Gene Therapy In Inflammatory Diseases

DOWNLOAD
AUDIOBOOK
READ ONLINE

Download Gene Therapy In Inflammatory Diseases PDF/ePub or read online books in Mobi eBooks. Click Download or Read Online button to get Gene Therapy In Inflammatory Diseases book now. This website allows unlimited access to, at the time of writing, more than 1.5 million titles, including hundreds of thousands of titles in various foreign languages. If the content not found or just blank you must refresh this page

Gene Therapy In Inflammatory Diseases

DOWNLOAD
AUDIOBOOK
READ ONLINE
Author : Christopher H. Evans
language : en
Publisher: Birkhäuser
Release Date : 2012-12-06

Gene Therapy In Inflammatory Diseases written by Christopher H. Evans and has been published by Birkhäuser this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.

Gene therapy for inflammatory diseases is a new , burgeoning field of medicine. Edited by the undisputed pioneers of this area of research, this volume is the first devoted to its topic. It contains thirteen chapters, each written by leaders in their respective fields, that summarize the state of the art in developing novel, gene based treatments for inflammatory diseases. As well as providing an introduction to the basic concepts of gene therapy and the use of naked DNA approaches, the book describes the advances that have been made in applying them to arthritis, lupus, multiple sclerosis, diabetes, Sjogren`s syndrome and transplantation.One chapter is devoted to discussing the first human clinical trials that apply gene therapy to the treatment of an inflammatory disease. As well as providing novel therapeutic approaches, gene therapy facilitates the development of new and improved animal models of disease; a chapter describing these advances is also included. As an up-to-date, timely book written by th

Gene Therapy In Inflammatory Diseases

DOWNLOAD
AUDIOBOOK
READ ONLINE
Author : Christopher Howard Evans
language : en
Publisher:
Release Date : 2000

Gene Therapy In Inflammatory Diseases written by Christopher Howard Evans and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000 with Anti-inflammatoires categories.

Gene Therapy For Autoimmune And Inflammatory Diseases

DOWNLOAD
AUDIOBOOK
READ ONLINE
Author : Yuti Chernajovsky
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-01-28

Gene Therapy For Autoimmune And Inflammatory Diseases written by Yuti Chernajovsky and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-01-28 with Medical categories.

In this monograph about gene therapy of autoimmune and inflammatory d- orders we have gathered international experts and leaders from different fields to review the state of the art advances on topics ranging from disease entities to vectors and engineered cells. The different approaches described in each chapter take into consideration the biomedical knowledge of these diseases and address the complexities of delivering long-term genetic interventions. Gene therapy also serves as a testing ground for new therapeutic entities and helps provide proof of principle for their potential therapeutic role in animal models of disease. Scaling up from mice to men still remains an important h- dle not only from the quantitative point of view, but also for currently unknown and unexpected secondary effects of the vector or the transgene. Some of these approaches have already been tested in the clinic, but much more needs to be done to understand the human conditions treated and the n- ural history of their pathology. We are indebted to the secretarial assistance of Ms. Lin Wells (Bone and Joint Research Unit, London, UK) and the help of Hans Detlef Klüber for his help in getting this book published. We hope this book will be of interest to c- nicians and scientists and inspiring to students of the subject who will use their own ingenuity and knowledge to further forward this discipline into clinical use.

Biologic And Gene Therapy Of Autoimmune Disease

DOWNLOAD
AUDIOBOOK
READ ONLINE
Author : C. Garrison Fathman
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 2000-01-01

Biologic And Gene Therapy Of Autoimmune Disease written by C. Garrison Fathman and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-01-01 with Medical categories.

The clinical management of autoimmune diseases has proven to be extremely difficult. Current therapies focus on trying to alleviate symptoms, but fail to correct the fundamental immune defects that lead to pathology. To achieve this goal, it is necessary to understand much of the biology of antigen presentation, lymphocyte activation and the effects of cytokines. The articles in this book provide an up-to-date review of current innovative therapies using both biologic and gene therapy for the treatment of selected autoimmune diseases. Therapeutical approaches discussed include oral tolerance, the use of anti-CD4 monoclonal antibodies, IL-10 and anti-TNFa antibodies, DNA vaccination, and gene therapy applied to organ-specific autoimmune disease. Although some of these techniques are still in their infancy, their potential efficacy has been demonstrated in several animal models of autoimmune disease, holding great promise for the future development of treatments. Written by recognized experts in the field, the chapters in this book illustrate the concept of technology transfer from bench to bedside and provide a valuable update for clinicians and scientists in clinical immunology.

Next Generation Therapies And Technologies For Immune Mediated Inflammatory Diseases

DOWNLOAD
AUDIOBOOK
READ ONLINE
Author : Paola Mina-Osorio
language : en
Publisher: Springer
Release Date : 2017-01-21

Next Generation Therapies And Technologies For Immune Mediated Inflammatory Diseases written by Paola Mina-Osorio and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-01-21 with Medical categories.

As our understanding of immune mediated chronic inflammatory diseases (IMIDs) grows, it becomes more and more clear that these conditions result from the convergence of a multitude of pathogenic mechanisms whose relative individual contribution is different in different patient subsets. Promising new technologies have been conceived that address the hypotheses that targeting multiple pathways simultaneously, selectively delivering therapeutics to areas of inflammation and/or resetting the immune system, could take efficacy to new levels. However, we have long waited for the arrival of some of these technologies to the bedside, or even far enough in the drug development process in spite of the initial enthusiasm. Some of the examples covered in this book include bispecific antibodies and genomic medicines, microparticles and targeted delivery of drugs to inflamed vasculature. Most published reviews and book chapters on novel therapies for inflammatory diseases describe positive attributes of molecules or technologies under investigation and the rationale for developing them into therapeutics. The originality and potential value of this book is not in the description of these targets or technologies from the point of view of their structure or mechanism of action exclusively, but rather, in making an effort to critically address the question of what is needed to move these technologies into the clinic. Has the technology not made it past the preclinical stage and why? Has it already been tested in humans and failed? What are the potential reasons behind those failures? What do experts in each field believe can be done better to increase the probabilities of success? In addition, the authors address the competitive landscape and summarize clinical studies that have failed in the respective area. They talk about the patient populations that would be required for the successful conduction of a clinical trial to test certain molecules, and they proactively share their views regarding both the potential and the drawbacks of targets or methodologies.

Gene Therapy Of Autoimmune Disease

DOWNLOAD
AUDIOBOOK
READ ONLINE
Author : Gerald J. Prud'homme
language : en
Publisher: Springer
Release Date : 2005-07-13

Gene Therapy Of Autoimmune Disease written by Gerald J. Prud'homme and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-07-13 with Medical categories.

Autoimmune diseases are diverse and responsible for considerable morbidity. Their etiology remains largely unknown, and current therapy with anti-inflammatory drugs is prone to adverse effects, and rarely curative. New therapies with anti-cytokine antibodies or receptors are promising, but require frequent administration of expensive protein drugs. Gene Therapy of Autoimmune Diseases comprehensively reviews research in gene therapy for autoimmune diseases with viral or non-viral vectors. Gene therapy offers the possibility of long-term, continuous delivery of a wide variety of immunosuppressive, anti-inflammatory, or tolerance-inducing agents. Moreover, highly specific genetically modified cells can be produced. This book discusses the most promising avenues in this exciting new field.

Gene Therapy For Acute And Acquired Diseases

DOWNLOAD
AUDIOBOOK
READ ONLINE
Author : Phillip Factor
language : en
Publisher: Springer Science & Business Media
Release Date : 2001-01-31

Gene Therapy For Acute And Acquired Diseases written by Phillip Factor and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-01-31 with Medical categories.

In recent years much enthusiasm and energy has been directed toward the development of human gene therapies, especially for inherited conditions and cancers. However, current gene transfer technology is limited in its transduction efficiency and ability to permanently and safely correct genomic defects. Thus the promise of gene therapy for these conditions is as yet unrealized. The progression of gene transfer technology will eventually surmount these limitations. Gene Therapy for Acute and Acquired Diseases includes selected examples of ongoing studies in molecular genetics that have the potential to evolve into human therapies for acute illnesses. These chapters are intended to highlight lesser known applications of gene therapy for acquired disorders. It is expected that human gene therapy trials for these conditions will be forthcoming in the near future, leading to previously unimaginable therapies. Thus, this first-ever book about gene therapy for acute and acquired diseases is intended to serve as a glimpse into the future.

Modern Therapeutics In Rheumatic Diseases

DOWNLOAD
AUDIOBOOK
READ ONLINE
Author : George C. Tsokos
language : en
Publisher: Springer Science & Business Media
Release Date : 2001-11-08

Modern Therapeutics In Rheumatic Diseases written by George C. Tsokos and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-11-08 with Medical categories.

Leading clinicians and clinical researchers discuss in practical detail the newest treatments used in rheumatic diseases, emphasizing-without neglecting current standard treatments-those experimental therapies now undergoing clinical trials and poised for early introduction into the rheumatology armamentarium. The diseases and therapeutic regimes examined here range from rheumatoid arthritis and its treatment by gene therapy, to osteoarthritis and systemic autoimune diseases. Each chapter is organized so that the busy clinician can quickly obtain all the information needed optimal patient treatment. This includes an analysis of the pathogenic mechanisms that explain the molecular basis of the newer therapeutics, reviews of animal data and the results of clinical trials, and recommendations concerning use, side effects, and precautions.

Somatic Gene Therapy

DOWNLOAD
AUDIOBOOK
READ ONLINE
Author : Patricia L. Chang
language : en
Publisher: CRC Press
Release Date : 1994-12-27

Somatic Gene Therapy written by Patricia L. Chang and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994-12-27 with Science categories.

As human gene therapy becomes a clinical reality, a new era in medicine dawns. Novel and innovative developments in molecular genetics now provide opportunities to treat the genetic bases of diseases often untreatable before. Somatic Gene Therapy documents these historical clinical trials, reviews current advances in the field, evaluates the use of the many different cell types and organs amenable to gene transfer, and examines the prospects of various exciting strategies for gene therapy.

Role Of The Il 23 Il 17 Pathway In Chronic Immune Mediated Inflammatory Diseases Mechanisms And Targeted Therapies

DOWNLOAD
AUDIOBOOK
READ ONLINE
Author : Elisabetta Bianchi
language : en
Publisher: Frontiers Media SA
Release Date : 2021-11-10

Role Of The Il 23 Il 17 Pathway In Chronic Immune Mediated Inflammatory Diseases Mechanisms And Targeted Therapies written by Elisabetta Bianchi and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-10 with Medical categories.