Lymphangiogenesis And Lymphatic Metastasis In Human Breast Cancer
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Lymphangiogenesis And Lymphatic Metastasis In Human Breast Cancer
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Author : Giles Harvey Cunnick
language : en
Publisher:
Release Date : 2002
Lymphangiogenesis And Lymphatic Metastasis In Human Breast Cancer written by Giles Harvey Cunnick and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with categories.
Lymphangiogenesis In Cancer Metastasis
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Author : Steven A. Stacker
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-09-30
Lymphangiogenesis In Cancer Metastasis written by Steven A. Stacker and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-09-30 with Medical categories.
Lymphangiogenesis and Cancer Metastasis introduces the new field of lymphatic vessel growth and development, and its relationship to the metastatic spread of cancer cells. The book covers all aspects of this new field from the fundamental role that protein growth factors and their receptors play in lymphangiogenesis to the potential application of these advances to cancer diagnosis and treatment. Other clinical aspects explored include the mechanisms and importance of lymph node metastasis, the role of the lymphatics in lymphangioleiomyomatosis and Kaposi’s sarcoma, and approaches for imaging lymphatics in cancer. The book also covers the innovative approaches taken by researchers to explore new roles for lymphatic vessel biology in the context of cancer. The information presented in this volume, which describes the revolutionary concepts of tumor lymphangiogenesis, will be of interest to all students, scientists and oncologists who are seeking to understand the complexities of tumor metastasis. Key Features: Presents fundamental concepts of tumor lymphangiogenesis and the molecules which control this process Provides a comprehensive summary of current research in this ground breaking area Provides a book which links progress in basic tumor and developmental biology with current and future oncology practise Is an essential text for molecular biologists, cell biologists and oncologists seeking to understand the implications of this rapidly developing area.
Regulation Of Lymphangiogenesis By Interleukin 7 Il7 And The Association With Lymphatic Metastasis In Human Breast Cancer
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Author : Mahir Ali Ahmed Al-Rawi
language : en
Publisher:
Release Date : 2004
Regulation Of Lymphangiogenesis By Interleukin 7 Il7 And The Association With Lymphatic Metastasis In Human Breast Cancer written by Mahir Ali Ahmed Al-Rawi and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with categories.
Significance Of Lymphangiogenesis For Metastatic Spread Of Breast Cancer
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Author :
language : en
Publisher:
Release Date : 2002
Significance Of Lymphangiogenesis For Metastatic Spread Of Breast Cancer written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with categories.
The lymphatic system serves as the primary route for the metastasis of breast cancer, and the extent of lymph node involvement is a key prognostic factor for the outcome of the disease. Whereas the significance of angiogenesis for tumor progression has been well documented, the ability of tumor cells to induce the growth of lymphatic vessels, (lymphangiogenesis) and the presence of intratumoral lymphatic vessels have been questioned. We demonstrate occurrence of intratumoral lymphangiogenesis within human breast cancers alter orthotopic transplantation onto nude mice, using a novel marker for lymphatic endothelium, LYVE-1-I. We show using green fluorescent protein-tagging that breast tumor cells which overexpress vascular endothelial growth factor-C (VEGF-C), display a potent increase in intratumoral lymphangiogenesis, and significantly enhanced metastasis to both regional lymph nodes and lungs. Furthermore we have found that the degree of tumor lymphangiogenesis is highly correlated with the extent of both lymph node and lung metastases. These results establish the occurrence and biological significance of intratumoral lymphangiogenesis in breast cancer and identify VEGF-C as a molecular link between tumor lymphangiogenesis and metastasis.
Cancer Metastasis And The Lymphovascular System
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Author : Stanley P. L. Leong
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-09-05
Cancer Metastasis And The Lymphovascular System written by Stanley P. L. Leong and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-09-05 with Medical categories.
This book details the anatomy and physiology of the lymphovascular system as well as describes the mechanisms of metastasis. It provides readers with an understanding of immune responses of draining lymph nodes against cancer. Coverage also explains the rationale of adopting molecular therapeutics against growth factor receptors, apoptotic factors, signaling pathways and angiogenesis.
Cancer Metastasis Through The Lymphovascular System
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Author : Stanley P. Leong
language : en
Publisher: Springer Nature
Release Date : 2022-06-24
Cancer Metastasis Through The Lymphovascular System written by Stanley P. Leong and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-06-24 with Medical categories.
This textbook describes in detail the process of cancer metastasis from a single cell in the primary site through its arduous journey to the sentinel lymph node as the main gateway and beyond to distant sites. The most up-to-date knowledge on key topics in the molecular biology, diagnosis, and treatment of metastatic cancer is highlighted by a large panel of experts. The book begins with a comprehensive overview of the genetic and molecular mechanisms that promote or inhibit cancer metastasis through lymphatic pathways to lymph nodes or through vascular pathways to distant sites, providing the reader with an essential basic knowledge. This is followed by further details on the role of the immune system within the primary tumor and the lymph node and the importance of the microenvironment at the metastatic site. The role of the sentinel lymph node in cancer metastasis is emphasized. Special attention is also given to state-of-the-art imaging techniques for the detection of early-stage cancer and cancer metastases, as well as the use of liquid biopsies in sarcoma, prostate, gastrointestinal, and lung cancer. Clinical patterns of malignant tumors arising in different organ systems are compared, described, and discussed with the goal of determining what similarities and/or differences exist. The book concludes with a detailed discussion of surgical intervention, radiation, and systemic therapy of primary and metastatic cancer, and briefly previews several emerging topics, such as the latest findings on personalized cancer therapy, cancer stem cells, unique molecular mechanisms of virus-induced cancer, the impact of the microbiome on cancer metastasis and the application of artificial intelligence in cancer metastasis research. By providing fundamental knowledge of the biological and clinical aspects of cancer metastasis, this book will be an important reference for cancer researchers, clinical oncologists, teachers, and students. Written by experts in the field, each chapter includes a summary of the chapter's key points and open-ended questions that address pressing issues in the field and encourage the reader to consider future directions.
From Local Invasion To Metastatic Cancer
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Author : Stanley P. L. Leong
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-10-09
From Local Invasion To Metastatic Cancer written by Stanley P. L. Leong and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-10-09 with Medical categories.
In human solid tumors, nodal status is the most important prognostic indicator for patient outcome. Recent developments in the sentinel lymph node concept have resulted in new procedures to define the first draining node as the primary gateway through which the cancer will spread. In From Local Invasion to Metastatic Cancer: Involvement of Distant Sites Through the Lymphovascular System, a panel of international authorities takes an in-depth look at the role of the lymphovascular system in the spread of cancer. The authors summarize the findings of the Second International Symposium on Cancer Metastasis: Basis for Rational Therapy summit. Specifically, the book presents important developments in the biology and clinical understanding of cancer metastasis, describes the relationship between tumor microenvironment and proliferation, and defines the process of lymphangiogenesis and angiogenesis with special reference to cancer metastasis. From Local Invasion to Metastatic Cancer: Involvement of Distant Sites Through the Lymphovascular System provides oncologists, radiologists, and cancer researchers the necessary information to study and develop new strategies to curb the process of metastasis.
Atlas Of Lymphatic System In Cancer
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Author : Shamil Gantsev
language : en
Publisher: Springer Nature
Release Date : 2020-04-01
Atlas Of Lymphatic System In Cancer written by Shamil Gantsev and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-04-01 with Medical categories.
This atlas contains a large number of original photographs illustrating the anatomy, research methods, and structural features of the structure of the lymphatic apparatus in oncological diseases. The tissue complexes of the axillary region have been studied in detail. The lymphatic maps of the axillary region in cancer are presented, including those with manifestations of lymphangiogenesis; newly formed lymph nodes formed as a result of neolymphogenesis are also considered. Atlas of Lymphatic System in Cancer: Sentinel Lymph Node, Lymphangiogenesis and Neolymphogenesis is intended for oncologists, anatomists, morphologists and doctors of other specialties. The book is the result of ten years of research. The applied technology of ultrasonic isolation of anatomical structures made it possible to take a fresh look at the lymphatic apparatus in cancer and describe the phenomenon of neolymphogenesis.
Metastasis Of Breast Cancer
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Author : R.E. Mansel
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-06-14
Metastasis Of Breast Cancer written by R.E. Mansel and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-06-14 with Health & Fitness categories.
Written by experts in the subject area, the book covers a broad range of topics in the metastasis of breast cancer, from genetics, biology to clinical management. Main topics include genetic control, biology, growth factors, cell adhesion, cell motility and invasion, natures of bone metastasis, sentinel node therapies, hormonal links, new biomarkers and detection of micrometastasis and diagnosis. This timely book also covers the current treatment options.
Vegf A Modulates Lymphangiogenic Mechanisms In An Orthotopic Model Of Human Breast Carcinoma Mda Mb 231
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Author : Brandt D. Whitehurst
language : en
Publisher:
Release Date : 2006
Vegf A Modulates Lymphangiogenic Mechanisms In An Orthotopic Model Of Human Breast Carcinoma Mda Mb 231 written by Brandt D. Whitehurst and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with categories.
Metastasis significantly contributes to cancer mortality and is facilitated by lymphangiogenesis. Recent reports indicate that VEGF-A can modulate this process. We therefore evaluated VEGF-A neutralization as a potential anti-lymphangiogenic treatment in an orthotopic model of human breast cancer MDA-MB-231. Anti-VEGF-A therapy caused an 80% reduction in lymphatic vessel density and inhibited metastasis. VEGF-A neutralization decreased expression of VEGF-C by 28% in cultured MDA-MB 231 cells but not affect global VEGF-C expression in vivo. Immunofluorescent staining of lymphatic vessels demonstrated robust expression of VEGFR-3 on LYVE-1-positive vessels in control tumors. However, decreased and aberrant expression of VEGFR-3 was detected on lymphatic vessels in VEGF-A depleted tumors. RT-PCR analysis revealed three-fold decreased expression of Ang-2 in treated tumors which correlated with decreased VEGFR-3 transcript. The study demonstrates VEGF-A neutralization is a potential target for anti-metastatic therapy and identifies a novel mechanism for VEGF-A dependent modulation of lymphangiogenesis.