The Role Of Micrornas In Osteoclastogenesis

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The Role Of Micrornas In Osteoclastogenesis

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Author : Tiziana Franceschetti
language : en
Publisher:
Release Date : 2014

The Role Of Micrornas In Osteoclastogenesis written by Tiziana Franceschetti and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014 with categories.

Genetic Determinants Of Skeletal Diseases

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Author :
language : en
Publisher:
Release Date : 2015

Genetic Determinants Of Skeletal Diseases written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015 with categories.

The Role Of Micrornas In Bone

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Author : Kristina Kapinas
language : en
Publisher:
Release Date : 2011

The Role Of Micrornas In Bone written by Kristina Kapinas and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with categories.

The Regulatory Roles Of Micrornas In Bone Remodeling And Osteoporosis

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Author : Laura de Ugarte Corbalán
language : en
Publisher:
Release Date : 2016

The Regulatory Roles Of Micrornas In Bone Remodeling And Osteoporosis written by Laura de Ugarte Corbalán and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016 with categories.

Analysis Of The Interaction Between Microrna 148a And Mitf In The Regulation Of Osteoclast Differentiation

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Author : Qi Fu
language : en
Publisher:
Release Date : 2011

Analysis Of The Interaction Between Microrna 148a And Mitf In The Regulation Of Osteoclast Differentiation written by Qi Fu and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with categories.

Abstract: Osteoclast differentiation plays an important role in maintaining a healthy bone density. Mitf is a transcription factor that plays a significant role in regulating osteoclast differentiation. Recently, microRNAs (miRs) have been shown to be heavily involved in development. I decided to investigate the interaction between microRNAs and Mitf during osteoclast differentiation. Preliminary results from a miR microarray comparing Mitf+/+ mice and Mitfmi/mi mice showed that many miRs were differentially regulated during osteoclast differentiation, but only a few miRs were significantly regulated. MiR-148a was one of the miRs that were significantly down regulated by 0.27 fold during osteoclast differentiation. A recent publication from the University of Iceland using a luciferase assay has shown that miR-148a translation is inhibited upon over-expression of Mitf. This led me to my hypothesis that Mitf and miR-148a interacted in a negative feedback-loop mechanism to regulate osteoclast differentiation. The down regulation of miR-148a in Mitf mutant mice was confirmed using Real-time PCR by comparing miR-148a expression between Mitf+/+ and Mitfvga/mi mice and miR-148a expression between Mitfce/+ and Mitfce/ce mice. Target analysis shows that Mitf has four putative binding sites on the miR-148a promoter. ChIP analysis showed an increase in miR-148a abundance on the Mitf protein complex, but not on the Pu. 1 protein complex during osteoclast differentiation, suggesting that miR-148a directly interacts with Mitf alone during osteoclast differentiation. Mitfce/ce mice are another type of Mitf mutant mice that haven't been well-studied. X-ray scans showed a decrease in bone density and MicroCT analysis showed a decrease in bone volume fraction in Mitfce/ce pups that was not present in Mitfce/ce adults, suggesting that Mitfce/ce mice exhibit a slight osteopetrotic phenotype that is resolved with age. TRAP Staining shows that Mitfce/ce mice exhibit defects in osteoclast differentiation that are not resolved with age. Chromatin Immunoprecipitation (ChIP) analysis and Real-time PCR show that Mitf recruitment and osteoclast-specific gene expression is decreased in Mitfce/ce mice. This shows that the defects in osteoclast differentiation are at least partially due to a dysregulation of Mitf. These results provide us with a better understanding of the bone biology of Mitfce/ce mice and how Mitf and miR-148a interact to regulate osteoclast differentiation.

Noncoding Rnas And Bone

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Author : Airong Qian
language : en
Publisher:
Release Date : 2021

Noncoding Rnas And Bone written by Airong Qian and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021 with categories.

The book provides an in-depth and comprehensive overview of the essential role of non-coding RNAs (ncRNAs) in bone formation. In combination with researches from multiple scholars in this field, the book reviews the mechanisms of ncRNA-related bone diseases, as well as the potential applications of RNA synthesis technology in bone disorder treatments. This volume covers the following topics: 1) basic introduction of non-coding RNA and bone development, how 2) microRNAs and 3) long noncoding RNAs (LncRNAs) regulate bone formation, 4) how ncRNAs and the corresponding pathways participate in bone metabolism diseases, 5) RNA synthesis technology and the possible RNA therapies in bone disease. Researchers and students in the fields of human genetics, human physiology, developmental biology and biomedical engineering, as well as professionals and scientists in Orthopedics, will particularly find this book helpful.

Clinical Implementation Of Bone Regeneration And Maintenance

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Author : Mike Barbeck
language : en
Publisher:
Release Date : 2021

Clinical Implementation Of Bone Regeneration And Maintenance written by Mike Barbeck and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021 with categories.

Micrornas Novel Biomarkers And Therapeutic Targets For Human Cancers

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Author : Takahiro Ochiya
language : en
Publisher: MDPI
Release Date : 2018-10-16

Micrornas Novel Biomarkers And Therapeutic Targets For Human Cancers written by Takahiro Ochiya and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-10-16 with Electronic books categories.

This book is a printed edition of the Special Issue "MicroRNAs: Novel Biomarkers and Therapeutic Targets for Human Cancers" that was published in JCM

Metastatic Bone Disease

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Author : R. Coleman
language : en
Publisher: Parthenon Publishing
Release Date : 1992-06

Metastatic Bone Disease written by R. Coleman and has been published by Parthenon Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992-06 with Bone and bones categories.

Microrna In Regenerative Medicine

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Author : Chandan K. Sen
language : en
Publisher: Academic Press
Release Date : 2023-05-08

Microrna In Regenerative Medicine written by Chandan K. Sen and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-05-08 with Science categories.

Regulating virtually all biological processes, the genome’s 2,654 newly discovered variants of mature microRNAs – short ribonucleic acid molecules found in eukaryotic cells – hold a key role in the body’s toolkit of regenerative and reparative capacities. Identifying how to activate and deliver these specialist molecules may aid in the repair and regeneration of major tissue and organ damage in future therapies. In MicroRNA and Regenerative Medicine, Second Edition, over 50 leading experts address foundational and emerging topics in the field. Concisely summarizing and evaluating key findings from new research and their translational application, contributors examine current and future significance of clinical research in the miRNA area. Coverage encompasses all major aspects of fundamental stem cell and developmental biology, including the uses of miRNA in cell and tissue plasticity, developmental biology, tissue repair, and regeneration. In particular, contributors provide focused coverage of methodologies for regenerative intervention and tissue engineering. Topics new to this edition include proteomic changes during tissue repair and regeneration, horizontal transfer of miRNAs in tissue regeneration, tissue stemness, peripheral nerve regeneration, miRNA as biomarkers, microRNA in pregnancy and embryo development, exogenous and diet derived microRNA in tissue development, ocular microRNA, mitochondrial microRNA, sensory hair cell death and regeneration, and microRNA in senescence. Features chapter contributions from international leaders in the field, covering the spectrum from bench to bedside Includes short, applied chapters offering focused discussion and practical examples Incorporates multi-color text layout with more than 150 color figures to illustrate important findings