Transforming Proteins Of Dna Tumor Viruses
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Transforming Proteins Of Dna Tumor Viruses
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Author : Rolf Knippers
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Transforming Proteins Of Dna Tumor Viruses written by Rolf Knippers and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
It is surprising, and even disappointing, that there have been very few meetings and published volumes resulting from these meetings that focus attention upon all of the groups of DNA tumor viruses. Historically, separate meetings were held each year for the adenovirus-SV40-polyoma researchers, the herpes viruses, hepatitis B virus and the papillomaviruses. It was as if these four virus groups were four fields of study developing independently with a literature and culture of their own. When a virologist crossed the field from the adenovirus group to the herpesvirus or papillomaviruses, he or she was lost to their former group because of the structure of separate meetings and remote literature. This, of course, has resulted from historical accident and is being rectified by the rapid progress made in our understanding of how these viruses contribute to the causation of cancer in animals and humans. It was pre cisely because of these factors that it was time to hold a meeting and publish its proceedings on the subject of transforming proteins of DNA tumor viruses. For the first time, DNA tumor viruses were defined as all of the virus groups that can contribute to cancer in animals with the exception, unfortunately, of the . poxviruses. The purpose of the meeting was to bring together scientists who rarely attend meetings together but actually work on the same problems with different viruses.
Mechanisms Of Dna Tumor Virus Transformation
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Author : Leonard J. Rosenthal
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 2001-01-01
Mechanisms Of Dna Tumor Virus Transformation written by Leonard J. Rosenthal and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-01-01 with Medical categories.
Approximately 15% of human cancer incidence can be attributed to virus infection, i.e. viruses represent the second most important risk factor (after tobacco consumption) for cancer development in humans. Today, five virus types are known to be involved in causing human cancer: papillomaviruses, retroviruses, herpesviruses, hepadnaviruses, and flaviviruses. This volume provides a comprehensive review of a number of DNA tumor viruses. Leading experts in the field of tumor virology discuss up-to-date information, focusing on the transforming genes of DNA tumor viruses, the mechanisms of transformation and the in vitro methodology used for their identification and characterization. In vitro studies have revealed several common mechanisms of viral transformation. Presented in a clear and concise manner, this book will be of value to students as well as researchers in the fields of general biology, molecular biology, cell biology and microbiology.
Viruses Cell Transformation And Cancer
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Author : Roger J. A. Grand
language : en
Publisher: Gulf Professional Publishing
Release Date : 2001-04-20
Viruses Cell Transformation And Cancer written by Roger J. A. Grand and has been published by Gulf Professional Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-04-20 with Medical categories.
Viruses are the agent responsible for perhaps up to one million cases of cancer worldwide each year. Significantly, the study of viruses has also provided important clues to the causes and development of the most common human cancers. This volume presents an account of those viruses which have been directly associated with common human malignancies such as human papillomavirus (HPV), cervical carcinoma, Epstein-Barr virus (EBV) and Burkitt's lymphoma. In addition, the biology and biochemistry of those viruses which have been shown to be capable of transforming cells in culture are described in detail. Thus adenovirus are discussed, as are the other small DNA tumour viruses - Simian virus 40 (SV40) and polyoma virus. Consideration has also been given to human T-cell leukaemia virus (HTLV), hepatitis B virus (HBV) and human herpes virus 8 (HHV8), amongst others. General themes such as the host's immune response to viral infection, virally-induced apoptosis and the use of viruses as a delivery system in gene therapy have been discussed. Individual chapters have been written by an international group of experts in their own field of research.
Dna Tumor Viruses
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Author : Giuseppe Barbanti-Brodano
language : en
Publisher: Springer
Release Date : 1995
Dna Tumor Viruses written by Giuseppe Barbanti-Brodano and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995 with Medical categories.
This single reference on DNA tumor viruses in animal models and humans presents the latest studies on mechanisms of virus transformation, their association with human tumors, and the possibility of prevention and control by vaccination. Chapters provide current information on the epidemiology and pathogenesis of virus-induced tumors and offer insights into future prospects of immunological intervention. Biomedical researchers, clinicians, and virologists will benefit from this key resource.
Dna Tumor Viruses
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Author : Giuseppe Barbanti-Brodano
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-11-21
Dna Tumor Viruses written by Giuseppe Barbanti-Brodano and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-21 with Medical categories.
DNA tumor viruses have long been useful experimental models of carcinogenesis and have elucidated several important mechanisms of cell transformation. Re search in recent years has shown that human tumors have a multifactorial nature and that some DNA tumor viruses may playa key role in their etiology. The aim of this book is to assess our knowledge of DNA tumor viruses by reviewing animal models, mechanisms of transformation, association with human tumors, and possi bilities of prevention and control by vaccination. Animal models of tumor virology have contributed significantly to our under standing of the epidemiology and pathogenesis of virus-induced tumors. Bovine papillomaviruses induce papillomas in the intestine of cattle. The papillomas undergo a transition to carcinomas in cows feeding on bracken fern, which pro duces a toxin with radiomimetic and immunosuppressive functions. This example of cooperation between a virus and chemical carcinogens parallels the cooperative role of human papillomaviruses (HPVs) and herpes simplex virus type 2 (HSV-2) with environmental carcinogens in the pathogenesis of cervical cancer. Likewise, hepatocarcinomas appearing in woodchucks chronically infected by woodchuck hepatitis virus (WIN) provide strong support for the relationship between hepatitis B virus (HBV) infection and human hepatocellular carcinoma. Also, the fact that WIN DNA integrates closely to cellular oncogenes suggests a possible molecular mechanism for the tumorigenesis induced by HBV.
Dna Tumor Viruses
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Author : Blossom Damania
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-12-19
Dna Tumor Viruses written by Blossom Damania and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-12-19 with Medical categories.
This unique book focuses on the DNA viruses in the human population that are associated with cancers. It covers most of the viruses that are thought to contribute to human malignancy. This book represents a comprehensive review of the field of DNA tumor virology. Right now, while there are books out there that cover individual viruses that are also covered in this book, there is no single book that covers this topic comprehensively. This book is the first current, comprehensive review of its kind in the market.
Viral Transformation And Endogenous Viruses
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Author : Albert Kaplan
language : en
Publisher: Elsevier
Release Date : 2012-12-02
Viral Transformation And Endogenous Viruses written by Albert Kaplan and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-02 with Medical categories.
Viral Transformation and Endogenous Viruses is a collection of papers presented at the symposium on ""Viral Transformation and Endogenous Viruses"" held at Vanderbilt University on April 1-2, 1974. Contributors discuss the viral function(s) responsible for the transformation of the cells that are infected with oncogenic viruses, emphasizing the type of changes that characterize transformed cells and the regulatory mechanisms that are altered after malignant transformations. This volume is organized into 10 chapters and begins with an overview of DNA-containing tumor viruses, particularly Simian Virus 40 (SV40) and its mutants with DNA deletions, insertions, and duplications. The integration and transcription of adenovirus DNA is considered, along with the characteristics of temperature-sensitive mutants of these viruses. The reader is then introduced to the chemistry and biology of RNA-containing tumor viruses, which are useful reagents to study neoplastic transformation both in vivo and in vitro. A major aspect of these viruses concerns the analysis of their genome at the chemical and genetic levels. The last part of the book is devoted to biochemical and genetic analyses of endogenous viruses isolated from avian cells. This book is a valuable resource for scientists and investigators in fields such as pathology, molecular virology, molecular biology, microbiology, oncology, and biochemistry.
Dna Tumor Viruses
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Author : Michael Botchan
language : en
Publisher: Cold Spring Harbor Laboratory Press
Release Date : 1986
Dna Tumor Viruses written by Michael Botchan and has been published by Cold Spring Harbor Laboratory Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1986 with Medical categories.
Small Dna Tumour Viruses
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Author : Kevin Gaston
language : en
Publisher: Caister Academic Press Limited
Release Date : 2012
Small Dna Tumour Viruses written by Kevin Gaston and has been published by Caister Academic Press Limited this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with Science categories.
Small DNA tumor viruses are a fascinating group of double-stranded DNA viruses, made up of the polyomavirus, the adenovirus, and the papillomavirus families. These viruses continue to provide fundamental insights into mammalian cell transformation, cell cycle control, and tumor formation. The causal link between papillomaviruses and some human cancers is well known, and a role for polyomavirus in human cancer has recently been established. Adenoviruses do not cause cancer in humans, but, as well as providing excellent tools for the study of host cell processes, these viruses have been exploited as delivery vehicles in gene therapy for diseases, such as cystic fibrosis and cancer. A common feature of small DNA tumor viruses is their heavy reliance on the host for survival and replication. Understanding the virus-host relationship is critical to understanding the tumorigenic process and how these viruses subvert the host's immune system. In this timely book, leading scientists from around the world review current hot topics in this area, providing a fascinating overview of the molecular biology of these viruses and their interactions with the host. The topics covered include: HPV infections and the production of HPV virion stocks * viral oncoproteins and their functions * the replication and maintenance of viral genomes * virus-induced alterations in cellular miRNAs * viral deregulation of DNA damage responses * the initiation of viral DNA replication * induction of genomic instability by viral oncoproteins * targeting of PML proteins and PML nuclear bodies by these viruses * adenoviruses and gene therapy. The book will be essential reading for scientists and researchers working on small DNA tumor viruses and their associated diseases. It is also a recommended text for anyone involved with DNA replication, DNA damage responses and genome instability, virus-host interactions, and viral tumorigenesis or antiviral drug development.
Dna Tumor Viruses
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Author : John Tooze
language : en
Publisher: Cold Spring Harbor Laboratory Press
Release Date : 1980
Dna Tumor Viruses written by John Tooze and has been published by Cold Spring Harbor Laboratory Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1980 with Medical categories.