Toxic Susceptibility
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Toxic Susceptibility
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Author : Edward J. Calabrese
language : en
Publisher: Wiley-Interscience
Release Date : 1985-09-23
Toxic Susceptibility written by Edward J. Calabrese and has been published by Wiley-Interscience this book supported file pdf, txt, epub, kindle and other format this book has been release on 1985-09-23 with Science categories.
A critical assessment of the animal models and human clinical and population-based studies that highlight the physiological and biochemical differences between male-female responses to toxic substances. Focuses on the organ systems that are especially sensitive to toxicants and pollutants. Investigates the extent to which the pregnant state may alter a susceptibility to toxic substances, with particular emphasis on alterations in drug metabolism. Shows the significance such findings have for regulatory agencies concerned with environmental health.
Contaminated Water Supplies At Camp Lejeune
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Author : National Research Council
language : en
Publisher: National Academies Press
Release Date : 2009-09-06
Contaminated Water Supplies At Camp Lejeune written by National Research Council and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-09-06 with Medical categories.
In the early 1980s, two water-supply systems on the Marine Corps Base Camp Lejeune in North Carolina were found to be contaminated with the industrial solvents trichloroethylene (TCE) and perchloroethylene (PCE). The water systems were supplied by the Tarawa Terrace and Hadnot Point watertreatment plants, which served enlisted-family housing, barracks for unmarried service personnel, base administrative offices, schools, and recreational areas. The Hadnot Point water system also served the base hospital and an industrial area and supplied water to housing on the Holcomb Boulevard water system (full-time until 1972 and periodically thereafter). This book examines what is known about the contamination of the water supplies at Camp Lejeune and whether the contamination can be linked to any adverse health outcomes in former residents and workers at the base.
Toxic Susceptibility Male Female Differences
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Author : EJ. CALABRESE
language : en
Publisher:
Release Date : 1985
Toxic Susceptibility Male Female Differences written by EJ. CALABRESE and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1985 with categories.
Human Variability In Susceptibility To Toxic Chemicals
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Author :
language : en
Publisher:
Release Date : 1987
Human Variability In Susceptibility To Toxic Chemicals written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1987 with Environmental impact analysis categories.
Age And Susceptibility To Toxic Substances
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Author : Edward J. Calabrese
language : en
Publisher: Wiley-Interscience
Release Date : 1986-09-22
Age And Susceptibility To Toxic Substances written by Edward J. Calabrese and has been published by Wiley-Interscience this book supported file pdf, txt, epub, kindle and other format this book has been release on 1986-09-22 with Medical categories.
Investigates the relationship between age and environmentally induced diseases, which must be taken into consideration in establishing acceptable exposure standards for high-risk groups in society. Assesses the effect of age on gastrointestinal and dermal absorption of toxic substances and drugs, and age differences in plasma protein binding and xenobiotic metabolism. Contains several chapters on organ-specific toxicity differences according to age. Also discusses genotoxicity and environmentally induced cancer. A final chapter synthesizes the information and addresses the relevance of this knowledge to biological basis of safety considerations.
Translational Toxicology And Therapeutics
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Author : Michael D. Waters
language : en
Publisher: John Wiley & Sons
Release Date : 2018-01-04
Translational Toxicology And Therapeutics written by Michael D. Waters and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-01-04 with Medical categories.
Written by leading research scientists, this book integrates current knowledge of toxicology and human health through coverage of environmental toxicants, genetic / epigenetic mechanisms, and carcinogenicity. Provides information on lifestyle choices that can reduce cancer risk Offers a systematic approach to identify mutagenic, developmental and reproductive toxicants Helps readers develop new animal models and tests to assess toxic impacts of mutation and cancer on human health Explains specific cellular and molecular targets of known toxicants operating through genetic and epigenetic mechanisms
Human Variability In Response To Chemical Exposures Measures Modeling And Risk Assessment
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Author : David A. Eckerman
language : en
Publisher: CRC Press
Release Date : 1998-08-25
Human Variability In Response To Chemical Exposures Measures Modeling And Risk Assessment written by David A. Eckerman and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998-08-25 with Medical categories.
and for those interested in toxic effects of chemicals on humans, Human Variability in Response to Chemical Exposures: Measures, Modeling, and Risk Assessment recognizes and addresses the increasing awareness that individual biological differences be reflected when assessing human health risks associated with exposure to chemicals. Eight original manuscripts, commissioned by the ILSI Risk Science Institute, address the evidence for variability in human response to chemicals associated with reproductive and developmental effects, effects on the nervous system and lungs, and cancer. Their reports convey both the current state of scientific understanding of response variability and the genetic basis for such observations. This book recognizes that understanding of variability in response is critical in accounting for interindividual variability in susceptibility and, hence, risk, if the regulatory community and others are expected to characterize human health risks associated with exposure to chemicals. Models for incorporating measures of response variability in the risk assessment process are critically reviewed and illustrated with published data. This authoritative work indicates that, in the case of certain chemicals and in the context of certain specific toxic effects, we have considerable ability to predictively and quantitatively characterize human variability, but, in the majority of cases, our ability to do so is limited. If we improve both quantity and quality of information available on response variability and increase our understanding of target tissue dosimetry, we should be better able to account for variability in human susceptibility to the toxic effects of chemicals.
Monitoring Human Tissues For Toxic Substances
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Author : National Research Council
language : en
Publisher: National Academies Press
Release Date : 1991-02-01
Monitoring Human Tissues For Toxic Substances written by National Research Council and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991-02-01 with Science categories.
The National Human Monitoring Program (NHMP) identifies concentrations of specific chemicals in human tissues, including toxicologic testing and risk assessment determinations. This volume evaluates the current activities of the NHMP; identifies important scientific, technical, and programmatic issues; and makes recommendations regarding the design of the program and use of its products.
Human Variability In Response To Chemical Exposures
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Author : David A. Neumann
language : en
Publisher: International Life Science Inst
Release Date : 1998
Human Variability In Response To Chemical Exposures written by David A. Neumann and has been published by International Life Science Inst this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998 with Medical categories.
and for those interested in toxic effects of chemicals on humans, Human Variability in Response to Chemical Exposures: Measures, Modeling, & Risk Assessment recognizes & addresses the increasing awareness that individual biological differences be reflected when assessing human health risks associated with exposure to chemicals. Eight original manuscripts, commissioned by the ILSI Risk Science Institute, address the evidence for variability in human response to chemicals associated with reproductive & developmental effects, effects on the nervous system & lungs, & cancer. Their reports convey both the current state of scientific understanding of response variability & the genetic basis for such observations. This book recognizes that understanding of variability in response is critical in accounting for interindividual variability in susceptibility and, hence, risk, if the regulatory community & others are expected to characterize human health risks associated with exposure to chemicals. Models for incorporating measures of response variability in the risk assessment process are critically reviewed & illustrated with published data. This authoritative work indicates that, in the case of certain chemicals & in the context of certain specific toxic effects, we have considerable ability to predictively & quantitatively characterize human variability, but, in the majority of cases, our ability to do so is limited. If we improve both quantity & quality of information available on response variability & increase our understanding of target tissue dosimetry, we should be better able to account for variability in human susceptibility to the toxic effects of chemicals.
Human Variability In Response To Chemical Exposures Measures Modeling And Risk Assessment
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Author : David A. Neumann
language : en
Publisher: CRC Press
Release Date : 1998-08-25
Human Variability In Response To Chemical Exposures Measures Modeling And Risk Assessment written by David A. Neumann and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998-08-25 with Medical categories.
and for those interested in toxic effects of chemicals on humans, Human Variability in Response to Chemical Exposures: Measures, Modeling, and Risk Assessment recognizes and addresses the increasing awareness that individual biological differences be reflected when assessing human health risks associated with exposure to chemicals. Eight original manuscripts, commissioned by the ILSI Risk Science Institute, address the evidence for variability in human response to chemicals associated with reproductive and developmental effects, effects on the nervous system and lungs, and cancer. Their reports convey both the current state of scientific understanding of response variability and the genetic basis for such observations. This book recognizes that understanding of variability in response is critical in accounting for interindividual variability in susceptibility and, hence, risk, if the regulatory community and others are expected to characterize human health risks associated with exposure to chemicals. Models for incorporating measures of response variability in the risk assessment process are critically reviewed and illustrated with published data. This authoritative work indicates that, in the case of certain chemicals and in the context of certain specific toxic effects, we have considerable ability to predictively and quantitatively characterize human variability, but, in the majority of cases, our ability to do so is limited. If we improve both quantity and quality of information available on response variability and increase our understanding of target tissue dosimetry, we should be better able to account for variability in human susceptibility to the toxic effects of chemicals.