Vascular Inflammation In Aging And Neurodegeneration

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Vascular Inflammation In Aging And Neurodegeneration

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Author : Donghui Zhu
language : en
Publisher: Frontiers Media SA
Release Date : 2022-11-16

Vascular Inflammation In Aging And Neurodegeneration written by Donghui Zhu and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-11-16 with Science categories.

Role Of Inflammation In Neurodegenerative Diseases

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Author : Maya Koronyo-Hamaoui
language : en
Publisher: Frontiers Media SA
Release Date : 2022-07-13

Role Of Inflammation In Neurodegenerative Diseases written by Maya Koronyo-Hamaoui and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-07-13 with Medical categories.

Interphase Between Aging And Neurodegenerative Diseases

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Author : Walter E. Müller
language : en
Publisher: Frontiers Media SA
Release Date : 2020-01-21

Interphase Between Aging And Neurodegenerative Diseases written by Walter E. Müller and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-01-21 with categories.

The purpose of this Research Topic is to discuss the latest developments in aging and neurodegenerative diseases. Aging represents the major risk factor of the two most relevant neurodegenerative diseases Parkinson’s disease (PD) and Alzheimer’s disease (AD). It is generally accepted that symptoms of PD correlate with the severity of degeneration of dopaminergic substantia nigra neurons. In most cases neuronal loss during aging is not sufficient to cause clinical symptoms but only leads to a preclinical state of PD. However, in a small number of our population, neurodegeneration by aging gets accelerated by individual (e.g. brain injuries), environmental (e.g. toxins) and genetic (e.g. mutations of the alpha-synuclein gene) factors to reach the critical threshold for clinical symptoms during lifetime. Thus, neurodegeneration in PD appears to represent the common final pathway of “normal brain aging” and all other risk factors including genetics and the accumulation of the neurotoxic alpha-synuclein protein. While aging alone is generally agreed to be sufficient for at least the preclinical state of PD, the situation in AD seems to be different. Aging as the major and well documented risk factor of AD has been neglected for decades. Biochemical mechanisms of brain aging and the cognitive deficits of “normal brain aging” were seen as two not related and independent processes not related to AD. AD has always been characterized for decades by the presence of histopathological alterations (extracellular amyloid- containing plaques and intracellular tangles of hyperphosphorylated tau-protein), by neurodegeneration (synaptic deficits and finally neuronal loss), as well as by severe cognitive deficits clinically often accompanied by neuropsychiatric symptoms like delusions, as already described in the first famous patient Auguste D at the Psychiatric Hospital of Frankfurt. If or if not one or both of the two histopathological hallmarks play a causative role remains unclear until now. The discovery of homocygotic risk genes in most of the very rare (probably less than 1%) cases of early onset AD which share increased production of β-amyloid (Aβ) as one (but probably not the only one) common property led to the hypothesis of Aβ as the major causative factor for the development of AD. It was neglected that plaques density in the brain of AD patients did not correlate with presence and severity of clinical symptoms, while synaptic deficits did so even in first observations already published many years ago. Based on the Amyloid hypothesis, many drug treatments to remove Aβ plaques were developed. Even if all seemed to remove Aβ to some extent, all strategies failed to improve the symptoms of dementia. Thus, other concepts to explain the development of clinical symptoms of AD over time are needed. These should include the brain aging process not only as a statistical but also as a causative contributing factor. These concepts should not only relay on cell or animal models but should much more take into account the disease and the patients. A closer look at the situation in PD will certainly be helpful.

The Role Of Neurovascular Unit In Neurodegeneration

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Author : Dennis Qing Wang
language : en
Publisher: Frontiers Media SA
Release Date : 2022-05-05

The Role Of Neurovascular Unit In Neurodegeneration written by Dennis Qing Wang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-05-05 with Science categories.

Aging Peripheral Inflammation And Neurodegeneration

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Author : Caroline Haikal
language : en
Publisher: Frontiers Media SA
Release Date : 2024-12-26

Aging Peripheral Inflammation And Neurodegeneration written by Caroline Haikal and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-12-26 with Science categories.

Aging is a major risk factor for several neurodegenerative diseases, including Parkinson’s and Alzheimer’s disease. The immune response is often dysregulated in aging, leading to a predisposition towards a state of chronic inflammation. The precise processes which support this inflammatory state are still a subject of debate, however, cell- and tissue-specific transcriptional changes in several immune-related genes have been identified as potential drivers. In addition to genetic changes, losses in the bacterial diversity within the microbiome are also observed during aging. However, it is unclear whether this may be a cause or consequence of inflammation. Host-microbiome interactions are highly complex and are known to modulate the immune response in several ways. For instance, while bacteria and some bacterial byproducts such as short chain fatty acids can induce differentiation of regulatory T cells and stimulate secretion of anti-inflammatory cytokines, other byproducts can activate pathogen recognition receptors to induce inflammation. Bacteria can also regulate the transcription of human genes that regulate immune homeostasis and pathogen response. In turn, microRNAs produced by the gut epithelium can regulate transcription in bacteria.

Novel Mechanisms Involved In Aging And Neurodegeneration Seeking Potential Therapeutic Targets For Neurodegenerative Diseases

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Author : Natalia Salvadores
language : en
Publisher: Frontiers Media SA
Release Date : 2023-01-10

Novel Mechanisms Involved In Aging And Neurodegeneration Seeking Potential Therapeutic Targets For Neurodegenerative Diseases written by Natalia Salvadores and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-01-10 with Science categories.

Decoding Aging And Neurodegeneration

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Author : Jan Barciszewski
language : en
Publisher: Springer Nature
Release Date : 2025-07-14

Decoding Aging And Neurodegeneration written by Jan Barciszewski and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-07-14 with Science categories.

This book focuses on the close relationship between aging and neurodegeneration. By highlighting the reversible nature of epigenetic changes, it provides a comprehensive overview of how these modifications can regulate gene expression without altering the DNA sequence, offering promising solutions for clinical intervention. Aging induces a gradual decline in cerebral function, leading to cognitive impairment, memory loss, motor dysfunction, and eventually functional decline and death. It is accompanied by the decline of organismal functions induced by whole genome alterations leading to neurodegeneration. Epigenetic modifications, including chromatin modifications, DNA methylation, and changes in regulatory RNAs, have a major impact on neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, and Huntington's disease. The chapters in this book address critical issues such as the contribution of epigenetic mechanisms to aging, the interaction between genetic and environmental factors in neurodegeneration, and the potential for epigenetic therapies to delay aging and mitigate disease progression. This volume, part of the RNA Technologies book series, is an invaluable resource for researchers and advanced students in genetics and neuroscience. It provides a deep understanding of the molecular basis of neurodegenerative diseases and offers innovative strategies to address the challenges of aging and neurodegeneration.

The Neurovascular Unit As A Potential Biomarker And Therapeutic Target In Cerebrovascular Disease

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Author : Shereen Nizari
language : en
Publisher: Frontiers Media SA
Release Date : 2022-05-26

The Neurovascular Unit As A Potential Biomarker And Therapeutic Target In Cerebrovascular Disease written by Shereen Nizari and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-05-26 with Science categories.

Update On Vascular Contributions To Age Related Neurodegenerative Diseases And Cognitive Impairment Research Of Isnvd 2020 Meeting

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Author : Yulin Ge
language : en
Publisher: Frontiers Media SA
Release Date : 2021-12-02

Update On Vascular Contributions To Age Related Neurodegenerative Diseases And Cognitive Impairment Research Of Isnvd 2020 Meeting written by Yulin Ge and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-12-02 with Medical categories.

Clinical Immunology

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Author : Robert R. Rich
language : en
Publisher: Mosby Incorporated
Release Date : 2008

Clinical Immunology written by Robert R. Rich and has been published by Mosby Incorporated this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with Medical categories.

Offers answers to challenges in clinical immunology. This book contains immunology knowledge and includes a companion web site to give you two ways to find the answers you need.