Time Resolved Methods In Structural Biology

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Time Resolved Methods In Structural Biology

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Author :
language : en
Publisher: Elsevier
Release Date : 2024-12-02

Time Resolved Methods In Structural Biology written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-12-02 with Science categories.

Time-Resolved Methods in Structural Biology series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors. - Provides the latest information on biological research - Offers outstanding and original reviews on a range of biological research topics - Serves as an indispensable reference for researchers and students alike

Scattering Methods In Structural Biology Part B

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Author :
language : en
Publisher: Elsevier
Release Date : 2023-01-12

Scattering Methods In Structural Biology Part B written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-01-12 with Science categories.

Scattering Methods in Structural Biology, Part B, Volume 676 in the Methods in Enzymology serial, highlights advances in the field, presenting chapters on Quality controls, Refining biomolecular structures and ensembles by SAXS-driven molecular dynamics simulations, Data analysis and modelling of small-angle scattering data with contrast variation, Observing protein degradation in solution by the PAN-20S proteasome complex: state-of-the-art and future perspectives of TR-SANS as a complementary tool to NMR, crystallography and Cryo-EM, Extracting structural insights from chemically-specific soft X-ray scattering, Reconstruction of 3D density of biological macromolecules from solution scattering, ATSAS- present state and new developments in computational methods, and much more. Additional chapters cover Modeling Structure and Dynamics of Protein Complexes with SAXS Profiles (FoXSDock and MultiFoXS), Validation of macromolecular flexibility in solution by SAXS, Combining NMR, SAXS and SANS to characterize the structure and dynamics of protein complexes, Application of Molecular Simulation Methods to Analyze SAS Data, and more. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in the Methods in Enzymology serial - Updated release includes the latest information on Small Angle Scattering Methods for Structural Interpretation

Advanced Methods In Structural Biology

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Author : Ângela Sousa
language : en
Publisher: Springer Nature
Release Date : 2023-04-24

Advanced Methods In Structural Biology written by Ângela Sousa and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-04-24 with Science categories.

This volume explores the latest integrated bioprocesses and technologies used to study the production of the target recombinant protein of therapeutic or diagnostic interest; its isolation, purification, and stabilization; and the bio-interaction and structural analyses. The chapters in this book are organized into four parts. Part One covers production methods of soluble and membrane proteins in prokaryotic and eukaryotic expression systems, such as Lactococcus lactis and Escherichia coli. Part Two describes traditional and novel approaches for recombinant protein purification and stabilization, and buffers and additives. Part Three discusses automated methods in structural biology based on in silico approaches; and Part Four provides examples of advanced protein investigation methodologies to assess structural analysis such as high-throughput protein crystallization and time-resolved serial crystallography. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, Advanced Methods in Structural Biology is a valuable resource to those in academia (i.e., graduate students and postdoctoral researchers) and researchers in the pharmaceutical industry who wish to learn more about this developing field. Chapter 5 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Synchrotron Radiation In Structural Biology

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Author : R. Sweet
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-09

Synchrotron Radiation In Structural Biology written by R. Sweet and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-09 with Technology & Engineering categories.

The development of synchrotron radiation (SR) as a research tool was driven largely by the needs of materials scientists and solid-state physi cists. However, the availability of SR has extended significantly the capa bility of scientists who study biological structure with radiation. This volume contains some of the results reported at a symposium held at Brookhaven National Laboratory in May 1988 to discuss the application of synchrotron radiation to structural biology. We are grateful for financial support from the u. s. Department of Energy, the National Institutes of Health, Genentech, Inc., Blake Indus tries, Inc., Evans and Sutherland Co., The Upjohn Company, Eli Lilly and Company, Enraf-Nonius Service Corp., and Associated Universities, Inc. We warmly thank Ms. Nancy Siemon for her tireless efforts with correspondence and the manuscripts for this symposium volume. Symposium Committee: Robert M. Sweet, Chair Malcolm S. Capel Benno P. Schoenborn John C. Sutherland Elizabeth C. Theil Stephen W. White Avril D. Woodhead Helen Z. Kondratuk, Coordinator v CONTENTS An Introduction to the Symposium . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 R. M. Sweet SYMPOSIUM LECTURE Developments in X-ray Technology and Their Contribution to Structural Biology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 H. E. Huxley SOME OF THE SYNCHROTRON FACILITIES FOR BIOLOGICAL STRUCTURAL STUDIES MacChess - A Macromolecular Diffraction Resource at the Cornell High Energy Synchrotron Source . . . . . . . . . . . . . . . . . . . 15 W. Schi1dkamp, K. Moffat, B. Batterman, D. Bilderback, T-Y. Teng, A. LeGrand and D. Szebenyi Facilities Available for Biophysics Research at the Stanford Synchrotron Radiation Laboratory. . . . . . . . . . . . . . . . . . . . . 19 R. P."

Dynamics And Kinetics In Structural Biology

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Author : Keith Moffat
language : en
Publisher: John Wiley & Sons
Release Date : 2023-11-06

Dynamics And Kinetics In Structural Biology written by Keith Moffat and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-11-06 with Science categories.

Dynamics and Kinetics in Structural Biology Understand the latest experimental tools in structural biology with this pioneering work Structural biology seeks to understand the chemical mechanisms and functions of biological molecules, such as proteins, based on their atomic structures. Until recently, these structures have been studied only statically, using procedures which deliberately freeze atomic motion. However, freezing eliminates the rapid structural motions so essential to biological activity and function; the molecules are inactive. But with the recent development of X-ray free electron laser (XFEL) sources, efforts to conduct dynamic experiments have expanded using the principles of dynamics and kinetics to capture active biological molecules as they function. Dynamics and Kinetics in Structural Biology promotes the development of these experiments and their successful application. It grounds readers in the foundational principles of dynamics and kinetics; proceeds through extended discussions of experimental procedures and data analysis techniques; and explores experimental frontiers in structural dynamics. The book will aid researchers to gather and interpret cutting-edge data on the dynamic structure of biological molecules, under conditions where they retain their biological functions. Dynamics and Kinetics in Structural Biology offers readers: Authorship by founding figures in the field In-depth presentation of time-resolved X-ray crystallography, solution scattering, and more A pioneering contribution to a rapidly developing field of study Dynamics and Kinetics in Structural Biology is essential reading for graduate students, scientists, researchers and industry professionals engaged in structural studies of biological systems. Industry professionals considering dynamic studies in the development of new product lines will also benefit.

Advances In Protein Molecular And Structural Biology Methods

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Author : Timir Tripathi
language : en
Publisher: Academic Press
Release Date : 2022-01-14

Advances In Protein Molecular And Structural Biology Methods written by Timir Tripathi and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-01-14 with Science categories.

Advances in Protein Molecular and Structural Biology Methods offers a complete overview of the latest tools and methods applicable to the study of proteins at the molecular and structural level. The book begins with sections exploring tools to optimize recombinant protein expression and biophysical techniques such as fluorescence spectroscopy, NMR, mass spectrometry, cryo-electron microscopy, and X-ray crystallography. It then moves towards computational approaches, considering structural bioinformatics, molecular dynamics simulations, and deep machine learning technologies. The book also covers methods applied to intrinsically disordered proteins (IDPs)followed by chapters on protein interaction networks, protein function, and protein design and engineering. It provides researchers with an extensive toolkit of methods and techniques to draw from when conducting their own experimental work, taking them from foundational concepts to practical application. - Presents a thorough overview of the latest and emerging methods and technologies for protein study - Explores biophysical techniques, including nuclear magnetic resonance, X-ray crystallography, and cryo-electron microscopy - Includes computational and machine learning methods - Features a section dedicated to tools and techniques specific to studying intrinsically disordered proteins

Small Angle Scattering Part A Methods For Structural Investigation

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Author :
language : en
Publisher: Academic Press
Release Date : 2022-11-19

Small Angle Scattering Part A Methods For Structural Investigation written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-11-19 with Science categories.

Small Angle Scattering, Part A: Methods for Structural Investigation, Volume 675 in the Methods in Enzymology series, highlights new advances in the field, with new chapters in this updated release including SAXS foundations and metrics, Contrast variation sample preparation protocols, experimental procedures, and rudimentary analysis, Molecular deuteration for neutron scattering, Planning, Executing and Assessing the Feasibility of SANS Contrast Variation Experiments, Technical considerations for small-angle neutron scattering from biological macromolecules, and Advanced sample environments and capabilities at our synchrotron X-ray beamline with example applications. Additional sections in the book cover SEC-SAXS-MALS data acquisition and processing pipeline at SIBYLS, SEC-SAXS: pros and cons, experimental set-up, examples and software developments, Radiation damage and sample economy for stopped-flow methods in the time regime of millisecond and above, Stopped-flow-time-resolved SAXS, Insights on Temp-jump, time-resolved SAXS, and much more. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in the Methods in Enzymology series - Includes the latest information on Small Angle Scattering: Methods for Structural Investigation

Computational Structural Biology Methods And Applications

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Author : Torsten Schwede
language : en
Publisher: World Scientific
Release Date : 2008-05-02

Computational Structural Biology Methods And Applications written by Torsten Schwede and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-05-02 with Science categories.

Computational structural biology has made tremendous progress over the last two decades, and this book provides a recent and broad overview of such computational methods in structural biology. It covers the impact of computational structural biology on protein structure prediction methods, macromolecular function and protein design, and key methods in drug discovery. It also addresses the computational challenges of experimental approaches in structural biology. In addition to reviewing the current state of computational structural biology, each chapter ends with a brief, visionary discussion on the future outlook, whereby the main challenges for the coming years are elucidated. Written by an international panel of expert contributors, this book can serve as a reference manual for students and practitioners alike.

Ultrafast Electronic And Structural Dynamics

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Author : Kiyoshi Ueda
language : en
Publisher: Springer Nature
Release Date : 2024-07-23

Ultrafast Electronic And Structural Dynamics written by Kiyoshi Ueda and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-07-23 with Science categories.

This book illustrates advanced technologies for imaging electrons and atoms in action in various forms of matter, from atoms and diatoms to protein molecules and condensed matter. The technologies that are described employ ultrafast pulsed lasers, X-ray free electron lasers, and pulsed electron guns, with pulse durations from femtoseconds, suitable to visualize atoms in action, to attoseconds, needed to visualize ballistic electron motion. Advanced theories, indispensable for understanding such ultrafast imaging and spectroscopy data on electrons and atoms in action, are also described. The book consists of three parts. The first part describes probing methods of attosecond electron dynamics in atoms, molecules, liquids, and solids. The second part describes femtosecond structural dynamics and coupling of structural change and electron motion in molecules and solids The last part is dedicated to ultrafast photophysical processes and chemical reactions of protein molecules responsible for biological functions.

Polysaccharide Degrading Biocatalysts

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Author : Rosana Goldbeck
language : en
Publisher: Elsevier
Release Date : 2023-02-15

Polysaccharide Degrading Biocatalysts written by Rosana Goldbeck and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-02-15 with Science categories.

The transformation of polysaccharides into valuable compounds for health and industry requires the careful application of enzyme protocols and controlled biocatalysis. Polysaccharide-Degrading Biocatalysts provides a thorough grounding in these biocatalytic processes and their growing role in the depolymerization of polysaccharides, empowering researchers to discover and develop new enzyme-based approaches across pharmaceuticals, fuels, and food engineering. Here, over a dozen leading experts offer a close examination of structural polysaccharides, genetic modification of polysaccharides, polysaccharide degradation routes, pretreatments for enzymatic hydrolysis, hemicellulose-degrading enzymes, biomass valorization processes, oligosaccharide production, and enzyme immobilization for the hydrolysis of polysaccharides, among other topics and related research protocols. A final chapter considers perspectives and challenges in an evolving, carbohydrate-based economy. - Describes the role of enzymes in the degradation of polysaccharides to obtain building blocks for biochemical processes - Covers new tools for enzymatic evolution, research protocols, and process strategies contributing to large-scale applications - Explores the use of polysaccharide hydrolysis products in the areas of pharmaceuticals, fuels, and food engineering - Features chapter contributions from international experts