The Vertebrate Neuromuscular Junction
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The Vertebrate Neuromuscular Junction
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Author : Miriam M. Salpeter
language : en
Publisher:
Release Date : 1987
The Vertebrate Neuromuscular Junction written by Miriam M. Salpeter and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1987 with Medical categories.
A Study Of Miniature Endplate Current Generation At The Vertebrate Neuromuscular Jucntion Using Electrophysiology And Monte Carlo Simulation
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Author : Thomas M. Bartol
language : en
Publisher:
Release Date : 1992
A Study Of Miniature Endplate Current Generation At The Vertebrate Neuromuscular Jucntion Using Electrophysiology And Monte Carlo Simulation written by Thomas M. Bartol and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992 with categories.
Vertebrate Motoneurons
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Author : Michael J. O'Donovan
language : en
Publisher: Springer Nature
Release Date : 2022-09-06
Vertebrate Motoneurons written by Michael J. O'Donovan and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-09-06 with Medical categories.
This book aims to provide a comprehensive and timely review of new findings in motoneuron research. Recent findings have revealed that motoneurons are more complex and have more extensive functions than previously imagined. Some of the molecular and genetic pathways that orchestrate the development of motoneurons have been discovered, as have the mechanisms responsible for the selective innervation of muscles by specific pools of motoneurons. These novel findings are revolutionizing ideas about the function of motoneurons and have important implications for motoneuron disease. Chapters from several of the foremost figures in the field are included in this book and will emphasize how basic science is the engine driving the discovery of novel treatments for degenerative motoneuron diseases. Cutting edge developments in the use of pluripotent stem cells to correct motoneuron disease will be also be covered. This book would be useful to students of basic motoneuron physiology, locomotor behavior and motor control. This book would also be of interest to professional neuroscientists, neurologists, and neurosurgeons.
Neuroscientific Foundations Of Anesthesiology
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Author : George A. Mashour
language : en
Publisher: Oxford University Press
Release Date : 2011-10-05
Neuroscientific Foundations Of Anesthesiology written by George A. Mashour and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-10-05 with Medical categories.
Although the perioperative care of patients by anesthesiologists draws on diverse clinical skills, the principles of anesthesiology and pain management are rooted in the neurosciences. The Neuroscientific Foundations of Anesthesiology thoroughly examines the anesthetic modulation of the central, peripheral, and autonomic nervous systems and will help redefine anesthesiology as a fundamentally neuroscientific field. The book is organized by sections, with each focusing on a different part of the nervous system. State-of-the-art chapters written by thought-leaders in anesthesiology and neuroscience provide a novel and invaluable resource.
Functional Ultrastructure
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Author : Margit Pavelka
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-07-16
Functional Ultrastructure written by Margit Pavelka and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-07-16 with Science categories.
The period between 1950 and 1980 were the golden unique insights into how pathological processes affect years of transmission electron microscopy and produced cell organization. a plethora of new information on the structure of cells This information is vital to current work in which that was coupled to and followed by biochemical and the emphasis is on integrating approaches from functional studies. TEM was king and each micrograph proteomics, molecular biology, genetics, genomics, of a new object produced new information that led to molecular imaging and physiology and pathology to novel insights on cell and tissue organization and their understand cell functions and derangements in disease. functions. The quality of data represented by the images In this current era, there is a growing tendency to of cell and tissues had been perfected to a very high level substitut e modern light microscopic techniques for by the great microscopists of that era including Palade, electron microscopy, because it is less technically Porter, Fawcett, Sjostrand, Rhodin and many others. At demanding and is more readily available to researchers- present, the images that we see in leading journals for This atlas reminds us that the information obtained by the most part do not reach the same technical level and electron microscopy is invaluable and has no substitute.
Neuromuscular Junctions In Drosophila
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Author :
language : en
Publisher: Academic Press
Release Date : 1999-04-29
Neuromuscular Junctions In Drosophila written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-04-29 with Medical categories.
Neuromuscular Junctions in Drosophila gathers the main contributions that research using the fruit fly Drosophila melanogaster has made in the area of synapse development, synapse physiology, and excitability of muscles and nerve cells. The chapters in this book represent a synthesis of major advances in our understanding of neuronal development and synaptic physiology, which have been obtained using the above approach. This book is directed to the general neuroscience audience: researchers, instructors, graduate students, and advanced undergraduates who are interested in the mechanisms of synapse development and physiology. However, the book will also be a valuable resource for those that use the fruit fly as a model system in their laboratories. Key Features * Synthesizes the genetic approaches used to study synaptic development and function at the neuromuscular junction, using flies as a model system * Covers major recent advances in muscle development, pathfinding, synapse maturation and plasticity, exo- and endocytosis, and ion channel function * Written in clear language that is easily understandable to readers not already familiar with fruit fly research * Includes numerous diagrams and extensive reference lists
The Fly Neuromuscular Junction Structure And Function
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Author : Vivian Budnik
language : en
Publisher: Elsevier
Release Date : 2006-11-02
The Fly Neuromuscular Junction Structure And Function written by Vivian Budnik and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-11-02 with Medical categories.
The Drosophila larval neuromuscular junction (NMJ) has become one of the most powerful model systems to ask key neurobiological questions. This synapse is unparalleled by its accessibility, its simplicity, and the ability to manipulate genes important for synapse development and function. Its synapses have properties shared by many organisms including humans. The vast majority of genes that when mutated cause congenital disorders of the nervous system in humans, are present in the fruit fly genome, and fly models of human disorders are available. Thus, this preparation is a powerful tool to understand the normal function of these genes. This book reviews outstanding work by recognized leaders in the fields of Drosophila cellular neurogenetics including developmental neurobiology, mechanisms of synaptic function, and experience dependent changes at synapses. The book also includes step-by-step protocols to study the cellular biology of the NMJ, making it a vital resource for researchers beginning their investigations with this system, for those who are training students and postdoctoral fellows in this area, or simply as a general reference material for neuroscientists and neuroscience professors in general. * Provides a synthesis of the main topics in modern neurogenetics * Includes step-by-step protocols for the use of the Drosophila NMJ system in neurobiology lab research * Offers genetic approaches to study synapse development and function *
The Sticky Synapse
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Author : Michael Hortsch
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-06-07
The Sticky Synapse written by Michael Hortsch and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-06-07 with Medical categories.
The molecular mechanisms, which are responsible for the functional differences between the various types of neuronal synapses, have become one of the central themes of modern neurobiology. It is becoming increasingly clear that a misregulation of synaptogenesis and synaptic remodeling and dysfunctional neuronal synapses are at the heart of several human diseases, both neurological disorders and psychiatric conditions. As synapses present specialized cellular junctions between neurons and their target cells, it may not come as a surprise that neural cell adhesion molecules (CAMs) are of special importance for the genesis and the maintenance of synaptic connections. Genes encoding adhesive molecules make up a significant portion of the human genome, and neural CAMs even have been postulated to be a major factor in the evolution of the human brain. These are just some of the many reasons why we thought a book on neural CAMs and their role in establishing and maintaining neuronal synapses would be highly appropriate for summarizing our current state of knowledge. Without question, over the near future, additional adhesive proteins will join the ranks of synaptic CAMs and our knowledge, and how these molecules enable neurons and their targets to communicate effectively will grow.
Spinal Muscular Atrophy
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Author : Charlotte J Sumner
language : en
Publisher: Academic Press
Release Date : 2016-10-24
Spinal Muscular Atrophy written by Charlotte J Sumner and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-10-24 with Medical categories.
Spinal Muscular Atrophy: Disease Mechanisms and Therapy provides the latest information on a condition that is characterized by motoneuron loss and muscle atrophy, and is the leading genetic cause of infant mortality. Since the identification of the gene responsible for SMA in 1995, there have been important advances in the basic understanding of disease mechanisms, and in therapeutic development. This book provides a comprehensive accounting of recent advances in basic and clinical research that covers SMA clinical features and standards of care, multifaceted aspects of SMN protein functions and SMA disease pathology, various animal models, and biomarkers, as well as current therapeutic development. This title is ideal for graduate students/postdocs and principal investigators who are already in the SMA field and need to keep updated on recent findings and approaches, and for those who are new to, or would like to join, the field. Likewise, users will find an excellent source of reading for biotech/pharma scientists, clinical researchers, and practitioners, regulators, and patients and their advocacy organizations. Furthermore, this book is a handy reference for researchers and clinicians who may want to apply the research strategies and therapeutic approaches in SMA to other rare diseases. Provides comprehensive, up-to-date reviews by leading investigators on diverse topics of SMA, including clinical features and patient care, SMN genetics and protein functions, animal models, disease pathology and mechanisms, biomarkers, current therapeutic development, and the role of non-profit organizations in therapeutic development Written to bridge multiple disciplines and promote better communications among basic scientists, clinical researchers, and health care providers on the latest developments in SMA Includes outstanding questions and perspectives for future investigations and key references for additional detailed study
Anesthetic Pharmacology
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Author : Alex S. Evers
language : en
Publisher: Cambridge University Press
Release Date : 2011-03-10
Anesthetic Pharmacology written by Alex S. Evers and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-03-10 with Medical categories.
In recent years our understanding of molecular mechanisms of drug action and interindividual variability in drug response has grown enormously. Meanwhile, the practice of anesthesiology has expanded to the preoperative environment and numerous locations outside the OR. Anesthetic Pharmacology: Basic Principles and Clinical Practice, 2nd edition, is an outstanding therapeutic resource in anesthesia and critical care: Section 1 introduces the principles of drug action, Section 2 presents the molecular, cellular and integrated physiology of the target organ/functional system and Section 3 reviews the pharmacology and toxicology of anesthetic drugs. The new Section 4, Therapeutics of Clinical Practice, provides integrated and comparative pharmacology and the practical application of drugs in daily clinical practice. Edited by three highly acclaimed academic anesthetic pharmacologists, with contributions from an international team of experts, and illustrated in full colour, this is a sophisticated, user-friendly resource for all practitioners providing care in the perioperative period.