Cell Interaction
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Cell Interaction
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Author : Bhawana Singh
language : en
Publisher: BoD – Books on Demand
Release Date : 2021-04-07
Cell Interaction written by Bhawana Singh and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-04-07 with Medical categories.
This book discusses contemporary ideas on different molecular and immunological aspects of diseases. Different signaling mediators drive the production of messenger molecules that mediate their action, leading to the elicitation/suppression of immune responses. It provides a balanced approach to the study of different molecular phenomena that eventually drive infection outcomes and that can be manipulated for therapeutic benefits.
Cell Interaction
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Author : Sivakumar Joghi Thatha Gowder
language : en
Publisher: BoD – Books on Demand
Release Date : 2012-10-10
Cell Interaction written by Sivakumar Joghi Thatha Gowder and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-10-10 with Science categories.
The book Cell Interaction focuses on various processes that occur within and outside the cells. Cell interactions are important for functioning of many organ systems: cell adhesion, tissue development, cellular communication, inflammation, tumor metastasis, and microbial infection. Key features include developmental cell interactions, immune and neural cell interactions, cell interactions in normal and disease conditions and advanced level methods to evaluate cell interactions. This book will be a significant resource to all scientists and physicians who are intended to explore more on cells.
Cell To Cell Interaction
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Author : M. M. Burger
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 1990-12-05
Cell To Cell Interaction written by M. M. Burger and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 1990-12-05 with Medical categories.
Intercellular communication involves processes such as cell-cell recognition, cell adhesion and cell migration, which are of fundamental importance during embryonic development and in the fully differentiated stage. Over the past decade an ever-growing number of new types of molecules that mediate cell-cell and cell-matrix interactions have been discovered, characterized and cloned. This book, based on an interdisciplinary symposium, contain the latest research findings on cell-cell and cell-matric interactions in the fields of neurobiology, oncology and immunology. Leading international investigators present current data on cell adhesion molecules, integrins, immunoglobulins, homing receptors and cytokines, and elicidates their role in morphogenesis, tumor invasion and metastasis. Furthermore, the differentiation, proliferation and cooperation of the multiple cell types of the immune system are discussed. The new insights gained are also evaluated for their potential clinical applications. Offering a unique perspective of this fast-expanding area of research, this collection of papers is indispensable reading for all cell, molecular and developmental biologists as well as for oncologists, immunologists and neurobiologists. (A Karger ""Publishing Highlights 1890–2015"" title.)
Glycans In Cell Interaction And Recognition
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Author : Michele Aubrey
language : en
Publisher: CRC Press
Release Date : 2002-01-17
Glycans In Cell Interaction And Recognition written by Michele Aubrey and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-01-17 with Science categories.
Glycoproteins play an important role in the regulation of gene expression, cell growth, migration, differentiation and apoptosis. Over the last decade, research has highlighted the therapeutic implications of glycoproteins for many physiological and pathological processes, such as inflammation, arthritis and metastasis. The first part of the book d
Cell Cell Interactions
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Author : Sean P. Colgan
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-02-04
Cell Cell Interactions written by Sean P. Colgan and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-02-04 with Science categories.
A versatile collection of readily reproducible cell-cell interaction assays for uncovering cellular interactions at the molecular level, both in vitro and in vivo. The protocols cover a diverse set of cell-cell interaction models in both normal and pathological states, are readily adaptable to nearly any cell type and organ system, and include primary data and outcome analysis. In addition, the protocols follow the successful Methods in Molecular BiologyTM series format, each offering step-by-step laboratory instructions, an introduction outlining the principles behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls.
Hepatocyte And Kupffer Cell Interactions
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Author : Timothy R. Billiar
language : en
Publisher: CRC Press
Release Date : 1992-09-11
Hepatocyte And Kupffer Cell Interactions written by Timothy R. Billiar and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992-09-11 with Science categories.
Hepatocyte and Kupffer Cell Interactions presents a comprehensive discussion of historical and recent information regarding this diverse field of research. The role of Kupffer cells and hepatoctyes in normal physiology, nonseptic pathological states, and in sepsis is examined. Microanatomy and methods of experimental study are covered as well. In each of the book's chapters, the role of the Kupffer cell and hepatocyte interaction is placed in context with information on particular liver functions or disease states. Hepatocyte and Kupffer Cell Interactions is an essential reference for leukocyte specialists, gastroenterologists, immunologists, and other researchers working in this fascinating field.
Effects Of Cell Interactions At The Endothelium In Leukocyte Differentiation And Polarization During Inflammation
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Author : Alain Haziot
language : en
Publisher: Frontiers Media SA
Release Date : 2023-11-27
Effects Of Cell Interactions At The Endothelium In Leukocyte Differentiation And Polarization During Inflammation written by Alain Haziot and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-11-27 with Medical categories.
A complex exchange of signals between endothelial cells and tissues occurs during steady-state and in inflammatory conditions. These interactions involve numerous cell types including an active contribution from endothelial cells and occur on both sides of the endothelial monolayer. In addition to functioning as selective permeability barriers, it is increasingly recognized that local cell attraction to endothelial cells provides the potential for focal interactions between relevant cells. In this context, cellular interactions taking place at the surface of the endothelium and within the perivascular spaces are thought to initiate crucial steps in the generation and shaping of immune responses. Blood elements (such as leukocytes, platelets, and vesicles) converge to the barrier formed by the endothelium where perivascular (such as macrophages, pericytes) initiate, convey, and/or amplify signals revealing tissue status. The innate and adaptative functions of endothelial cells themselves together with the immune functions of assembled cells at a focal point in capillaries create the potential for exchange of signals and dynamic fine tuning of responses through cell programming and cell selection. The resulting immune response may range from inadequate immunity and/or exhaustion to excess tissue destruction and fibrosis. Productive inflammation and its resolution are critically reliant on which cells are recruited and in which order, their state of activation, and interactions between recruited cells. Tissue-dependent signals further shape the recruitment of leukocytes to the endothelium. In the kidney for instance, in the presence of immune complexes, perivascular resident macrophages located in subendothelial spaces coupled with endothelial cells induce monocyte and neutrophil tissue infiltration, operating therefore as an anatomical and functional unit. The goals of this Research Topic are (i) to analyze how signal integration and partnering of cell types in transendothelial migration contribute to the development of tissue inflammation and how responses are geared towards specific profiles of reactions to injury; (ii) how the interplay between cell types including, but not limited to, endothelial cells, monocytes, resident macrophages, and T and B cells dynamically governs the immune responses that take place in the tissue; (iii) in which way do integrative capacities of endothelial and subendothelial cells shape and coordinate the successive recruitment of leukocyte populations.
Cell Cell Interactions Controlling Neuronal Functionality In Health And Disease
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Author : Stefano Angiari
language : en
Publisher: Frontiers Media SA
Release Date : 2022-07-27
Cell Cell Interactions Controlling Neuronal Functionality In Health And Disease written by Stefano Angiari and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-07-27 with Science categories.
Cell Interactions In Differentiation
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Author : Marketta Karkinen-Jaaskelainen
language : en
Publisher: Elsevier
Release Date : 2012-12-02
Cell Interactions In Differentiation written by Marketta Karkinen-Jaaskelainen and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-02 with Science categories.
Cell Interactions in Differentiation is a collection of papers presented at the Sixth Sigrid Jusélius Foundation Symposium held in Helsinki, Finland, in August 1976. Contributors discuss cell interactions during differentiation, particularly referring to the problem of embryonic induction. They also consider how a cell becomes adjusted to the synchronized development of an entire multicellular organism, so as to express its genetic information at a strictly controlled time and place. This volume is organized into five sections encompassing 30 chapters and begins with an overview of embryonic cells and their two fundamental properties. Cells are not necessarily predetermined and can be experimentally diverted from their normal developmental pathway, and those within an embryonic organism require extrinsic messages to express their developmental capacities. The next chapters focus on early determinative events in embryogenesis, touching on topics such as the genetic aspects of cell type determination, interactions between embryonic cells during the early development of the mouse, and the differentiation of teratocarcinoma stem cells in vitro. The reader is then introduced to positional information and morphogenetic signals; the biological ""specificity"" of morphogenetic tissue interactions; and the molecular mechanisms underlying cell contact interactions. The remaining chapters explore some of the most important conceptual and methodological approaches to the problems of cell-cell recognition and the integration of cells into multicellular systems. This book will be of interest to scientists and investigators in developmental biology and related fields.
The Role Of Aire Micrornas And Cell Cell Interactions On Thymic Architecture And Induction Of Tolerance
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Author : Geraldo Aleixo Passos
language : en
Publisher: Frontiers Media SA
Release Date : 2016-02-03
The Role Of Aire Micrornas And Cell Cell Interactions On Thymic Architecture And Induction Of Tolerance written by Geraldo Aleixo Passos and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-02-03 with Immunologic diseases. Allergy categories.
The focus of this eBook is to bring new insights into central immune tolerance. To fulfill that, much has been discussed about the master in the regulation of tolerance, the autoimmune regulator (Aire) gene the main thymus cell type that expresses this gene, the medullary thymic epithelial cells (mTECs). It includes one Editorial and 12 other excellent contributions in the format of mini reviews or original research papers covering one or more of these aspects: promiscuous gene expression (PGE), epigenetics, miRNAs, association of the Aire gene and miRNAs, thymocyte–TEC interaction, coxsackievirus and type 1 diabetes, exosomes in the thymus, thymic crosstalk, thymic B cells, T cell development, chemokines and migration of T cells, miRNAs and the thymic atrophy, cell–cell interactions, and thymus ontogeny. Authors raised hypothesis, discuss concepts, and show open questions. The remaining important issues to resolve questions within the central tolerance research are briefly discussed below. The first mini review is authored by Olga Ucar and Kristin Rattay. They focused on the posttranscriptional control of PGE by miRNAs as well as epigenetic control involving DNA methylation, histone modifications, and topology of chromosomes. These processes represent additional factors to be explored and that might regulate the expression of Aire-independent tissue restricted antigens (TRAs), which are implicated in the central tolerance. Are the Eph/ephrins important for thymocyte–TEC interaction? This issue was reviewed by Javier Garcia-Ceca and cols. The maturation of thymocytes is depending on their interaction with TECs within the thymus. Authors argue the importance of Ephs and ephrins on the intrathymic maturation of both thymic epithelial microenvironment and thymocyte maturation and on the recruitment of lymphoid progenitors into the thymus. Another stimulating mini review is authored by Hélène Michaux and cols in which they discuss the hypothesis that infection by coxsackievirus B4 (CV-B4) could be associated with etiopathogenesis of type 1 diabetes mellitus (T1D). Authors consider that besides their tropism to the pancreatic beta cells, CV-B4 could also involve the thymus. Once within this organ the virus might somehow perturbs central tolerance to the insulin family triggering thus autoimmune T1D. Our group contributed with a mini review focusing on cell–cell interactions within the thymus involving TECs and thymocytes and the role of the Aire gene on the induction of central tolerance throughout the modulation of TRA expression in mTECs. In addition, we discuss the recent evidence that Aire also regulate the expression of miRNAs in these cells. On its turn, the Aire-dependent miRNAs might exert control over TRAs. We raise issues that besides the transcriptional control exerted by Aire, PGE could also be being controlled through posttranscriptional mechanism involving miRNAs. A very pertinent question raised by Gabriel Skogberg and cols is on the role of exosomes on TRA presentation by TECs to thymocytes and its implication in the thymocyte selection. Exosomes may be liberated by TECs to the extracellular milieu and transport TRAs as well as MHC molecules, establishing intercellular communication to enhance antigen presentation to developing thymocytes. Authors discuss how intercellular communication via exosomes within the thymus could have consequences on TRA presentation and finally on central tolerance. The thymic crosstalk, i.e., the reciprocal control by the close contact between TECs and thymocytes, which influences the differentiation of both types of cells was elegantly reviewed by Noëlla Lopes and cols. Authors discuss the role of dendritic cells (DCs) subsets in the process of deletion of autoreactive T cells and the generation of natural Tregs and raise questions how hematopoietic cells may control the organization of the thymic medulla. Thymus is an organ composed of different cell types including TECs, DCs, macrophages among other cell types, and of course thymocytes. Recently, researchers have identified an unexpected cell type formed by B cells, which may be originated from intrathymic B lymphopoiesis or immigration from the periphery. Tomoyoshi Yamano and cols contributed with a mini review discussing the role of thymic B cells expressing MHC-II, CD80, and Aire, in the crosstalk with CD4 single positive cells. Authors raise questions how these cells might play a role as antigen presenting cells in an unpredicted way within the thymus. The regulation of T cell development is apparently well resolved; however, several unsolved questions remain. This important aspect is represented in this Research Topic through the mini review by Iris Caramalho and cols. Authors show new questions on the beginning of Treg lineage commitment, their spatial localization within the human thymus and their molecular components. Cell migration within the thymus is crucial for the central tolerance. Developing thymocytes migrate throughout the thymus being exposed initially to the cortex and then to the thymic medulla were they respectively undergo positive and negative selection. Chemokines represent key regulators for thymocyte migration. Zicheng Hu and cols argue the role of chemokines in the thymic cell migration and induction of central tolerance. Thymic atrophy during senescence is widely recognized; however, poorly understood. In addition to the atrophy due to senescence, thymus involutes in response to a variety of stimuli including microbial infections. The mouse model of Trypanosoma cruzi infection corresponds to an adequate mouse model to access this question. Leandra Linhares-Lacerda and cols show results on the role of miRNAs on regulation of chemotaxis, which contribute to a better understanding, while incites new issues, of thymic involution. Cellularity of mTECs is pivotal for cell–cell interactions within the thymus, which is required for central tolerance. Taishin Akiyama and cols argue the role of cytokines on cellularity of mTECs focusing into the molecular basis of cell–cell interactions opening perspective on the use of mathematical models for understanding these processes. Thymus morphogenesis is a central point with many open questions. The mini review authored by Arnon Dias Jurberg and cols addresses the role of the large superfamily of TGF-beta/bone morphogenetic protein ligands in the thymus morphogenesis and in T cell differentiation. This eBook provides an international and updated insight into the latest developments and open questions on the cellular and molecular bases of central tolerance induction.