Drugs And The Cell Cycle
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Drugs And The Cell Cycle
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Author : A Zimmerman
language : en
Publisher: Elsevier
Release Date : 2012-12-02
Drugs And The Cell Cycle written by A Zimmerman and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-02 with Medical categories.
Drugs and the Cell Cycle provides an introduction to fundamental principles and studies on the mechanisms of drug action on proliferating cells. The book is intended to reduce the time lag between observation and practical application. Comprised of 10 chapters, the book describes the plant alkaloids, alkylating agents, mercurials, adrenergic agents, radiomimetics, narcotics, hallucinogens, mitogens, hepatotoxins, antiobiotics, and antimetabolites of various types. The text also emphasizes the drugs used in cancer chemotherapy, and the in vitro and in vivo cell systems of bacteria, protozoa, sea urchins, and mammals. The concepts are presented with comprehensive illustrations and tables to help readers obtain more efficient understanding and learning. The information and concepts presented in this volume will be of great interest to scientists and students in many disciplines, including physiology, pharmacology, and oncology, as well as cellular, molecular, and developmental biology. The book will also fill the gap between drug experimental observations and their potential relevance to man.
Cell Cycle Effects Of Drugs
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Author : Lyle A. Dethlefsen
language : en
Publisher: Pergamon
Release Date : 1986
Cell Cycle Effects Of Drugs written by Lyle A. Dethlefsen and has been published by Pergamon this book supported file pdf, txt, epub, kindle and other format this book has been release on 1986 with Medical categories.
An understanding of the mechanism of action of anticancer agents depends on investigations into the cell cycle effects of these agents. The intent of this volume is to review our current knowledge about these basic cell cycle effects and suggest what directions future investigations should take. Chapters 1 and 2 are general, basic chapters dealing with the biology of the cell cycle per se and quantitative cytokinetics (techniques) respectively. The remaining nine chapters each cover a specific anticancer compound as examples of various classes of anticancer agents. In bringing this information together for the first time this volume represents a major step in the understanding of the mechanisms that are involved in the treatment of cell cycle disorders.
Cell Cycle Inhibitors In Cancer Therapy
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Author : Antonio Giordano
language : en
Publisher: Springer Science & Business Media
Release Date : 2002-11-20
Cell Cycle Inhibitors In Cancer Therapy written by Antonio Giordano and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-11-20 with Medical categories.
Leading clinicians and investigators review in a comprehensible and user-friendly style all the latest information about the molecular biology of cell cycle control and demonstrate its clinical relevance to understanding neoplastic diseases. Topics range from Cdk inhibitors and cell cycle regulators to the prognostic value of p27 and tumor suppressor genes as diagnostic tools. Actual case studies show how the new molecular understanding has produced such drugs as Flavopiridol and Sulindac. The book brings all the recent critical research findings to bear on clinical practice, and clearly shows their powerful impact on the diagnostics, prognostics, and therapeutics of cancer, AIDS, and cardiovascular disease.
Effects Of Drugs On The Cell Nucleus
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Author : Harris Busch
language : en
Publisher:
Release Date : 1979
Effects Of Drugs On The Cell Nucleus written by Harris Busch and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1979 with Antineoplastic agents categories.
Cell Division Machinery And Disease
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Author : Monica Gotta
language : en
Publisher: Springer
Release Date : 2017-06-09
Cell Division Machinery And Disease written by Monica Gotta and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-06-09 with Science categories.
This book critically evaluates the causal link between cell division machinery and disease. Further, it identifies key open questions in the field and the means for exploring them. Throughout the various chapters, internationally known contributors present the evidence for and against a causal link between key elements of the cell division machinery and diseases such as cancer, neuropathologies, aging, and infertility. A more clinically oriented chapter further discusses the current and future applications of anti-mitotic drugs in these diseases. Cell Division Machinery and Disease is essential reading for graduate or advanced graduate students, researchers or scientists working on cell division as well as clinicians interested in the molecular mechanisms of the discussed diseases.
Cell Cycle Regulation
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Author : Robert R. Ruffolo, Jr.
language : en
Publisher: CRC Press
Release Date : 1997-12-23
Cell Cycle Regulation written by Robert R. Ruffolo, Jr. and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997-12-23 with Science categories.
Focuses on recent key discoveries made relating to the cell cycle and its regulation - a critical new horizon in therapeutics. Research into all aspects of cell cycle regulation has undergone explosive growth during the past decade due to the powerful techniques of molecular biology. An overall view of the cellular processes, both at the enzymatic and genetic level, has been identified in continually finer detail, as described inside this text. This has enabled significant progress in the identification of drugs capable of acting on specific components of the cell cycle, with the result that we may soon have the ability to manipulate the cell cycle pharmacologically. The potential impact on clinical conditions such as cancer, hematopoiesis, angiogenesis, inflammation, organ remodelling and apoptosis is vast. Originating from presentations at the Eighth SmithKline Beecham Pharmaceuticals United States Research Symposium, each chapter in this volume is written by an opinion leader in the field.
Anticancer Drug Development
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Author : Bruce C. Baguley
language : en
Publisher: Elsevier
Release Date : 2001-11-17
Anticancer Drug Development written by Bruce C. Baguley and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-11-17 with Medical categories.
Here in a single source is a complete spectrum of ideas on the development of new anticancer drugs. Containing concise reviews of multidisciplinary fields of research, this book offers a wealth of ideas on current and future molecular targets for drug design, including signal transduction, the cell division cycle, and programmed cell death. Detailed descriptions of sources for new drugs and methods for testing and clinical trial design are also provided. One work that can be consulted for all aspects of anticancer drug development Concise reviews of research fields, combined with practical scientific detail, written by internationally respected experts A wealth of ideas on current and future molecular targets for drug design, including signal transduction, the cell division cycle, and programmed cell death Detailed descriptions of the sources of new anticancer drugs, including combinatorial chemistry, phage display, and natural products Discussion of how new drugs can be tested in preclinical systems, including the latest technology of robotic assay systems, cell culture, and experimental animal techniques Hundreds of references that allow the reader to access relevant scientific and medical literature Clear illustrations, some in color, that provide both understanding of the field and material for teaching
Cell Cycle Materials And Methods
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Author : Michele Pagano
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Cell Cycle Materials And Methods written by Michele Pagano and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
During their lifetime, especially when growing and dividing, cells go through various steps of the cell cycle. Knowledge of the individual steps of the cell cycle will help us understand the development of a variety of diseases better, including cancer, and also to design new drugs against it. New techniques for studying the molecular basis of these processes have recently been developed and are described in detail in this manual. A glossary helps the reader to cope with the complex cell cycle terminology.
Checkpoint Responses In Cancer Therapy
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Author : Wei Dai
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-05-01
Checkpoint Responses In Cancer Therapy written by Wei Dai and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-05-01 with Medical categories.
Extensive research has uncovered a set of molecular surveillance mechanisms – commonly called “checkpoints” – which tightly monitor cell-cycle processes. Today’s anticancer drug development has identified many of these cell-cycle checkpoint molecules as effective targets. Research now promises to uncover a new generation of anticancer drugs with improved therapeutic indices based on their ability to target emerging checkpoint components. Checkpoint Responses in Cancer Therapy summarizes the advances made over the past 20 years, identifying components of cell-cycle checkpoints and their molecular regulation during checkpoint activation and validating the use of checkpoint proteins as targets for the development of anticancer drugs. This book’s distinguished panel of authors takes a close look at topics ranging from the major molecular players affecting DNA synthesis and the response to DNA damage to advances made in the identification of chemical compounds capable of inhibiting individual mitotic kinases. Illuminating and authoritative, Checkpoint Responses in Cancer Therapy offers a critical summary of findings for researchers in the pharmaceutical and biotechnology industries and a valuable resource for academic scientists in cancer research and the study of cell-cycle regulation, signal transduction and apoptosis.
Control Of Cell Cycle And Cell Proliferation
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Author : Rossen Donev
language : en
Publisher: Elsevier
Release Date : 2023-04-13
Control Of Cell Cycle And Cell Proliferation written by Rossen Donev and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-04-13 with Science categories.
Control of Cell Cycle and Cell Proliferation, Volume 135 in the Advances in Protein Chemistry and Structural Biology series, presents chapters on a variety topics, including Exploiting pivotal mechanisms behind the senescence-like cell cycle arrest, Viral infection on through Cell Cycle Regulation, Analyzing drug resistant mutation in CDK4 gene and identification of potential inhibitors through structure based virtual screening approach, Controlling cell proliferation by targeting CDK6 using drug repurposing approach, The role of the nucleolus in regulating cell cycle, Chromatin regulators in DNA replication and genome stability maintenance during S-phase, Role of macrophage in cancer cell progression and targeted immunotherapies, and much more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Advances in Protein Chemistry and Structural Biology series Includes the latest information on Control of Cell Cycle and Cell Proliferation