Thyroid Hormone Dependency Of Developing Brain

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Thyroid Hormone Dependency Of Developing Brain

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Author : Ann-Charlotte Granholm
language : en
Publisher:
Release Date : 1984

Thyroid Hormone Dependency Of Developing Brain written by Ann-Charlotte Granholm and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1984 with Brain categories.

Thyroid Hormones And Brain Development

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Author : Gilman D. Grave
language : en
Publisher:
Release Date : 1977

Thyroid Hormones And Brain Development written by Gilman D. Grave and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1977 with Medical categories.

Thyroid Hormones And Brain Development

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Author : Gilman D. Grave
language : en
Publisher:
Release Date :

Thyroid Hormones And Brain Development written by Gilman D. Grave and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on with categories.

Thyroid Hormone And The Developing Brain

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Author :
language : en
Publisher:
Release Date : 1989

Thyroid Hormone And The Developing Brain written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1989 with categories.

Thyroid Hormone In Brain And Brain Cells

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Author : Frédéric Flamant
language : en
Publisher: Frontiers Media SA
Release Date : 2016-01-21

Thyroid Hormone In Brain And Brain Cells written by Frédéric Flamant and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-01-21 with Diseases of the endocrine glands. Clinical endocrinology categories.

Thyroid hormone signaling has been known for a long time to be required for proper neurodevelopment and the maintenance of cognitive functions in the adult brain. As thyroid hormone excess or deficiency is usually well handled by clinicians, research dedicated to the neural function of thyroid hormone, have not been a priority within the field. This is changing mainly for two reasons. First, new genetic diseases have been discovered, altering thyroid hormone signaling in brain (THRA, MCT8, SBP2), with neurodevelopmental consequences which are currently incurable. Second, there is a growing concern that exposition of the general population to environmental chemicals able to interfere with thyroid hormone signaling compromises children neurodevelopment or induces central disorders in adults. Finally thyroid hormone is acting directly on gene transcription, by binding nuclear receptors, and therefore is an interesting entry point to identify genetic programs controlling brain development and function. Reaching a broad understanding of the multiple processes involving thyroid hormone in brain is a tremendous task which will necessitate a multidisciplinary approach: animal genetics, molecular biology, brain imaging, developmental biology, genomics, etc... This topic will be the occasion to combine recent contributions in the field and to identify priorities for future investigations. Due to devastating consequences of congenital hypothyroidism, the neurodevelopmental consequences of altered thyroid hormone signaling have been extensively studied over the years. The discovery of new genetic diseases, the concern about the possible neurotoxicity of environmental thyroid hormone disruptors, recently renewed the interest for an important research field. This Ebook gathers reviews and original data from experts in various disciplines. It provides a broad view of ongoing research and outlines key issues for future investigation.

Thyroid Hormone And Brain Development

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Author : R. Balázs
language : en
Publisher:
Release Date : 1980

Thyroid Hormone And Brain Development written by R. Balázs and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1980 with categories.

Thyroid Hormone Disruption And Neurodevelopment

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Author : Noriyuki Koibuchi
language : en
Publisher: Springer
Release Date : 2016-11-11

Thyroid Hormone Disruption And Neurodevelopment written by Noriyuki Koibuchi and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-11-11 with Medical categories.

Thyroid hormone plays an important role in development and functional maintenance in the central nervous system. Deficiency of thyroid hormone during fetal and early postnatal life induces abnormal development known as cretinism in humans. However, the molecular mechanism of thyroid hormone action has not yet been fully understood. Thyroid hormone action in the brain may be disrupted under various pathological conditions. In addition, environmental factors including endocrine-disrupting chemicals and bacterial endotoxins may disrupt thyroid hormone action in brain, causing abnormal brain development and functional disruption. This is a first book to comprehensively describe the effect of thyroid hormone disruption in the central nervous system. The first section deals with the disruption of thyroid hormone action at the molecular level. First the authors provide a summary of the possible molecular mechanisms of thyroid hormone action in the brain, then they discuss several factors that may disrupt thyroid hormone action. In the second section, animal models to study thyroid hormone action will be introduced. An interesting character of thyroid hormone deficiency is that, without thyroid hormone, the thyroid hormone receptor may act as a “repressor” of gene expression, causing more severe consequence than those of thyroid hormone receptor knockout animals. Thus, several different kind of animal models may be used to clarify the role of thyroid hormone and its receptor in the brain. In the third section, human studies on thyroid disease and neurodevelopment will be introduced. Although endemic cretinism induced by iodine deficiency and sporadic cretinism by various thyroid mutation are well known, the pathophysiological mechanisms that create each abnormal phenotype are not fully understood. ​

Brain Development And Thyroid Deficiency

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Author : Arie Querido
language : en
Publisher: North-Holland
Release Date : 1975

Brain Development And Thyroid Deficiency written by Arie Querido and has been published by North-Holland this book supported file pdf, txt, epub, kindle and other format this book has been release on 1975 with Brain categories.

Thyroid Hormone Metabolism

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Author : Georg Hennemann
language : en
Publisher: Marcel Dekker
Release Date : 1986

Thyroid Hormone Metabolism written by Georg Hennemann and has been published by Marcel Dekker this book supported file pdf, txt, epub, kindle and other format this book has been release on 1986 with Medical categories.

Hypothyroidism And Brain Developmental Players

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Author : Ahmed R. G.
language : en
Publisher:
Release Date : 2017

Hypothyroidism And Brain Developmental Players written by Ahmed R. G. and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with categories.

Most of our knowledge on the mechanisms of thyroid hormone (TH) dependent brain development is based on clinical observations and animal studies of maternal/fetal hypothyroidism. THs play an essential role in brain development and hormone deficiency during critical phases in fetal life may lead to severe and permanent brain damage. Maternal hypothyroidism is considered the most common cause of fetal TH deficiency, but the problem may also arise in the fetus. In the case of congenital hypothyroidism due to defects in fetal thyroid gland development or hormone synthesis, clinical symptoms at birth are often mild as a result of compensatory maternal TH supply. TH transporters (THTs) and deiodinases (Ds) are important regulators of intracellular triiodothyronine (T3) availability and therefore contribute to the control of thyroid receptors (TRs)-dependent CNS development and early embryonic life. Defects in fetal THTs or Ds may have more impact on fetal brain since they can result in intracellular T3 deficiency despite sufficient maternal TH supply. One clear example is the recent discovery of mutations in the TH transporter (monocarboxylate transporter 8; MCT8) that could be linked to a syndrome of severe and non reversible psychomotor retardation. Even mild and transient changes in maternal TH levels can directly affect and alter the gene expression profile, and thus disturb fetal brain development. Animal studies are needed to increase our understanding of the exact role of THTs and Ds in prenatal brain development.