The Renin Angiotensin Aldosterone System
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The Local Cardiac Renin Angiotensin Aldosterone System
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Author : Edward D. Frohlich
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-09-18
The Local Cardiac Renin Angiotensin Aldosterone System written by Edward D. Frohlich and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-09-18 with Medical categories.
Until recently, the renin-angiotensin-aldosterone system has been considered a systemic endocrine hormonal system exclusively. It is now known that each component of the renin-angiotensin system is produced, synthesized and indeed, present in many organisms including the heart and vessels. This volume presents the most recent clinical and laboratory experiences of the leading physicians and investigators in the field of the local cardiac renin-angiotensin aldosterone system. Cardiovascular, renal and hypertension oriented physicians, investigators and scientists would find this book of interest. Edward D. Frohlich, M.D., M.A.C.P, F.A.C.C., is the Alton Ochsner Distinguished Scientist at the Ochsner Clinic Foundation in New Orleans, Louisiana. He is also Professor of Medicine and of Physiology at Louisiana State University School of Medicine, New Orleans, and Clinical Professor of Medicine and Adjunct Professor of Pharmacology at Tulane University School of Medicine, New Orleans. He is past Editor-in-Chief of the American Heart Association journal HYPERTENSION. Richard N. Re, M.D., is the Section Head, Hypertension at the Ochsner Clinic Foundation in New Orleans, Louisiana. He is also Ochsner's Scientific Director of Research.
Renin Angiotensin Aldosterone System
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Author : Samy I. McFarlane
language : en
Publisher: BoD – Books on Demand
Release Date : 2021-11-24
Renin Angiotensin Aldosterone System written by Samy I. McFarlane and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-24 with Medical categories.
The Renin-Angiotensin Aldosterone System (RAAS) plays an important role not only in salt and water homeostasis but also in the cardiovascular system, the kidney, and the brain. While several volumes address different aspects of the RAAS function, this book provides cutting-edge information on the pathogenesis of various disorders related to RAAS overactivation. It also presents unique aspects of RAAS functioning that have not been sufficiently described in the literature. Topics covered include assessment of hypoaldosteronism in infancy, RASS and cognitive decline, and the role of RAAS in the pathogenesis of COVID-19. Written by experts in the field in an easy-to-follow and illustrated format, this volume will benefit students and practitioners, as well as clinical and basic science investigators alike.
Selected Chapters From The Renin Angiotensin System
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Author : Aleksandar Kibel
language : en
Publisher: BoD – Books on Demand
Release Date : 2020-08-19
Selected Chapters From The Renin Angiotensin System written by Aleksandar Kibel and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-08-19 with Medical categories.
Selected Chapters from the Renin-Angiotensin System aims to provide a comprehensive overview of the most important physiological and pathophysiological roles of the renin-angiotensin system (RAS). The complex and convoluted RAS has been investigated for many years and, through rigorous scientific research, many important and previously unknown components and functions of the RAS have come to light. These discoveries have been crucial in the understanding of this system and provide a basis for effective modulation of the system as part of therapeutic strategies for a number of widespread disorders. New studies are continuing to elucidate the RAS and the mechanisms associated with its functions. This book discusses relevant scientific knowledge about the RAS and intends to introduce the reader to cutting-edge research with an accentuation on the mechanisms at the functional/physiological and molecular/cellular levels.
The Renin Angiotensin Aldosterone System
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Author : Sean E. Thatcher
language : en
Publisher: Humana
Release Date : 2018-08-08
The Renin Angiotensin Aldosterone System written by Sean E. Thatcher and has been published by Humana this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-08-08 with Science categories.
This volume discusses protocols that aid in measuring different components in the renin-angiotensin-aldosterone system (RAAS). The book also looks at the methods used to assess angiotensin peptides and discerning the influence of RAAS components on different mammalian diseases. The chapters cover topics such as the use of fluorescent substrate to measure ACE2 activity in the mouse abdominal aorta, blood pressure monitoring using the radio telemetry method, and the analysis of angiotensin metabolism in the kidney using mass spectrometry. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting edge and comprehensive, The Renin-Angiotensin-Aldosterone Systems: Methods and Protocols is a valuable resource that provides scientists and researchers with the best approaches to examine RAAS.
Renin Angiotensin System And Cardiovascular Disease
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Author : Walmor C. DeMello
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-09-01
Renin Angiotensin System And Cardiovascular Disease written by Walmor C. DeMello and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-09-01 with Medical categories.
This book offers the latest research into the role of the renin angiotensin system on cardiac and vascular functions and in cardiovascular diseases. It covers vital aspects such as intracellular signaling and regulation of cell volume in the failing heart.
The Renin Angiotensin System In Cancer Lung Liver And Infectious Diseases
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Author : Sukhwinder K. Bhullar
language : en
Publisher: Springer Nature
Release Date : 2023-03-14
The Renin Angiotensin System In Cancer Lung Liver And Infectious Diseases written by Sukhwinder K. Bhullar and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-03-14 with Medical categories.
This book of the series on “Advances in Biochemistry in Health and Disease” includes state-of-the-art information on the status of renin-angiotensin system (RAS) in the form of 24 chapters. This book has been organized into three sections: (i) General Implications of RAS in human health and Infectious Diseases, (ii) Lung, Liver and Kidney Diseases, and (iii) Development of Cancer. Each chapter has discussed comprehensive knowledge regarding the molecular and cellular aspects of the role of RAS in the pathophysiology and pharmacotherapy of different disease processes. Biochemical mechanisms associated with angiotensin II type 1 and type II receptors, and angiotensin (1-7) MAS receptors for the occurrence of both harmful and beneficial effects of prolonged activation of RAS in different diseases have been outlined. It is noteworthy to point out that different chapter in this book were prepared by recognized global expertise in the area of inflammation, oxidative stress and signal transduction pathways to highlight the role of RAS in different diseases. It is our sincere hope that this book will be of great interest to both biomedical investigators and health professionals as well as graduate students and postdoctoral fellows all over the world.
The Renin Angiotensin System
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Author : Hideshi Kobayashi
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
The Renin Angiotensin System written by Hideshi Kobayashi and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
The renin-angiotensin system and the mechanisms regulating this system developed during the adaptive evolution of verte brates, along with many other systems involved in the in tegrated survival of the organism. Because animal species have evolved from common ancestral populations, a basis for the comparison of body structures and physiological processes ex ists among animal groups belonging to different classifications. The comparative approach provides a better understanding of the structure and function of adaptive systems and facilitates the development of general principles governing these systems among animal groups; further, this approach reveals significant characteristics specific to certain animal groups. As the evolu tion of adaptation of animals to environmental conditions is explored, directions for future research are suggested. In this book, advances in research on the renin-angiotensin system are described with emphasis on the comparative aspects. However, since studies on the renin-angiotensin system of birds, reptiles, amphibians and fishes are limited compared with those con ducted in mammals, in some chapters descriptions are con cerned primarily with mammals. It has taken a long time to write this volume, and the topic is a broad one, with new data always emerging; therefore, certain aspects, and sometimes the most recent information, may not be included. Chapters 1-3 and sections 8. 1-8. 4,8. 6, 8. 7 were written by H. K. ; Chapters 4-7 and Section 8. 5 by Y. T. ; Chapter 9 was written by both authors. H. Uemura, M. Nozaki, Y. Okawara, We are indebted to Drs.
Renin Angiotensin System
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Author : Anna Tolekova
language : en
Publisher: BoD – Books on Demand
Release Date : 2017-07-12
Renin Angiotensin System written by Anna Tolekova and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-07-12 with Medical categories.
Exploring the contractile activity of smooth muscle segments isolated from various organs of healthy animals and animals with experimentally induced diabetes, she obtained original data about angiotensin II-induced force and time parameters. For the first time, she established the effect of ghrelin on angiotensin II-provoked contraction of the urinary bladder. Original data on the role of both types of angiotensin receptors for the contractile activity of the various segments of the gastrointestinal tract and bladder were obtained. By applying specific software for force and time parameter analysis, the contribution of different types of angiotensin receptors on muscle contractility has been shown. The new methodology was used to analyze the data obtained during the registration of smooth muscle relaxation activity, which allows the determination of not only the magnitude of the mechanical response but also the parameters related to the time and speed of the contractions. Plasma renin activity models have been developed using mathematical approaches to predict the effect of different drug doses on the behavior of the system.
Renin Angiotensin Mechanisms
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Author : May Sherman
language : en
Publisher:
Release Date : 1970
Renin Angiotensin Mechanisms written by May Sherman and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1970 with Angiotensin categories.
The Renin Angiotensin System And The Kidney
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Author : Xiao C. Li
language : en
Publisher: Biota Publishing
Release Date : 2015-03-01
The Renin Angiotensin System And The Kidney written by Xiao C. Li and has been published by Biota Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-03-01 with Medical categories.
The renin-angiotensin system (RAS) is one of the most important endocrine (tissue-to-tissue), paracrine (cell-to-cell) and intracrine (intracellular/nuclear) humoral systems in the regulation of blood pressure, cardiovascular, and kidney function in health and disease. The RAS has remarkably evolved from the initial discovery of the rate-limiting enzyme renin to a complex biochemical and physiological cascade involving more than a dozen members. Currently, there are up to five axes or pathways identified in the RAS; each has its substrate, enzyme, effector peptide, receptor, and downstream signaling pathways. These include the renin/ACE/ANG II/AT1 receptor, the APA/ANG III/AT2 receptor, the ACE2/ANG (1-7)/Mas receptor, the prorenin/prorenin receptor (PRR), and the ANG IV/AT4 receptor (IRAP) pathways. Accordingly, the roles of the RAS have expanded well beyond the classic endocrine paradigm as a powerful vasoconstrictor, a potent aldosterone stimulator, or a sodium-retaining hormonal system. The goals of this article are to review and discuss the current insights into and new perspectives on the expression, localization, and novel actions of the RAS with a focus in the kidney. Special emphasis will be placed on recently discovered new members of the RAS derived from studies using innovative mutant rats or mice that either overexpress (knockin) or are deficient (knockout) of a particular substrate, enzyme, ANG peptide, or receptor. This new knowledge will help improve our understanding how each of these pathways act directly or indirectly to regulate blood pressure, cardiovascular and kidney function in physiology, and can be targeted to treat hypertension, cardiovascular and renal diseases.
