The Role Of Micrornas In Bone
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The Role Of Micrornas In Bone
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Author : Kristina Kapinas
language : en
Publisher:
Release Date : 2011
The Role Of Micrornas In Bone written by Kristina Kapinas and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with categories.
The Role Of Micrornas In Osteoclastogenesis
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Author : Tiziana Franceschetti
language : en
Publisher:
Release Date : 2014
The Role Of Micrornas In Osteoclastogenesis written by Tiziana Franceschetti and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014 with categories.
Genetic Determinants Of Skeletal Diseases
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Author :
language : en
Publisher:
Release Date : 2015
Genetic Determinants Of Skeletal Diseases written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015 with categories.
The Regulatory Roles Of Micrornas In Bone Remodeling And Osteoporosis
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Author : Laura de Ugarte Corbalán
language : en
Publisher:
Release Date : 2018
The Regulatory Roles Of Micrornas In Bone Remodeling And Osteoporosis written by Laura de Ugarte Corbalán and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018 with categories.
In bone field, microRNAs (miRNAs) have been described as key factors regulating bone formation, remodeling, and homeostasis. The identification of miRNAs involved in skeletal function will be essential to the development of miRNA-based therapeutic strategies for bone disorders. As with other regulatory molecules, miRNAs are frequently subject to change during the development of human diseases. In this regard, we identified a subset of miRNAs with altered expression in osteoporotic bone and demonstrate the functional involvement of some of those miRNAs in the regulation of bone formation and the pathways regulating the progression of osteoporosis. We also have depicted an overview of miRNAs in the human bone tissue and in primary bone cells. Furthermore, we have identified genetic variants in human osteoblast-related miRNAs associated with bone mineral density and this association was functionally demonstrated in bone and osteoblast samples. This work has provided evidences of the marked complexity behind this regulatory system and opens novel prospect for research and therapy.
The Role Of Mirnas In Cell Fate Decisions During Osteogenesis
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Author : Devon Duron Ehnes
language : en
Publisher:
Release Date : 2016
The Role Of Mirnas In Cell Fate Decisions During Osteogenesis written by Devon Duron Ehnes and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016 with Bones categories.
Bone is a complex mineralized tissue that functions as a structural support for the body, as well as in mineral storage and homeostasis. Its development is as complex as it's function, with multiple molecular cues governing several aspects of its development and maintenance. Multiple previous studies over several decades have shown that failure to maintain tight regulation of these cues results in varying degrees of bone malformation, most frequently of the craniofacial variety. Various reports have cited a fundamental importance of both non-canonical and canonical Wnt signaling in regulating osteogenesis. Multiple studies have also revealed the importance of temporal-spatial regulation of their expression in promoting proper bone development. MicroRNAs (miRNAs) are small non-coding RNAs that are able to negatively regulate protein expression, serving as a regulatory mechanism in a variety of developmental processes and diseases. They function by binding to the 3' Untranslated Region of target mRNAs to induce mRNA degradation or translational inhibition. They are crucial for early embryonic differentiation, as studies have shown that embryonic stem cells that cannot generate miRNA exhibit impaired differentiation. The work presented in this dissertation focuses on two miRNAs that have not been previously characterized in osteogenesis: miR-690 and miR-361. These miRNAs were selected from a screen based on their differential patterns of accumulation in response to osteogenic factors, and their ability to positively regulate osteogenesis. Using embryonic stem cells as a model for early embryonic development, we observed that both miRNAs were capable of affecting Wnt signaling. We also noted a correlation of miRNA expression with accelerated and/or sustained expression of genes that are associated with neural crest specification or differentiation. These studies have established (i) that miR-690 supports osteogenesis by directly regulating Ctnnb1 during differentiation from the mesenchyme; and (ii) that miR-361 promotes osteogenesis by directly regulating the non- canonical Wnt inhibitor Prickle during mesenchymal commitment. This research presents novel possibilities in miRNA-mediated regulation of early osteogenic development, specifically with regard to regulation of Ctnnb1.
The Role Of Microrna 302 In Regulation Of Human Bone Marrow Mesenchymal Stem Cell Fate Determination
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Author : Bahareh Ghasemi
language : en
Publisher:
Release Date : 2019
The Role Of Microrna 302 In Regulation Of Human Bone Marrow Mesenchymal Stem Cell Fate Determination written by Bahareh Ghasemi and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019 with categories.
Clinical Implementation Of Bone Regeneration And Maintenance
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Author : Mike Barbeck
language : en
Publisher:
Release Date : 2021
Clinical Implementation Of Bone Regeneration And Maintenance written by Mike Barbeck and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021 with categories.
Multiple Myeloma
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Author : Morie A. Gertz
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-10-01
Multiple Myeloma written by Morie A. Gertz and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-10-01 with Medical categories.
This is a comprehensive, state-of-the-art guide to the diagnosis, treatment, and biology of multiple myeloma and related plasma disorders. Edited and written by a multidisciplinary group of recognized authorities from the Mayo Clinic, it presents clear guidelines on diagnosis and therapy and covers all aspects of multiple myeloma, from molecular classification and diagnosis, to risk stratification and therapy. Closely related plasma cell disorders such as solitary plasmacytoma, Waldenstrom macroglobulinemia, and light chain amyloidosis are discussed in detail as well. The book addresses often overlooked topics, including the role of radiation therapy, vertebral augmentation, and supportive care. Our understanding of this group of disorders is developing at an unprecedented rate, and Multiple Myeloma meets the need among oncologists and hematologists for a clear, timely, and authoritative resource on their biology, diagnosis, and treatment.
Metastatic Bone Disease
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Author : R. Coleman
language : en
Publisher: Parthenon Publishing
Release Date : 1992-06
Metastatic Bone Disease written by R. Coleman and has been published by Parthenon Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992-06 with Bone and bones categories.
Cell Engineering And Regeneration
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Author : Heinz Redl
language : en
Publisher: Springer
Release Date : 2017-02-16
Cell Engineering And Regeneration written by Heinz Redl and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-02-16 with Technology & Engineering categories.
This reference work presents the origins of cells for tissue engineering and regeneration, including primary cells, tissue-specific stem cells, pluripotent stem cells and trans-differentiated or reprogrammed cells. There is particular emphasis on current understanding of tissue regeneration based on embryology and evolution studies, including mechanisms of amphibian regeneration. The book covers the use of autologous versus allogeneic cell sources, as well as various procedures used for cell isolation and cell pre-conditioning , such as cell sorting, biochemical and biophysical pre-conditioning, transfection and aggregation. It also presents cell modulation using growth factors, molecular factors, epigenetic approaches, changes in biophysical environment, cellular co-culture and other elements of the cellular microenvironment. The pathways of cell delivery are discussed with respect to specific clinical situations, including delivery of ex vivo manipulated cells via local and systemic routes, as well as activation and migration of endogenous reservoirs of reparative cells. The volume concludes with an in-depth discussion of the tracking of cells in vivo and their various regenerative activities inside the body, including differentiation, new tissue formation and actions on other cells by direct cell-to-cell communication and by secretion of biomolecules.