Zebrafish Models Of Neurodegenerative Disorders
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Zebrafish Models Of Neurodegenerative Disorders
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Author : Ebru Emekli-Alturfan
language : en
Publisher: CRC Press
Release Date : 2025-09-08
Zebrafish Models Of Neurodegenerative Disorders written by Ebru Emekli-Alturfan and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-09-08 with Science categories.
Advancing our understanding of neurodegenerative diseases demands innovative tools and approaches. Zebrafish Models in Neurodegenerative Disorders offers a comprehensive examination of zebrafish as a translational model for studying the molecular and cellular mechanisms of diseases such as Alzheimer’s, Parkinson’s, and Huntington’s diseases. Beginning with the first section informing about the basic molecular mechanisms of neurodegenerative disorders, biomarkers, and therapeutic approaches, the book continues with the detailed exploration of zebrafish physiology, genetics, and behavioural phenotypes as they pertain to neurodegenerative pathologies; insight into cutting-edge technologies, including CRISPR/Cas9 genome editing; and in-depth analysis of zebrafish models, highlighting their strengths in modelling disease progression and therapeutic testing.
Handbook Of Animal Models In Neurological Disorders
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Author : Colin R Martin
language : en
Publisher: Elsevier
Release Date : 2022-11-29
Handbook Of Animal Models In Neurological Disorders written by Colin R Martin and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-11-29 with Medical categories.
Handbook of Animal Models in Neurological Disorders will better readers' understanding of a large variety of animal models and their applicability in studying a number of neurological disorders. Featuring sections on brain injury, stroke and neuroinflammation, this volume discusses in detail the utility, success and pitfalls of multiple models for each condition. Multiple disorders are covered, ranging from neurodegenerative diseases like Alzheimer's, Parkinson's, and ALS, to multiple sclerosis, headache, migraine, and others. With expert authors, this book has applicability for anyone pursuing neuroscience or biomedical research working to better understand, study and ultimately treat neurological dysfunction. - Summarizes animal models for a variety of neurological conditions - Contains chapter abstracts, key facts, a dictionary and a summary - Covers both neurodegenerative diseases and other neurological conditions - Compares and contrasts different models and experimental systems - Includes sections on Alzheimer's, Parkinson's, brain injury, migraine, multiple sclerosis, and more
Animal Models For Neurological Disorders
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Author : Anil Kumar
language : en
Publisher: Bentham Science Publishers
Release Date : 2021-12-24
Animal Models For Neurological Disorders written by Anil Kumar and has been published by Bentham Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-12-24 with Science categories.
Animal disease models are a vital tool to study diseases and associated conditions. Studies on animal models can, in some cases, be used as a basis for modeling and understanding human diseases. Biomedical scientists face a challenge to choose the correct animal model to study disease pathology, and neurological diseases are no exception to this rule. Animal Models for Neurological Disorders covers different animal models which have been used for studying neurological disorders. 13 topical chapters have been contributed by a group of experts on the subject with an aim to cover emerging experimental models of a range of neurological diseases encountered in the clinic including Alzheimer’s disease, psychosis, Parkinson’s, Huntington’s disease, vascular dementia, schizophrenia, multiple sclerosis and brain tumors, among others. The chapters also inform readers about relevant clinical correlations in each disease model where appropriate. Animal Models for Neurological Disorders is intended for all scholarly researchers and students of biomedical sciences, pharmacology, medicine (oncology, neurology, psychiatry), pharmacy, biochemistry, and biotechnology. The organized contents of the book also serve as a quick reference point for scientists working in applied areas of neuroscience including the study of neurodegenerative diseases and cognitive dysfunction in living organisms.
Neurobiological Underpinnings Of Neurodegenerative And Neuropsychiatric Disorders From Models To Therapy
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Author : Ferdinando Di Cunto
language : en
Publisher: Frontiers Media SA
Release Date : 2025-07-29
Neurobiological Underpinnings Of Neurodegenerative And Neuropsychiatric Disorders From Models To Therapy written by Ferdinando Di Cunto and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-07-29 with Science categories.
During the last two decades, advances in different areas of Neurosciences have clearly highlighted the complex nature of neuropsychiatric and neurodegenerative disorders. The proper assembly, maturation and maintenance of neuronal circuits underlying normal functioning of the nervous system require the execution of specific genetic programs, finely tuned in space and time. The widespread detection of genes, mRNA, proteins, and metabolites has shed much light on relevant missteps in these delicate processes that may cause detrimental consequences for brain wiring and function. A clear role of cell-autonomous alterations, involving cell adhesion molecules, ion channels and intracellular pathways impinging on synaptic function is well established in neuropsychiatric diseases. Similarly, modifications in protein sequence and structure resulting in the accumulation of insoluble aggregates are widely acknowledged as culprits of most neurodegenerative disorders. On the other hand, the careful study of pathophysiological mechanisms that may translate genetic predisposition into full manifested disease phenotypes has revealed the involvement of non-genetic and non-neuronal factors in establishment and propagation of the damage from cell to network level. Indeed, current research is emphasizing the crucial role of epigenetic modifications, metabolic rewiring, brain-immune system cross-talk, glial cell functions, gut-to-brain axis, and blood-brain barrier, both in neuropsychiatric and neurodegenerative disorders. Importantly, these additional layers of complexity represent a rich interface between genetic variants and environmental stressors, whose nature and relevance are also being elucidated.
Animal Models For The Study Of Human Disease
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Author : Angela L. Shamchuk
language : en
Publisher: Elsevier Inc. Chapters
Release Date : 2013-05-29
Animal Models For The Study Of Human Disease written by Angela L. Shamchuk and has been published by Elsevier Inc. Chapters this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-05-29 with Medical categories.
Olfactory dysfunction, although caused by many factors including physical damage and genetic abnormalities, is an early stage symptom of several neurodegenerative diseases. Not only is the olfactory system subject to the specific histological abnormalities but patients also lose the capacities to detect, identify, and discriminate among odors. In addition to olfactory deficits, motor dysfunction is another prominent manifestation of these conditions. Recent studies have begun to create zebrafish (Danio rerio) models for neurodegenerative diseases. Despite successful execution, there remains a great deal of potential in testing the models using established methods of olfactory and motion assessment. This chapter discusses the current zebrafish models and suggests olfactory and motor endpoints for Parkinson's, Alzheimer's, Huntington's, multiple system atrophy, and amyotrophic lateral sclerosis.
Human Motor Neuron Diseases
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Author : Lewis P. Rowland
language : en
Publisher: Lippincott Williams & Wilkins
Release Date : 1982
Human Motor Neuron Diseases written by Lewis P. Rowland and has been published by Lippincott Williams & Wilkins this book supported file pdf, txt, epub, kindle and other format this book has been release on 1982 with Medical categories.
Environmental Factors In Neurodevelopmental And Neurodegenerative Disorders
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Author : Michael Aschner
language : en
Publisher: Academic Press
Release Date : 2015-06-18
Environmental Factors In Neurodevelopmental And Neurodegenerative Disorders written by Michael Aschner and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-06-18 with Technology & Engineering categories.
Environmental Factors in Neurodevelopmental and Neurodegenerative Disorders presents a state-of-the-art review of the effects of environmental contaminants on the development and degeneration of the human nervous system, brought together by world-leading experts in the field. Part One describes the adverse effects that the environment can have on neurological development, and how these effects may exhibit. Specific contaminants and their possible consequences of exposure are addressed (lead, methylmercury, alcohol), as well as specific disorders and the environmental factors associated with them, such as the effect of diet on attention deficit and hyperactivity disorders. Part Two tackles neurodegenerative disorders, specifically addressing their potential neurotoxic origins, and discussing the increasing interest in the effects that early exposure may have in later life. Environmental Factors in Neurodevelopmental and Neurodegenerative Disorders is an invaluable reference for those professionals working in the fields of toxicology, environmental health and neuroscience. - Provides, for the first time, the cutting-edge theory of environmental impacts on both neurodegenerative and neurodevelopmental disorders - Written by an international selection of the world's foremost experts in the field of neurotoxicology - Full-colour throughout, providing accurate and illustrative examples of neurotoxic effects in action - An invaluable reference for those professionals working in the fields of toxicology, environmental health, and neuroscience
Animal Models For The Study Of Human Disease
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Author : P. Michael Conn
language : en
Publisher: Academic Press
Release Date : 2013-05-29
Animal Models For The Study Of Human Disease written by P. Michael Conn and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-05-29 with Science categories.
Animal Models for the Study of Human Disease identifies important animal models and assesses the advantages and disadvantages of each model for the study of human disease. The first section addresses how to locate resources, animal alternatives, animal ethics and related issues, much needed information for researchers across the biological sciences and biomedicine.The next sections of the work offers models for disease-oriented topics, including cardiac and pulmonary diseases, aging, infectious diseases, obesity, diabetes, neurological diseases, joint diseases, visual disorders, cancer, hypertension, genetic diseases, and diseases of abuse. - Organized by disease orientation for ease of searchability - Provides information on locating resources, animal alternatives and animal ethics - Covers a broad range of animal models used in research for human disease
Model Systems To Study The Mechanisms Of Neural Development And Disease
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Author : Parthiv Haldipur
language : en
Publisher: Frontiers Media SA
Release Date :
Model Systems To Study The Mechanisms Of Neural Development And Disease written by Parthiv Haldipur and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on with Science categories.
Translational Models Of Parkinson S Disease And Related Movement Disorders
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Author : Wael Mohamed
language : en
Publisher: Elsevier
Release Date : 2024-11-26
Translational Models Of Parkinson S Disease And Related Movement Disorders written by Wael Mohamed and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-11-26 with Medical categories.
Translational Models of Parkinson's Disease and Related Movement Disorders focuses on cutting-edge techniques for creating and validating current Parkinson's Disease translational experimental models. Various characteristics of these models are examined, including the prion-like properties of -synuclein, mitochondrial functions connected to the PINK1-Parkin pathway/CHCHD2, the endolysosome pathway connected to LRRK2, VPS35, and ATP13A2 using cultured cells (including patient iPS cells). This book also highlights the future possibilities of introducing new models for Parkinson's Disease and related movements disorders, underscoring current advancements, pre-clinical and clinical developments, and future scope related to numerous models. - Highlights induction and validation of different available experimental models of Parkinson's Disease - Provides a comparative prospect of different experimental models of Parkinson's Disease - Discusses the advantages and disadvantages of each model, including associated limitations