Type I Chaperonins Mechanism And Beyond


Type I Chaperonins Mechanism And Beyond
DOWNLOAD

Download Type I Chaperonins Mechanism And Beyond PDF/ePub or read online books in Mobi eBooks. Click Download or Read Online button to get Type I Chaperonins Mechanism And Beyond book now. This website allows unlimited access to, at the time of writing, more than 1.5 million titles, including hundreds of thousands of titles in various foreign languages. If the content not found or just blank you must refresh this page





Type I Chaperonins Mechanism And Beyond


Type I Chaperonins Mechanism And Beyond
DOWNLOAD

Author : Adina Breiman
language : en
Publisher: Frontiers Media SA
Release Date : 2018-09-14

Type I Chaperonins Mechanism And Beyond written by Adina Breiman and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-09-14 with categories.


Type I chaperonins are key players in maintaining the proteome of bacteria and organelles of bacterial origin. They are well known for their crucial role in mediating protein folding. For almost three decades, the molecular mechanism of chaperonin function has been the subject of intensive research. Still, surprising new mechanistic discoveries are constantly reported. It seems that we are far from having a full understanding of the chaperonin mode of action. Chaperonins are not simply protein folding machines. They also perform diverse extramitochondrial tasks, mainly related to inflammatory and signal transduction processes. This eBook constitutes ten articles highlighting the latest developments related to the divers functions of Type I chaperonins. As its title, mechanism and beyond, the collection starts with mechanistic view, continues with extracellular functions and ends with biotechnological applications of Type I chaperonins.



Type I Chaperonins Mechanism And Beyond


Type I Chaperonins Mechanism And Beyond
DOWNLOAD

Author :
language : en
Publisher:
Release Date : 2018

Type I Chaperonins Mechanism And Beyond written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018 with categories.


Type I chaperonins are key players in maintaining the proteome of bacteria and organelles of bacterial origin. They are well known for their crucial role in mediating protein folding. For almost three decades, the molecular mechanism of chaperonin function has been the subject of intensive research. Still, surprising new mechanistic discoveries are constantly reported. It seems that we are far from having a full understanding of the chaperonin mode of action. Chaperonins are not simply protein folding machines. They also perform diverse extramitochondrial tasks, mainly related to inflammatory and signal transduction processes. This eBook constitutes ten articles highlighting the latest developments related to the divers functions of Type I chaperonins. As its title, mechanism and beyond, the collection starts with mechanistic view, continues with extracellular functions and ends with biotechnological applications of Type I chaperonins.



Prokaryotic Chaperonins


Prokaryotic Chaperonins
DOWNLOAD

Author : C. M. Santosh Kumar
language : en
Publisher: Springer
Release Date : 2017-08-30

Prokaryotic Chaperonins written by C. M. Santosh Kumar and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-08-30 with Science categories.


This book focuses on a topical and timely aspect of prokaryotic biology - the biology of prokaryotic multiple chaperonins. Chaperonins are a class of molecular chaperones, the proteins that assist folding of other proteins in the cell. The book begins with an introductory chapter on the structural and functional aspects of chaperonins, followed by an outline on different mechanisms of their regulation. Subsequently, the book provides a comprehensive overview on how the multiple-chaperonins have embraced biological requirements in different classes of microbes, discussing their functional diversity, evolutionary paths and the latest advances in the field. It brings together leading experts from across the globe in offering a detailed account of the structural, biochemical, functional and phylogenetic characteristics of microbial chaperonins for students, researchers and teachers working in the area of microbiology/ biophysics/ parasitology – more specifically, in protein folding pathways.



The Networking Of Chaperones By Co Chaperones


The Networking Of Chaperones By Co Chaperones
DOWNLOAD

Author : Adrienne L. Edkins
language : en
Publisher: Springer Nature
Release Date : 2022-12-15

The Networking Of Chaperones By Co Chaperones written by Adrienne L. Edkins and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-12-15 with Science categories.


Co-chaperones are important mediators of the outcome of chaperone assisted protein homeostasis, which is the dynamic integration of the processes of protein folding, degradation and translocation to ensure that cellular function is finely tuned in space and time. This third edition of the book The Networking of Chaperones by Co-chaperones describes how the function of the major molecular chaperones is regulated by co-chaperones, a diverse cohort of non-client proteins. Since the second edition was released, not only has knowledge deepened on how co-chaperones act as nodes to network and functionalise chaperones, but an understanding of their broader biological function has started to emerge. The third edition provides new and updated chapters highlighting recent developments and emerging themes on co-chaperones, such as their extracellular functions, their role in human disease and their status as putative drug targets. The book is a useful resource for both newcomers and established researchers in the field of cell stress and chaperones, as well as those interested in cross-cutting disciplines such as cellular networks and systems biology.



The Chaperonopathies


The Chaperonopathies
DOWNLOAD

Author : Alberto J.L. Macario
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-04-10

The Chaperonopathies written by Alberto J.L. Macario and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-04-10 with Medical categories.


This Brief provides a concise review of chaperonopathies, i.e., diseases in which molecular chaperones play an etiologic-pathogenic role. Introductory chapters deal with the chaperoning system and chaperoning teams and networks, HSP-chaperone subpopulations, the locations and functions of chaperones, and chaperone genes in humans. Other chapters present the chaperonopathies in general, including their molecular features and mechanistic classification into by defect, excess, or mistake. Subsequent chapters discuss the chaperonopathies in more detail, focusing on their distinctive characteristics: primary or secondary; quantitative and/or qualitative; structural and hereditary or acquired; genetic polymorphisms; gene dysregulation; age-related; associated with cancer, chronic inflammatory conditions, and autoimmune diseases. The interconnections between the chaperoning and the immune systems in cancer development, chronic inflammation, autoimmunity, and ageing are outlined, which leads to a discussion on the future prospects of chaperonotherapy. The latter may consist of chaperone gene and protein replacement/supplementation in cases of deficiency and of gene or protein blocking when the chaperone actively promotes disease. The last chapter presents the extracellular chaperones and details on how the chaperone Hsp60 is secreted into the extracellular space and, thus, appears in the blood of cancer patients with potential to participate in carcinogenesis and chronic inflammation and autoimmunity. Chaperones as clinically useful biomarkers are mentioned when pertinent. Likewise, guidelines for clinical evaluation of chaperonopathies and for their histopathological and molecular identification are provided throughout. The book also provides extensive bibliography organized by chapter and topic with comments.



Comprehensive Biophysics


Comprehensive Biophysics
DOWNLOAD

Author :
language : en
Publisher: Academic Press
Release Date : 2012-04-12

Comprehensive Biophysics written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-04-12 with Science categories.


Biophysics is a rapidly-evolving interdisciplinary science that applies theories and methods of the physical sciences to questions of biology. Biophysics encompasses many disciplines, including physics, chemistry, mathematics, biology, biochemistry, medicine, pharmacology, physiology, and neuroscience, and it is essential that scientists working in these varied fields are able to understand each other's research. Comprehensive Biophysics, Nine Volume Set will help bridge that communication gap. Written by a team of researchers at the forefront of their respective fields, under the guidance of Chief Editor Edward Egelman, Comprehensive Biophysics, Nine Volume Set provides definitive introductions to a broad array of topics, uniting different areas of biophysics research - from the physical techniques for studying macromolecular structure to protein folding, muscle and molecular motors, cell biophysics, bioenergetics and more. The result is this comprehensive scientific resource - a valuable tool both for helping researchers come to grips quickly with material from related biophysics fields outside their areas of expertise, and for reinforcing their existing knowledge. Biophysical research today encompasses many areas of biology. These studies do not necessarily share a unique identifying factor. This work unites the different areas of research and allows users, regardless of their background, to navigate through the most essential concepts with ease, saving them time and vastly improving their understanding The field of biophysics counts several journals that are directly and indirectly concerned with the field. There is no reference work that encompasses the entire field and unites the different areas of research through deep foundational reviews. Comprehensive Biophysics fills this vacuum, being a definitive work on biophysics. It will help users apply context to the diverse journal literature offering, and aid them in identifying areas for further research Chief Editor Edward Egelman (E-I-C, Biophysical Journal) has assembled an impressive, world-class team of Volume Editors and Contributing Authors. Each chapter has been painstakingly reviewed and checked for consistent high quality. The result is an authoritative overview which ties the literature together and provides the user with a reliable background information and citation resource



Molecular Chaperones And Human Disease


Molecular Chaperones And Human Disease
DOWNLOAD

Author : Graham Chakafana
language : en
Publisher: Frontiers Media SA
Release Date : 2022-12-19

Molecular Chaperones And Human Disease written by Graham Chakafana and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-12-19 with Science categories.




The Chaperonins


The Chaperonins
DOWNLOAD

Author : Robert L. Ellis
language : en
Publisher: Elsevier
Release Date : 1996-04-01

The Chaperonins written by Robert L. Ellis and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996-04-01 with Science categories.


The first of its kind, this volume presents the latest research findings on the chaperonins, the best studied family of a class of proteins known as molecular chaperones. These findings are changing our view of some fundamental cellular processes involving proteins, especially how proteins fold into their functional conformations. Origins of the new view of protein folding Prokaryotic chaperonins Eukaryotic chaperonins Evolution of the chaperonins Refolding of denatured proteins Organelle biosynthesis Biomedical aspects



Journal Of The Royal Society Interface


Journal Of The Royal Society Interface
DOWNLOAD

Author :
language : en
Publisher:
Release Date : 2008

Journal Of The Royal Society Interface written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with Life sciences categories.




Mechanisms Of Lymphocyte Activation And Immune Regulation Viii


Mechanisms Of Lymphocyte Activation And Immune Regulation Viii
DOWNLOAD

Author : Sudhir Gupta
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06

Mechanisms Of Lymphocyte Activation And Immune Regulation Viii written by Sudhir Gupta and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.


Advances in biochemistry, cell biology, genome-wide mutagenesis - coupled with molecular technology, including gene microarray and transgenic and knock-out animals - have been instrumental in understanding the cellular processes and molecular pathways of self-tolerance and autoimmune diseases. The molecular definition of these pathways and processes has led to novel treatments for certain auto-immune diseases that are based on the pathogenesis of diseases rather than on broad-spectrum immunosuppression. This book reviews many of these current developments and proposes future novel approaches for understanding the pathogenesis of auto-immune diseases and designing novel therapy. This book covers three major areas of auto-immunity: the basic mechanisms of immunological tolerance, pathogenesis of auto-immune diseases, and some novel therapies. This book should be useful for immunologists, molecular biologists, rheumatologists, and clinical scientists.