Emerging Immune Functions Of Non Hematopoietic Stromal Cells

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Emerging Immune Functions Of Non Hematopoietic Stromal Cells

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Author : Burkhard Ludewig
language : en
Publisher: Frontiers E-books
Release Date : 2014-12-17

Emerging Immune Functions Of Non Hematopoietic Stromal Cells written by Burkhard Ludewig and has been published by Frontiers E-books this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-12-17 with Allergy categories.

The development and function of the immune system is dependent on interactions between haematopoietic cells and non-hematopoietic stromal cells. The non-hematopoietic stromal cells create the microenvironment in which the immune system operates, providing an architectural landscape for hematopoietic cell-cell interactions and molecular cues governing haematopoietic cell positioning, growth and survival. Not surprisingly, therefore, aberrant stromal cell function has recently been shown to play a key role in the development of disease pathologies associated with immune dysfunction. For example, remodelling of lymphoid tissue stroma and the development of ectopic tertiary lymphoid tissues are characteristic of many infectious and inflammatory diseases and stromal cells have a recognised role in lymphoma and tumour development and resistance to therapy. An increased understanding of the molecular basis of stromal cell differentiation and function in these varied contexts will provide new tools to promote research on stromal cell biology and immune dysfunction, and potential new targets for therapeutic intervention in diseases with a major impact on public health. The importance of stromal cells and the molecular mechanisms of stromal cell function in the regulation of immune responses have only recently been appreciated and thus represent an exciting new area in immunology.

New Insights Into The Complexity Of Tumor Immunology In B Cell Malignancies Tumor Immunology And Immunotherapy

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Author : Jérôme Paggetti
language : en
Publisher: Frontiers Media SA
Release Date : 2022-03-02

New Insights Into The Complexity Of Tumor Immunology In B Cell Malignancies Tumor Immunology And Immunotherapy written by Jérôme Paggetti and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-03-02 with Medical categories.

Topic Editor MS received funding from Bayer AG.

Fish And Fisheries Structure And Functions

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Author : Mr. Rohit Manglik
language : en
Publisher: EduGorilla Publication
Release Date : 2024-07-19

Fish And Fisheries Structure And Functions written by Mr. Rohit Manglik and has been published by EduGorilla Publication this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-07-19 with Technology & Engineering categories.

EduGorilla Publication is a trusted name in the education sector, committed to empowering learners with high-quality study materials and resources. Specializing in competitive exams and academic support, EduGorilla provides comprehensive and well-structured content tailored to meet the needs of students across various streams and levels.

Emerging Roles And Mechanisms Of Stromal Cells In Carcinomas At The Molecular Level

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Author : Jaewoo Hong
language : en
Publisher: Frontiers Media SA
Release Date : 2022-10-18

Emerging Roles And Mechanisms Of Stromal Cells In Carcinomas At The Molecular Level written by Jaewoo Hong and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-10-18 with Medical categories.

Tumor Microenvironment Tme And Tumor Immune Microenvironment Time New Perspectives For Prognosis And Therapy

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Author : Ana Karina de Oliveira
language : en
Publisher: Frontiers Media SA
Release Date : 2022-09-30

Tumor Microenvironment Tme And Tumor Immune Microenvironment Time New Perspectives For Prognosis And Therapy written by Ana Karina de Oliveira and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-09-30 with Science categories.

New Insights On Liver Transplant And Tolerance

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Author : Xiao-Kang Li
language : en
Publisher: Frontiers Media SA
Release Date : 2021-11-24

New Insights On Liver Transplant And Tolerance written by Xiao-Kang Li and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-24 with Medical categories.

Biology Of Mesenchymal Stromal Cells Emerging New Concepts To Improve Function And Scalability

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Author : Tokiko Nagamura-Inoue
language : en
Publisher: Frontiers Media SA
Release Date : 2024-10-28

Biology Of Mesenchymal Stromal Cells Emerging New Concepts To Improve Function And Scalability written by Tokiko Nagamura-Inoue and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-10-28 with Science categories.

Human mesenchymal stromal cells (MSCs) can be harvested from many tissues, including bone marrow (BM), cord blood (CB), adipose tissue, umbilical cord (UC), placenta and others. In recent years, there has been an overwhelming interest in MSC as reflected in the number of reports regarding their characterization, biological properties and clinical application. One of the specific areas of research involves the characterization of MSCs derived from different sources as well as the potential differences between them. More recently, reports have been published on derivatives from MSCs such as extracellular vesicles (EVs)/exosomes and mitochondria, but their characterization, mechanisms of action in immunomodulatory functions and regeneration aspects have not been fully elucidated.

New Insights Into Thymic Functions During Stress Aging And In Disease Settings

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Author : Nicolai Stanislas van Oers
language : en
Publisher: Frontiers Media SA
Release Date : 2020-12-23

New Insights Into Thymic Functions During Stress Aging And In Disease Settings written by Nicolai Stanislas van Oers and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-12-23 with Medical categories.

This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Mathematical Modeling Of The Immune System In Homeostasis Infection And Disease

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Author : Gennady Bocharov
language : en
Publisher: Frontiers Media SA
Release Date : 2020-02-24

Mathematical Modeling Of The Immune System In Homeostasis Infection And Disease written by Gennady Bocharov and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-02-24 with categories.

The immune system provides the host organism with defense mechanisms against invading pathogens and tumor development and it plays an active role in tissue and organ regeneration. Deviations from the normal physiological functioning of the immune system can lead to the development of diseases with various pathologies including autoimmune diseases and cancer. Modern research in immunology is characterized by an unprecedented level of detail that has progressed towards viewing the immune system as numerous components that function together as a whole network. Currently, we are facing significant difficulties in analyzing the data being generated from high-throughput technologies for understanding immune system dynamics and functions, a problem known as the ‘curse of dimensionality’. As the mainstream research in mathematical immunology is based on low-resolution models, a fundamental question is how complex the mathematical models should be? To respond to this challenging issue, we advocate a hypothesis-driven approach to formulate and apply available mathematical modelling technologies for understanding the complexity of the immune system. Moreover, pure empirical analyses of immune system behavior and the system’s response to external perturbations can only produce a static description of the individual components of the immune system and the interactions between them. Shifting our view of the immune system from a static schematic perception to a dynamic multi-level system is a daunting task. It requires the development of appropriate mathematical methodologies for the holistic and quantitative analysis of multi-level molecular and cellular networks. Their coordinated behavior is dynamically controlled via distributed feedback and feedforward mechanisms which altogether orchestrate immune system functions. The molecular regulatory loops inherent to the immune system that mediate cellular behaviors, e.g. exhaustion, suppression, activation and tuning, can be analyzed using mathematical categories such as multi-stability, switches, ultra-sensitivity, distributed system, graph dynamics, or hierarchical control. GB is supported by the Russian Science Foundation (grant 18-11-00171). AM is also supported by grants from the Spanish Ministry of Economy, Industry and Competitiveness and FEDER grant no. SAF2016-75505-R, the “María de Maeztu” Programme for Units of Excellence in R&D (MDM-2014-0370) and the Russian Science Foundation (grant 18-11-00171).

Immunology Of Aging

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Author : Sudhir Gupta
language : en
Publisher: Frontiers Media SA
Release Date : 2019-11-05

Immunology Of Aging written by Sudhir Gupta and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-11-05 with categories.