Tissue Specific Estrogen Action
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Tissue Specific Estrogen Action
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Author : Kenneth S. Korach
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-05-16
Tissue Specific Estrogen Action written by Kenneth S. Korach and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-05-16 with Medical categories.
Current molecular understanding of estrogen action has greatly profited from advances in molecular cell biology. These advances, and their implications for clinical use, were discussed by leading researchers from industry and academia during an international symposium held in Berlin, 1-3 March 2006 and are featured in this volume.
Tissue Specific Estrogen Action
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Author : Kenneth S. Korach
language : en
Publisher: Springer
Release Date : 2009-09-02
Tissue Specific Estrogen Action written by Kenneth S. Korach and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-09-02 with Medical categories.
Current molecular understanding of estrogen action has greatly profited from advances in molecular cell biology. These advances, and their implications for clinical use, were discussed by leading researchers from industry and academia during an international symposium held in Berlin, 1-3 March 2006 and are featured in this volume.
Tissue Specific Estrogen Action
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Author :
language : en
Publisher:
Release Date : 2007
Tissue Specific Estrogen Action written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007 with categories.
Tissue Specific Regulation Of Gene Expression By Estrogens And Selective Estrogen Receptor Modulators
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Author : Robert D. Nerenz
language : en
Publisher:
Release Date : 2010
Tissue Specific Regulation Of Gene Expression By Estrogens And Selective Estrogen Receptor Modulators written by Robert D. Nerenz and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with categories.
Estrogen Action Selective Estrogen Receptor Modulators And Women S Health
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Author : V. Craig Jordan
language : en
Publisher: World Scientific
Release Date : 2013
Estrogen Action Selective Estrogen Receptor Modulators And Women S Health written by V. Craig Jordan and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with Medical categories.
This volume presents the evolution of the authors' ideas about estrogen action and its modulation by a new group of drugs called SERMs (Selective Estrogen Receptor Modulators). The pioneering SERMs OCo tamoxifen and raloxifene OCo are known to have saved the lives of millions of women around the world and improved the health of millions more. Estrogen is the central hormone of women's health and reproduction. The book is a journey through 40 years of discovery and success in advancing women's health, with the prospect of improved innovation through medicinal chemistry for the future.
New Molecular Mechanisms Of Estrogen Action And Their Impact On Future Perspectives In Estrogen Therapy
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Author : Kenneth S. Korach
language : en
Publisher: Springer Science & Business Media
Release Date : 2004-06-21
New Molecular Mechanisms Of Estrogen Action And Their Impact On Future Perspectives In Estrogen Therapy written by Kenneth S. Korach and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-06-21 with Medical categories.
From our current knowledge, it is obvious that estrogen action in volves more than reproduction and fertility. Rather, estrogens affect and influence a number of other organ systems such as the immune, cardiovascular and central nervous system as well as the gastrointes tinal tract, urinary tract and skeleton. The importance of estrogens and estrogen receptor activity is appreciated from the spectrum of significant physiological dysfunctions that occur when there is a loss The participants of the workshop VI Preface of the hormone or the receptor activity. Loss of estrogen, however (for instance during menopause), occurs with time and results in a variety of clinical conditions. We know that the developmental loss of estrogen, as seen in clinical cases of aromatase gene mutations and experimental models, has dramatic effects in both men and women alike. The evidence that these effects are mediated through the estrogen receptor(s) is based on similar but not always identical phenotypes as observed in experimental animal models of estrogen receptor mutations as well as the single clinical case of an estrogen receptor alpha mutant patient. Developing an understanding of the spectrum of estrogen in a variety of tissues related to the condition of estrogen loss is a major and highly active clinical as well as basic scientific research area. Following the discovery of a second estrogen receptor and possible receptor ligand-independent activity as well as the genomic and non genomic actions of estrogen, it is clear that the mechanisms of the effects of estrogen are multifaceted.
Selective Estrogen Receptor Modulators
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Author : Antonio Cano
language : en
Publisher: Springer Science & Business Media
Release Date : 2006-09-22
Selective Estrogen Receptor Modulators written by Antonio Cano and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-09-22 with Medical categories.
The increasing awareness on the varied consequences of hypogonadism in distinct organs and systems has supported the notion of estrogens as systemic agents. This observation is congruent with the variety of tissues affected by - trogens when used in hormone therapy formulations on hypogonadic women. Apart from the genital tract and the breast, recognized as traditional targets for estrogens, the skeleton, the vascular tree, or the central nervous system, are good examples of territories that have demonstrated sensitivity to estrogens. This evidence has created great interest, as shown by the great amount of lit- ature that has been produced on the bene?ts and risks associated with the use of estrogens. In parallel to the clinical interest, basic research has improved our kno- edge on the complexities involved in estrogen action at the molecular level. Together with effects mediated through speci?c receptors, a concept that has been the mainstay of the interpretation of estrogen action for years, there is enough evidence to hold the notion of receptor-independent effects. The substantial advances in modern technology applied to research have helped in enlightening the particulars of this versatile action of estrogens. This more detailed knowledge on the sophisticated mechanism of action of estrogens has nourished the emergence of multiple hypotheses speculating with the p- sibility of manipulating estrogen action. The notion that a widely extended regulatory system of cell function, as it is the estrogen receptor machinery, might be modulated at wish has arisen as an attractive, although still elusive postulate.
Bioactive Natural Products
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Author : Goutam Brahmachari
language : en
Publisher: John Wiley & Sons
Release Date : 2015-03-23
Bioactive Natural Products written by Goutam Brahmachari and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-03-23 with Science categories.
Ein multidisziplinärer Überblick über die aktuellen Themen und Zukunftstrends in der Erforschung von Naturstoffen mit Schwerpunkt auf pharmazeutischen und medizinischen Anwendungen.
A Handbook On Estrogen Receptors In The Brain
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Author : Vijay Paramanik
language : en
Publisher:
Release Date : 2016
A Handbook On Estrogen Receptors In The Brain written by Vijay Paramanik and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016 with Medical categories.
The present book covers estrogen, its receptors and estrogen mediated gene regulation in the brain. Further, it explains the mechanism of estrogen action and dysfunction leading to diseases. Briefly, estrogen mediates its multiple functions in the brain through two well-characterized receptors: ER? and ER?. Upon binding with estrogen, ER recruits coregulators, which are responsible for tissue specific regulation. When coregulators activate the transcription of a particular gene, they become coactivators; when they repress the activity of particular gene, they are called corepressors. These coregulators make a bridge between the basal transcription machinery and the receptors by protein-protein interaction. Estrogen disrupters are also explained in this book. Furthermore, the role of estrogen and its receptors are explained in the context of aging. Taken together, this book shall be self-explanatory concerning estrogen action in the brain in various aspects. Therefore, it is intended for researchers interested in the aforementioned aspects.
Organ Selective Actions Of Steroid Hormones
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Author : D.T. Baird
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-09
Organ Selective Actions Of Steroid Hormones written by D.T. Baird and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-09 with Medical categories.
Steroids regulate differentiation, growth and functioning of many tissues via a nuclear receptor gene activation mechanism. Molecular biology has opened the way for more detailed investigation of the complex set of intracellular interactions contributing to organ-selective actions of steroids and steroid-like compounds such as vitamin D. In this volume leading experts address basic molecular mechanisms of tissue specificity and related issue, with the goal of attaining a better understanding of the underlying mechanisms of organ selective actions of steroids. Discussed is the extent to which tissue specificity might selectively be modified by chemical modification of the hormones and how this may be applied towards improved therapies by taking advantage of tissue selectivity.