Viral Interactions With The Nucleus
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Viral Interactions With The Nucleus
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Author : Erin Joanne Walker
language : en
Publisher: Frontiers Media SA
Release Date : 2017-08-16
Viral Interactions With The Nucleus written by Erin Joanne Walker and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-08-16 with Electronic book categories.
Viruses cause numerous medically important diseases, affecting developing, developed, rich and poor alike. The diseases vary in severity, including chickenpox, smallpox, influenza, shingles, herpes, rabies, polio, Ebola, hanta fever, AIDS and the common cold, amongst others. Regardless of the type of tissue or organ affected, all viruses follow the same basic steps to infect host cells. Once in contact with host cells viruses release their genetic material into the cell followed by genome replication, production of viral proteins, assembly of the virus particle and egress from the infected cell. Viruses disrupt normal host cell processes in order to facilitate their own replication/assembly by re-directing cellular machinery for viral transcription, translation, assembly, release and by inhibiting antiviral responses. Regulated nuclear transport of macromolecules through the nuclear pore complex, the only means of transport across the nuclear membrane, is essential for normal cell function and an effective antiviral response. Many viruses disrupt or exploit the nucleocytoplasmic trafficking pathways in host cells. Cytoplasmic viruses exploit the host cell nucleocytoplasmic trafficking machinery to access nuclear functions and/or disrupt nuclear transport, while several DNA viruses use the trafficking pathways to enable export of their components into the cytoplasm; yet others complete their assembly within the nucleus and use nuclear export pathways to access the cytoplasm. Indeed, the many and varied interactions of viruses and viral proteins with nucleocytoplasmic trafficking components have been invaluable in pathway discovery. Importantly, mounting evidence suggests that these interactions play essential roles in virus replication/assembly and hence may be key to understanding pathophysiology of viral diseases. This Frontiers Research Topic is dedicated to the importance of nucleocytoplasmic trafficking to viral pathogenesis.
Viruses And The Nucleus
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Author : Julian A. Hiscox
language : en
Publisher: John Wiley & Sons
Release Date : 2006-05-26
Viruses And The Nucleus written by Julian A. Hiscox and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-05-26 with Science categories.
Presents a global overview of viral (DNA, retro and RNA) interactions with the nucleus and its components. Including contributions from aleading experts in their fields, this is designed to be a definitive text on viral interactions with the nucleus. The book presents a gallery of microscopic images to illustrate the diversity of viral nuclear interactions in full color.
Membrane Trafficking In Viral Replication
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Author : Mark Marsh
language : en
Publisher: Springer Science & Business Media
Release Date : 2005-10-25
Membrane Trafficking In Viral Replication written by Mark Marsh and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-10-25 with Medical categories.
Viruses are major pathogens in humans, and in the organisms with which we share this planet. The massive health and economic burden these agents impose has spurred a huge research effort to understand their most intimate details. One outcome of this effort has been the production, in many but certainly not all cases, of effective vaccines and therapies. - other consequence has been the realization that we can exploit viruses and put them to work on our behalf. Viruses are still seen to have the most - tential as vehicles for gene delivery and other therapeutic applications. However, their ability to exploit cellular functions to their own ends makes viruses not only highly effective pathogens but also exquisite experimental tools. Work with viruses underpins much of our current understanding of molecular cell biology and related fields. For membrane traffic in parti- lar, viruses have been crucial in providing insights into key cellular fu- tions and the molecular mechanisms underlying these events.
Viral Interactions With Host Rna Decay Pathways
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Author : J. Robert Hogg
language : en
Publisher: MDPI
Release Date : 2018-07-10
Viral Interactions With Host Rna Decay Pathways written by J. Robert Hogg and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-07-10 with Electronic book categories.
This book is a printed edition of the Special Issue "Viral Interactions with Host RNA Decay Pathways" that was published in Viruses
Retrovirus Cell Interactions
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Author : Leslie Parent
language : en
Publisher: Academic Press
Release Date : 2018-08-09
Retrovirus Cell Interactions written by Leslie Parent and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-08-09 with Medical categories.
Retrovirus-Cell Interactions provides an up-to-date review of the interactions between retroviruses and the cells they infect, offering a comprehensive understanding of how retroviruses hijack cellular factors to facilitate virus replication. Drugs targeting viral enzymes have been developed to treat HIV; the next challenge is to inhibit virus-cell interactions as next generation treatment strategies. Organized according to the retrovirus' replication cycle, this book does not focus exclusively on HIV, but rather includes important findings in other retroviral systems, including animal retroviruses, retrotransposons, and endogenous retroelements to allow broad comparisons on important commonalities and differences. Provides a valuable starting point for people who want to develop a detailed understanding of retroviral replication Includes future-thinking strategies, such as next-generation treatment and anti-retroviral therapeutics Features important commonalities and differences among retroviral systems
Cell Organelle Exploitation By Viruses During Infection
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Author : Parikshit Bagchi
language : en
Publisher: Frontiers Media SA
Release Date : 2021-06-28
Cell Organelle Exploitation By Viruses During Infection written by Parikshit Bagchi and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-06-28 with Science categories.
Membrane Trafficking In Viral Replication
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Author : Mark Marsh
language : en
Publisher:
Release Date : 2005
Membrane Trafficking In Viral Replication written by Mark Marsh and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with Biological transport categories.
The ability of viruses to exploit cellular functions for their own ends makes them highly effective pathogens and exquisite experimental tools. Work with viruses underpins much of our current understanding of molecular cell biology and related fields. Each of the eight chapters in this volume deals with a specific aspect of viral interactions with cellular membranes. These include chapters on viral entry, viral membrane fusion, viral membrane protein synthesis and transport, viral replication, viral interactions with cytoskeletal systems and the nucleus, the trafficking of viral membrane proteins and viral perturbation of host cell protein trafficking. These chapters should provide both an overview of cellular membrane trafficking mechanisms and viral interactions with these systems, as well as reviews of the current state of each of the fields.
Molecular Biology Of The Cell
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Author : Bruce Alberts
language : en
Publisher:
Release Date : 2002
Molecular Biology Of The Cell written by Bruce Alberts and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Cytology categories.
Molecular Virology
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Author : Susanne Modrow
language : en
Publisher: Springer
Release Date : 2013-09-18
Molecular Virology written by Susanne Modrow and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-09-18 with Science categories.
The book gives a comprehensive overview on the knowledge of virus infection relevant for humans and animals. For each virus family the molecular details of the virus particle and the viral replication cycle are described. In the case of virus types with relevance for human and/or animal health the data on molecular biology, genetics and virus-cell interaction are combined with those concerning, pathogenesis, epidemiology, clinics, prevention and therapy.
Human Herpesviruses
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Author : Ann Arvin
language : en
Publisher: Cambridge University Press
Release Date : 2007-08-16
Human Herpesviruses written by Ann Arvin and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-08-16 with Medical categories.
This comprehensive account of the human herpesviruses provides an encyclopedic overview of their basic virology and clinical manifestations. This group of viruses includes human simplex type 1 and 2, Epstein–Barr virus, Kaposi's Sarcoma-associated herpesvirus, cytomegalovirus, HHV6A, 6B and 7, and varicella-zoster virus. The viral diseases and cancers they cause are significant and often recurrent. Their prevalence in the developed world accounts for a major burden of disease, and as a result there is a great deal of research into the pathophysiology of infection and immunobiology. Another important area covered within this volume concerns antiviral therapy and the development of vaccines. All these aspects are covered in depth, both scientifically and in terms of clinical guidelines for patient care. The text is illustrated generously throughout and is fully referenced to the latest research and developments.