Cell Interactions In Differentiation
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Cell Interactions In Differentiation
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Author : Marketta Karkinen-Jaaskelainen
language : en
Publisher: Elsevier
Release Date : 2012-12-02
Cell Interactions In Differentiation written by Marketta Karkinen-Jaaskelainen and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-02 with Science categories.
Cell Interactions in Differentiation is a collection of papers presented at the Sixth Sigrid Jusélius Foundation Symposium held in Helsinki, Finland, in August 1976. Contributors discuss cell interactions during differentiation, particularly referring to the problem of embryonic induction. They also consider how a cell becomes adjusted to the synchronized development of an entire multicellular organism, so as to express its genetic information at a strictly controlled time and place. This volume is organized into five sections encompassing 30 chapters and begins with an overview of embryonic cells and their two fundamental properties. Cells are not necessarily predetermined and can be experimentally diverted from their normal developmental pathway, and those within an embryonic organism require extrinsic messages to express their developmental capacities. The next chapters focus on early determinative events in embryogenesis, touching on topics such as the genetic aspects of cell type determination, interactions between embryonic cells during the early development of the mouse, and the differentiation of teratocarcinoma stem cells in vitro. The reader is then introduced to positional information and morphogenetic signals; the biological ""specificity"" of morphogenetic tissue interactions; and the molecular mechanisms underlying cell contact interactions. The remaining chapters explore some of the most important conceptual and methodological approaches to the problems of cell-cell recognition and the integration of cells into multicellular systems. This book will be of interest to scientists and investigators in developmental biology and related fields.
Effects Of Cell Interactions At The Endothelium In Leukocyte Differentiation And Polarization During Inflammation
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Author : Alain Haziot
language : en
Publisher: Frontiers Media SA
Release Date : 2023-11-27
Effects Of Cell Interactions At The Endothelium In Leukocyte Differentiation And Polarization During Inflammation written by Alain Haziot and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-11-27 with Medical categories.
A complex exchange of signals between endothelial cells and tissues occurs during steady-state and in inflammatory conditions. These interactions involve numerous cell types including an active contribution from endothelial cells and occur on both sides of the endothelial monolayer. In addition to functioning as selective permeability barriers, it is increasingly recognized that local cell attraction to endothelial cells provides the potential for focal interactions between relevant cells. In this context, cellular interactions taking place at the surface of the endothelium and within the perivascular spaces are thought to initiate crucial steps in the generation and shaping of immune responses. Blood elements (such as leukocytes, platelets, and vesicles) converge to the barrier formed by the endothelium where perivascular (such as macrophages, pericytes) initiate, convey, and/or amplify signals revealing tissue status. The innate and adaptative functions of endothelial cells themselves together with the immune functions of assembled cells at a focal point in capillaries create the potential for exchange of signals and dynamic fine tuning of responses through cell programming and cell selection. The resulting immune response may range from inadequate immunity and/or exhaustion to excess tissue destruction and fibrosis. Productive inflammation and its resolution are critically reliant on which cells are recruited and in which order, their state of activation, and interactions between recruited cells. Tissue-dependent signals further shape the recruitment of leukocytes to the endothelium. In the kidney for instance, in the presence of immune complexes, perivascular resident macrophages located in subendothelial spaces coupled with endothelial cells induce monocyte and neutrophil tissue infiltration, operating therefore as an anatomical and functional unit. The goals of this Research Topic are (i) to analyze how signal integration and partnering of cell types in transendothelial migration contribute to the development of tissue inflammation and how responses are geared towards specific profiles of reactions to injury; (ii) how the interplay between cell types including, but not limited to, endothelial cells, monocytes, resident macrophages, and T and B cells dynamically governs the immune responses that take place in the tissue; (iii) in which way do integrative capacities of endothelial and subendothelial cells shape and coordinate the successive recruitment of leukocyte populations.
Gene Expression And Cell Cell Interactions In The Developing Nervous System
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Author : Jean M. Lauder
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-14
Gene Expression And Cell Cell Interactions In The Developing Nervous System written by Jean M. Lauder and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-14 with Science categories.
The dramatic advances in molecular genetics are becoming incorporated into neurobiologic studies at an ever increasing rate. In developmental neurobiology, the importance of cell cell interactions for neurogenesis and gene expression is be ginning to be understood in terms of the molecular bases for these interactions. This book seeks to emphasize the importance of molecular technology in the study of neurogenetic mechanisms and to explore the possible relationships between specific cell cell interactions and regulated gene expression in the develop ing nervous ~stem. This volume consists of nineteen chapters which address ques tions of gene expression and the importance of cell-cell interac tions as key factors in the developing nervous ~stem. Rather than viewing these two processes as separate mechanisms, as the organi zation of these chapters might suggest, we would like to emphasize the interplay of these genetic and epigenetic influences in all phases of neural ontogeny, a concept which is made clear by the subject matter of the contributions themselves. The authors of these chapters were participants in selected ~mposia from the Fourth Congress of the International Society of Developmental Neuroscience held in Salt Lake City, Utah, July 3-7, 1983.
Cellular Interactions
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Author : H. F. Linskens
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Cellular Interactions written by H. F. Linskens and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
H. F. LINSKENS and J. HESLOP-HARRISON The chapters of this volume deal with intercellular interaction phenomena in plants. Collectively they provide a broad conspectus of a highly active, if greatly fragmented, research field. Certain limitations have been imposed on the subject matter, the most impor tant being the exclusion of long-range interactions within the plant body. It is true that pervasive hormonal control systems cannot readily be demarcated from controls mediated by pheromones or information-carrying molecules with more limited spheres of action, but consideration is given in this volume to the main classes of plant hormones and their functions only incidentally, since these are treated adequately in other volumes of this Encyclopedia series (V - ume 9-11) and in numerous other texts and reviews. Similarly, certain other effects, such as those associated with nutrients and ions, are not considered in any detail. Furthermore, we have excluded intracellular interactions, and also consideration of transport phenomena, which are treated in detail in Vol ume 3 of this Series. Other aspects of inter-cellular interaction, such as cell surface phenomena and implications of lectin-carbohydrate interactions, and plant-virus inter-relationships, are treated in other sections of this Encyclopedia (Volumes 13B and 14B, respectively). In the volume on physiological plant pathology (Volume 4 of this series) special attention has been given to host pathogen interaction. These aspects of our subject will therefore be excluded in the present treatise.
Cell Interaction
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Author : Sivakumar Joghi Thatha Gowder
language : en
Publisher: BoD – Books on Demand
Release Date : 2012-10-10
Cell Interaction written by Sivakumar Joghi Thatha Gowder and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-10-10 with Science categories.
The book Cell Interaction focuses on various processes that occur within and outside the cells. Cell interactions are important for functioning of many organ systems: cell adhesion, tissue development, cellular communication, inflammation, tumor metastasis, and microbial infection. Key features include developmental cell interactions, immune and neural cell interactions, cell interactions in normal and disease conditions and advanced level methods to evaluate cell interactions. This book will be a significant resource to all scientists and physicians who are intended to explore more on cells.
The Role Of Aire Micrornas And Cell Cell Interactions On Thymic Architecture And Induction Of Tolerance
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Author : Geraldo Aleixo Passos
language : en
Publisher: Frontiers Media SA
Release Date : 2016-02-03
The Role Of Aire Micrornas And Cell Cell Interactions On Thymic Architecture And Induction Of Tolerance written by Geraldo Aleixo Passos and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-02-03 with Immunologic diseases. Allergy categories.
The focus of this eBook is to bring new insights into central immune tolerance. To fulfill that, much has been discussed about the master in the regulation of tolerance, the autoimmune regulator (Aire) gene the main thymus cell type that expresses this gene, the medullary thymic epithelial cells (mTECs). It includes one Editorial and 12 other excellent contributions in the format of mini reviews or original research papers covering one or more of these aspects: promiscuous gene expression (PGE), epigenetics, miRNAs, association of the Aire gene and miRNAs, thymocyte–TEC interaction, coxsackievirus and type 1 diabetes, exosomes in the thymus, thymic crosstalk, thymic B cells, T cell development, chemokines and migration of T cells, miRNAs and the thymic atrophy, cell–cell interactions, and thymus ontogeny. Authors raised hypothesis, discuss concepts, and show open questions. The remaining important issues to resolve questions within the central tolerance research are briefly discussed below. The first mini review is authored by Olga Ucar and Kristin Rattay. They focused on the posttranscriptional control of PGE by miRNAs as well as epigenetic control involving DNA methylation, histone modifications, and topology of chromosomes. These processes represent additional factors to be explored and that might regulate the expression of Aire-independent tissue restricted antigens (TRAs), which are implicated in the central tolerance. Are the Eph/ephrins important for thymocyte–TEC interaction? This issue was reviewed by Javier Garcia-Ceca and cols. The maturation of thymocytes is depending on their interaction with TECs within the thymus. Authors argue the importance of Ephs and ephrins on the intrathymic maturation of both thymic epithelial microenvironment and thymocyte maturation and on the recruitment of lymphoid progenitors into the thymus. Another stimulating mini review is authored by Hélène Michaux and cols in which they discuss the hypothesis that infection by coxsackievirus B4 (CV-B4) could be associated with etiopathogenesis of type 1 diabetes mellitus (T1D). Authors consider that besides their tropism to the pancreatic beta cells, CV-B4 could also involve the thymus. Once within this organ the virus might somehow perturbs central tolerance to the insulin family triggering thus autoimmune T1D. Our group contributed with a mini review focusing on cell–cell interactions within the thymus involving TECs and thymocytes and the role of the Aire gene on the induction of central tolerance throughout the modulation of TRA expression in mTECs. In addition, we discuss the recent evidence that Aire also regulate the expression of miRNAs in these cells. On its turn, the Aire-dependent miRNAs might exert control over TRAs. We raise issues that besides the transcriptional control exerted by Aire, PGE could also be being controlled through posttranscriptional mechanism involving miRNAs. A very pertinent question raised by Gabriel Skogberg and cols is on the role of exosomes on TRA presentation by TECs to thymocytes and its implication in the thymocyte selection. Exosomes may be liberated by TECs to the extracellular milieu and transport TRAs as well as MHC molecules, establishing intercellular communication to enhance antigen presentation to developing thymocytes. Authors discuss how intercellular communication via exosomes within the thymus could have consequences on TRA presentation and finally on central tolerance. The thymic crosstalk, i.e., the reciprocal control by the close contact between TECs and thymocytes, which influences the differentiation of both types of cells was elegantly reviewed by Noëlla Lopes and cols. Authors discuss the role of dendritic cells (DCs) subsets in the process of deletion of autoreactive T cells and the generation of natural Tregs and raise questions how hematopoietic cells may control the organization of the thymic medulla. Thymus is an organ composed of different cell types including TECs, DCs, macrophages among other cell types, and of course thymocytes. Recently, researchers have identified an unexpected cell type formed by B cells, which may be originated from intrathymic B lymphopoiesis or immigration from the periphery. Tomoyoshi Yamano and cols contributed with a mini review discussing the role of thymic B cells expressing MHC-II, CD80, and Aire, in the crosstalk with CD4 single positive cells. Authors raise questions how these cells might play a role as antigen presenting cells in an unpredicted way within the thymus. The regulation of T cell development is apparently well resolved; however, several unsolved questions remain. This important aspect is represented in this Research Topic through the mini review by Iris Caramalho and cols. Authors show new questions on the beginning of Treg lineage commitment, their spatial localization within the human thymus and their molecular components. Cell migration within the thymus is crucial for the central tolerance. Developing thymocytes migrate throughout the thymus being exposed initially to the cortex and then to the thymic medulla were they respectively undergo positive and negative selection. Chemokines represent key regulators for thymocyte migration. Zicheng Hu and cols argue the role of chemokines in the thymic cell migration and induction of central tolerance. Thymic atrophy during senescence is widely recognized; however, poorly understood. In addition to the atrophy due to senescence, thymus involutes in response to a variety of stimuli including microbial infections. The mouse model of Trypanosoma cruzi infection corresponds to an adequate mouse model to access this question. Leandra Linhares-Lacerda and cols show results on the role of miRNAs on regulation of chemotaxis, which contribute to a better understanding, while incites new issues, of thymic involution. Cellularity of mTECs is pivotal for cell–cell interactions within the thymus, which is required for central tolerance. Taishin Akiyama and cols argue the role of cytokines on cellularity of mTECs focusing into the molecular basis of cell–cell interactions opening perspective on the use of mathematical models for understanding these processes. Thymus morphogenesis is a central point with many open questions. The mini review authored by Arnon Dias Jurberg and cols addresses the role of the large superfamily of TGF-beta/bone morphogenetic protein ligands in the thymus morphogenesis and in T cell differentiation. This eBook provides an international and updated insight into the latest developments and open questions on the cellular and molecular bases of central tolerance induction.
Cellular Interactions By Environmental Tumor Promoters
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Author : Hirota Fujiki
language : en
Publisher: VSP
Release Date : 1984-12
Cellular Interactions By Environmental Tumor Promoters written by Hirota Fujiki and has been published by VSP this book supported file pdf, txt, epub, kindle and other format this book has been release on 1984-12 with Science categories.
Considerable progress in our understanding of tumor promotion has been made by cancer researchers throughout the world. In addition, scientists in several other disciplines have made significant contributions in elucidating the pleiotropic effects of tumor promotion. This international symposium was specifically convened to review research progress in these areas and to consider the relevance of these findings to human cancer causation and prevention. The proceedings include the contributions of leading researchers from Europe, Japan and the USA. Several papers report the exciting progress made in understanding how tumor promoters act at the cellular and biochemical levels. Elsewhere attention is focused on tumor promotion as an important phase in the occurrence of certain human tumors. It is hoped that advances in the understanding of the mechanism of tumor promotion in experimental systems will lead to new and effective approaches to human cancer prevention. The proceedings will be of interest and value to researchers working in cancer research, biochemistry, molecular genetics, mutagenesis and cell biology.
Immune Cell Interactions With Target Cells In Physiological And Pathological Conditions Of The Nervous System
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Author : Antje Kroner
language : en
Publisher: Frontiers Media SA
Release Date : 2020-09-02
Immune Cell Interactions With Target Cells In Physiological And Pathological Conditions Of The Nervous System written by Antje Kroner and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-09-02 with Medical categories.
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Cell Cell Interactions Controlling Neuronal Functionality In Health And Disease
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Author : Stefano Angiari
language : en
Publisher: Frontiers Media SA
Release Date : 2022-07-27
Cell Cell Interactions Controlling Neuronal Functionality In Health And Disease written by Stefano Angiari and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-07-27 with Science categories.
Biological Interactions On Materials Surfaces
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Author : David A. Puleo
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-06-26
Biological Interactions On Materials Surfaces written by David A. Puleo and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-06-26 with Technology & Engineering categories.
Success or failure of biomaterials, whether tissue engineered constructs, joint and dental implants, vascular grafts, or heart valves, depends on molecular-level events that determine subsequent responses of cells and tissues. This book presents the latest developments and state-of-the-art knowledge regarding protein, cell, and tissue interactions with both conventional and nanophase materials. Insight into these biomaterial surface interactions will play a critical role in further developments in fields such as tissue engineering, regenerative medicine, and biocompatibility of implanted materials and devices. With chapters written by leaders in their respective fields, this compendium will be the authoritative source of information for scientists, engineers, and medical researchers seeking not only to understand but also to control tissue-biomaterial interactions.