Release Date : 2023-05-09

The Interleukin Revolution written by Kendall Smith and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-05-09 with categories.

The immune system has only been understood by immunologists since 1980, and most of us never had a course in immunology while in school. Trying to grasp the complexities of the dangers of Covid and the rationale of the public health policies has been daunting. This book, a memoir of Smith's first twenty years as a young scientist at Dartmouth Medical School, chronicles the revolution that has occurred in our understanding of how the immune system is regulated. This revolution has been made possible by pioneering experiments that Smith and his team accomplished in the 1970s and '80s, and by many others who have since followed their leads. The keys that unlocked the mysteries of cellular behaviors was the discovery of new molecules that direct and dictate immune responses to microbial infections. It was necessary to coin a new name for these molecules, interleukins, because they had been totally unrecognized. The most important aspect of these new molecules was the startling revelation that they function like classic hormones, and they comprise an immunoendocrine system. Like neurotransmitters in the nervous system, they convey information by interacting with receptors that appear on immune system cells. The excitement and euphoria of discovery of new knowledge in this book are unparalleled.Kendall Smith, a physician scientist for more than fifty years, is Cornell University Professor Emeritus of Medicine and Immunology at Weill Cornell Medicine in New York. He graduated from Denison University, and summa cum laude from The Ohio State College of Medicine. He then trained at Yale New Haven Hospital, The National Cancer Institute, and L'Institut de Cancerologie et d'Immunogenetique in Villejuif, France. He has published articles in more than 200 medical and scientific journals, including Nature, Science, Journal of Experimental Medicine, Proceedings of the National Academy of Sciences, Journal of Immunology, and was founding editor of Frontiers in Immunology. He is the editor of Interleukin-2, and author of The Quantal Theory of Immunity: The Molecular Basis of Autoimmunity and Leukemia, and Molecular Immunity: A Chronology of 60 Years of Discovery.

The Interleukins

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Author : Steven Gillis
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-14

The Interleukins written by Steven Gillis and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-14 with Medical categories.

Investigations of the activation, proliferation, and, in some cases, differentia tion of mononuclear cells involved in the immune response are proceeding rapidly. These studies have resulted in the discovery of several factors that promote these cellular events, some of which have been characterized biochemically to various extents. Because of the considerable interest in understanding these cellular changes at the molecular level, we chose to produce the first thematic volume for Contemporary Topics in Molecular Immunology; the theme deals with certain regulatory factors that promote proliferation and differentiation. We have com piled contributions from numerous scientists well known for their work with several regulatory factors. In the following paragraphs, the reader will find an overview of the contents of this volume. Greene and Robb review data they have generated over the past 2-3 years with respect to characterization of hormone-specific Interleukin-2 (IL-2) recep tors on the surface of activated T cells. Their chapter traces the development of a quantitative assay for assessment of IL-2 receptors based on the preparation and use of radiolabeled IL-2 prepared biosynthetically with the aid of IL-2-pro ducer leukemic cells. The authors then describe an alternate approach, the prep aration of a monoclonal antibody previously determined to be directed against a T -cell-activation antigen. This so-called anti-Tac antibody was later found to recognize a determinant on or near the IL-2 receptor.

Interleukin 2

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Author : Kendall A. Smith
language : en
Publisher:
Release Date : 1984

Interleukin 2 written by Kendall A. Smith and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1984 with categories.

A Revolution In Biotechnology

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Author : Jean L. Marx
language : en
Publisher: Cambridge University Press
Release Date : 1989-03-16

A Revolution In Biotechnology written by Jean L. Marx and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1989-03-16 with Medical categories.

Heredity, genes and DNA. Synthesis without cells. Microorganisms as producers of feedstock chemicals. Gene cloning opens up a new frontier in health. The microbial production of biochemicals. Single-cell proteins. Bacterial leaching and biomining. Bacteria and the environment. Biological nitrogen fixation. Plant cell and tissue culture. Improving crop plants by the introduction of isolated genes. Monoclonal antibodies and their applications. Site-directed antibodies in biology and medicine. New methods for the diagnosis of genetic diseases. The prospect of gene therapy for human hereditary diseases. Biotechnology, international competition and regulatory strategies.

The Optimal Health Revolution

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Author : Duke Johnson
language : en
Publisher: BenBella Books
Release Date : 2009-04-14

The Optimal Health Revolution written by Duke Johnson and has been published by BenBella Books this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-04-14 with Health & Fitness categories.

Cutting-edge science is coming to a startling realization. The bulk of our most lethal diseases have a common underlying cause: persistent inflammation, an over-active reaction of our natural immune system function resulting in cell and tissue destruction. This persistent inflammation is triggered by our industrial lifestyles, including exposure to chemicals, synthetic food ingredients, pollution and processed foods. "Researchers are linking inflammation to an ever-wider array of chronic illnesses," reports Newsweek's Anne Underwood. "Suddenly medical puzzles seem to be fitting together, such as why hypertension puts patients at increased risk of Alzheimer's, or why rheumatoid-arthritis sufferers have higher rates of sudden cardiac death. They're all connected on some fundamental level." But inflammation, and the risks of chronic diseases it brings, can be managed. Lifestyle and nutritional change is part of the answer. But the other part of the answer lies with ground-breaking information from the newest field of science—nutrigenomics. Nutrigenomics is the science of how your genes interact with nutrients. It is the study of how DNA and the genetic code affect a person's need for certain nutrients and help maintain optimal health throughout life. The Optimal Health Revolution combines leading-edge science — including 600 scientific references — with an easy to read, conversational writing style that make this critical information accessible to every reader. Relevant to both the researcher and medical doctor interested in the latest science and the casual reader looking to improve his or her health, The Optimal Health Revolution makes a critical contribution to our understanding of health.

Interleukin 6 Type Cytokines

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Author : Andrzej Mackiewicz
language : en
Publisher:
Release Date : 2006

Interleukin 6 Type Cytokines written by Andrzej Mackiewicz and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with categories.

Exploring The Biomedical Revolution

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Author : Howard Hughes Medical Institute
language : en
Publisher:
Release Date : 1999

Exploring The Biomedical Revolution written by Howard Hughes Medical Institute and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999 with Medical categories.

Over the course of more than 22 years of service with the Federal government Nathan Gjovik has seen first-hand how it uses tools like affirmative action and various preferences and set asides to award positions, promotions, and contracts. These tools are nearly all designed to serve populations who the Government has deemed to be 'disadvantaged' while Caucasian males, who the Government has apparently determined as a class to be advantaged, are relegated to whatever they are able to muster on their own, outside the Federal sector. With the increasing proportion of Federal control of the US economy these tools determine in large part economic winners and losers within the US. These tools also indirectly impact how Federal laws are promulgated and enforced by program managers, many of whom were awarded their positions based primarily on their race or gender (or other non-merit based factors), determine how to best ensure the continuance of their program as well as the manner in which it will follow, enforce, or ignore Federal law. CAPT Nathan D. Gjovik, USPHS (Ret.) This book is an accounting of Mr. Gjovik's attempts to make positive changes from within the Federal government and the Federal responses to same. It also documents some of the asinine, incompetent, and potentially criminal activities which occur routinely within the Federal sector through the eyes of one who came from the private sector.

Interleukins

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Author :
language : en
Publisher: Elsevier
Release Date : 2011-08-09

Interleukins written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-08-09 with Science categories.

First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. In the early days of the serial, the subjects of vitamins and hormones were quite distinct. The Editorial Board now reflects expertise in the field of hormone action, vitamin action, X-ray crystal structure, physiology, and enzyme mechanisms. Under the capable and qualified editorial leadership of Dr. Gerald Litwack, Vitamins and Hormones continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists, and molecular biologists. Others interested in the structure and function of biologically active molecules like hormones and vitamins will, as always, turn to this series for comprehensive reviews by leading contributors to this and related disciplines.

Neo Adjuvant Chemotherapy

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Author : Claude Jacquillat
language : en
Publisher: John Libbey Eurotext
Release Date : 1988

Neo Adjuvant Chemotherapy written by Claude Jacquillat and has been published by John Libbey Eurotext this book supported file pdf, txt, epub, kindle and other format this book has been release on 1988 with Medical categories.

This book presents the Proceedings of the Second International Congress on Neo-Adjuvant Chemotherapy which took place on 19 to 21 February 1988 in Paris.

Cytokine Storm Syndrome

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Author : Randy Q. Cron
language : en
Publisher: Springer Nature
Release Date : 2019-09-09

Cytokine Storm Syndrome written by Randy Q. Cron and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-09-09 with Medical categories.

Cytokine Storm Syndromes, including HLH and MAS, are frequently fatal disorders, particularly if not recognized early and treated during presentation. The genetics of Cytokine Storm Syndromes are being defined with many of the risk alleles giving rise to mutations in the perforin-mediated cytolytic pathway used by CD8 cytotoxic T cells and natural killer cells. These are being studied using murine models. Up to 10% of the general population may carry risk alleles for developing Cytokine Storm Syndromes, and Cytokine Storm Syndromes are being increasingly recognized around the world in pediatric and adult hospitals. A variety of infectious, rheumatic, and oncologic triggers are commonly associated with Cytokine Storm Syndromes, but understanding this disorder is critical for all researchers and physicians to ensure timely and appropriate therapy. This textbook, the first of its kind, addresses all aspects of the disorder – from genetics, pathophysiology, and ongoing research, to clinical presentations, risk factors, and treatment.