Multi Scale Extracellular Matrix Mechanics And Mechanobiology

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Multi Scale Extracellular Matrix Mechanics And Mechanobiology

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Author : Yanhang Zhang
language : en
Publisher: Springer
Release Date : 2019-07-12

Multi Scale Extracellular Matrix Mechanics And Mechanobiology written by Yanhang Zhang and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-07-12 with Technology & Engineering categories.

This book describes the current state of knowledge in the field of multi-scale ECM mechanics and mechanobiology with a focus on experimental and modelling studies in biomechanical characterization, advanced optical microscopy and imaging, as well as computational modeling. This book also discusses the scale dependency of ECM mechanics, translation of mechanical forces from tissue to cellular level, and advances and challenges in improving our understanding of cellular mechanotransduction in the context of living tissues and organisms.

Mechanobiology Of Cell Cell And Cell Matrix Interactions

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Author : A. Wagoner Johnson
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-02-21

Mechanobiology Of Cell Cell And Cell Matrix Interactions written by A. Wagoner Johnson and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-02-21 with Technology & Engineering categories.

Mechanobiology of Cell-Matrix Interactions focuses on characterization and modeling of interactions between cells and their local extracellular environment, exploring how these interactions may mediate cell behavior. Studies of cell-matrix interactions rely on integrating engineering, (molecular and cellular) biology, and imaging disciplines. Recent advances in the field have begun to unravel our understanding of how cells gather information from their surrounding environment, and how they interrogate such information during the cell fate decision making process. Topics include adhesive and integrin-ligand interactions; extracellular influences on cell biology and behavior; cooperative mechanisms of cell-cell and cell-matrix interactions; the mechanobiology of pathological processes; (multi-scale) modeling approaches to describe the complexity or cell-matrix interactions; and quantitative methods required for such experimental and modeling studies.

Cell And Matrix Mechanics

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Author : Roland Kaunas
language : en
Publisher: CRC Press
Release Date : 2014-10-23

Cell And Matrix Mechanics written by Roland Kaunas and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-10-23 with Medical categories.

Explores a Range of Multiscale Biomechanics/Mechanobiology Concepts Cell and Matrix Mechanics presents cutting-edge research at the molecular, cellular, and tissue levels in the field of cell mechanics. This book involves key experts in the field, and covers crucial areas of cell and tissue mechanics, with an emphasis on the roles of mechanical forces in cell–matrix interactions. Providing material in each chapter that builds on the previous chapters, it effectively integrates length scales and contains, for each length scale, key experimental observations and corresponding quantitative theoretical models. Summarizes the Three Hierarchical Levels of Cell Mechanics The book contains 14 chapters and is organized into three sections. The first section focuses on the molecular level, the second section details mechanics at the cellular level, and the third section explores cellular mechanics at the tissue level. The authors offer a thorough description of the roles of mechanical forces in cell and tissue biology, and include specific examples. They incorporate descriptions of associated theoretical models, and provide the data and modeling framework needed for a multi-scale analysis. In addition, they highlight the pioneering studies in cell–matrix mechanics by Albert K. Harris. The topics covered include: The passive and active mechanical properties of cytoskeletal polymers and associated motor proteins along with the behavior of polymer networks The mechanical properties of the cell membrane, with an emphasis on membrane protein activation caused by membrane forces The hierarchical organization of collagen fibrils, revealing that a delicate balance exists between specific and nonspecific interactions to result in a structure with semicrystalline order as well as loose associations The roles of matrix mechanical properties on cell adhesion and function along with different mechanical mechanisms of cell–cell interactions The effects of mechanical loading on cell cytoskeletal remodeling, summarizing various modeling approaches that explain possible mechanisms regulating the alignment of actin stress fibers in response to stretching The mechanical testing of cell-populated collagen matrices, along with theory relating the passive and active mechanical properties of the engineered tissues Cell migration behavior in 3-D matrices and in collective cell motility The role of mechanics in cartilage development The roles of both cellular and external forces on tissue morphogenesis The roles of mechanical forces on tumor growth and cancer metastasis Cell and Matrix Mechanics succinctly and systematically explains the roles of mechanical forces in cell–matrix biology. Practitioners and researchers in engineering and physics, as well as graduate students in biomedical engineering and mechanical engineering related to mechanobiology, can benefit from this work.

Biomechanics Of The Aorta

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Author : T. Christian Gasser
language : en
Publisher: Elsevier
Release Date : 2024-06-18

Biomechanics Of The Aorta written by T. Christian Gasser and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-06-18 with Science categories.

Biomechanics of the Aorta: Modelling for Patient Care is a holistic analysis of the aorta towards its biomechanical description. The book addresses topics such as physiology, clinical imaging, tissue and blood flow modeling, along with knowledge that is needed in diagnostics, aortic rupture prediction, assist surgical planning, and more. It encompasses a wide range of topics from the basic sciences (Vascular biology, Continuum mechanics, Image analysis) to clinical applications, as well as describing and presenting computational studies and experimental benches to mimic, understand and propose the best treatment of aortic pathologies. The book begins with an introduction to the fundamental aspects of the anatomy, biology and physiopathology of the aorta and proceeds to present the main computational fluid dynamic studies and biomechanical and mechanobiological models developed over the last decade. With approaches, methodologies and findings from contributors all over the world, this new volume in the Biomechanics of Living Organs series will increase understanding of aortic function as well as improve the design of medical devices and clinical interventions, including surgical procedures. - Comprehensive coverage of the main computational fluid dynamic studies and biomechanical and mechanobiological models developed over the last decade - Introduces the most recent imaging technologies to characterize factors, including aortic geometry, mechanical properties of aortic tissues, and cellular activity in the vessel wall - Synthesizes advances in vascular biomechanics, medical imaging, and computational modeling of finite element fluid and solid models

Structure And Function Of The Extracellular Matrix

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Author : Bela Suki
language : en
Publisher: Academic Press
Release Date : 2021-11-27

Structure And Function Of The Extracellular Matrix written by Bela Suki and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-27 with Technology & Engineering categories.

Structure and Function of the Extracellular Matrix: A Multiscale Quantitative Approach introduces biomechanics and biophysics with applications to understand the biological function of the extracellular matrix in health and disease. A general multiscale approach is followed by investigating behavior from the scale of single molecules, through fibrils and fibers, to tissues of various organ systems. Through mathematical models and structural information, quantitative description of the extracellular matrix function is derived with tissue specific details. The book introduces the properties and organization of extracellular matrix components and quantitative models of the matrix, and guides the reader through predicting functional properties. This book integrates evolutionary biology with multiscale structure to quantitatively understand the function of the extracellular matrix. This approach allows a fresh look into normal functioning as well as the pathological alterations of the extracellular matrix. Professor Suki's book is written to be useful to undergraduates, graduate students, and researchers interested in the quantitative aspects of the extracellular matrix. Researchers working in mechanotransduction, respiratory and cardiovascular mechanics, and multiscale biomechanics of tendon, cartilage, skin, and bone may also be interested in this book. - Examines the evolutionary origins and consequences of the extracellular matrix - Delivers the first book to quantitatively treat the extracellular matrix as a multiscale system - Presents problems and a set of computational laboratory projects in various chapters to aid teaching and learning - Provides an introduction to the properties and organization of the extracellular matrix components

Extracellular Matrix Dynamics In Biology Bioengineering And Pathology Volume Ii

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Author : Rajprasad Loganathan
language : en
Publisher: Frontiers Media SA
Release Date : 2023-01-05

Extracellular Matrix Dynamics In Biology Bioengineering And Pathology Volume Ii written by Rajprasad Loganathan and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-01-05 with Science categories.

Emerging Technologies For Musculoskeletal Disease Modeling And Regenerative Medicine

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Author : Andrea Vernengo
language : en
Publisher: Frontiers Media SA
Release Date : 2023-09-06

Emerging Technologies For Musculoskeletal Disease Modeling And Regenerative Medicine written by Andrea Vernengo and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-09-06 with Science categories.

Multiscale Mechanobiology In Tissue Engineering

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Author : Damien Lacroix
language : en
Publisher: Springer
Release Date : 2018-07-31

Multiscale Mechanobiology In Tissue Engineering written by Damien Lacroix and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-07-31 with Science categories.

This book focuses on the mechanobiological principles in tissue engineering with a particular emphasis on the multiscale aspects of the translation of mechanical forces from bioreactors down to the cellular level. The book contributes to a better understanding of the design and use of bioreactors for tissue engineering and the use of mechanical loading to optimize in vitro cell culture conditions. It covers experimental and computational approaches and the combination of both to show the benefits that computational modelling can bring to experimentalists when studying in vitro cell culture within a scaffold. With topics from multidisciplinary fields of the life sciences, medicine, and engineering, this work provides a novel approach to the use of engineering tools for the optimization of biological processes and its application to regenerative medicine. The volume is a valuable resource for researchers and graduate students studying mechanobiology and tissue engineering. For undergraduate students it also provides deep insight into tissue engineering and its use in the design of bioreactors. The book is supplemented with extensive references for all chapters to help the reader to progress through the study of each topic.

Mathematical Modeling Of The Healthy And Diseased Lung

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Author : Béla Suki
language : en
Publisher: Springer Nature
Release Date : 2025-07-11

Mathematical Modeling Of The Healthy And Diseased Lung written by Béla Suki and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-07-11 with Technology & Engineering categories.

The lung is a complex multiscale organ that serves as the primary interface between the environment and the tissues of the body. Homeostatic maintenance of lung function throughout life is essential for health. While failure of lung homeostasis underlies many of the most common chronic diseases that afflict mankind, the precise pathophysiologic mechanisms involved are often unclear. Investigative techniques such as microscopic imaging and atomic force microscopy are providing new insights into lung tissue properties at the micro scale. It nevertheless remains to be seen how this growing body of information can be integrated into a comprehensive picture of the lung. Mathematical and computational modeling has emerged as an essential tool for gaining such a holistic understanding. This book introduces the reader to the art of modeling as a means of linking lung structure to function over multiple length scales from the intracellular level to that of the whole organ, with specific attention given to the pathophysiology of a number of common lung diseases and aging.

Multiscale Mechanobiology Of Bone Remodeling And Adaptation

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Author : Peter Pivonka
language : en
Publisher: Springer
Release Date : 2017-06-20

Multiscale Mechanobiology Of Bone Remodeling And Adaptation written by Peter Pivonka and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-06-20 with Science categories.

The book presents state-of-the-art developments in multiscale modeling and latest experimental data on multiscale mechanobiology of bone remodeling and adaptation including fracture healing applications. The multiscale models include musculoskeletal models describing bone-muscle interactions during daily activities such as walking or running, micromechanical models for estimation of bone mechanical properties, bone remodeling and adaptation models, cellular models describing the complex bone-cell interactions taking into account biochemical and biomechanical regulatory factors. Also subcellular processes are covered including arrangement of actin filaments due to mechanical loading and change of receptor configurations.