Centrosomes In Development And Disease
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Centrosomes In Development And Disease
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Author : Erich A. Nigg
language : en
Publisher: John Wiley & Sons
Release Date : 2006-01-24
Centrosomes In Development And Disease written by Erich A. Nigg and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-01-24 with Science categories.
Discovered over a century ago, the centrosome is the major microtubule organizing center of the animal cell. It is a tiny organelle of surprising structural complexity. Over the last few years our understanding of the structure and composition of centrosomes has greatly advanced, and the demonstration of frequent centrosome anomalies in most common human tumors has sparked additional interest in the role of this organelle in a broader scientific community. The centrosome controls the number and distribution of microtubules - a major element of the cell cytoskeleton - and hence influences many important cellular functions and properties. These include cell shape, polarity, and motility, as well as the intracellular transport and positioning of various organelles. Of particular interest, centrosome function is critical for chromosome segregation and cell division. This book is meant to summarize our current knowledge of the structure, function and evolution of microtubule organizing centers, primarily centrosomes. Emphasis is on the role of these organelles in development and disease (particularly cancer).
The Centrosome In Cell Replication And Early Development
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Author :
language : en
Publisher: Elsevier
Release Date : 2000-09-26
The Centrosome In Cell Replication And Early Development written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-09-26 with Science categories.
Centrosomes play an integral role in the growth of cells and the ultimate development of many animals, and sometimes plants. In addition to the normal growth of cells, centrosomes can also play a key role in the spread of cancer and are of increased interest to both the genetics and oncology communities. Volume 49 of Current Topics in Developmental Biology will present all known research surrounding the centrosome, across a variety of systems, will be well referenced, and speculate where the research is headed. Discusses centrosomes and cancer, centrosomes and early development, and molecular biology of the centrosome Heavily illustrated, with many color figures Chapters written by international leaders in the field
The Centrosome
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Author : Heide Schatten
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-07-13
The Centrosome written by Heide Schatten and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-07-13 with Science categories.
The Centrosome: Cell and Molecular Mechanisms of Functions and Dysfunctions in Disease includes chapters on classic and modern aspects of centrosome research to cover topics of current interest that have not been covered in depth in most books on the market so far. It extends on previous topics and includes new exciting aspects of centrosome research focused on primary cilia and their dysfunctions that are implicated in numerous diseases. Each chapter will be written by experts in their fields who will contribute their unique expertise in specific research fields and include cell and molecular details that are important for the specific subtopics. The book will be comprehensive, concise and will include reviews of key topics in the field. Cutting edge new information will be balanced with background information that will be readily understandable for the newcomer and the experienced centrosome researcher alike.
The Centrosome And Its Functions And Dysfunctions
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Author : Heide Schatten
language : en
Publisher:
Release Date : 2022
The Centrosome And Its Functions And Dysfunctions written by Heide Schatten and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022 with categories.
The book provides a comprehensive overview of classic and modern approaches of centrosome research, including new aspects of centrosome functions focusing on primary cilia and their implications in numerous diseases. In addition, several chapters raise awareness of centrosomes in areas that have not yet fully considered the centrosome as an organelle that impacts other organelle functions directly or indirectly. It further relates centrosome functions to other research areas such as aging and stem cell research. Since its discovery almost 150 years ago the centrosome is increasingly being recognized as a most impactful organelle for its role, not only as primary microtubule organizing center (MTOC) but also as a major communication center for signal transduction pathways and as a center for proteolytic activities. Its significance for cell cycle regulation has been well studied and we now also know that centrosome dysfunctions are implicated in numerous diseases and disorders including cancer, cystic diseases of the kidney, liver fibrosis, cardiac defects, obesity and several other diseases and disorders. This new volume reviews the latest advances in the field and provides valuable background information that is readily understandable for the newcomer and the experienced centrosome researcher alike. Due to the interdisciplinary of the subject, it is a valuable resource for researchers and clinicians working in biomedical research, cell biology, cancer biology, reproduction and developmental biology, neuroscience and stem cell research. .
Eukaryotic Membranes And Cytoskeleton
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Author : Gáspár Jékely
language : en
Publisher: Springer
Release Date : 2010-10-27
Eukaryotic Membranes And Cytoskeleton written by Gáspár Jékely and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-10-27 with Science categories.
The presence/absence of gene families with central roles in endomembrane and cytoskeleton dynamics in a variety of eukaryotic taxa and an understanding of eukaryote phylogeny allow the cellular machineries present in the last common ancestor of eukaryotes to be accurately reconstructed. Such a reconstruction is fundamental in order to understand eukaryotic diversification, since this is the ancestral cell from which all diversity arose. This book discusses the evolutionary origin and diversification of eukaryotic endomembranes and cytoskeleton from a cell biological and comparative genomic perspective.
Centrosomes And Spindle Pole Bodies
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Author : Robert E. Palazzo
language : en
Publisher: Elsevier
Release Date : 2001-09-07
Centrosomes And Spindle Pole Bodies written by Robert E. Palazzo and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-09-07 with Science categories.
Containing a comprehensive collection of convenient and quantitative methods for studying centrosomes, spindle pole bodies and related organelles, this text is a valuable resource for researchers and others interested in studying the role of these organelles in cell replication. Chapters outlining the role of these organelles in other cell functions are also included, and a wide variety of experimental systems for analyzing these organelles are presented. Detailed protocols for experiments are contained in each chapter for researchers to perform in their own labs. This volume outlines key methodologies used to analyze centrosomes and spindle pole bodies, their replication, and reproduction in the clear, well-illustrated style of the Methods in Cell Biology series.
Cell Division Machinery And Disease
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Author : Monica Gotta
language : en
Publisher: Springer
Release Date : 2017-06-09
Cell Division Machinery And Disease written by Monica Gotta and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-06-09 with Science categories.
This book critically evaluates the causal link between cell division machinery and disease. Further, it identifies key open questions in the field and the means for exploring them. Throughout the various chapters, internationally known contributors present the evidence for and against a causal link between key elements of the cell division machinery and diseases such as cancer, neuropathologies, aging, and infertility. A more clinically oriented chapter further discusses the current and future applications of anti-mitotic drugs in these diseases. Cell Division Machinery and Disease is essential reading for graduate or advanced graduate students, researchers or scientists working on cell division as well as clinicians interested in the molecular mechanisms of the discussed diseases.
The Synapse In Development Health And Disease
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Author : B.W. Festoff
language : en
Publisher: Elsevier Science
Release Date : 1997-05-16
The Synapse In Development Health And Disease written by B.W. Festoff and has been published by Elsevier Science this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997-05-16 with Science categories.
This volume came out of discussions with Professeur Michel Fardeau my long-time colleague in Paris and now Directeur of the Institut de Myologie at the Hopital Pitie-Salpetriere there, and Professeur Emeritus Rene Couteaux, Universite de Paris VI. During my sabbatical year 1994-95, as Professeur de L'Academie des Sciences and Chaire Elf Aquitaine in Paris, Professeur Couteaux and I had a number of discussions, centering on the development of the field of synaptology from his perspective as one who had experienced many of the significant advances during his active professional career. Following these discussions, my colleagues, Daniel Hantai in Paris, and Bruce Citron in Kansas City, and I began to contact scientists in various areas of current synapse research. The result in this volume which seeks to incorporate studies in development, maintenance, and disease states. The foreword by Professeur Couteaux is a remarkable personal journey through the beginnings of this field up to the present day. Professeur Couteaux has continued to be active in his own research on the neuromuscular synapse to this day.
The Golgi Apparatus And Centriole
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Author : Malgorzata Kloc
language : en
Publisher: Springer
Release Date : 2020-09-04
The Golgi Apparatus And Centriole written by Malgorzata Kloc and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-09-04 with Science categories.
This volume takes a closer look how the cell organelles Golgi apparatus (also known as the Golgi complex or Golgi body), and centriole are structurally and functionally intertwined. Initially, it was believed that the role of Golgi complex is limited to the packaging and preparation for secretion of various cellular proteins, while the centriole participates in cell division and cilia formation. However, since their discovery nearly 200 years ago, it became clear that these two organelles are interacting, and that their functions are much more complex and far reaching than previously thought. Recent findings indicate that the Golgi–Centriole relationship may be important for directional protein transport, cell polarization and cell cycle progression. Current studies indicate that Golgi and centriole also participate in development and act as cellular and immunological sensors, and that their abnormalities lead to cell and developmental abnormalities, Alzheimer, cancer, various lipid disorders and neurological and immunological diseases in humans. This volume combines the latest information on the structure, molecular composition, and roles of Golgi and centriole in various cellular functions and diseases. The better understanding of the Golgi–centriole interactions may lead to the development of novel therapies for the treatment of various diseases, including cancer.
Centrosome And Centriole
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Author :
language : en
Publisher: Academic Press
Release Date : 2015-09-10
Centrosome And Centriole written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-09-10 with Science categories.
This new volume of Methods in Cell Biology looks at methods for analyzing centrosomes and centrioles. Chapters cover such topics as methods to analyze centrosomes, centriole biogenesis and function in multi-ciliated cells, laser manipulation of centrosomes or CLEM, analysis of centrosomes in human cancers and tissues, proximity interaction techniques to study centrosomes, and genome engineering for creating conditional alleles in human cells. Covers sections on model systems and functional studies, imaging-based approaches and emerging studies Chapters are written by experts in the field Cutting-edge material