Transmission Colonization And Molecular Pathogenesis Of Pneumococcus

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Transmission Colonization And Molecular Pathogenesis Of Pneumococcus

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Author : Jorge Eugenio Vidal
language : en
Publisher: Frontiers Media SA
Release Date : 2022-11-23

Transmission Colonization And Molecular Pathogenesis Of Pneumococcus written by Jorge Eugenio Vidal and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-11-23 with Science categories.

Molecular Pathogenesis Of Pneumococcus

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Author : Guangchun Bai
language : en
Publisher: Frontiers Media SA
Release Date : 2017-10-10

Molecular Pathogenesis Of Pneumococcus written by Guangchun Bai and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-10-10 with categories.

Streptococcus pneumoniae has been for decades the number one bacterial killer of children in the world. Although vaccination with pneumococcal vaccines [PCV7, PCV10, and PCV13 (children) or PPSV23 (adults)] has helped decrease the burden of pneumococcal disease (PD), mortality remains high. Therefore, pathogenesis studies are still key toward our understanding of PD and its control. The introduction of pneumococcal vaccines has also created a niche for vaccine-escape clones. Moreover, the rise of multi-drug resistant clones around the world has also posed a serious threat in recent years. The proposed special issue of Frontiers in Cellular and Infection Microbiology highlights many of the recent advances that have been made in pneumococcal pathogenesis, colonization and antibiotic resistance by groups in Latino America, Europe, and the USA.

Molecular Pathogenesis Of Pneumococus

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Author : Jorge Eugenio Vidal
language : en
Publisher: Frontiers Media SA
Release Date : 2023-05-11

Molecular Pathogenesis Of Pneumococus written by Jorge Eugenio Vidal and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-05-11 with Science categories.

Streptococcus pneumoniae (the pneumococcus) is a commensal of the human nasopharynx during childhood, but also causes a variety of infections, such as otitis media (OM), pneumonia, bacteremia, and meningitis, mainly affecting infants, the elderly and immunocompromised patients. Pneumococcal pneumonia alone produces more child deaths, every year, than any other bacterial disease worldwide. To date, more than 90 distinct capsular serotypes have been identified. Current pneumococcal conjugate vaccines (PCV) protect against 7, 10 or 13 different pneumococcal types. These vaccines have decreased the burden of pneumococcal disease produced by vaccine types but provide poor protection against non-vaccine serotypes. Additionally, the increasing prevalence of multi-drug resistant S. pneumoniae strains results in more challenge for treatment of pneumococcal infections. Therefore, it is imperative to continue investigating the molecular pathogenesis of the pneumococcus. There are currently a variety of key virulence determinants known to be involved in pathogenesis of pneumococcal disease. Virulence factors and host immune defense are major players during pathogen - host interactions. Some metabolic pathways have also been shown to play a role in pneumococcal pathogenesis. These metabolic pathways include proteins involved in copper efflux, arginine metabolism, and zinc homeostasis. From the human host side, new host factors have been found to play essential roles in clearance of S. pneumoniae during infection, such as microRNA-155. Moreover, biofilm-like structures may alter both pneumococcal phenotypes and the host immunity during nasopharyngeal carriage and/or during disease. Understanding the interaction between pneumococcus and its human host is a key to combat pneumococcal infections. It has been well known for several years that pneumococcal pneumonia is worsened during poly-microbial infection. During the past few years, rapid progress has been made in this area. For example, it was recently shown that influenza A virus increases pneumococcal nasal colonization and it is a risk factor for pneumococcal pneumonia. Other important respiratory viruses and bacterial pathogens, such as Moraxella catarrhalis and Haemophilus influenzae, appear to increase the risk of pneumococcal colonization and disease. A better understanding of the molecular mechanism leading to these pathogenic synergisms will provide a fundamental basis for prevention and treatment of secondary pneumococcal infection. The elderly population is generally more susceptible to pneumococcal infections. In addition to their declined immunity, alteration of the microbiome seen in the elderly may play a role for the susceptibility of infection. Research with the elderly or using elderly animal infection models will largely enhance our knowledge and significantly reduce the morbidity and mortality caused by pneumococcal infections.

Bacterial Pathogenesis

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Author : Brenda A. Wilson
language : en
Publisher: John Wiley & Sons
Release Date : 2020-08-11

Bacterial Pathogenesis written by Brenda A. Wilson and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-08-11 with Medical categories.

This highly anticipated update of the acclaimed textbook draws on the latest research to give students the knowledge and tools to explore the mechanisms by which bacterial pathogens cause infections in humans and animals. Written in an approachable and engaging style, the book uses illustrative examples and thought-provoking exercises to inspire students with the potential excitement and fun of scientific discovery. Completely revised and updated, and for the first time in stunning full-color, Bacterial Pathogenesis: A Molecular Approach, Fourth Edition, builds on the core principles and foundations of its predecessors while expanding into new concepts, key findings, and cutting-edge research, including new developments in the areas of the microbiome and CRISPR as well as the growing challenges of antimicrobial resistance. All-new detailed illustrations help students clearly understand important concepts and mechanisms of the complex interplay between bacterial pathogens and their hosts. Study questions at the end of each chapter challenge students to delve more deeply into the topics covered, and hone their skills in reading, interpreting, and analyzing data, as well as devising their own experiments. A detailed glossary defines and expands on key terms highlighted throughout the book. Written for advanced undergraduate, graduate, and professional students in microbiology, bacteriology, and pathogenesis, this text is a must-have for anyone looking for a greater understanding of virulence mechanisms across the breadth of bacterial pathogens.

Molecular Medical Microbiology

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Author : Yi-Wei Tang
language : en
Publisher: Academic Press
Release Date : 2023-11-21

Molecular Medical Microbiology written by Yi-Wei Tang and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-11-21 with Science categories.

Molecular Medical Microbiology, Third Edition presents the latest release in what is considered to be the first book to synthesize new developments in both molecular and clinical research. The molecular age has brought about dramatic changes in medical microbiology, along with great leaps in our understanding of the mechanisms of infectious disease. This third edition is completely updated, reviewed and expanded, providing a timely and helpful update for microbiologists, students and clinicians in the era of increasing use of molecular techniques, changing epidemiology and prevalence, and increasing resistance of many pathogenic bacteria. Written by experts in the field, chapters include cutting-edge information and clinical overviews for each major bacterial group, along with the latest updates on vaccine development, molecular technology and diagnostic technology. - Completely updated and revised edition of this comprehensive and accessible reference on molecular medical microbiology - Includes full color presentations throughout - Delves into in-depth discussions on individual pathogenic bacteria in a system-oriented approach - Includes a clinical overview for each major bacterial group - Presents the latest information on vaccine development, molecular technology and diagnostic technology - Provides more than 100 chapters on all major groups of bacteria

Host Pathogen Interaction During Pneumococcal Infections

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Author : Masaya Yamaguchi
language : en
Publisher: Frontiers Media SA
Release Date : 2021-12-30

Host Pathogen Interaction During Pneumococcal Infections written by Masaya Yamaguchi and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-12-30 with Science categories.

Streptococcus Pneumoniae

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Author : Jeremy Brown
language : en
Publisher: Academic Press
Release Date : 2015-05-08

Streptococcus Pneumoniae written by Jeremy Brown and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-05-08 with Science categories.

Streptococcus Pneumoniae: Molecular Mechanisms of Host-Pathogen Interactions provides a comprehensive overview of our existing knowledge on Streptococcus pneumoniae antibiotic resistance, dissemination, and pathogenesis, including immunology. It presents a state-of-the-art overview of the implications of existing data, along with the areas of research that are important for future insights into the molecular mechanisms of pneumococcal infections and how to combat these infections. Users will find a timely update on the topic, as the dramatic increase in antibiotic resistance pneumoniae cases and limitations of the currently available pneumoniae vaccines are creating new concerns on these gram-positive bacteria that are endowed with a high virulence potential, and are the most common etiologic agent of respiratory and life-threatening invasive diseases. - Provides an updated overview of our existing knowledge on Streptococcus pneumoniae antibiotic resistance, dissemination, and pathogenesis, including immunology - Helps strengthen interdisciplinary networking and the focus of scientific resources by targeting epidemiology, vaccines, genetics, antibiotic resistance, clonal dissemination, Streptococcus pneumoniae biology, functional genomics, inflammasome, biomarkers, and more - Multi-authored by leaders in the field who present a state-of-the-art overview of what the implications are of existing data, and the areas of research that are important for future insights into the molecular mechanisms of pneumococcal infections - Supports combinatory networking in order to find new solutions in clinical therapies - Reflects the most topical pneumococcal research trends

Biomedical Index To Phs Supported Research

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Author :
language : en
Publisher:
Release Date : 1995

Biomedical Index To Phs Supported Research written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995 with Medicine categories.

Mitochondrial Dna And The Immuno Inflammatory Response New Frontiers To Control Specific Microbial Diseases

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Author : Dilvani Oliveira Santos
language : en
Publisher: Bentham Science Publishers
Release Date : 2022-08-02

Mitochondrial Dna And The Immuno Inflammatory Response New Frontiers To Control Specific Microbial Diseases written by Dilvani Oliveira Santos and has been published by Bentham Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-08-02 with Medical categories.

Mitochondria are multifunctional organelles that actively participate in the immune-inflammatory response in various pathologies. This volume updates readers on knowledge about mitochondria function. The editors have compiled six chapters about inflammation in its broadest sense, with contributions from active groups of cell biologists, infectologists and pathologists. The chapters in this volume focus on research related to five notable diseases: (1) two diseases (one bacterial and one viral) in which the exacerbation of the inflammatory response can lead to neuropathies: leprosy (one of the oldest diseases in the world) and Zika fever (a disease relatively new in Brazil) (2) three diseases (two bacterial and one viral) in which the exacerbation of the inflammatory response can lead to irreversible lung damage that can cause rapid death: tuberculosis, pneumonia and the most recent global disease, COVID- 19. New information about mitochondrial biology is presented, such as the effect of aerobic physical exercise as a stimulator for mitochondria multiplication, and the role of mitochondrial damage in inducing immune-inflammatory responses to pathogens. The contents shed light on mitochondrial biochemical pathways that could serve as potential therapeutic targets. This is an important reference for scholars (cell biologists, microbiologists) in universities, hospitals and scientific research centers working on biological and biomedical problems, and for health professionals involved in infection control.

Neurobiology Of Infectious Diseases

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Author : Tatiana Barichello
language : en
Publisher: Elsevier
Release Date : 2024-11-30

Neurobiology Of Infectious Diseases written by Tatiana Barichello and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-11-30 with Medical categories.

Neurobiology of Infectious Diseases covers mechanisms underlying infectious diseases. It is divided into six distinct sections, beginning with the foundations of Neuroinfection. This section includes chapters on the role microbiota-gut-brain axis and specialized blood-neuronal barriers play in neurobiology of infectious diseases. The next three sections detail various bacterial infections, parasitic infections, viral infections, and fungal infections of the central nervous system. The last section reviews the proteins and other peripheral mediators that affect the central nervous system. Internationally contributed by experts in the field this book sets the foundation of neurobiology and infectious disease.Neurobiology is the study of cells of the nervous system and the organization of these cells into functional circuits that process information and mediate behavior. Current research is vital for determining pharmaceutical and medicinal treatments for neurological disorders, psychiatric disorders and diseases. - Reviews the role and function of specialized Blood-Neuronal Barriers - Covers various forms of brain infections, encephalitis, and meningitis - Features content on SARS-Cov-2 and CNS, including pathogenesis to clinical manifestation