The Myostatin Project
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The Myostatin Project
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Author : G Robert Tait
language : en
Publisher: Xlibris Corporation
Release Date : 2014-08-22
The Myostatin Project written by G Robert Tait and has been published by Xlibris Corporation this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-08-22 with Fiction categories.
The Myostatin Project
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Author : G Robert Tait
language : en
Publisher: Xlibris Corporation
Release Date : 2014-08-22
The Myostatin Project written by G Robert Tait and has been published by Xlibris Corporation this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-08-22 with Fiction categories.
Julian Reichert stared in disbelief as the woman who called herself Angeline Reichert walked into the courtroom. It was as if time was moving one frame at a time; click, click, click when he watched this woman, an image from his past, walk to the plaintiff’s table and sit next to her attorneys. It was his sister Angeline, the Angeline he saw lowered into her grave more than thirty years earlier. Julian sat stunned and numb. This could not be! It was only when Gavin McGowan, the Veterinarian and friend of his father, took the witness stand that Julian learned of the bizarre chain of events that dropped this sister into his life where she would challenge his role as the heir to the Reichert empire. Conspiracy and murder, including two attempts on his own life, awaken Julian to the realization that his father has harbored a diabolical secret, a secret known only to the charismatic vet who stuns the court with his story.
Myostatin
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Author : Dolores Christensen
language : en
Publisher:
Release Date : 2016
Myostatin written by Dolores Christensen and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016 with Muscle proteins categories.
Myostatin, also known as growth and differentiation factor-8, is a member of the TGF-β family member and is mainly produced by skeletal muscle. Myostatin circulates in the serum in a latent form, whereas it acts almost exclusively on skeletal muscle. Chapter One of this book discusses the role of myostatin and related factors in muscle hypertrophy and atophy. Chapter Two concentrates on specific alterations of positive and negative regulators of muscle mass in patients with chronic kidney disease. Chapter Three examines the potential benefits of the myostatin gene polymorphisms in livestock animals. Chapter Four studies myostatin functions in fish.
Gene Doping
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Author : Katrin Gerlinger
language : en
Publisher: BoD – Books on Demand
Release Date : 2013-12-06
Gene Doping written by Katrin Gerlinger and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-12-06 with Political Science categories.
Just like a phantom, the topic of »gene doping« keeps haunting the debates regarding the future of competitive sports for years. Very often, corresponding fantasies and visions culminate in the imagination of super athletes who are permanently manipulated with regard to their genetic disposition. However, the application scenarios to be expected will be far more unspectacular, but more probable and more obvious at the same time. Very soon, we will have to expect the use of new substances as well as of methods in gene and cell therapy for targeted manipulation of gene activity. Their use promises a highly efficient performance enhancement and will be difficult to prove, if at all. This book provides comprehensive answers to the key questions of the further development: Which scientific results could cater to the needs of potential gene doping? Where are the future gateways in top-level and popular sports? And how can prohibitions and monitoring be used in responding to this? Another question will be which individual behavioural patterns of athletes and which social contexts will play a role with regard to the potential »career« of gene doping.
Genome Editing And Biological Weapons
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Author : Katherine Paris
language : en
Publisher: Springer Nature
Release Date : 2022-12-15
Genome Editing And Biological Weapons written by Katherine Paris and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-12-15 with Science categories.
This monograph introduces current genome editing technologies—clustered regularly interspaced short palindromic repeat (CRISPR)-CRISPR-associated (Cas) systems, transcription activator-like effector nucleases (TALENs), and zinc-finger nucleases (ZFNs)—and provides an assessment of the risk of misuse of these technologies based on the following parameters: accessibility, ease of misuse, magnitude of potential harm, and imminence of potential misuse. The findings from this assessment are applied to analyze and evaluate the threat posed by the intentional misuse of genome editing technologies to develop biological weapons. Furthermore, the book discusses the implications of misuse for different applications of genome editing, such as making existing pathogens more dangerous, modifying the human microbiome, weaponizing gene drives, engineering super soldiers, and augmenting the general population to confer economic advantages. Technologies that enable genome editing with programmable nucleases—including CRISPR, TALEN, and ZFN—allow for the precise genetic modification of organisms and cultured cells. While these technologies are used for a variety of beneficial applications, intelligence and defense experts have raised concerns that genome editing technologies, especially CRISPR, could be misused to develop new and improved biological weapons. Furthermore, experts worry that the number and type of actors who could potentially misuse genome editing is dramatically increasing given the democratization of biology, which is allowing biology to become more accessible to everyone including nonexperts. The book provides a comprehensive assessment of how feasible it is for users with different levels of knowledge and skill to acquire and then to apply the technologies to develop a biological weapon. It also provides an assessment of governability and a tailored set of recommendations that address security concerns. These recommendations are sensitive to the cost-benefit trade-off of regulating genome editing technologies. The book targets researchers as well as intelligence analysts, defense and security personnel, and policymakers.
Meat Biotechnology
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Author : Fidel Toldrá
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-09-03
Meat Biotechnology written by Fidel Toldrá and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-09-03 with Technology & Engineering categories.
Meat and meat products constitute one of the most important foods in western societies. However, the area of meat biotechnology is not as comprehensively covered as other areas of food biotechnology. Missing from this area are the recent developments for better sensory and nutritional quality as well as improved safety. The main goal of this book is to provide the reader with the recent developments in biotechnology and their applications in the meat processing chain. To achieve this goal, the book is divided into four parts. The first part deals with the use of modern biotechnology applied to farm animals. The second part focuses on the recent biotechnological developments in starter cultures for better meat fermentation. The third part discusses current approaches to improve the quality and nutritional properties of meats. The final part presents the latest advances in protection against foodborne pathogens, and other recent trends in the field. Written by distinguished international contributors, this book brings together the advances in such varied and different biotechnological topics.
Molecular Basis Of Resilience
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Author : Patrick L. Iversen
language : en
Publisher: Springer
Release Date : 2018-09-29
Molecular Basis Of Resilience written by Patrick L. Iversen and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-09-29 with Medical categories.
This book illuminates mechanisms of resilience. Threats and defense systems lead to adaptive changes in gene expression. Environmental conditions may dampen adaptive responses at the level of RNA expression. The first seven chapters elaborate threats to human health. Human populations spontaneously invade niche boundaries exposing us to threats that drive the resilience process. Emerging RNA viruses are a significant threat to human health. Antiviral drugs are reviewed and how viral genomes respond to the environment driving genome sequence plasticity. Limitations in predicting the human outcome are described in “nonlinear anomalies.” An example includes medical countermeasures for Ebola and Marburg viruses under the “Animal Rule.” Bacterial infections and a review of antibacterial drugs and bacterial resilience mediated by horizontal gene transfer follow. Chapter 6 shifts focus to cancer and discovery of novel therapeutics for leukemia. The spontaneous resolution of AML in children with Down syndrome highlights human resilience. Chapter 7 explores chemicals in the environment. Examples of chemical carcinogenesis illustrate how chemicals disrupt genomes. Historic research ignored RNA damage from chemically induced nucleic acid damage. The emergence of important forms of RNA and their possible role in resilience is proposed. Chapters 8-10 discuss threat recognition and defense systems responding to improve resilience. Chapter 8 describes the immune response as a threat recognition system and response via diverse RNA expression. Oligonucleotides designed to suppress specific RNA to manipulate the immune response including exon-skipping strategies are described. Threat recognition and response by the cytochrome P450 enzymes parallels immune responses. The author proposes metabolic clearance of small molecules is a companion to the immune system. Chapter 10 highlights RNA diversity expressed from a single gene. Molecular Resilience lists paths to RNA transcriptome plasticity forms the molecular basis for resilience. Chapter 11 is an account of ExonDys 51, an approved drug for the treatment of Duchenne muscular dystrophy. Chapter 12 addresses the question “what informs molecular mechanisms of resilience?” that drives the limits to adaptation and boundaries for molecular resilience. He speculates that radical oxygen, epigenetic modifications, and ligands to nuclear hormone receptors play critical roles in regulating molecular resilience.
Fragility Fracture Nursing
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Author : Karen Hertz
language : en
Publisher: Springer
Release Date : 2018-06-15
Fragility Fracture Nursing written by Karen Hertz and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-06-15 with Medical categories.
This open access book aims to provide a comprehensive but practical overview of the knowledge required for the assessment and management of the older adult with or at risk of fragility fracture. It considers this from the perspectives of all of the settings in which this group of patients receive nursing care. Globally, a fragility fracture is estimated to occur every 3 seconds. This amounts to 25 000 fractures per day or 9 million per year. The financial costs are reported to be: 32 billion EUR per year in Europe and 20 billon USD in the United States. As the population of China ages, the cost of hip fracture care there is likely to reach 1.25 billion USD by 2020 and 265 billion by 2050 (International Osteoporosis Foundation 2016). Consequently, the need for nursing for patients with fragility fracture across the world is immense. Fragility fracture is one of the foremost challenges for health care providers, and the impact of each one of those expected 9 million hip fractures is significant pain, disability, reduced quality of life, loss of independence and decreased life expectancy. There is a need for coordinated, multi-disciplinary models of care for secondary fracture prevention based on the increasing evidence that such models make a difference. There is also a need to promote and facilitate high quality, evidence-based effective care to those who suffer a fragility fracture with a focus on the best outcomes for recovery, rehabilitation and secondary prevention of further fracture. The care community has to understand better the experience of fragility fracture from the perspective of the patient so that direct improvements in care can be based on the perspectives of the users. This book supports these needs by providing a comprehensive approach to nursing practice in fragility fracture care.
Osteosarcopenia Bone Muscle And Fat Interactions
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Author : Gustavo Duque
language : en
Publisher: Springer Nature
Release Date : 2019-11-06
Osteosarcopenia Bone Muscle And Fat Interactions written by Gustavo Duque and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-11-06 with Science categories.
This edited work presents the most current evidence on osteosarcopenia from bench to bedside, which is expected to facilitate the understanding of this syndrome and to develop preventive and therapeutic strategies. With our aging population, chronic diseases such as osteoporosis and sarcopenia are becoming highly prevalent. Fortunately, our understanding of the bone and muscle interactions has increased in recent years. This has allowed to the coining of the term osteosarcopenia to describe a syndrome in which these two diseases overlap. This overlap between osteoporosis and sarcopenia has major negative effects not only on our older adults but also on health systems worldwide. Readers will find a highly translational approach that starts with a summary of recent discoveries on stem cells biology, muscle and bone interactions – including the role of local bone and muscle fat – followed by comprehensive reviews on myokines (i.e. myostatin), osteokines (i.e. osteocalcin) and adipokines (i.e. interleukins) as major players and determinants of bone and muscle loss with aging. In addition, the role of sex steroids (i.e. estrogens, androgens), and calciotropic hormones (i.e. parathyroid hormone, vitamin D) in the pathogenesis of this syndrome is also reviewed. Moreover, using practical diagnostic and therapeutic tips, this book summarizes the clinical characteristics of osteosarcopenic patients thus facilitating the diagnosis and treatment of this syndrome in clinical practice. Finally, the book presents the case for the Falls and Fractures Clinic as the optimal model of care for this syndrome, aimed to avoid fragmentation and optimize osteosarcopenia care, and simultaneously prevent falls and fractures in older persons. This book offers relevant information on the mechanisms of osteosarcopenia, and a practical guide on how to identify and treat this geriatric syndrome and its adverse outcomes, which are dramatically affecting our aging population. The work is written by leaders in the field and is especially suited not only to any researcher in the musculoskeletal arena but also to medical specialists and allied health professionals involved in the care of older persons.
Muscle Development Of Livestock Animals
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Author : M. F. W. te Pas
language : en
Publisher: Cabi
Release Date : 2004-01-01
Muscle Development Of Livestock Animals written by M. F. W. te Pas and has been published by Cabi this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-01-01 with Medical categories.
Number and size of muscle fibres in relation to meat production. Fibre type identification and functional characterization in adult livestock animals. Manipulation of muscle fibre number during prenatal development. The effect of growth and exercise on muscle characteristics in relation to meat quality. Nutrition, hormone receptor expression and gene interactions: implications for development and disease. The impact of minerals and micronutrients on growth control. Na+ K+-ATPase in skeletal muscle: significance of exercise and thyroid hormones for development and performance. local and ystemic regulation of muscle growth. Proteolytic systems and the regulation of muscle remodelling and breakdown. Themuscle regulatory factors gene family in relation to meat production.The muscle transcriptome. Genome analysis of QTL for muscle tissue development and meat quality. Functional genomics and proteomics in relation to muscle tissue. Role of myostatin in muscle growth. The callipyge mutation for sheep muscular hypertrophy genetics, physiology and meat quality. Genetic control of intramuscular fat accretion, Post-mortem muscle proteolysis and meat tenderness.Water-holding capacity of meat.
