Zinc Signaling
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Zinc Signaling In Physiology And Pathogenesis
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Author : Toshiyuki Fukada
language : en
Publisher: MDPI
Release Date : 2018-05-04
Zinc Signaling In Physiology And Pathogenesis written by Toshiyuki Fukada and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-05-04 with categories.
This book is a printed edition of the Special Issue "Zinc Signaling in Physiology and Pathogenesis" that was published in IJMS
Zinc Signaling
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Author : Toshiyuki Fukada
language : en
Publisher: Springer Nature
Release Date : 2019-12-13
Zinc Signaling written by Toshiyuki Fukada and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-12-13 with Medical categories.
This book, now in an extensively revised second edition, describes the crucial role of zinc signaling in biological processes on a molecular and physiological basis. Global leaders in the field review the latest knowledge, including the very significant advances in understanding that have been achieved since publication of the first edition. Detailed information is provided on all the essentials of zinc signaling, covering molecular aspects and the roles of zinc transporters, the zinc sensing receptor, and metallothioneins. Detection techniques for zinc signals, involving genetically encoded and chemical probes, are also described. The critical contributions of the zinc signal in maintaining health and the adverse consequences of any imbalance in the signal are then thoroughly addressed. Here, readers will find up-to-date information on the significance of the zinc signal in a wide range of conditions, including cardiovascular disorders, neurodegenerative diseases, diabetes, autoimmune diseases, inflammatory conditions, skin disease, osteoarthritis, and cancer. The book will be of value for researchers, clinicians, and advanced students.
Zinc Signals In Cellular Functions And Disorders
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Author : Toshiyuki Fukada
language : en
Publisher: Springer
Release Date : 2014-09-25
Zinc Signals In Cellular Functions And Disorders written by Toshiyuki Fukada and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-09-25 with Science categories.
This book describes the crucial role of "zinc signals" in biological processes on a molecular and physiological basis, discussing future directions and questions underlying this unique phenomenon. To accomplish this, a group of worldwide leaders in the field, who have made outstanding contributions, overview zinc signals from a professional standpoint. Zinc plays an indispensable role in various cellular processes. It regulates a great number of protein functions including transcription factors, enzymes, adapters, and growth factors as a structural or catalytic factor or both. Recently, another function of zinc has received extensive interest and attention because of its potential importance as a signaling mediator. Zinc plays a dynamic role as an intracellular and extracellular signaling factor and thus regulates cellular signaling pathways, which enables communication between cells, conversion of extracellular stimuli to intracellular signals, and control of various intracellular events. These functions of zinc have become recognized as “zinc signals,” which play critical roles in physiology, and therefore their imbalance can cause a variety of problems with regard to human health. Because the notion of zinc signals is quite new and no integrative review books focusing on them have yet been published, we believe this book will provide very timely information on the subject and thus should be of importance and interest to a wide range of readers.
Zinc Biochemistry Physiology And Homeostasis
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Author : W. Maret
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-11-11
Zinc Biochemistry Physiology And Homeostasis written by W. Maret and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-11 with Science categories.
Chapters in this book review the remarkable advances in the field of zinc biology over the last decade. Zinc is essential for life, in particular for growth and development, through its role in hundreds of zinc enzymes and thousands of zinc proteins. Its catalytic, structural, and regulatory functions in these proteins impact metabolism, gene expression, and signal transduction, including neurotransmission. Among the micronutrients, zinc may rank with iron as to its importance for public health. The topics covered range from single molecules to cells and to whole organisms: the chemistry, design, and application of fluorophores for the determination of cellular zinc; the role of zinc in proliferation, differentiation, and apoptosis of cells; proteins that transport, sense, and distribute zinc and together form a cellular homeostatic system; the coordination chemistry of zinc in metalloproteins; the role of zinc in the brain as a neuromodulator/transmitter; the dependence of the immune system on zinc; zinc homeostasis in the whole human body.
Signaling Pathways Involved In Zinc Induced Apoptosis
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Author : James J. Mann
language : en
Publisher:
Release Date : 2005
Signaling Pathways Involved In Zinc Induced Apoptosis written by James J. Mann and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with Apoptosis categories.
Dietary Polyphenols Display Zinc Ionophore Activity And Modulate Zinc Signaling In Hepatocarcinoma Cells
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Author :
language : en
Publisher:
Release Date : 2015
Dietary Polyphenols Display Zinc Ionophore Activity And Modulate Zinc Signaling In Hepatocarcinoma Cells written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015 with categories.
El zinc és el metall de transició més abundant després del ferro a totes les cèl·lules, i un micronutrient essencial, presentant diverses funcions en sistemes biològics. D'altra banda, els polifenols de la dieta són micronutrients bioactius que mostren nombrosos beneficis per a la salut, com ara activitat antitumoral i neuroprotectora. Anteriors treballs del nostre grup d'investigació han demostrat que els polifenols interaccionen amb cations de zinc i tenen la capacitat de modular l'expressió de diferents gens implicats en l'homeòstasi d'aquest. En aquest treball van ser usats els flavonoides gal·lat d'Epigalocatequina i Quercetina com a models per polifenols hidrofílics i lipofílics respectivament, observant-se que, un cop combinats amb el zinc, presenten activitat ionófora per aquest metall en un sistema liposomal, similar a l'efecte del Clioquinol, fàrmac utilitzat en teràpies anti-càncer i anti-Alzheimer. A través d'aquest mecanisme, s'augmenten el pool de zinc làbil citoplasmàtic, intercanviable i de senyalització en el model de carcinoma hepatocel·lular Hepa 1-6. Per tant, els polifenols de la dieta es poden afegir a l'arsenal de fàrmacs que modulen l'homeòstasi del zinc i regulen les vies biològiques dependents d'aquest. Com a prova d'aquest principi, hem demostrat aquí, que en concentracions molt baixes, el gal·lat d'Epigalocatequina i la Quercetina quan es combinen amb el zinc, poden activar o inhibir la fosforilació d'Akt en cèl·lules Hepa 1-6. A més, vam demostrar que la Quercetina desencadena l'apoptosi en el carcinoma hepatocel·lular Hepa 1-6 de manera dependent de zinc.
Dietary Zn And Human Health
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Author : Elad Tako
language : en
Publisher: MDPI
Release Date : 2018-07-10
Dietary Zn And Human Health written by Elad Tako and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-07-10 with Electronic books categories.
This book is a printed edition of the Special Issue "Dietary Zn and Human Health" that was published in Nutrients
Zinc
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Author : Masayoshi Yamaguchi
language : en
Publisher: Nova Science Publishers
Release Date : 2012
Zinc written by Masayoshi Yamaguchi and has been published by Nova Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with Zinc categories.
Zinc is one of the most abundant transition metals in the human body, and it has various benefits as an essential trace element in the regulation of the living body. Nutritional deficiency of zinc is known to induce many chronic diseases such as immune system disorders, rheumatoid arthritis, diabetes, obesity, atherosclerosis, cancers, bone growth retardation, osteoporosis and others. This book introduces the recent topics concerning the characteristics, uses and benefits of zinc. This book will be helpful in research development and also in the understanding of the various physiological-pathophysiological roles of zinc.
The Role Of Zinc Transporter 1 In Regulating Zinc And Calcium Cellular Homeostasis And Hras Ek1 2 Signaling
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Author : Eden Shusterman
language : en
Publisher:
Release Date : 2017
The Role Of Zinc Transporter 1 In Regulating Zinc And Calcium Cellular Homeostasis And Hras Ek1 2 Signaling written by Eden Shusterman and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with Cellular signal transduction categories.
Synaptic Plasticity And Transsynaptic Signaling
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Author : Patric K. Stanton
language : en
Publisher: Springer Science & Business Media
Release Date : 2006-06-14
Synaptic Plasticity And Transsynaptic Signaling written by Patric K. Stanton and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-06-14 with Medical categories.
Brain functions are realized by the activity of neuronal networks composed of a huge number of neurons. The efficiency of information transfer within the networks is changeable. Even the networks themselves can change through experience. Information transfer between neurons is performed at the synapse (the site of the neurons’ contact) by release of neurotransmitters from the pre-synaptic cell and capture of neurotransmitters by the post-synaptic cell. The amount of released neurotransmitter or the efficacy of capture can change. Moreover, synapses are found to be newly formed upon activity or abandoned upon inactivity. These changes are called "synaptic plasticity". This text focuses on one component of synaptic plasticity called transsynaptic signaling, or communication of synapses during their formation.