Brown Adipose Tissue
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Brown Adipose Tissue
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Author : Alexander Pfeifer
language : en
Publisher: Springer
Release Date : 2019-04-02
Brown Adipose Tissue written by Alexander Pfeifer and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-04-02 with Science categories.
The main focus of this book is on brown adipose tissue and its metabolic function. The book provides a timely update on the latest research and shows where the field is heading. Brown adipose tissue (BAT) dissipates energy and has received considerable attention in the last few years, having been re-discovered in adult humans in 2007/9. Moreover, BAT might offer a target for novel therapies to address obesity, a health condition that has reached pandemic dimensions.
Insights Into Brown Adipose Tissue Functions And Browning Phenomenon
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Author : Rita De Matteis
language : en
Publisher: Frontiers Media SA
Release Date : 2020-04-20
Insights Into Brown Adipose Tissue Functions And Browning Phenomenon written by Rita De Matteis and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-04-20 with categories.
Adipose Tissue
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Author : Susanne Klaus
language : en
Publisher: CRC Press
Release Date : 2001-09-01
Adipose Tissue written by Susanne Klaus and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-09-01 with Science categories.
Today we know that white and brown adipocytes share many metabolic and molecular pathways, although their physiological function, i.e., energy storage and energy dissipation, respectively, are quite opposite for WAT (white adipose tissue) and BAT (brown adipose tissue). The authors in this book provide a comprehensive volume covering the whole rang
Biology And Therapeutic Potential Of Brown Adipose Tissue
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Author : Patrick Seale
language : en
Publisher: Frontiers E-books
Release Date : 2013-06-03
Biology And Therapeutic Potential Of Brown Adipose Tissue written by Patrick Seale and has been published by Frontiers E-books this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-03 with categories.
Brown adipose tissue (BAT) has long been recognized as a key thermogenic tissue in eutherian mammals. Brown fat cells contain large numbers of highly specialized mitochondria that oxidize fat and carbohydrate to produce heat. This metabolic inefficiency is due to the presence of Ucp1 in the inner mitochondrial membrane of brown fat cells which dissociates the electrochemical gradient from ATP production. BAT presumably evolved to protect animals against hypothermia in response to cold exposure. However, energy expended by BAT has the added benefit of counteracting obesity and associated metabolic disease, at least in rodents. A very large number of studies have consistently shown that mice carrying increased amounts of active brown fat are lean and healthy. Until recently, it was generally believed that the amount of brown fat tissue was negligible in healthy adult humans. However, PET imaging studies have refuted this notion, and revealed the existence of active BAT in most, if not all, adult humans. Notably, there is a very strong inverse correlation between the amount of activated BAT and fatness in humans. Moreover, activated brown fat is lost with ageing, which also correlates with tendency to gain weight. The field must now address whether variation in brown fat activity is a cause or consequence of weight gain. Brown fat cells are localized in discrete depots of BAT and are also found as clusters interspersed in white fat tissues. The prevalence and function of these so-called “brite” (brown in white) cells in humans remains unknown. The development of strategies to increase the amount and/or activity of brown fat may hold exciting prospects for the treatment of obesity and its associated health consequences. In this Research Topics issue, we would propose to examine the following areas related to brown fat biology: 1. Development of brown and “brite” cells (including: historical/evolutionary perspective, transcriptional pathways, developmental origins) 2. Pathways that influence brown fat cell development (BMP7, TZDs, Prostaglandins, FGF21) 3. Activation of brown fat - focus on sympathetic and sensory innervation (signaling by beta-adrenergic receptors, nerve-fat connections 4. Brown fat thermogenesis in response to cold, diet and hibernation 5. Brown fat in humans including: human brown fat precursors, methods for imaging, factors that influence prevalence, relationship between body mass/obesity and amount of brown fat. 6. Brown fat mitochondria including mechanism of uncoupling (Ucp1 history/structure/function, mitochondrial biogenesis.
Brown Adipose Tissue
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Author : David A. Guertin
language : en
Publisher: Springer Nature
Release Date : 2022-02-15
Brown Adipose Tissue written by David A. Guertin and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-02-15 with Science categories.
This detailed volume explores techniques for researching brown adipose tissue (BAT) and the fascinating biology and therapeutic potential of thermogenic adipocytes. The content reflects the advancing technologies in genetics, imaging, and 'omics strategies that are allowing researchers to probe BAT biology at unprecedented depths and detail, yet it also presents classic physiology principles, which remain the core tenets of BAT biology. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Brown Adipose Tissue: Methods and Protocols provides perspectives and detailed protocols for the benefit of both new BAT researchers looking for guidance as well as seasoned researchers who would like to expand their toolkits. Chapter 12 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Adipose Tissue Protocols
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Author : Gérard Ailhaud
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-02-03
Adipose Tissue Protocols written by Gérard Ailhaud and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-02-03 with Science categories.
Adipose tissue is recognized to be exquisitely sensitive to hormone action, and is also now recognized as a secretory and endocrine organ required for reproduction and good health. Adipocytes are “smart” cells able within the tissue to communicate with surrounding cells, but also with various organs, particularly via leptin acting on the central nervous system. Brown adipose tissue (BAT) and white adipose tissue (WAT) are known to be distinct tissues, whereas the heterogeneity of WAT depots is well est- lished. Unfortunately, excess WAT leads to obesity, which is the most common health problem in industrialized countries. Therefore, from both a scientific and a technical point of view, the time has come to create a survey of adipose tissues and their neglected adipocytes. In Adipose Tissue Protocols, I have attempted to gather together chapters from all areas of adipose tissue research—from in vivo to in vitro studies—and to provide methods covering a wide variety of techniques, including the choice of adipose tissue depot and of morphological techniques for the study of BAT and WAT; the isolation, subcellular fractionation, and transfection of adipocytes where the low density of these cells must be taken into account; assays of nutrient and ion fluxes and the metabolic aspects of nutrient uptake; assays of lipid-related enzymes; biopsies and quantification of lipid-related mRNAs; cultures of adipose precursor cells from WAT and BAT of various species, including human tissue; measurements of adipose secretory products; and assessment of WAT metabolism in vivo.
New Perspectives In Adipose Tissue
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Author : A. Cryer
language : en
Publisher: Butterworth-Heinemann
Release Date : 2014-04-24
New Perspectives In Adipose Tissue written by A. Cryer and has been published by Butterworth-Heinemann this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-04-24 with Medical categories.
New Perspectives in Adipose Tissue: Structure, Function and Development reviews the state of knowledge on adipose tissue. The book begins with discussions of the anatomy and morphology of adipose tissue. This is followed by separate chapters on the nervous control of circulation and metabolism in white adipose tissue; hormonal regulation of biosynthetic activities in white adipose tissue; hormonal control of lipid degradation; and plasma membrane properties and receptors in white adipose tissue. Subsequent chapters cover topics such as lipoproteins and adipose tissue; brown adipose tissue thermogenesis and energy balance in animals and man; methodological approaches to the study of the adipose tissues; adipose tissue growth following lipectomy; the adipocyte precursor cell; and adipose tissue dysfunction and its consequences. In addition to being authoritative source material, the chapters presented in this book are wide in their coverage and appeal.
Current Challenges For Targeting Brown Fat Thermogenesis To Combat Obesity
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Author : Takeshi Yoneshiro
language : en
Publisher: Frontiers Media SA
Release Date : 2020-12-28
Current Challenges For Targeting Brown Fat Thermogenesis To Combat Obesity written by Takeshi Yoneshiro and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-12-28 with Science categories.
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Adipose Tissue
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Author : Susanne Klaus
language : en
Publisher: CRC Press
Release Date : 2001-09-01
Adipose Tissue written by Susanne Klaus and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-09-01 with Medical categories.
Today we know that white and brown adipocytes share many metabolic and molecular pathways, although their physiological function, i.e., energy storage and energy dissipation, respectively, are quite opposite for WAT (white adipose tissue) and BAT (brown adipose tissue). The authors in this book provide a comprehensive volume covering the whole range of topics of adipose biology from morphology to function, development to physiological and molecular regulation and heterogeneity. Their aim is specifically to tie together most recent findings on molecular mechanisms of adipocyte development and gene expression with the most important histological, physiological, and metabolic characteristics of the different adipose tissues.
Adipose Tissue Biology
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Author : Michael E. Symonds
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-11-20
Adipose Tissue Biology written by Michael E. Symonds and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-11-20 with Medical categories.
This book is designed to provide a comprehensive insight into current perspectives and challenges in adipose tissue biology. In Adipose Tissue Biology, scientists and clinicians discuss adipocyte precursors, differentiation and growth, brown and white adipose tissue, gender, inflammation, dietary and genetic determinants of fat mass, together with evolutionary and developmental aspects of adiposity.
