Voltage Gated Sodium Channels
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Voltage Gated Sodium Channels
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Author : Peter C. Ruben
language : en
Publisher: Springer Science & Business Media
Release Date : 2014-04-15
Voltage Gated Sodium Channels written by Peter C. Ruben and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-04-15 with Medical categories.
A number of techniques to study ion channels have been developed since the electrical basis of excitability was first discovered. Ion channel biophysicists have at their disposal a rich and ever-growing array of instruments and reagents to explore the biophysical and structural basis of sodium channel behavior. Armed with these tools, researchers have made increasingly dramatic discoveries about sodium channels, culminating most recently in crystal structures of voltage-gated sodium channels from bacteria. These structures, along with those from other channels, give unprecedented insight into the structural basis of sodium channel function. This volume of the Handbook of Experimental Pharmacology will explore sodium channels from the perspectives of their biophysical behavior, their structure, the drugs and toxins with which they are known to interact, acquired and inherited diseases that affect sodium channels and the techniques with which their biophysical and structural properties are studied.
Voltage Gated Sodium Channels Structure Function And Channelopathies
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Author : Mohamed Chahine
language : en
Publisher: Springer
Release Date : 2018-06-04
Voltage Gated Sodium Channels Structure Function And Channelopathies written by Mohamed Chahine and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-06-04 with Medical categories.
This book provides a timely state-of-the-art overview of voltage-gated sodium channels, their structure-function, their pharmacology and related diseases. Among the topics discussed are the structural basis of Na+ channel function, methodological advances in the study of Na+ channels, their pathophysiology and drugs and toxins interactions with these channels and their associated channelopathies.
Calcium Entry Channels In Non Excitable Cells
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Author : Juliusz Ashot Kozak
language : en
Publisher: CRC Press
Release Date : 2017-07-14
Calcium Entry Channels In Non Excitable Cells written by Juliusz Ashot Kozak and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-07-14 with Science categories.
Calcium Entry Channels in Non-Excitable Cells focuses on methods of investigating the structure and function of non-voltage gated calcium channels. Each chapter presents important discoveries in calcium entry pathways, specifically dealing with the molecular identification of store-operated calcium channels which were reviewed by earlier volumes in the Methods in Signal Transduction series. Crystallographic and pharmacological approaches to the study of calcium channels of epithelial cells are also discussed. Calcium ion is a messenger in most cell types. Whereas voltage gated calcium channels have been studied extensively, the non-voltage gated calcium entry channel genes have only been identified relatively recently. The book will fill this important niche.
Ion Channels In Health And Sickness
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Author : Fatima Shad Kaneez
language : en
Publisher: BoD – Books on Demand
Release Date : 2018-10-10
Ion Channels In Health And Sickness written by Fatima Shad Kaneez and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-10-10 with Science categories.
Ion channels are proteins that make pores in the membranes of excitable cells present both in the brain and the body. These cells are not only responsible for converting chemical and mechanical stimuli into the electrical signals but are also liable for monitoring vital functions. All our activities, from the blinking of our eyes to the beating of our heart and all our senses from smell to sight, touch, taste and hearing are regulated by the ion channels. This book will take us on an expedition describing the role of ion channels in congenital and acquired diseases and the challenges and limitations scientist are facing in the development of drugs targeting these membrane proteins.
Recent Advances In Voltage Gated Sodium Channels Their Pharmacology And Related Diseases
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Author : Mohamed Chahine
language : en
Publisher: Frontiers E-books
Release Date :
Recent Advances In Voltage Gated Sodium Channels Their Pharmacology And Related Diseases written by Mohamed Chahine and has been published by Frontiers E-books this book supported file pdf, txt, epub, kindle and other format this book has been release on with categories.
It is our pleasure to co-edit a Research Topic on voltage-gated sodium channels pharmacology and related diseases. We are in a process to inviting submissions of novel research article, state-of-the-art review papers and viewpoints on this topic. All the papers will follow a peer-review process according to the guidelines of Frontiers in Pharmacology. Voltage-gated sodium channel play a critical role in electrical signalling in many excitable cells such as neurons, skeletal muscle cells and cardiac myocytes. They are responsible for the initiation and the propagation of action potential, allowing integration of higher processes. They are formed by one alpha subunit that forms the pore of the channel and one or several regulatory subunits. Sodium channels are the target for local anaesthetics, antiarrhythmic drugs, and anticonvulsants. This class of ion channels is prime target to several toxins. Recently, a number of mutations in sodium channels that often results in alterations of rapid channel gating have been identified and linked to human diseases. Such channelopathies cause periodic paralysis, myotonia, long QT syndrome and other cardiac conductance disturbances, pain, hemiplegic migraine, and epilepsy. Sodium channels play also a negative role in malignant cellular proliferation, chronic pain, and other diseases. Considering these crucial physiological and pathological implications, it is not surprising that sodium channels have been and still are key targets for drug development. This Research Topic of Frontiers of Pharmacology of Ion Channels and Channelopathies will focus on this important class of ion channels how they operate, their pharmacology and their implication in diseases.
Voltage Gated Ion Channels As Drug Targets
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Author : David J. Triggle
language : en
Publisher: John Wiley & Sons
Release Date : 2006-08-21
Voltage Gated Ion Channels As Drug Targets written by David J. Triggle and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-08-21 with Science categories.
Edited by the most prominent person in the field and top researchers at US pharmaceutical companies, this is a unique resource for drug developers and physiologists seeking a molecular-level understanding of ion channel pharmacology. After an introduction to the topic, the authors evaluate the structure and function of ion channels, as well as related drug interaction. A section on assay technologies is followed by a section each on calcium, sodium and potassium channels. Further chapters cover genetic and acquired channelopathies, before the book closes with a look at safety issues in ion channel drug development. For medicinal and pharmaceutical chemists, biochemists, molecular biologists and those working in the pharmaceutical industry.
Jasper S Basic Mechanisms Of The Epilepsies
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Author : Jeffrey L. Noebels
language : en
Publisher: OUP USA
Release Date : 2012-06-29
Jasper S Basic Mechanisms Of The Epilepsies written by Jeffrey L. Noebels and has been published by OUP USA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-06-29 with Medical categories.
Jasper's Basic Mechanisms, Fourth Edition, is the newest most ambitious and now clinically relevant publishing project to build on the four-decade legacy of the Jasper's series. In keeping with the original goal of searching for "a better understanding of the epilepsies and rational methods of prevention and treatment.", the book represents an encyclopedic compendium neurobiological mechanisms of seizures, epileptogenesis, epilepsy genetics and comordid conditions. Of practical importance to the clinician, and new to this edition are disease mechanisms of genetic epilepsies and therapeutic approaches, ranging from novel antiepileptic drug targets to cell and gene therapies.
Molecular Biology Of The Cell
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Author : Bruce Alberts
language : en
Publisher:
Release Date : 2002
Molecular Biology Of The Cell written by Bruce Alberts and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Cytology categories.
Handbook Of Ion Channels
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Author : Jie Zheng
language : en
Publisher: CRC Press
Release Date : 2015-02-25
Handbook Of Ion Channels written by Jie Zheng and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-02-25 with Medical categories.
The New Benchmark for Understanding the Latest Developments of Ion ChannelsIon channels control the electrical properties of neurons and cardiac cells, mediate the detection and response to sensory stimuli, and regulate the response to physical stimuli. They can often interact with the cellular environment due to their location at the surface of ce
Sodium Channels Pain And Analgesia
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Author : Kevin Coward
language : en
Publisher: Springer Science & Business Media
Release Date : 2006-01-17
Sodium Channels Pain And Analgesia written by Kevin Coward and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-01-17 with Medical categories.
Sodium channels confer excitability on neurons in nociceptive pathways and exhibit neuronal tissue specific and injury regulated expression. This volume provides recent insights into the control of expression, functioning and membrane trafficking of nervous system sodium channels and reviews why sodium channel sub-types are potentially important drug targets in the treatment of pain. The roles of sodium channels in dental and visceral pain are also addressed. The emerging role of sodium channel Nav1.3 in neuropathic states is another important theme. Authors from the pharmaceutical industry discuss pharmacological approaches to the drug targeting of sodium channels, and in particular Nav1.8, exclusively expressed in nociceptive neurons. The final chapter highlights the functional diversity of sodium channels in part provided by post-transcriptional processing and the insights into sodium channel function that are being provided by tissue specific and inducible gene knock-out technology.