The World And The Sickle Cell Gene
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The World And The Sickle Cell Gene
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Author : Mohamed Ismail Johnson
language : en
Publisher:
Release Date : 1984
The World And The Sickle Cell Gene written by Mohamed Ismail Johnson and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1984 with Health education categories.
Sickle Cell Simply Explained
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Author : Dr. John Koramoa
language : en
Publisher: Author House
Release Date : 2014
Sickle Cell Simply Explained written by Dr. John Koramoa and has been published by Author House this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014 with Health & Fitness categories.
Sickle cell disease is the most common genetic disease world-wide. For a person to suffer the disease, he or she has to inherit the faulty gene from each parent. It affects millions of people in the world. It is a chronic illness of serious proportions. Medical, psychological and socioeconomic consequences place a great burden on sufferers and their Carers. In the past sufferers of sickle cell anaemia survived for a few years only.When only one sickle cell gene is inherited by a person with normal haemoglobin, the condition is referred to as the carrier state or the trait. Individuals with the trait have no medical problems under normal conditions of life. This is how the gene has been able to survive and be passed on from generation to generation. The trait can thus have serious implications for marriage and childbearing. It is therefore, imperative for people intending to have children to know about it in order to help prevent the disease. Sickle cell disease which was once thought to be restricted to only a few areas, especially among Black people, is now known to be world-wide. It has been described as a world health problem.This book provides information in an easily readable format for everybody to understand sickle cell and its related conditions. There is the need for greater awareness and knowledge of the disease and the trait to avoid confusion, misunderstanding and myths, which hamper their proper management and prevention. At present there is no readily available cure for sickle cell disease. However, with proper management of the many ill-effects of the disease, sufferers can be assisted to live comfortable lives and for many years. Life-style measures are paramount and are referred to in some detail in the book. It is a great resource."
Gene And Cell Therapies For Beta Globinopathies
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Author : Punam Malik
language : en
Publisher: Springer
Release Date : 2017-11-09
Gene And Cell Therapies For Beta Globinopathies written by Punam Malik and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-11-09 with Medical categories.
Hemoglobin defects, specifically sickle cell disease & thalassemia, combined, constitute the most common monogenic disorders in the world. In fact, nearly 2% of the world’s population carries a globin gene mutation. The transfer of the corrective globin gene through the HSC compartment by allogeneic HSC transplantation (HSCT) has already proven curative in both SCD and thalassemia patients, and provides the proof of concept that genetic manipulation of the defective organ might be equally therapeutic. However, procedural toxicities and the requirement of an HLA-matched sibling donor limit this approach to a fraction of affected individuals. The editors review the progress & the state of the field in HSCT for hemoglobinopathies & shed light on the major changes expected in the next decade. Although allogeneic HSCT is a curative option, it is limited by the availability of matched donors, which are often available only to 15-20% of patients. An alternative to allogeneic HS CT is genetic correction of autologous HSCs, to overcome donor availability & immune side effects. This Book reviews the progress made on additive gene therapy approaches & the current state of the field. Finally, targeted genetic correction is emerging as a novel therapeutic strategy in the hemoglobinopathies. Although ideal, the inefficiency of targeted correction was rate limiting for translation of this technology to the clinic. With advancements in zinc finger nucleases and TALE endonuclease mediated targeted correction, correction frequencies in hematopoietic stem cells is now reaching levels that may become clinically relevant. Furthermore, the ability to generate autologous embryonic stem cell like cells from primary somatic cells (skin fibroblasts or hematopoietic cells) of the affected individual has allowed for the potential application of genetic correction strategies.This Book reviews upcoming genetic strategies to reactivate fetal hemoglobin production and research advances.
The Enculturated Gene
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Author : Duana Fullwiley
language : en
Publisher: Princeton University Press
Release Date : 2011-11-07
The Enculturated Gene written by Duana Fullwiley and has been published by Princeton University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-11-07 with Social Science categories.
In the 1980s, a research team led by Parisian scientists identified several unique DNA sequences, or haplotypes, linked to sickle cell anemia in African populations. After casual observations of how patients managed this painful blood disorder, the researchers in question postulated that the Senegalese type was less severe. The Enculturated Gene traces how this genetic discourse has blotted from view the roles that Senegalese patients and doctors have played in making sickle cell "mild" in a social setting where public health priorities and economic austerity programs have forced people to improvise informal strategies of care. Duana Fullwiley shows how geneticists, who were fixated on population differences, never investigated the various modalities of self-care that people developed in this context of biomedical scarcity, and how local doctors, confronted with dire cuts in Senegal's health sector, wittingly accepted the genetic prognosis of better-than-expected health outcomes. Unlike most genetic determinisms that highlight the absoluteness of disease, DNA haplotypes for sickle cell in Senegal did the opposite. As Fullwiley demonstrates, they allowed the condition to remain officially invisible, never to materialize as a health priority. At the same time, scientists' attribution of a less severe form of Senegalese sickle cell to isolated DNA sequences closed off other explanations of this population's measured biological success. The Enculturated Gene reveals how the notion of an advantageous form of sickle cell in this part of West Africa has defined--and obscured--the nature of this illness in Senegal today. Some images inside the book are unavailable due to digital copyright restrictions.
Renaissance Of Sickle Cell Disease Research In The Genome Era
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Author : Betty Pace
language : en
Publisher: World Scientific
Release Date : 2007-01-24
Renaissance Of Sickle Cell Disease Research In The Genome Era written by Betty Pace and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-01-24 with Science categories.
The Human Genome Project has spawned a Renaissance of research faced with the daunting expectation of personalized medicine for individuals with sickle cell disease in the Genome Era. This book offers a comprehensive and timeless account of emerging concepts in clinical and basic science research, and community concerns of health disparity to educate professionals, students and the general public about meeting this challenging expectation. Contributions from physicians, research scientists, scientific administrators and community workers make Renaissance of Sickle Cell Disease Research in the Genome Era unique among the catalogue of books on this genetic disorder.Part 1 offers detailed review of the National Heart Lung and Blood Institute's leadership role in funding sickle cell research, as well as developing progressive research initiatives and the predicted impact of the Human Genome Project. Part 2 gives an account of several clinical research perspectives based on the Cooperative Study of Sickle Cell Disease. These include recommendations for newborn screening, pain management, stroke, transfusion therapy and pediatric and adult healthcare. Part 3 offers novel insights into basic science research progress and the impact of the Human Genome Project on the direction of hemoglobinopathy research, including hemoglobin switching, bone marrow transplantation and gene therapy. Part 4 engages the reader in a culture-based discussion of the stigma attached to sickle cell disease in the African American community and the apprehensions about genetic research in this community. It concludes with a global perspective on sickle cell disease from African, European and American experiences. For readers seeking a definitive account of sickle cell disease appropriate for students, researchers and community workers, this collaborative effort is an ideal textbook./a
Sickle Cell Disease
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Author : Todd Eckdahl
language : en
Publisher:
Release Date : 2017-01-09
Sickle Cell Disease written by Todd Eckdahl and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-01-09 with Science categories.
Sickle cell disease (SCD) is the most common genetic blood disorder in the world. Millions of people in the world have SCD and about 300,000 babies are born with it each year. Readers will learn about the major symptoms of SCD, including chronic anemia, delayed growth, spleen dysfunction, opportunistic infections, vision loss, leg ulcers, stroke, and heart problems. The book explains how the primary cause of SCD is a gene mutation that causes hemoglobin to polymerize in red blood cells, making them adopt an abnormal sickle shape. Sickled cells carry less oxygen and occlude blood vessels in tissues and organs throughout the body. The reader will learn how SCD is inherited and how genetic testing can provide information that prospective parents can use to make reproductive decisions. The book presents treatments for SCD such as pain medications, antibiotic therapy, blood transfusions, and bone mar-row transplantation. Future prospects for diagnosing, treating, and curing SCD are evaluated, including maternal blood screening, preimplantation genetic diagnosis, gene therapy, and genome editing.
Genetics And Global Public Health
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Author : Simon M. Dyson
language : en
Publisher: Routledge
Release Date : 2014-06-11
Genetics And Global Public Health written by Simon M. Dyson and has been published by Routledge this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-06-11 with Medical categories.
Sickle cell and thalassaemia are among the world’s most common genetic conditions. They are especially common in Africa, Brazil, the Caribbean, the Middle East and Asia. They affect all ethnic groups but they particularly impact on minority ethnic groups in North America, Europe and Australasia. Much research has focused on clinical, laboratory and genetic studies of these conditions. Through a wide-ranging selection of readings based on social scientific research into sickle cell and thalassaemia, this book seeks to redress this imbalance. This is important as, through an examination of the different social, economic and cultural contexts of the lives of people living with sickle cell or thalassaemia, the contributors demonstrate that people are more than the sum of their genes and that their life experiences are rarely derived solely from the clinical severity of their condition but depend on the social context of their lives. Genetics and Global Public Health presents a new concluding chapter which highlights the critical nature of social science research for sickle cell and thalassaemia communities, providing key insights into the social contexts of human behaviour and analysing how societal arrangements could change to assist people living with either condition. It will be of great interest to postgraduate and research students as well as professionals working in the field of public health. This book was originally published as a special issue of the journal Ethnicity and Health.
Single Gene Disorder
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Author : Michael V Fernandez
language : en
Publisher: Independently Published
Release Date : 2023-12-27
Single Gene Disorder written by Michael V Fernandez and has been published by Independently Published this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-12-27 with Medical categories.
"Single-gene Disorder: Sickle Cell Anemia and Cystic Fibrosis" is a book by Michael V. Fernandez that delves into the world of genetic disorders, specifically focusing on two prominent diseases: Sickle Cell Anemia and Cystic Fibrosis. The book aims to provide a comprehensive understanding of these diseases, their causes, and potential treatments.In this book, Fernandez discusses the following topics: 1. **Sickle Cell Anemia**: The author explores the pathogenesis, diagnosis, and treatment of Sickle Cell Anemia, a genetic blood disorder that affects millions of people worldwide. The book covers the historical background of the disease, its genetic basis, and the various therapeutic approaches being explored to manage and cure the condition. 2. **Cystic Fibrosis**: Fernandez delves into the causes, symptoms, and treatment of Cystic Fibrosis, a genetic lung disease that affects the respiratory system and digestive system. The book discusses the genetic mutations responsible for the disease, the symptoms and complications associated with it, and the latest advancements in treatment and care. Throughout the book, Fernandez emphasizes the importance of genetic research and its impact on the understanding and management of these genetic disorders. The author also highlights the role of interdisciplinary collaboration between clinical geneticists, basic science researchers, and healthcare professionals in advancing the field of genetic medicine. By providing a detailed overview of Sickle Cell Anemia and Cystic Fibrosis, "Single-gene Disorder: Sickle Cell Anemia and Cystic Fibrosis" serves as a valuable resource for medical professionals, researchers, and anyone interested in learning more about these genetic disorders. The book also highlights the need for continued research and investment in genetic medicine to improve the lives of those affected by these and other genetic diseases.
Sickle Cell And The Social Sciences
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Author : Simon M. Dyson
language : en
Publisher: Routledge
Release Date : 2019-03-27
Sickle Cell And The Social Sciences written by Simon M. Dyson and has been published by Routledge this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-03-27 with Social Science categories.
Sickle cell disease (SCD) is a severe chronic illness and one of the world’s most common genetic conditions, with 400,000 children born annually with the disorder, mainly in Sub-Saharan Africa, India, Brazil, the Middle East and in diasporic African populations in North America and Europe. Biomedical treatments for SCD are increasingly available to the world’s affluent populations, while such medical care is available only in attenuated forms in Africa, India and to socio-economically disadvantaged groups in North America and Europe. Often a condition rendered invisible in policy terms because of its problematic association with politically marginalized groups, the social study of sickle cell has been neglected. This illuminating volume explores the challenges and possibilities for developing a social view of sickle cell, and for improving the quality of lives of those living with SCD. Tackling the controversial role of screening and genetics in SCD, the book offers a brief thematic history of approaches to the condition, queries the role of ethnicity and includes a discussion of how the social model of disability can be applied, as well as featuring chapters focusing on athletics, prisons and schools. Bringing together a wide range of original research conducted in the USA, the UK, Ghana and Nigeria, Sickle Cell and the Social Sciences is anchored in the discipline of sociology, but draws upon a diverse range of fields, including public health, anthropology, social policy and disability studies.
The Ebmt Handbook
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Author : Nicolaus Kröger
language : en
Publisher:
Release Date : 2020-10-08
The Ebmt Handbook written by Nicolaus Kröger and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-10-08 with Medical categories.
This Open Access edition of the European Society for Blood and Marrow Transplantation (EBMT) handbook addresses the latest developments and innovations in hematopoietic stem cell transplantation and cellular therapy. Consisting of 93 chapters, it has been written by 175 leading experts in the field. Discussing all types of stem cell and bone marrow transplantation, including haplo-identical stem cell and cord blood transplantation, it also covers the indications for transplantation, the management of early and late complications as well as the new and rapidly evolving field of cellular therapies. This book provides an unparalleled description of current practices to enhance readers' knowledge and practice skills. This work was published by Saint Philip Street Press pursuant to a Creative Commons license permitting commercial use. All rights not granted by the work's license are retained by the author or authors.