Unveiling The Tumor Microenvironment By Machine Learning To Develop New Immunotherapeutic Strategies Volume I A
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Unveiling The Tumor Microenvironment By Machine Learning To Develop New Immunotherapeutic Strategies Volume I A
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Author : Nan Zhang
language : en
Publisher: Frontiers Media SA
Release Date : 2023-10-24
Unveiling The Tumor Microenvironment By Machine Learning To Develop New Immunotherapeutic Strategies Volume I A written by Nan Zhang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-10-24 with Medical categories.
The tumor microenvironment (TME) plays a critical role in tumor proliferation, progression, and therapeutic responses. TME is a complex network of cancer cells, stromal cells, and, most importantly, infiltrating immune cells. Cancer cells regulate numerous biological functions through direct or indirect interaction with TME components. Emerging evidence suggests that TME crucially influences the response to both chemotherapy and immunotherapy. As scientific research has entered the big data era with the fast development of high-throughput sequencing technologies, machine learning has been gradually widely applied to extract important knowledge from big data bioinformatics. Thus, characterizing the TME landscape in cancer and identifying different immune-related TME phenotypes using machine learning-based bioinformatics analyses, in vitro experiments, and in vivo experiments are of great interest and significance.
Community Series In Unveiling The Tumor Microenvironment By Machine Learning To Develop New Immunotherapeutic Strategies Volume Ii
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Author : Ping Zheng
language : en
Publisher: Frontiers Media SA
Release Date : 2024-02-06
Community Series In Unveiling The Tumor Microenvironment By Machine Learning To Develop New Immunotherapeutic Strategies Volume Ii written by Ping Zheng and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-02-06 with Medical categories.
Unveiling The Impact Of Local Or Systemic Therapeutic Strategies On The Tumor Microenvironment
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Author : Jian Huang
language : en
Publisher: Frontiers Media SA
Release Date : 2022-02-14
Unveiling The Impact Of Local Or Systemic Therapeutic Strategies On The Tumor Microenvironment written by Jian Huang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-02-14 with Science categories.
Cancer Immunotherapies From Efficacy To Resistance Mechanisms
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Author : Morten Hansen
language : en
Publisher: Frontiers Media SA
Release Date : 2022-06-29
Cancer Immunotherapies From Efficacy To Resistance Mechanisms written by Morten Hansen and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-06-29 with Medical categories.
Dr. Koguchi receives funding from Tesaro, a GSK company, Bristol-Myers Squibb, and Shimadzu Corporation.. Dr. Vujanovic is a co-inventor of a methodology licensed to INmune Bio, Inc. where a selective inhibitor of soluble TNF can be used to prevent or treat malignancies. Dr. Hansen is the recipient of a private grant from Eurostars Eureka. The other Topic Editors declare no competing interests.
Hepatocellular Carcinoma Novel Treatment Strategies Volume Ii
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Author : Fan Feng
language : en
Publisher: Frontiers Media SA
Release Date : 2023-10-17
Hepatocellular Carcinoma Novel Treatment Strategies Volume Ii written by Fan Feng and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-10-17 with Medical categories.
Advanced Interpretable Machine Learning Methods For Clinical Ngs Big Data Of Complex Hereditary Diseases Volume Ii
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Author : Yudong Cai
language : en
Publisher: Frontiers Media SA
Release Date : 2023-02-13
Advanced Interpretable Machine Learning Methods For Clinical Ngs Big Data Of Complex Hereditary Diseases Volume Ii written by Yudong Cai and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-02-13 with Science categories.
Combinational Immunotherapy Of Cancer Novel Targets Mechanisms And Strategies
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Author : Xuyao Zhang
language : en
Publisher: Frontiers Media SA
Release Date : 2024-01-15
Combinational Immunotherapy Of Cancer Novel Targets Mechanisms And Strategies written by Xuyao Zhang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-01-15 with Medical categories.
Cancer immunotherapy, including immune checkpoint inhibitors (ICIs) and chimeric antigen receptor T-cell (CAR-T) therapy, has revolutionized the paradigm in cancer treatment. However, the clinical outcome of immunotherapy varies considerably among patients and only a minority of patients achieve long-term clinical benefits. This is largely attributed to the fact that existing cancer immunotherapies, which concentrate on several classical targets (CTAL-4, PD-1/PD-L1, etc.) and limited types of immune cell populations (T cells), are insufficient to cope with the complexity of highly heterogeneous tumor microenvironment (TME). This calls for more efforts to not only expand our toolbox for manipulating anticancer immunity but also diversify our combinational strategies. To this end, it is urgent to deeper our understanding of cancer immunotherapy by using both experimental and computational methodologies from multi-scale perspectives: 1) novel targets from either tumor cells or non-tumor cells within TME (e.g., tumor intrinsic resistance drivers, new immune checkpoints, neoantigens), 2) in-depth characterization of more immune cell populations (e.g., macrophages, Tregs, B cells) and their interactions and dynamics within TME, 3) landscape of actionable targets in patient populations for combination design. These efforts will open the avenue of rational design of combinational immunotherapies, allowing researchers and clinicians to design novel targeting therapeutics or to optimally orchestrate combinatory strategies aiming to surmount resistance mechanisms and improve clinical outcomes.
Tumor Microenvironment Tme And Tumor Immune Microenvironment Time New Perspectives For Prognosis And Therapy
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Author : Ana Karina de Oliveira
language : en
Publisher: Frontiers Media SA
Release Date : 2022-09-30
Tumor Microenvironment Tme And Tumor Immune Microenvironment Time New Perspectives For Prognosis And Therapy written by Ana Karina de Oliveira and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-09-30 with Science categories.
Bioinformatics Analysis Of Omics Data For Biomarker Identification In Clinical Research Volume Ii
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Author : Lixin Cheng
language : en
Publisher: Frontiers Media SA
Release Date : 2023-09-05
Bioinformatics Analysis Of Omics Data For Biomarker Identification In Clinical Research Volume Ii written by Lixin Cheng and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-09-05 with Science categories.
This Research Topic is part of a series with, "Bioinformatics Analysis of Omics Data for Biomarker Identification in Clinical Research - Volume I" (https://www.frontiersin.org/research-topics/13816/bioinformatics-analysis-of-omics-data-for-biomarker-identification-in-clinical-research) The advances and the decreasing cost of omics data enable profiling of disease molecular features at different levels, including bulk tissues, animal models, and single cells. Large volumes of omics data enhance the ability to search for information for preclinical study and provide the opportunity to leverage them to understand disease mechanisms, identify molecular targets for therapy, and detect biomarkers of treatment response. Identification of stable, predictive, and interpretable biomarkers is a significant step towards personalized medicine and therapy. Omics data from genomics, transcriptomics, proteomics, epigenomics, metagenomics, and metabolomics help to determine biomarkers for prognostic and diagnostic applications. Preprocessing of omics data is of vital importance as it aims to eliminate systematic experimental bias and technical variation while preserving biological variation. Dozens of normalization methods for correcting experimental variation and bias in omics data have been developed during the last two decades, while only a few consider the skewness between different sample states, such as the extensive over-repression of genes in cancers. The choice of normalization methods determines the fate of identified biomarkers or molecular signatures. From these considerations, the development of appropriate normalization methods or preprocessing strategies may promote biomarker identification and facilitate clinical decision-making.
Engineered Targeted Cancer Immunotherapies
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Author : Massimo Fantini
language : en
Publisher: Frontiers Media SA
Release Date : 2022-08-01
Engineered Targeted Cancer Immunotherapies written by Massimo Fantini and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-08-01 with Medical categories.