Animal Models Of Human Inflammatory Skin Diseases
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Animal Models Of Human Inflammatory Skin Diseases
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Author : Lawrence S. Chan
language : en
Publisher: CRC Press
Release Date : 2003-12-29
Animal Models Of Human Inflammatory Skin Diseases written by Lawrence S. Chan and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-12-29 with Medical categories.
Progress in understanding skin diseases has been aided enormously by the use of tissues derived from animals, by studying normal processes in animals, and by the development of animal models. The cellular activities in animals and humans are remarkably similar and the actual pathological process of an inflammatory skin disease can only be accurately observed and analyzed in a living animal model, and not in any in vitro model system. These factors have led to the regular use of animal tissues and models to allow the disease processes to be studied at a much greater depth. Animal Models of Human Inflammatory Skin Diseases features the principles and practices of how to go about studying inflammatory skin diseases using live animal models. On the principle side, the book describes the comparative structure and function of the skin, and the comparative immunology system in animal species commonly used as models. From the practical perspective, it presents a general discussion on methods of experimental animal modeling and contains specific expert experience on individual models. The authors include a detailed method of disease induction for each model, present chapters on comparative histology and immunology, and discuss potential targets of disease intervention. Written by biomedical investigators with first-hand experience in their chosen fields, this book is a valuable guide and reference for investigators in the biomedical and pharmaceutical sciences. It provides an instantaneous comparison between the skin structure and immunology of humans and animals, aiding in the interpretation and application of pathologic and immunologic findings.
Animal Models Of T Cell Mediated Skin Diseases
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Author : T. Zollner
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-01-19
Animal Models Of T Cell Mediated Skin Diseases written by T. Zollner and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-01-19 with Science categories.
Pharmaceutical companies are spending increasing amounts of money on drug discovery and development. Nevertheless, attrition rates in clinical development are still very high, and up to 90% of new compounds fail in clinical phase I - III trials, which is partially due to lack of clinical efficacy. This indicates a strong need for highly predictive in vitro and in vivo models. The "50th International Workshop of the Ernst Schering Research Foundation" focussed on "Animal Models of T Cell-Mediated Skin Diseases". Such animal models should have impact not only on inflammatory dermatoses but also on other inflammatory disorders due to their model character. The current volume summarises recent advances in animal research that are important for anti-inflammatory drug discovery.
Targeting Human Inflammatory Skin Diseases With Natural Products Exploring Potential Mechanisms And Regulatory Pathways
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Author : Bey Hing Goh
language : en
Publisher: Frontiers Media SA
Release Date : 2022-01-07
Targeting Human Inflammatory Skin Diseases With Natural Products Exploring Potential Mechanisms And Regulatory Pathways written by Bey Hing Goh and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-01-07 with Science categories.
Skin Models
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Author : Ronald Marks
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Skin Models written by Ronald Marks and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
In the last fifty years dramatic progress has been made in the under standing of skin and skin diseases. Although we are still someway off understanding the ultimate causes of such disorders as psoriasis, atopic dermatitis and the congenital disorder of keratinization, we now have considerable information on the physiological disturbances in various diseases. This has permitted and encouraged a rational approach to treatment. The successful use of antimitotic agents, immunomodulators and retinoids may be cited as examples. A major reason for this im provement may be the fact that researchers accept models for the in vestigation of skin diseases. Increasing numbers of them have become available in the past years. So many have been described that it is doubtful whether anyone researcher is aware of all the other models described - even in his own field of interest. This book is a challenge for those involved in the study of skin and its disorders to use the sundry models of skin that have proven helpful. It would be impossible for this work to be all-embracing but it is hoped that the choice of models offered in this publication will be stimulating and helpful in the solution of knotty skin questions. April,1986 Ronald Marks, Cardiff Gerd Plewig, DUsseldorf Table of Contents In Vivo Models Human Model for Acne . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 L. C Brummitt, W. J. Cunliffe, G. Gowland Models to Study Follicular Diseases l3 G. Plewig Models for Wound Healing. . . . . . . . . . . . . . . . . . . . . . . . . 24 R. Marks, D. Williams, A. D.
Pharmacology Of The Skin I
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Author :
language : en
Publisher: Springer
Release Date : 2011-12-21
Pharmacology Of The Skin I written by and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-12-21 with Medical categories.
The recent interest in the pharmacology of the skin and the treatment of its diseases has come about for two reasons. The first is a realisation that many aspects of pharmacology can be studied as easily in human skin, where they may be more relevant to human physiology and diseases, as in animal models. Examples of this are the action of various vasoactive agents and the isolation of mediators of inflammation after UV irradiation and antigen-induced dermatitis. The second reason is the fortuitous realisation that a pharmacological approach to the treatment of skin disease need not always await the full elucidation of etiology and mechanism. For example, whilst the argument continued unresolved as to whether the pilo-sebaceous infection which constitutes acne was due to a blocked duct or to a simple increase in sebum production, 13-cis-retinoic acid was found quite by chance totally to ablate the disease; again, whilst cyclosporin, fresh from its triumphs in organ transplantation, has been found able to suppress the rash of psoriasis, it has resuscitated the debate on etiology. We are therefore entering a new era in which the pharmacology and clinical pharmacology of skin are being studied as a fascinating new way of exploring questions of human physiology and pharmacology as well as an important step in the development and study of new drugs, use of which will improve disease control and at the same time help to define pathological mechanisms.
In Vivo Models Of Inflammation
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Author : Douglas W. Morgan
language : en
Publisher: Springer Science & Business Media
Release Date : 1999
In Vivo Models Of Inflammation written by Douglas W. Morgan and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999 with Health & Fitness categories.
Purpose of In vivo Models of Inflammation is to provide the biomedical researcher in both the pharmaceutical industry and academia with a description of the state of the art animal model systems used to emulate diseases with components of inflammation. The aim of this second edition is to act as a complement to the first by describing and updating the standard models that are most utilized for specific disease areas. In addition, this 2nd edition includes new models exploring emerging areas of inflammation research. It provides detailed descriptions of the methodologies and uses of the most significant models. This includes current information regarding agents that demonstrate efficacy, those that do not and those that can be used as standard controls. The focus remains on those models that serve as pre-clinical correlates to human disease as well as those that represent components of the inflammatory response. New approaches to the development of future models in selected therapeutic areas have been highlighted. The focus on novel technologies that are vital for innovative in vivo research has also been expanded to include chapters on the use of transgenic and gene transfer technologies, nanotechnology, and stem cells. The book provides the scientist with an up-to-date reference manual for selecting the best animal model for their specific question. Chapters describing current regulations in the United States, United Kingdom, and Japan are also included.
Skin Tissue Models
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Author : Alexandra P. Marques
language : en
Publisher: Academic Press
Release Date : 2017-11-14
Skin Tissue Models written by Alexandra P. Marques and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-11-14 with Science categories.
Skin Tissue Models provides a translational link for biomedical researchers on the interdisciplinary approaches to skin regeneration. As the skin is the largest organ in the body, engineered substitutes have critical medical application to patients with disease and injury – from burn wounds and surgical scars, to vitiligo, psoriasis and even plastic surgery. This volume offers readers preliminary description of the normal structure and function of mammalian skin, exposure to clinical problems and disease, coverage of potential therapeutic molecules and testing, skin substitutes, models as study platforms of skin biology and emerging technologies. The editors have created a table of contents which frames the relevance of skin tissue models for researchers as platforms to study skin biology and therapeutic approaches for different skin diseases, for clinicians as tissue substitutes, and for cosmetic and pharmaceutical industries as alternative test substrates that can replace animal models. Offers descriptions of the normal structure/function of mammalian skin, exposure to clinical problems, and more Presents coverage of skin diseases (cancer, genodermatoses, vitiligo and psoriasis) that extends to clinical requirements and skin diseases in vitro models Addresses legal requirements and ethical concerns in drugs and cosmetics in vitro testing Edited and authored by internationally renowned group of researchers, presenting the broadest coverage possible
Buruli Ulcer
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Author : Gerd Pluschke
language : en
Publisher: Springer
Release Date : 2019-04-29
Buruli Ulcer written by Gerd Pluschke and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-04-29 with Medical categories.
A major objective of this open access book is to summarize the current status of Buruli Ulcer (BU) research for the first time. It will identify gaps in our knowledge, stimulate research and support control of the disease by providing insight into approaches for surveillance, diagnosis, and treatment of Buruli Ulcer. Book chapters will cover the history, epidemiology diagnosis, treatment and disease burden of BU and provide insight into the microbiology, genomics, transmission and virulence of Mycobacterium ulcerans.
Experimental Animal Models Of Human Diseases
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Author : Bartholomew Ibeh
language : en
Publisher: BoD – Books on Demand
Release Date : 2018-05-23
Experimental Animal Models Of Human Diseases written by Bartholomew Ibeh and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-05-23 with Science categories.
The world has recorded losses in terms of human life as well as extensive time spent in experimentation with development of new drugs, elucidation of disease mechanism(s), and therapeutic agent discovery. Ethical and legal issues cojoin in slowing down scientific discoveries in medicine and biology. The past two (2) decades, therefore, have seen tremendous attempts that largely are successful in developing animal models with the characteristics of mimicking, approximating, or expressing transplanted human organs/tissues. These models or rather approaches seem to be fast, cost-effective, and easy to maintain compared to primates. This book is a collection of expert essays on animal models of human diseases of global interest. A visible objective of the book is to provide real-time experimental approach to scientists, clinicians, ethicists, medicolegal/medical jurisprudence workers, immunologists, postgraduate students, and vaccinologists and informative and multidisciplinary approach for the identification of new therapeutic targets and biomarkers using animal models as well as investigating the pathogenesis and therapeutic strategies of human diseases. An increased understanding of the genetic, molecular, and cellular mechanisms responsible for the development of human diseases has laid out the foundation for the development of rational therapies mainly with animal models.
Animal Models For The Study Of Human Disease
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Author : P. Michael Conn
language : en
Publisher: Academic Press
Release Date : 2017-06-20
Animal Models For The Study Of Human Disease written by P. Michael Conn and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-06-20 with Medical categories.
Animal Models for the Study of Human Disease, Second Edition, provides needed information on model sharing, animal alternatives, animal ethics and access to databanks of models, bringing together common descriptions of models for busy researchers across biomedical and biological sciences. Offering easily searchable advantages and disadvantages for each animal model and organized by disease topics, this resource aids researchers in finding the best animal model for research in human disease. Organized by disease orientation for ease of searchability Provides information on locating resources, animal alternatives, and animal ethics Covers a broad range of animal models used in research for human disease Contributed by leading experts across the globe Expanded coverage of diabetes and neurological diseases