Impact Of The Glioma Microenvironment On Antitumor Immunity
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Impact Of The Glioma Microenvironment On Antitumor Immunity
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Author : Valérie Dutoit
language : en
Publisher: Frontiers Media SA
Release Date : 2022-01-31
Impact Of The Glioma Microenvironment On Antitumor Immunity written by Valérie Dutoit and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-01-31 with Medical categories.
Immune Microenvironment And Immunotherapy In Malignant Brain Tumors
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Author : Liangxue Zhou
language : en
Publisher: Frontiers Media SA
Release Date : 2023-12-19
Immune Microenvironment And Immunotherapy In Malignant Brain Tumors written by Liangxue Zhou and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-12-19 with Medical categories.
Adult Diffuse Glioma Microenvironment Insight Into Cancer Ecology
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Author : Aleksi Sedo
language : en
Publisher: Frontiers Media SA
Release Date : 2023-03-29
Adult Diffuse Glioma Microenvironment Insight Into Cancer Ecology written by Aleksi Sedo and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-03-29 with Medical categories.
Combinational Immunotherapy Of Cancer Novel Targets Mechanisms And Strategies
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Author : Xuyao Zhang
language : en
Publisher: Frontiers Media SA
Release Date : 2024-01-15
Combinational Immunotherapy Of Cancer Novel Targets Mechanisms And Strategies written by Xuyao Zhang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-01-15 with Medical categories.
Cancer immunotherapy, including immune checkpoint inhibitors (ICIs) and chimeric antigen receptor T-cell (CAR-T) therapy, has revolutionized the paradigm in cancer treatment. However, the clinical outcome of immunotherapy varies considerably among patients and only a minority of patients achieve long-term clinical benefits. This is largely attributed to the fact that existing cancer immunotherapies, which concentrate on several classical targets (CTAL-4, PD-1/PD-L1, etc.) and limited types of immune cell populations (T cells), are insufficient to cope with the complexity of highly heterogeneous tumor microenvironment (TME). This calls for more efforts to not only expand our toolbox for manipulating anticancer immunity but also diversify our combinational strategies. To this end, it is urgent to deeper our understanding of cancer immunotherapy by using both experimental and computational methodologies from multi-scale perspectives: 1) novel targets from either tumor cells or non-tumor cells within TME (e.g., tumor intrinsic resistance drivers, new immune checkpoints, neoantigens), 2) in-depth characterization of more immune cell populations (e.g., macrophages, Tregs, B cells) and their interactions and dynamics within TME, 3) landscape of actionable targets in patient populations for combination design. These efforts will open the avenue of rational design of combinational immunotherapies, allowing researchers and clinicians to design novel targeting therapeutics or to optimally orchestrate combinatory strategies aiming to surmount resistance mechanisms and improve clinical outcomes.
Ferroptosis In Malignant Brain Tumors
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Author :
language : en
Publisher: Frontiers Media SA
Release Date : 2023-10-25
Ferroptosis In Malignant Brain Tumors written by and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-10-25 with Medical categories.
Community Series In Novel Biomarkers In Tumor Immunity And Immunotherapy Volume Ii
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Author : Eyad Elkord
language : en
Publisher: Frontiers Media SA
Release Date : 2025-05-15
Community Series In Novel Biomarkers In Tumor Immunity And Immunotherapy Volume Ii written by Eyad Elkord and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-05-15 with Medical categories.
This Research Topic is the second volume of the “Novel Biomarkers in Tumor Immunity and Immunotherapy” Community Series. Please see Volume I here. Immune checkpoint inhibitors (ICIs) such as anti-PD-1 and anti-PD-L1 antibodies are highly effective against many types of cancer, yet durable responses are limited to a subset of patients highlighting the need for the development of effective biomarkers to predict prognosis and efficacy. Currently, PD-L1 expression in tumors, microsatellite instability (MSI) or mismatch repair deficiency (dMMR), and tumor mutation burden (TMB) are known as biomarkers for cancer immunotherapy but are not sufficient. Combination therapy with immune checkpoint inhibitors and chemotherapy or radiation therapy, as well as diverse therapies targeting intra-tumoral regulatory T cells have been described, but there are currently no unifying biomarkers that are applicable to clinically, a simple, fast, non-invasive method that can yield biomarkers of disease with a minimal adverse effect on patients is desirable. Recent findings suggest that the balancing of effector T cells and regulatory cells in the tumor microenvironment is associated with cancer progression and prognosis. Cells and molecules involved in the control of cancer are complex, and a better understanding of the tumor immune environment will lead to the development of truly effective biomarkers. This research topic will focus on novel biomarkers that predict efficacy, prognosis, or the development of adverse events in various cancer immunotherapies, and extensive basic research leading to the development of biomarkers. We expect a wide range of research, not only in serology, genetics, and immunocytochemistry but also in bacterial flora. Research on the development of novel assays and bioinformatics methods is also welcome: • Non-invasive biomarkers for cancer immunotherapy. • Bulk RNA-seq, scRNA-seq, or Rep-seq methods. • Correlation of tumor immune cells with gut microbiota in tumor immunotherapy. • Impact of Teff and Treg balance in the tumor microenvironment on tumor prognosis. • Inflammatory and immune signatures associated with drug response versus resistance in cancer. Please note that Topic Editor Dr. Takaji Matsutani is employed by Maruho Co., Ltd. The other Topic Editors declare no competing interests with regard to the Research Topic subject. Please also note that manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by robust and relevant validation (clinical cohort or biological validation in vitro or in vivo) are out of scope for this topic.
Clinical Therapy Of Brain Tumors
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Author : Bo yuan Huang
language : en
Publisher: Frontiers Media SA
Release Date : 2025-06-09
Clinical Therapy Of Brain Tumors written by Bo yuan Huang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-06-09 with Medical categories.
Brain tumors are devastating diseases, accounting for a significant proportion of cancer-related mortality and morbidity in both adults and children. Over the past few years, we have witnessed dramatic progress in clinical treatment for brain tumors. This is largely due to advancements in surgical skills, a more reasonable and personalized approach to radiotherapy and chemotherapy, and continuously updated immune therapy methods that modulate the immune microenvironment or specifically target tumor cells. However, various factors affect brain tumor treatments. These include the blood-brain barrier, tumor heterogeneity, the tumor immune microenvironment, and so on. Consequently, it is worthwhile that research conducted in these fields, both pre- and clinical, should be shared with the larger scientific community to further improve the clinical treatment for brain tumors. The Research Topic’s ambitions are to bring together new discoveries in the clinical treatment for brain tumors. Manuscripts consisting of surgical approaches, radiotherapy, chemotherapy, immunotherapy, and other therapies on brain tumors are welcomed. Manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases that are not accompanied by validation (clinical cohort or biological validation in vitro or in vivo) are out of scope for this Topic section. We welcome manuscripts in the form of Original Research and Review focusing on, but not limited to, the following sub-topic: 1) The advancements in surgical techniques, including updated operative routes, minimally invasive approaches, and image-guided navigation systems. 2) In vitro, ex vivo, and in vivo tumor-related models analyzing the tumor and immune microenvironment and response to targeted brain tumor therapies. 3) Fundamental experimental studies, pre-clinical, and clinical research on novel strategies of chemotherapy, radiotherapy, and/or immunotherapy.
Recent Advances In Molecular Targets For Drug Discovery And Delivery In Tumor
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Author : Sanjun Shi
language : en
Publisher: Frontiers Media SA
Release Date : 2022-05-05
Recent Advances In Molecular Targets For Drug Discovery And Delivery In Tumor written by Sanjun Shi and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-05-05 with Science categories.
Impact Of Cancer Plasticity On Drug Resistance And Treatment In Solid Tumors
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Author : Dong-Hua Yang
language : en
Publisher: Frontiers Media SA
Release Date : 2020-12-24
Impact Of Cancer Plasticity On Drug Resistance And Treatment In Solid Tumors written by Dong-Hua Yang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-12-24 with Medical categories.
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
New Frontiers In Gene Modified T Cell Technology
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Author : Ignazio Caruana
language : en
Publisher: Frontiers Media SA
Release Date : 2024-06-13
New Frontiers In Gene Modified T Cell Technology written by Ignazio Caruana and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-06-13 with Medical categories.
The development, clinical translation and recent efficacy of novel gene therapies targeting refractory malignancies has led to research that extends this technology to a variety of infectious and rheumatological diseases. Unlike conventional drugs or antibodies, T cells have the potential to target and exert effector function in response to disease in a dynamic manner, acting as a “living drug”. The most efficacious form of gene-modified T cells to date is the chimeric antigen receptor (CAR)-modified T cell, which redirects the specificity of T cells to an antigen expressed by tumor cells. Clinical experience with autologous CAR-T cells, primarily in hematologic malignancies, has underscored the feasibility and safety of the approach, while also demonstrating dramatic and sustained antitumor effects through mechanisms orthogonal to those of traditional anticancer therapies. However, several challenging obstacles must be surmounted in order to improve the broader efficacy of this approach.