Methods And Applications In Neurodegeneration

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Methods And Applications In Neurodegeneration

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Author : Tingyuan Lang
language : en
Publisher: Frontiers Media SA
Release Date : 2024-09-20

Methods And Applications In Neurodegeneration written by Tingyuan Lang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-09-20 with Science categories.

This Research Topic is part of the Methods and Applications in Frontiers in Neuroscience series. This series aims to highlight the latest experimental techniques and methods used to investigate fundamental questions in neuroscience research, with a major focus on neurodegeneration. Review articles or opinions on methodologies or applications including the advantages and limitations of each are welcome. This Topic includes technologies and up-to-date methods which help advance science. The contributions to this collection will undergo peer-review. Novelty may vary, but the utility of a method or protocol must be evident. We welcome contributions covering all aspects of Neurodegeneration, including xenobiotic and bioagents-induced neurotoxicity as a tool to study neurodegeneration and neuroprotection as well as neurotoxicity models of neurodegeneration. Submissions will be handled by the team of Topic Editors.

Methods In Neurodegenerative Disease Drug Discovery

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Author : Diego Muñoz-Torrero
language : en
Publisher: Springer Nature
Release Date : 2024-12-26

Methods In Neurodegenerative Disease Drug Discovery written by Diego Muñoz-Torrero and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-12-26 with Science categories.

This book explores the latest developments in the identification of biomarkers for early diagnosis of neurodegenerative diseases and methodologies for the biophysical; in vitro; cell-based; and in vivo profiling, during the early phases of drug discovery, new hits, leads, and drug candidates directed to a variety of biological targets with key pathogenic roles in neurodegenerative diseases. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Comprehensive and thorough, Methods in Neurodegenerative Disease Drug Discovery offers practical guidance to researchers in the medicinal chemistry community. The methods described in this book can be readily implemented in many laboratories and will aid new and experienced researchers with creating future treatments for these devastating diseases.

Neurodegenerative Diseases

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Author : Nagehan Ersoy Tunalı
language : en
Publisher: BoD – Books on Demand
Release Date : 2021-01-20

Neurodegenerative Diseases written by Nagehan Ersoy Tunalı and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-01-20 with Science categories.

Neurodegenerative diseases represent a very large group of heterogeneous disorders affecting specific subtypes of neurons in the brain. This book contributes insight both to the awareness of the brain and its neurodegenerative states. The chapters present current knowledge regarding genetics, molecular mechanisms, and new therapeutic strategies against neurodegenerative disorders. The book is intended to serve as a source to aid clinicians and researchers in the field, and also life science readers to increase their understanding and awareness of the clinical correlations, genetic aspects, neuropathological findings, and current therapeutic interventions in neurodegenerative diseases. I believe that this book will enlighten the curiosity for neurodegeneration and also encourage researchers to work on potentially effective molecular therapies for still mysterious neurodegenerative disorders.

Joint Imaging Applications In General Neurodegenerative Disease

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Author : Yongxia Zhou
language : en
Publisher:
Release Date : 2021

Joint Imaging Applications In General Neurodegenerative Disease written by Yongxia Zhou and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021 with Brain categories.

Multiple advanced neuroimaging applications in various neurodegenerative diseases including Parkinson's disease (PD), frontotemporal dementia (FTD), vascular dementia (VaD) and autism spectrum disorder (ASD) are covered in this book. Relatively novel techniques such as integrated PET/MRI and independent component analysis (ICA)-based dual regression (DR) methods were developed to capture multi-level molecular/functional and structural/microstructural as well as high-order inter-network coordination abnormalities. For instance, both PET dopamine transporter and striatal binding ratio reductions in the caudate and putamen were found in PD, consistent with the diffusion tensor imaging (DTI) fractional anisotropy (FA) reduction and fMRI voxel-mirrored homotopic correlation (VMHC) in the substantia nigra (swallow tail sign signature of PD). Furthermore, dopamine storage and pathway labeled with the vesicular monoamine transporter tracer identified decreased densities in the bilateral mesial temporal cortex, caudate, orbitofrontal cortex, left frontal and occipital cortices, consistent with the morphological atrophy, functional connectivity and conductivity deficits in PD. Similarly in FTD patients, the advanced MRI methods such as ICA-DR, VMHC, voxel-based morphometry (VBM) as well as PET tracer for amyloid accumulation and FDG glucose uptake identified typical brain atrophy, structural dis-connectivity, glucose hypometabolism, higher neuropathological burden, lower interhemispheric correlation as well as disrupted intra- and inter-network modulation in the orbitofrontal and anterior temporal cortices together with insular and frontoparietal networks, with the cerebellum and dorsolateral attentional network as typical compensations.Functional and structural abnormalities had further been elucidated in the VaD dependent participants and autistic children. For instance, both lower FA and VMHC, brain atrophy and functional connectivity deficits, demyelination, axonal degeneration and white matter integrity damage in several white matter tracts were present in the dependent compared to independent participants in VaD data cohort. Increased neuronal activity with higher global fractional amplitude of low frequency fluctuation (fALFF) in the conventional and slow-wave sub-band was confirmed with less efficiency of systematic integration in VaD dependent group. Moreover, in ASD compared to controls, regional gray matter volume and cortical thickness in all four brain lobes increased, whereas white matter volume were decreased in addition to the lower temporal, visual and superior frontal but higher inferior and dorsolateral prefrontal cortical functional connectivities exhibited in ASD. The differences in each type of disease could also be revealed with the same imaging method based on either unique region or distinct brain circuit inter-connection, using VMHC, ICA-DR, DTI, VBM, fALFF and graph-theory based small-worldness analysis.In this book, we have developed and generalized conventional and advanced imaging methodologies to several common neurodegenerative diseases. For instance, we have identified the unique imaging signature for each disease type and the underlying neuropathological mechanism connections with conductivity, structural and microstructural connectivity, intra- and inter-network correlation, systematic integration and efficiency analyses. Our objective, comprehensive and confirmative results indicated great potential in utilizing these quantifications for accurate disease classification and staging. With solid imaging evidence, thorough analysis and generalized applications, this book should capture the interests of readers in the broad fields of brain science, disease diagnosis and effective treatment.

From Imaging To Inflammation Exploring Neurodegenerative Mechanisms Through Advanced Techniques

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Author : Ali Keshavarzian
language : en
Publisher: Nobel Sciences
Release Date : 2025-04-07

From Imaging To Inflammation Exploring Neurodegenerative Mechanisms Through Advanced Techniques written by Ali Keshavarzian and has been published by Nobel Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-04-07 with Medical categories.

Chapters Chapter 1: Advances in Neuroimaging Techniques: Applications of fMRI, PET, and EEG in Understanding Brain Dynamics Chapter 2: Neuroinflammation: Mechanisms and Therapeutic Targets in Neurodegenerative Diseases Chapter 3: Multimodal Imaging Approaches in Neuroscience Chapter 4: Biomarkers of Neuroinflammation in Neurodegenerative Diseases

Handbook Of Computational Neurodegeneration

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Author : Panagiotis Vlamos
language : en
Publisher: Springer Nature
Release Date : 2023-07-25

Handbook Of Computational Neurodegeneration written by Panagiotis Vlamos and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-07-25 with Medical categories.

The Handbook of Computational Neurodegeneration provides a comprehensive overview of the field and thus bridges the gap between standard textbooks of research on neurodegeneration and dispersed publications for specialists that have a narrowed focus on computational methods to study this complicated process. The handbook reviews the central issues and methodological approaches related to the field for which the reader pursues a thorough overview. It also conveys more advanced knowledge, thus serving both as an introductory text and as a starting point for an in-depth study of a specific area, as well as a quick reference source for the expert by reflecting the state of the art and future prospects. The book includes topics that are usually missing in standard textbooks and that are only marginally represented in the specific literature. The broad scope of this handbook is reflected by five major parts that facilitate an integration of computational concepts, methods and applications in the study of neurodegeneration. Each part is intended to stand on its own, giving an overview of the topic and the most important problems and approaches, which are supported by examples, practical applications, and proposed methodologies. The basic concepts and knowledge, standard procedures and methods are presented, as well as recent advances and new perspectives.

Computational Modeling And Machine Learning Methods In Neurodevelopment And Neurodegeneration From Basic Research To Clinical Applications

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Author : Pablo Martinez-Cañada
language : en
Publisher: Frontiers Media SA
Release Date : 2024-11-22

Computational Modeling And Machine Learning Methods In Neurodevelopment And Neurodegeneration From Basic Research To Clinical Applications written by Pablo Martinez-Cañada and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-11-22 with Science categories.

Computational models and machine-learning methods are increasingly valuable tools to shed light on the dynamics that govern information processing in the nervous system, as well as their disruption in pathological conditions. A variety of techniques has been used to understand how networks of neurons in the brain encode, elaborate and transmit information about the external world, and how this information influences decision-making and behavior. Structural and functional abnormalities in the above-mentioned networks can lead to a wide range of brain disorders. Recent advances in brain simulation and machine-learning techniques, together with progress in the neuroimaging field, have been essential for bridging the different spatial scales in the brain and uncovering the processes underlying cognitive, motor and behavioral impairment in neurodevelopmental and neurodegenerative disorders.

Nanobiotechnology In Neurodegenerative Diseases

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Author : Mahendra Rai
language : en
Publisher: Springer Nature
Release Date : 2019-12-02

Nanobiotechnology In Neurodegenerative Diseases written by Mahendra Rai and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-12-02 with Medical categories.

This book focuses on neurodegenerative diseases which have become a major threat to human health. Neurodegenerative diseases are age related disorders and have become increasingly prevalent in the elderly population in recent years. Hence, there is an urgent need to study and develop new strategies and alternative methods for the treatment of neurodegenerative diseases. This book showcases the promises that nanobiotechnology brings in research, diagnosis, and treatment of neurodegenerative diseases. It is very beneficial for varied group of readers including nanotechnologists, biotechnologists, pharmacists, medical professionals, bioengineers, biochemists and researchers working in this field. Nanobiotechnology in Neurodegenerative Diseases include various chapters including neurodegeneration and neurodegenerative diseases, nanotechnology for the rescue of neurodegenerative diseases, promising potential of nanomaterials for diagnosis and therapy of neurodegenerative diseases, nanotechnology mediated nose-to-brain drug delivery, and formulation and characterization of intranasal nanoparticles of antiretroviral drugs.

Handbook Of Neurodegenerative Disorders

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Author : Musthafa M. Essa
language : en
Publisher: Springer Nature
Release Date : 2024-10-23

Handbook Of Neurodegenerative Disorders written by Musthafa M. Essa and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-10-23 with Science categories.

This Handbook discusses the pathology, etiology, pathogenesis, and therapeutic interventions of different neurodegenerative diseases. The initial section of the Handbook reviews the recent advances in understanding neurodegenerative diseases and the commonalities and differences between the major pathologies. The subsequent section presents recent developments in understanding fundamental biological mechanisms that influence the onset and development of neurodegenerative diseases. It provides current biomedical studies that are aimed at identifying the underlying causes of neurodegeneration. The book also examines the recent observations from biological, cellular, and studies from the model organisms for gaining mechanistic insights into neurodegenerative disorders. It also presents the epidemiological and genetics studies relevant to clinical aspects of neurodegenerative diseases. The book's subsequent chapters offer new and more effective therapeutic strategies to combat these devastating diseases. Towards the end, the Handbook presents recent advances in molecular diagnostics for neurodegenerative disorders and a perspective on the future directions to provide a framework for further developments and refinements of molecular diagnostics to combat neurodegenerative diseases.

Multimodal Neuroimaging Computing For The Characterization Of Neurodegenerative Disorders

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Author : Sidong Liu
language : en
Publisher: Springer
Release Date : 2017-01-11

Multimodal Neuroimaging Computing For The Characterization Of Neurodegenerative Disorders written by Sidong Liu and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-01-11 with Computers categories.

This thesis covers various facets of brain image computing methods and illustrates the scientific understanding of neurodegenerative disorders based on four general aspects of multimodal neuroimaging computing: neuroimaging data pre-processing, brain feature modeling, pathological pattern analysis, and translational model development. It demonstrates how multimodal neuroimaging computing techniques can be integrated and applied to neurodegenerative disease research and management, highlighting relevant examples and case studies. Readers will also discover a number of interesting extension topics in longitudinal neuroimaging studies, subject-centered analysis, and the brain connectome. As such, the book will benefit all health informatics postgraduates, neuroscience researchers, neurology and psychiatry practitioners, and policymakers who are interested in medical image computing and computer-assisted interventions. “br>