Tumor Microenvironment And Resistance To Current Therapies
DOWNLOAD
Download Tumor Microenvironment And Resistance To Current Therapies PDF/ePub or read online books in Mobi eBooks. Click Download or Read Online button to get Tumor Microenvironment And Resistance To Current Therapies book now. This website allows unlimited access to, at the time of writing, more than 1.5 million titles, including hundreds of thousands of titles in various foreign languages. If the content not found or just blank you must refresh this page
Tumor Microenvironment And Resistance To Current Therapies
DOWNLOAD
Author : Ahmed Lasfar
language : en
Publisher: Frontiers Media SA
Release Date : 2020-01-27
Tumor Microenvironment And Resistance To Current Therapies written by Ahmed Lasfar and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-01-27 with categories.
Current Applications For Overcoming Resistance To Targeted Therapies
DOWNLOAD
Author : Myron R. Szewczuk
language : en
Publisher: Springer
Release Date : 2019-07-15
Current Applications For Overcoming Resistance To Targeted Therapies written by Myron R. Szewczuk and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-07-15 with Medical categories.
Targeted therapies were initially developed to exploit the upregulation and dependence on key oncogenic pathways critical to cancer progression. Additionally, they also presented as a method to overcome chemoresistance by supplementing conventional therapeutic regimens with targeted therapies. However, the development of resistance to these combinatorial approaches has led to the reassessment of currently available therapeutic options to overcome resistance to targeted therapy. This book aims to provide an update on the advancements in the therapeutic arms race between cancer, clinicians and scientists alike to overcome resistance to targeted therapies. Subject experts provide a comprehensive overview of the challenges and solutions to resistance to several conventional targeted therapies in addition to providing a discussion on broad topics including targeting components of the tumor microenvironment, emerging therapeutic options, and novel areas to be explored concerning nanotechnology and the epigenome.
Tumor Microenvironment
DOWNLOAD
Author : Peter P. Lee
language : en
Publisher: Springer Nature
Release Date : 2020-03-25
Tumor Microenvironment written by Peter P. Lee and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-03-25 with Medical categories.
This book addresses the biological processes relevant to the immune phenotypes of cancer and their significance for immune responsiveness, based on the premise that malignant cells manipulate their surroundings through an evolutionary process that is controlled by interactions with innate immune sensors as well as the adaptive recognition of self/non-self. Checkpoint inhibitor therapy is now an accepted new form of cancer treatment. Other immuno-oncology approaches, such as adoptive cell therapy and metabolic inhibitors, have also shown promising results for specific indications. Immune resistance is common, however, limiting the efficacy of immunotherapy in many common cancer types. The reasons for such resistance are diverse and peculiar to the immune landscapes of individual cancers, and to the treatment modality used. Accordingly, approaches to circumvent resistance need to take into account context-specific genetic, biological and environmental factors that may affect the cancer immune cycle, and which can best be understood by studying the target tissue and correlated systemic immune markers. Understanding the major requirements for the evolutionary process governing human cancer growth in the immune-competent host will guide effective therapeutic choices that are tailored to the biology of individual cancers.
Tumor Microenvironment Inflammation And Resistance To Immunotherapies
DOWNLOAD
Author : Apostolos Zaravinos
language : en
Publisher: Frontiers Media SA
Release Date : 2023-06-29
Tumor Microenvironment Inflammation And Resistance To Immunotherapies written by Apostolos Zaravinos and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-06-29 with Medical categories.
Overcoming Physiologic Barriers To Treatments For Hematologic Malignancies By Molecularly Targeting The Tumor Microenvironment
DOWNLOAD
Author : Qin Wang
language : en
Publisher: Frontiers Media SA
Release Date : 2024-01-29
Overcoming Physiologic Barriers To Treatments For Hematologic Malignancies By Molecularly Targeting The Tumor Microenvironment written by Qin Wang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-01-29 with Science categories.
Hematologic malignancies (HMs) represent a group of hematologic cancers originating from bone marrow or lymphoid organs. Currently, leukaemia, lymphoma, and multiple myeloma are the most common HMs. Conventional treatments for HMs include bone marrow transplantation, radiotherapy, chemotherapy, and immunotherapy. Despite the significant achievements obtained over the past decade in the drug therapy of HMs, tumor metastasis and relapse in patients often occurred after an initial response, indicating the generation of drug resistance to current therapies. Moreover, many clinically used therapeutic drugs are often associated with dose-related side effects and a lack of specificity to tumor tissues. The tumor microenvironment (TME) in HMs consists of a complicated network of cellular interactions and signaling cross-talking within the bone marrow cavity, and it plays an essential role in the progression and metastasis of HM. Furthermore, the TME in HMs has formed physiologic barriers such as immunosuppressive microenvironment, upregulated anti-apoptotic system, drug resistance, etc. to facilitate drug resistance and relapse of HMs. It has become widely accepted that effective treatment against HMs may require targeting both the cancer cell and TME.
Cancer Plasticity And The Microenvironment Implications For Immunity And Therapy Response
DOWNLOAD
Author : Petranel T. Ferrao
language : en
Publisher: Frontiers Media SA
Release Date : 2019-11-01
Cancer Plasticity And The Microenvironment Implications For Immunity And Therapy Response written by Petranel T. Ferrao and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-11-01 with categories.
Cancer cells can change and adapt, especially within the host environment; a phenomenon known as cancer plasticity. Several factors, including the immune system can influence, and be influenced by, cancer plasticity which in turn can impact upon patient responses to treatment. As such, we currently face several challenges for implementing combination therapies as effective cancer treatment strategies. We have compiled a topic with a number of articles that emphasize the various aspects of cancer plasticity, describing in particular the important role of the tumor microenvironment. As we embark on a new era of precision medicine with multi-modal therapies for improving patient outcomes, this topic highlights some relevant points for consideration that are pertinent to the incorporation and effective use of new treatments as part of cancer treatment regimens, including immune-modulating drugs.
Cancer Stem Cell Resistance To Targeted Therapy
DOWNLOAD
Author : Cristina Maccalli
language : en
Publisher: Springer
Release Date : 2019-06-04
Cancer Stem Cell Resistance To Targeted Therapy written by Cristina Maccalli and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-06-04 with Medical categories.
This book represents an up-dated summary of the state of the art of the characterization of cancer stem cell/ cancer initiating cell (CSC/CIC) properties. An overview of the definition and biological properties of CSCs/CICs as well as the role of these cells in determining the resistance to standard and immune-based therapies is provided. It also discusses limitations in the achievement of a definitive biological characterization of CSCs/CICs due to their high extent of plasticity and heterogeneity that is also mutually driven by the interaction of these cells with the tumor microenvironment. The limitations in targeting CSCs/CICs with immunotherapy are also explained together with explorative combination approaches that could increase the susceptibility of these cells to the recognition by immune cells. This book is conceived for a broad audience, including students, teachers, scientific experts. The critical revision of available results in terms of immunological profile of CSCs/CICs and the efficacy in targeting these cells by immunological approaches, results in a comprehensive and up to date recapitulation of the field and provides interesting suggestions on how to focus future investigations in order to assess the role of CSCs/CICs as prognostic and predictive biomarkers of responsiveness to therapies for cancer patients.
Drug Resistance In Cancer Mechanisms And Strategies
DOWNLOAD
Author : Sameer Khan
language : en
Publisher: Springer
Release Date : 2024-05-26
Drug Resistance In Cancer Mechanisms And Strategies written by Sameer Khan and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-05-26 with Medical categories.
This book tries to emphasize the mechanisms associated with the resistance towards various anti-cancer therapies The focus has been given to the role of cancer stem cells, immune cells, and the multiway impact of tumor microenvironment in drug resistance. The book delves into the role of epigenetic alterations, autophagy, intracellular compartments, and the impact of gut microbiome on therapeutic resistance. Each chapter of the book has elaborated on these aspects that are exclusively or mutually driving the therapeutic non-responsiveness towards various current clinical candidates. In addition to that the book has also discussed novel strategies to overcome the therapeutic challenge by employing Combinatorial therapies that can prove to be useful and effective. Overall the book reflects on the current treatment challenges, futuristic strategies and new research initiatives that explore novel treatment options.
Resistance To Molecular Therapies For Hepatocellular Carcinoma
DOWNLOAD
Author : Augusto Villanueva
language : en
Publisher: Springer
Release Date : 2017-07-14
Resistance To Molecular Therapies For Hepatocellular Carcinoma written by Augusto Villanueva and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-07-14 with Medical categories.
This volume evaluates the clinical patterns of resistance to sorafenib, the impact of trial design in the second-line setting and the current gold standard to define radiological resistance; describes the molecular mechanisms responsible for treatment resistance in HCC patients, including components of the immune system and tumor microenvironment; determines the role of the cancer stem cell phenotype in resistance; reviews the experimental models to study resistance; and addresses new approaches to overcome resistance to sorafenib, using successful examples from other malignancies.
Drug Resistance In Cancer Mechanisms And Strategies
DOWNLOAD
Author : Sameer Ullah Khan
language : en
Publisher: Springer Nature
Release Date :
Drug Resistance In Cancer Mechanisms And Strategies written by Sameer Ullah Khan and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on with categories.