The Role Of Neurovascular Unit In Neurodegeneration
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The Role Of Neurovascular Unit In Neurodegeneration
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Author : Dennis Qing Wang
language : en
Publisher: Frontiers Media SA
Release Date : 2022-05-05
The Role Of Neurovascular Unit In Neurodegeneration written by Dennis Qing Wang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-05-05 with Science categories.
Connectivity And Functional Specialization In The Brain
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Author : Thomas Heinbockel
language : en
Publisher: BoD – Books on Demand
Release Date : 2021-06-02
Connectivity And Functional Specialization In The Brain written by Thomas Heinbockel and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-06-02 with Medical categories.
‘Connectivity and Functional Specialization in the Brain’ is a topic that describes nerve cells in terms of their anatomical and functional connections. The term connectome refers to a comprehensive map of neural connections, like a wiring diagram of an organism’s nervous system. Connectomics, the study of connectomes, can be applied to individual neurons and their synaptic connections, as well as to connections between neuronal populations or to functional and structural connectivity of different brain regions. This book addresses neural connectivity at these various scales in health and disease. The chapters review novel findings related to neuroanatomy and cell biology, neurophysiology, neural plasticity, changes of connectivity in neurological disorders, and sensory system connectivity. The book provides the reader with an overview of the current state-of-the-art of research of neural connectivity and focuses on the most important evidence-based developments in this area. Individual chapters focus on recent advances in specific areas of neural connectivity and in different brain regions. All chapters represent recent contributions to the rapidly developing field of neural connectivity.
Pathobiology Of Alzheimer S Disease
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Author :
language : en
Publisher: Elsevier
Release Date : 1995-10-17
Pathobiology Of Alzheimer S Disease written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995-10-17 with Medical categories.
Neuroscience Perspectives provides multidisciplinary reviews of topics in one of the most diverse and rapidly advancing fields in the life sciences. Whether you are a new recruit to neuroscience, or an established expert, look to this series for 'one-stop' sources of the historical, physiological, pharmacological, biochemical, molecular biological and therapeutic aspects of chosen research areas. The last decade has seen tremendous advances in our understanding of the pathobiology of Alzheimer's disease. These will lead to the first generation of drugs aimed at prevention rather than cure. This book covers some of the most important and exciting of these advances, with chapters written by many of the leading researchers in the field. With genetic studies as a backbone to this volume many chapters are devoted to the function and regulation of amyloid b-protein precursor (APP) and apolipoprotein E (ApoE). Other chapters describe cell biological approaches helping to piece together the link between the genetic alterations and the phenotype we call Alzheimer's disease. Although APP and its proteolytic cleavage product, amyloid b-protein, do not answer all the questions, detailed research into this system has undoubtedly increased our knowledge of the pathobiology of AD and has lead to the identification of other risk factors. Understanding the role of ApoE in the pathology of Alzheimer's disease promises to open a whole new field in AD research. * * Reviews the current knowledge of the pathogenesis of Alzheimer's Disease from a clinical perspective to a genetic and cell biological perspective * A comprehensive description of the role of amyloid B-protein precursor in Alzheimer's disease. * Up-to-date research data * Clear illustrations complement the text
Biology Of Pericytes Recent Advances
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Author : Alexander Birbrair
language : en
Publisher: Springer Nature
Release Date : 2021-04-08
Biology Of Pericytes Recent Advances written by Alexander Birbrair and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-04-08 with Science categories.
Pericytes were originally discovered and named more than hundred years ago as contractile cells around the blood vessel endothelial cells. Due to the lack of exclusive markers, pericytes are now defined by a combination of location, morphology and gene expression. Pericytes are attracting increasing attention as important regulators during development and during normal and disturbed organ function. In recent years, remarkable progress has been made in the identification and characterization of pericytes subpopulations and their amazing functions using state-of-art techniques. These advantages facilitated identification of molecular basis of interaction between these cells with several other more well studied cell types, and revealed key signals derived from pericytes involved in homeostasis, regeneration, and disease regulation. In the last ten years, several unexpected roles of pericytes have been discovered. It has been demonstrated that pericytes from different tissues differ in their properties as well as functions. Even more, pericytes are heterogeneous also within the same organ. This book is will describe the major contributions of pericytes to different organs biology in physiological and pathological conditions. The book will teach the readers about this so special cell type that 10 years ago was almost completely forgotten, and it was associated basically only with vascular stability. Recently, it become a very hot topic to work in. Several articles in Nature, Science and Cell have been and are being currently published about this cell type. These recent works are revealing how important those cells are for before unimaginable biological processes. Thus, this book will update us on what are the most novel functions attributed to these cells. Also, will introduce to the young generation all the history about these cells from when they were discovered in different organs till where we are now in this field. So it will be a great book for both cell biology students as well as researchers that will have an update on these cells biology in different organs.
Cyclin Dependent Kinase 5 Cdk5
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Author : Nancy Y. Ip
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-02-28
Cyclin Dependent Kinase 5 Cdk5 written by Nancy Y. Ip and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-02-28 with Medical categories.
Cyclin Dependent Kinase 5 provides a comprehensive and up-to-date collection of reviews on the discovery, signaling mechanisms and functions of Cdk5, as well as the potential implication of Cdk5 in the treatment of neurodegenerative diseases. Since the identification of this unique member of the Cdk family, Cdk5 has emerged as one of the most important signal transduction mediators in the development, maintenance and fine-tuning of neuronal functions and networking. Further studies have revealed that Cdk5 is also associated with the regulation of neuronal survival during both developmental stages and in neurodegenerative diseases. These observations indicate that precise control of Cdk5 is essential for the regulation of neuronal survival. The pivotal role Cdk5 appears to play in both the regulation of neuronal survival and synaptic functions thus raises the interesting possibility that Cdk5 inhibitors may serve as therapeutic treatment for a number of neurodegenerative diseases.
Gene Therapy Of The Central Nervous System From Bench To Bedside
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Author : Michael G. Kaplitt
language : en
Publisher: Gulf Professional Publishing
Release Date : 2006
Gene Therapy Of The Central Nervous System From Bench To Bedside written by Michael G. Kaplitt and has been published by Gulf Professional Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with Medical categories.
Few areas of biomedical research provide greater opportunities to capitalize upon the revolution in genomics and molecular biology than gene therapy. This is particularly true for the brain and nervous system, where gene transfer has become a key technology for basic research and has recently been translated to human therapy in several landmark clinical trials. Gene Therapy in the Brain: From Bench to Bedside represents the definitive volume on this subject. Edited by two pioneers of neurological gene therapy, this volume contains contributions by leaders who helped to create the field as well as those who are expanding the promise of gene therapy for the future of basic and clinical neuroscience. Drawing upon this extensive collective experience, this book provides clear and informative reviews on a variety of subjects which would be of interest to anyone who is currently using or contemplating exploring gene therapy for neurobiological applications. Basic gene transfer technologies are discussed, with particular emphases upon novel vehicles, immunological issues and the role of gene therapy in stem cells. Numerous research applications are reviewed, particularly in complex fields such as behavioral neurobiology. Several preclinical areas are also covered which are likely to translate into clinical studies in the near future, including epilepsy, pain and amyotrophic lateral sclerosis. Among the most exciting advances in recent years has been the use of neurological gene therapy in human clinical trials, including Parkinson's disease, Canavan disease and Batten disease. Finally, readers will find "insider" information on technological and regulatory issues which can often limit effective translation of even the most promising idea into clinical use. This work provides up-to-date information and key insights into those gene therapy issues which are important to both scientists and clinicians focusing upon the brain and central nervous system.
Animal Models Of Dementia
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Author : Peter Paul De Deyn
language : en
Publisher: Humana Press
Release Date : 2010-12-01
Animal Models Of Dementia written by Peter Paul De Deyn and has been published by Humana Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-12-01 with Medical categories.
With an ever-increasing elderly population and the resultant rising levels of dementia-related disorders, preclinical research based on animal models is pivotal to our knowledge of underlying molecular mechanisms and drug discovery aiming at the development of therapeutic strategies alleviating or preventing the neurological devastation. In Animal Models of Dementia, expert researchers provide contributions that stress the importance of extensively validated animal models in drug discovery and development in order to predict clinical activity. Beginning with general aspects of animal modeling, related ethical issues, and essential methodological considerations, the highly detailed volume then continues with various levels of model validation, including pathological, behavioral, neurochemical, pharmacological, and imaging aspects, followed by sections focused on specific disorders, such as Alzheimer’s disease, Parkinson’s disease, metachromatic leukodystrophy and adrenoleukodystrophy, amyotrophic lateral sclerosis, frontotemporal dementia as well as vascular dementia and more. As a volume in the renowned Neuromethods series, this book offers a detailed, yet accessible, overview of currently available animal models in the field of dementia research, and touches, as well, upon more general areas linked to the development and use of animal models. Comprehensive and efficient, Animal Models of Dementia will significantly aid both experienced animal researchers as well as investigators on the verge of beginning animal model-based dementia research.
White Matter Dementia
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Author : Christopher M. Filley
language : en
Publisher: Cambridge University Press
Release Date : 2016-04-28
White Matter Dementia written by Christopher M. Filley and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-04-28 with Medical categories.
Presenting the novel concept of white matter dementia, this unique book offers hope for a better understanding and treatment of dementia.
Endothelial Cell Culture
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Author : Roy Bicknell
language : en
Publisher: Cambridge University Press
Release Date : 1996-09-28
Endothelial Cell Culture written by Roy Bicknell and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996-09-28 with Science categories.
The aim of the Handbooks in Practical Animal Cell Biology is to provide practical workbooks for those involved in primary cell culture. Each volume addresses a different cell lineage, and contains an introductory section followed by individual chapters on the culture of specific differentiated cell types. The authors of each chapter are leading researchers in their fields and use their first-hand experience to present reliable techniques in a clear and thorough manner. Endothelial Cell Culture contains chapters on endothelial cells derived from 1) lung, 2) bone marrow, 3) brain, 4) mammary glands, 5) skin, 6) adipose tissue, 7) female reproductive system, and 8) synovium.
Inflammation And Epilepsy New Vistas
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Author : Damir Janigro
language : en
Publisher: Springer Nature
Release Date : 2021-05-18
Inflammation And Epilepsy New Vistas written by Damir Janigro and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-05-18 with Medical categories.
This book provides comprehensive information, both for clinicians and scientists, on the basic mechanisms, clinical features, and therapeutic approaches to epilepsy as an inflammatory disease. Inflammation has been for many years considered as an etiologic player (and a therapeutic target) for a specific group of epilepsies. However, it turns out that this concept underestimated the impact of inflammation in seizure disorders. Many accepted therapies for non-inflammatory epilepsies act in part as an inflammatory drug. The CNS actively responds to acute immune challenges by altering body temperature, stimulating the HPA axis, as well as up- and down-regulating specific sympathetic pathways.