Zinc Signals In Cellular Functions And Disorders

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Zinc Signals In Cellular Functions And Disorders

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Author : Toshiyuki Fukada
language : en
Publisher: Springer
Release Date : 2014-09-25

Zinc Signals In Cellular Functions And Disorders written by Toshiyuki Fukada and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-09-25 with Science categories.

This book describes the crucial role of "zinc signals" in biological processes on a molecular and physiological basis, discussing future directions and questions underlying this unique phenomenon. To accomplish this, a group of worldwide leaders in the field, who have made outstanding contributions, overview zinc signals from a professional standpoint. Zinc plays an indispensable role in various cellular processes. It regulates a great number of protein functions including transcription factors, enzymes, adapters, and growth factors as a structural or catalytic factor or both. Recently, another function of zinc has received extensive interest and attention because of its potential importance as a signaling mediator. Zinc plays a dynamic role as an intracellular and extracellular signaling factor and thus regulates cellular signaling pathways, which enables communication between cells, conversion of extracellular stimuli to intracellular signals, and control of various intracellular events. These functions of zinc have become recognized as “zinc signals,” which play critical roles in physiology, and therefore their imbalance can cause a variety of problems with regard to human health. Because the notion of zinc signals is quite new and no integrative review books focusing on them have yet been published, we believe this book will provide very timely information on the subject and thus should be of importance and interest to a wide range of readers.

Protein Kinase Ck2 Cellular Function In Normal And Disease States

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Author : Khalil Ahmed
language : en
Publisher: Springer
Release Date : 2015-03-03

Protein Kinase Ck2 Cellular Function In Normal And Disease States written by Khalil Ahmed and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-03-03 with Medical categories.

Protein kinase CK2 (formerly casein kinase II or 2) is known to play a critical role in the control of cell growth and cell death and is thus intimately involved in the development of cancer. More specifically, CK2 has been found to be elevated in all cancers examined. While CK2 levels are known to be high in proliferating normal cells, CK2 has also been found to be a potent suppressor of apoptosis and is a link to the cancer cell phenotype, which is characterized by deregulation of both cell proliferation and cell death. Indeed, it would appear that CK2 impacts many of the hallmarks of cancer and it has now gained considerable attention as a potential target for cancer therapy. Protein Kinase CK2 and Cellular Function in Normal and Disease States increases knowledge of the role of CK2 in the development of cellular dysfunction and emphasizes that this protein may serve as a target of drug development for improved cancer therapy. In addition, it is a handy tool that provides cancer researchers, graduate students, and all scientists involved in CK2 research with one main source for the latest advances in CK2 research. ​

Zinc Signaling

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Author : Toshiyuki Fukada
language : en
Publisher: Springer Nature
Release Date : 2019-12-13

Zinc Signaling written by Toshiyuki Fukada and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-12-13 with Medical categories.

This book, now in an extensively revised second edition, describes the crucial role of zinc signaling in biological processes on a molecular and physiological basis. Global leaders in the field review the latest knowledge, including the very significant advances in understanding that have been achieved since publication of the first edition. Detailed information is provided on all the essentials of zinc signaling, covering molecular aspects and the roles of zinc transporters, the zinc sensing receptor, and metallothioneins. Detection techniques for zinc signals, involving genetically encoded and chemical probes, are also described. The critical contributions of the zinc signal in maintaining health and the adverse consequences of any imbalance in the signal are then thoroughly addressed. Here, readers will find up-to-date information on the significance of the zinc signal in a wide range of conditions, including cardiovascular disorders, neurodegenerative diseases, diabetes, autoimmune diseases, inflammatory conditions, skin disease, osteoarthritis, and cancer. The book will be of value for researchers, clinicians, and advanced students.

Zinc Signaling In Physiology And Pathogenesis

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Author : Toshiyuki Fukada
language : en
Publisher: MDPI
Release Date : 2018-05-04

Zinc Signaling In Physiology And Pathogenesis written by Toshiyuki Fukada and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-05-04 with Science categories.

This book is a printed edition of the Special Issue "Zinc Signaling in Physiology and Pathogenesis" that was published in IJMS

Studies Of Epithelial Transporters And Ion Channels

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Author : Kirk L. Hamilton
language : en
Publisher: Springer Nature
Release Date : 2021-03-04

Studies Of Epithelial Transporters And Ion Channels written by Kirk L. Hamilton and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-03-04 with Medical categories.

This book discusses unique ion channels and transporters that are located within epithelial tissues of various organs including the kidney, intestine, pancreas and respiratory tract. The authors will show, that each of these channels and transporters play crucial roles in transepithelial ion and fluid transport across epithelia and their responsibility in maintaining homeostasis. The reader gains an understanding of the fundamentals of epithelial ion transport, in terms of function, modelling, regulation, trafficking, structure and pharmacology. This is the third of three volumes highlighting the importance of epithelial ion channels and transporters in basic physiology and pathophysiology of human diseases. The focus of this volume lies with different ion channel and transporter families. Additionally, this volume benefits from pharmaceutical contributors and their insights into recent pre-clinical drug discovery efforts and results from clinical trials. Overall, these chapters offer a more thorough coverage of individual epithelial ion channels and transporters from the 1st Edition, along with eleven new chapters. That makes Volume 3 an insightful contribution for physiology students, scientists and clinicians.

Molecular Genetic And Nutritional Aspects Of Major And Trace Minerals

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Author : James F Collins
language : en
Publisher: Academic Press
Release Date : 2016-09-14

Molecular Genetic And Nutritional Aspects Of Major And Trace Minerals written by James F Collins and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-09-14 with Health & Fitness categories.

Molecular, Genetic, and Nutritional Aspects of Major and Trace Minerals is a unique reference that provides a complete overview of the non-vitamin micronutrients, including calcium, copper, iodine, iron, magnesium, manganese, molybdenum, phosphorus, potassium, selenium, sodium, and zinc. In addition, the book covers the nutritional and toxicological properties of nonessential minerals chromium, fluoride and boron, and silicon and vanadium, as well as ultra-trace minerals and those with no established dietary requirement for humans. Users will find in-depth chapters on each essential mineral and mineral metabolism, along with discussions of dietary recommendations in the United States and around the world. - Presents the only scientific reference to cover all of the nutritionally relevant essential major and trace minerals - Provides a broad introductory chapter on each mineral to give readers valuable background and context - Clarifies the cellular and molecular aspects of each mineral and its genetic and genomic aspects - Includes coverage of all nutritionally relevant minerals—essential major trace minerals and ultra-trace minerals - Underscores the important interactions between minerals so readers learn how metabolism of one mineral influences another

Personalized Food Intervention And Therapy For Autism Spectrum Disorder Management

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Author : M. Mohamed Essa
language : en
Publisher: Springer Nature
Release Date : 2020-01-31

Personalized Food Intervention And Therapy For Autism Spectrum Disorder Management written by M. Mohamed Essa and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-01-31 with Medical categories.

The book focuses on implications of traditional and processed foods for autism spectrum disorder (ASD) intervention and management. Numerous phytonutrients and pharmacologically active compounds in edible natural products and diet could influence and offer protection to neuronal dysfunction that occurs due to ASD. The neuroprotective effects of various fruits, vegetables, nuts and seeds phytochemicals, and other natural bioactive ingredients against ASD and related conditions are discussed. Topics such as the possible neuroprotective mechanism of action of these foods and the therapeutic role of antioxidants in relation to ASD are addressed. This book also highlights the scope of using anti-inflammatory agents and antioxidants to promote neurogenesis and improve other symptoms in ASD. It emphasizes personalized nutritional approaches with dietary management of neurodevelopmental disorders/ASD cases. Information in this book is relevant to researchers in the field of complementary and alternative medicine, nutraceuticals, neuroscience, agriculture, nutrition, and food science. This volume is beneficial to students of varying levels, and across multiple disciplines.

Trace Metals And Infectious Diseases

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Author : Jerome O. Nriagu
language : en
Publisher: MIT Press
Release Date : 2024-06-11

Trace Metals And Infectious Diseases written by Jerome O. Nriagu and has been published by MIT Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-06-11 with Medical categories.

Experts explore the influence of trace metals on the pathogenesis of infectious diseases. Many parts of the world in which common infectious diseases are endemic also have the highest prevalence of trace metal deficiencies or rising rates of trace metal pollution. Infectious diseases can increase human susceptibility to adverse effects of metal exposure (at suboptimal or toxic levels), and metal excess or deficiency can increase the incidence or severity of infectious diseases. The co-clustering of major infectious diseases with trace metal deficiency or toxicity has created a complex web of interactions with serious but poorly understood health repercussions, yet has been largely overlooked in animal and human studies. This book focuses on the distribution, trafficking, fate, and effects of trace metals in biological systems. Its goal is to enhance our understanding of the relationships between homeostatic mechanisms of trace metals and the pathogenesis of infectious diseases. Drawing on expertise from a range of fields, the book offers a comprehensive review of current knowledge on vertebrate metal-withholding mechanisms and the strategies employed by different microbes to avoid starvation (or poisoning). Chapters summarize current, state-of-the-art techniques for investigating pathogen-metal interactions and highlight open question to guide future research. The book makes clear that improving knowledge in this area will be instrumental to the development of novel therapeutic measures against infectious diseases. Contributors M. Leigh Ackland, Vahid Fa Andisi, Angele L. Arrieta, Michael A. Bachman, J. Sabine Becker, Robert E. Black, Julia Bornhorst, Sascha Brunke, Joseph A. Caruso, Jennifer S. Cavet, Anson C. K. Chan, Christopher H. Contag, Heran Darwin, George V. Dedoussis, Rodney R. Dietert, Victor J. DiRita, Carol A. Fierke, Tamara Garcia-Barrera, David P. Giedroc, Peter-Leon Hagedoorn, James A. Imlay, Marek J. Kobylarz, Joseph Lemire, Wenwen Liu, Slade A. Loutet, Wolfgang Maret, Andreas Matusch, Trevor F. Moraes, Michael E. P. Murphy, Maribel Navarro, Jerome O. Nriagu, Ana-Maria Oros-Peusquens, Elisabeth G. Pacyna, Jozef M. Pacyna, Robert D. Perry, John M. Pettifor, Stephanie Pfaffen, Dieter Rehder, Lothar Rink, Anthony B. Schryvers, Ellen K. Silbergeld, Eric P. Skaar, Miguel C. P. Soares, Kyrre Sundseth, Dennis J. Thiele, Richard B. Thompson, Meghan M. Verstraete, Gonzalo Visbal, Fudi Wang, Mian Wang, Thomas J. Webster, Jeffrey N. Weiser, Günter Weiss, Inga Wessels, Bin Ye, Judith T. Zelikoff, Lihong Zhang

Metal Metabolism In Animals

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Author : Reinhard Dallinger
language : en
Publisher: MDPI
Release Date : 2018-04-20

Metal Metabolism In Animals written by Reinhard Dallinger and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-04-20 with Science categories.

This book is a printed edition of the Special Issue "Metal Metabolism in Animals" that was published in IJMS

Metallomics

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Author : Marco Aurélio Zezzi Arruda
language : en
Publisher: Springer
Release Date : 2018-06-08

Metallomics written by Marco Aurélio Zezzi Arruda and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-06-08 with Science categories.

This book covers the new Omics area, Metallomics. As Metallomics is intrinsically a transdisciplinary area, this book is authored by experts in the field on such diverse topics as Environmental, Nuclear, and Human Metallomics. Within these topics metals play important role, as being part of biomolecules, controlling different biochemical process, being signaling agents, being catalyst of biochemical reactions, among others. This volume demonstrates the importance of more investigation about metals and their interactions with biomolecules. As the knowledge in this field is growing and growing daily, then new challenges concerning studies involving Metallomics is appearing, such as comparative metallomics, speciation metallomics, real-time metallomics, new predictions of metals in biomolecules, metalloprotein databank expansion, interactions between metalloprotein-metalloprotein, among others.