Thyroid Hormones And Brain Development

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Thyroid Hormones And Brain Development

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Author : Gilman D. Grave
language : en
Publisher:
Release Date : 1977

Thyroid Hormones And Brain Development written by Gilman D. Grave and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1977 with Medical categories.

Thyroid Hormones And Brain Development

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Author : Gilman D. Grave
language : en
Publisher:
Release Date :

Thyroid Hormones And Brain Development written by Gilman D. Grave and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on with categories.

Thyroid Hormone And Brain Development

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Author : R. Balázs
language : en
Publisher:
Release Date : 1980

Thyroid Hormone And Brain Development written by R. Balázs and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1980 with categories.

Thyroid Hormone In Brain And Brain Cells

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Author : Frédéric Flamant
language : en
Publisher: Frontiers Media SA
Release Date : 2016-01-21

Thyroid Hormone In Brain And Brain Cells written by Frédéric Flamant and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-01-21 with Diseases of the endocrine glands. Clinical endocrinology categories.

Thyroid hormone signaling has been known for a long time to be required for proper neurodevelopment and the maintenance of cognitive functions in the adult brain. As thyroid hormone excess or deficiency is usually well handled by clinicians, research dedicated to the neural function of thyroid hormone, have not been a priority within the field. This is changing mainly for two reasons. First, new genetic diseases have been discovered, altering thyroid hormone signaling in brain (THRA, MCT8, SBP2), with neurodevelopmental consequences which are currently incurable. Second, there is a growing concern that exposition of the general population to environmental chemicals able to interfere with thyroid hormone signaling compromises children neurodevelopment or induces central disorders in adults. Finally thyroid hormone is acting directly on gene transcription, by binding nuclear receptors, and therefore is an interesting entry point to identify genetic programs controlling brain development and function. Reaching a broad understanding of the multiple processes involving thyroid hormone in brain is a tremendous task which will necessitate a multidisciplinary approach: animal genetics, molecular biology, brain imaging, developmental biology, genomics, etc... This topic will be the occasion to combine recent contributions in the field and to identify priorities for future investigations. Due to devastating consequences of congenital hypothyroidism, the neurodevelopmental consequences of altered thyroid hormone signaling have been extensively studied over the years. The discovery of new genetic diseases, the concern about the possible neurotoxicity of environmental thyroid hormone disruptors, recently renewed the interest for an important research field. This Ebook gathers reviews and original data from experts in various disciplines. It provides a broad view of ongoing research and outlines key issues for future investigation.

Brain Development And Thyroid Deficiency

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Author : Arie Querido
language : en
Publisher: North-Holland
Release Date : 1975

Brain Development And Thyroid Deficiency written by Arie Querido and has been published by North-Holland this book supported file pdf, txt, epub, kindle and other format this book has been release on 1975 with Brain categories.

Iodine Nutrition Thyroxine And Brain Development

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Author : N. Kochupillai
language : en
Publisher: TATA McGraw-Hill Publishing Company
Release Date : 1986

Iodine Nutrition Thyroxine And Brain Development written by N. Kochupillai and has been published by TATA McGraw-Hill Publishing Company this book supported file pdf, txt, epub, kindle and other format this book has been release on 1986 with Medical categories.

Thyroid Hormone Disruption And Neurodevelopment

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Author : Noriyuki Koibuchi
language : en
Publisher: Springer
Release Date : 2016-11-11

Thyroid Hormone Disruption And Neurodevelopment written by Noriyuki Koibuchi and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-11-11 with Medical categories.

Thyroid hormone plays an important role in development and functional maintenance in the central nervous system. Deficiency of thyroid hormone during fetal and early postnatal life induces abnormal development known as cretinism in humans. However, the molecular mechanism of thyroid hormone action has not yet been fully understood. Thyroid hormone action in the brain may be disrupted under various pathological conditions. In addition, environmental factors including endocrine-disrupting chemicals and bacterial endotoxins may disrupt thyroid hormone action in brain, causing abnormal brain development and functional disruption. This is a first book to comprehensively describe the effect of thyroid hormone disruption in the central nervous system. The first section deals with the disruption of thyroid hormone action at the molecular level. First the authors provide a summary of the possible molecular mechanisms of thyroid hormone action in the brain, then they discuss several factors that may disrupt thyroid hormone action. In the second section, animal models to study thyroid hormone action will be introduced. An interesting character of thyroid hormone deficiency is that, without thyroid hormone, the thyroid hormone receptor may act as a “repressor” of gene expression, causing more severe consequence than those of thyroid hormone receptor knockout animals. Thus, several different kind of animal models may be used to clarify the role of thyroid hormone and its receptor in the brain. In the third section, human studies on thyroid disease and neurodevelopment will be introduced. Although endemic cretinism induced by iodine deficiency and sporadic cretinism by various thyroid mutation are well known, the pathophysiological mechanisms that create each abnormal phenotype are not fully understood. ​

Thyroid Hormone Dependency Of Developing Brain

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Author : Ann-Charlotte Granholm
language : en
Publisher:
Release Date : 1984

Thyroid Hormone Dependency Of Developing Brain written by Ann-Charlotte Granholm and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1984 with Brain categories.

Iodine And The Brain

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Author : G. Robert Delong
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06

Iodine And The Brain written by G. Robert Delong and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.

This volume contains the proceedings of a conference held at the National Institutes of Health in Bethesda on March 21-23. 1988. jointly sponsored by the International Council for Control of Iodine Deficiency Disorders (ICCIDD) and the Fogarty International Center of the National Institutes of Health. Several themes converged to make this meeting timely. The first is an increasing awareness of iodine deficiency disorders as a world-wide problem of public health and a preventable cause of mental deficiency. and as a subject of scientific effort. Increased interest in these problems owes a great deal to accessibility to remote and under developed areas of the world where iodine deficiency persists. As with any subject. greater scrutiny yields unexpected complexity and interest. It is true that provision of iodine. typically as iodized salt, is the necessary and sufficient preventative for iodine deficiency disorders. without including endemic cretinism. This provision is a governmental, economic and social problem. Apart from this, however, the scientific and medical problem of iodine deficiency and its effect on brain development and function is one of great interest and importance for developmental neurology and psychology. Even though the specific preventative agent is known, we do not totally understand the neurobiological questions raised.

Effects Of Maternal Thyroid Hypofunction On Fetal Brain Development During Pregnancy

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Author : Caroline R. Hobson
language : en
Publisher:
Release Date : 2020

Effects Of Maternal Thyroid Hypofunction On Fetal Brain Development During Pregnancy written by Caroline R. Hobson and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020 with categories.

Thyroid hormone regulates essential processes in brain development such as neural cell migration, differentiation, signaling, and myelination, particularly during the early stages of gestation. During this time, fetal thyroid hormone accessibility depends on the placental transfer of thyroid hormones. Deficiency of thyroid hormone during fetal and postnatal periods may lead to permanent mental retardation and neurological deficits. Clinical studies have been conducted demonstrating links between maternal hypothyroidism and numerous neurodevelopmental disorders such as Autism Spectrum Disorder (ASD), Attention Deficit Hyperactivity Disorder, lower IQ, behavioral disorders, and psychiatric disorders. To investigate the effects of thyroid hormone actions on perinatal brain development potentially present in ASD, a literature review was conducted using PubMed, UCF EBSCOhost, and Google Scholar to obtain relevant papers for analysis. Across the board, abnormal maternal thyroid function, especially suboptimal maternal free thyroxine hormone, was associated with increased risk for neurological disorders, including ASD. The implications of this study emphasize the importance of managing maternal hypothyroidism during pregnancy to possibly reduce the incidence of neurodevelopmental disorders such as ASD.