The Three Dimensional Organization
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The Three Dimensional Organization
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Author : Barbara Czarniawska
language : en
Publisher:
Release Date : 1993
The Three Dimensional Organization written by Barbara Czarniawska and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993 with Organizational effectiveness categories.
Approaching The Three Dimensional Organization Of The Human Genome
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Author : Tobias A. Knoch
language : en
Publisher:
Release Date : 2002
Approaching The Three Dimensional Organization Of The Human Genome written by Tobias A. Knoch and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with categories.
To approach the still largely unknown sequential and three-dimensional organization of the human cell nucleus, the structural-, scaling- and dynamic properties of interphase chromosomes and cell nuclei were simulated on the 30 nm chromatin fiber level with Monte Carlo, Brownian Dynamics and parallel computing methods. Differences between used models explain various experimental conditions, favouring a Multi-Loop-Subcompartment model with 63-126 kbp loops aggregated to possibly rosettes connected by 63-126 kbp linkers, and predict correctly the transport of molecules by moderately obstructed diffusion excluding the Interchromosomal Domain hypothesis. Correlation analyses of completely sequenced Archaea, Bacteria and Eucaria chromosomes revealed fine-structured positive long-range correlations due to codon, nucleosomal or block organization of the genomes, allowing classification and tree construction. By construction and expression of fusionproteins from the histones H1, H2A, H2B, H3, H4 and mH2A1.2 with the autofluorescent proteins CFP, GFP, YFP, DsRed-1 and DsRed-2 the chromatin morphology could be investigated in vivo during interphase, mitosis or apoptosis and revealed different interphase morphologies for cell lines quantifiable by scaling analyses. Finally, construct conversions in simultaneous co-transfections due to recombination/repair/replication were discovered in 25 % of cells and led to a variety of new applications.
Approaching The Three Dimensional Organization Of The Human Genome
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Author : Tobias A. Knoch
language : en
Publisher:
Release Date : 2012*
Approaching The Three Dimensional Organization Of The Human Genome written by Tobias A. Knoch and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012* with categories.
Modeling The 3d Conformation Of Genomes
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Author : Guido Tiana
language : en
Publisher: CRC Press
Release Date : 2019-01-15
Modeling The 3d Conformation Of Genomes written by Guido Tiana and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-01-15 with Science categories.
This book provides a timely summary of physical modeling approaches applied to biological datasets that describe conformational properties of chromosomes in the cell nucleus. Chapters explain how to convert raw experimental data into 3D conformations, and how to use models to better understand biophysical mechanisms that control chromosome conformation. The coverage ranges from introductory chapters to modeling aspects related to polymer physics, and data-driven models for genomic domains, the entire human genome, epigenome folding, chromosome structure and dynamics, and predicting 3D genome structure.
Three Dimensional Leader
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Author : Earl C. Wallace
language : en
Publisher: Tate Publishing
Release Date : 2009
Three Dimensional Leader written by Earl C. Wallace and has been published by Tate Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009 with Leadership categories.
The Three-Dimensional Leader provides a scalable paradigm to rate and improve leadership, regardless of your type of organization or position you hold. It details how to achieve cohesive strategic planning, get synergy from diversity, improve your culture's core operational success dynamics, franchise values to avoid silos, and propel innovation through the five factors of out-of-the-box thinking! The Three-Dimensional Leader interviews others who model principles and provides insight to improve your focus and channel what is perceived into process steps that achieve long-term performance. Three-dimensional leaders leave legacies of success while vying with organizational vampires and swashbuckling pirates who try to commandeer and undermine the 'missions that matter most.' This book is an entertaining and revealing must-read!
Anatomy Of Gene Regulation
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Author : Panagiotis A. Tsonis
language : en
Publisher: Cambridge University Press
Release Date : 2003-01-13
Anatomy Of Gene Regulation written by Panagiotis A. Tsonis and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-01-13 with Science categories.
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Three Dimensional Electron Microscopy
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Author :
language : en
Publisher: Academic Press
Release Date : 2019-07-18
Three Dimensional Electron Microscopy written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-07-18 with Science categories.
Three-Dimensional Electron Microscopy, Volume 152 in the Methods in Cell Biology series, highlights new advances in the field, with this new volume presenting interesting chapters focusing on FIB-SEM of mouse nervous tissue: fast and slow sample preparation, Serial-section electron microscopy using ATUM - Automated Tape collecting Ultra-Microtome, Software for automated acquisition of electron tomography tilt series, Scanning electron tomography of biological samples embedded in plastic, Cryo-STEM tomography for Biology, CryoCARE: Content-aware denoising of cryo-EM images and tomograms using artificial neural networks, Expedited large-volume 3-D SEM workflows for comparative vertebrate microanatomical imaging, and many other interesting topics. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Methods in Cell Biology series Includes the latest information on the Three-Dimensional Electron Microscopy technique
Dreidimensionale Organisation Von Chromosomen Dom Nen In Simulation Und Experiment
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Author : Tobias A. Knoch
language : de
Publisher:
Release Date : 2012*
Dreidimensionale Organisation Von Chromosomen Dom Nen In Simulation Und Experiment written by Tobias A. Knoch and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012* with categories.
Three Dimensional Computer Graphics Brain Mapping Project
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Author : Robert B. Livingston
language : en
Publisher:
Release Date : 1987
Three Dimensional Computer Graphics Brain Mapping Project written by Robert B. Livingston and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1987 with Computer graphics categories.
Evolution Of 3d Chromatin Architecture
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Author : Liene Astica
language : en
Publisher:
Release Date : 2023*
Evolution Of 3d Chromatin Architecture written by Liene Astica and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023* with categories.
Englische Version: The three-dimensional organization of animal genomes, known as topologically associating domains (TADs), is crucial for controlling gene activity. TADs are regions with increased genetic interactions, separated by zones with fewer contacts. In vertebrates, the formation of TADs involves a dynamic process called loop extrusion, where cohesin and CTCFs bind to the chromatin. This process creates chromatin loops, with cohesin complexes pausing when they encounter CTCF molecules in a specific orientation. However, although CTCF is highly conserved among bilaterian species, its vital role in organizing genomes spatially has not been observed in invertebrates like flies. This study investigates the chromatin structure in Ciona robusta, a chordate species situated evolutionarily between well-studied organisms like mice and fruit flies. A unique approach was developed to explore the evolution of CTCF as a mediator of three-dimensional chromatin organization. By swapping CTCF orthologs from representative species across the bilaterian group, the research examined their impact on viability, traits, gene expression, genome architecture, and binding patterns across the genome. The findings indicate that Ciona robusta, a non-vertebrate chordate, lacks typical TAD structures, even in the presence of CTCF. However, although the Ciona ortholog cannot create TADs in mouse embryonic stem cells, it can act as a transcription factor, restoring the expression of specific genes and viability in cases of complete CTCF loss. This suggests that CTCF serves a conserved role as a transcription regulator, beyond its recognized role as a structural component in some species. Furthermore, when the mouse ortholog of CTCF was introduced into the fruit fly genome, it failed to induce the formation of chromatin loops, suggesting that the vertebrate version of CTCF alone is insufficient for effective loop extrusion. [...].