Neuronal Network Dysfunction In Neurodegenerative Disorders
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Neuronal Network Dysfunction In Neurodegenerative Disorders
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Author : Andrea Kwakowsky
language : en
Publisher: Frontiers Media SA
Release Date : 2023-03-28
Neuronal Network Dysfunction In Neurodegenerative Disorders written by Andrea Kwakowsky and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-03-28 with Science categories.
Neuronal Networks In Brain Function Cns Disorders And Therapeutics
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Author : Carl Faingold
language : en
Publisher: Academic Press
Release Date : 2013-12-26
Neuronal Networks In Brain Function Cns Disorders And Therapeutics written by Carl Faingold and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-12-26 with Medical categories.
Neuronal Networks in Brain Function, CNS Disorders, and Therapeutics, edited by two leaders in the field, offers a current and complete review of what we know about neural networks. How the brain accomplishes many of its more complex tasks can only be understood via study of neuronal network control and network interactions. Large networks can undergo major functional changes, resulting in substantially different brain function and affecting everything from learning to the potential for epilepsy. With chapters authored by experts in each topic, this book advances the understanding of: - How the brain carries out important tasks via networks - How these networks interact in normal brain function - Major mechanisms that control network function - The interaction of the normal networks to produce more complex behaviors - How brain disorders can result from abnormal interactions - How therapy of disorders can be advanced through this network approach This book will benefit neuroscience researchers and graduate students with an interest in networks, as well as clinicians in neuroscience, pharmacology, and psychiatry dealing with neurobiological disorders. - Utilizes perspectives and tools from various neuroscience subdisciplines (cellular, systems, physiologic), making the volume broadly relevant - Chapters explore normal network function and control mechanisms, with an eye to improving therapies for brain disorders - Reflects predominant disciplinary shift from an anatomical to a functional perspective of the brain - Edited work with chapters authored by leaders in the field around the globe – the broadest, most expert coverage available
Brain Network Dysfunction In Neuropsychiatric Illness
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Author : Vaibhav A. Diwadkar
language : en
Publisher: Springer Nature
Release Date : 2021-05-11
Brain Network Dysfunction In Neuropsychiatric Illness written by Vaibhav A. Diwadkar and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-05-11 with Medical categories.
Brain network function and dysfunction is the dominant model for understanding how the brain gives rise to normal and abnormal behavior. Moreover, neuropsychiatric illnesses continue to resist attempts to reveal an understanding of their bases. Thus, this timely volume provides a synthesis of the uses of multiple analytic methods as they are applied to neuroimaging data, to seek understanding of the neurobiological bases of psychiatric illnesses, understanding that can subsequently aid in their management and treatment. A principle focus is on the analyses and application of methods to functional magnetic resonance imaging (fMRI) data. fMRI remains the most widely used neuroimaging technique for estimating brain network function, and several of the methods covered can estimate brain network dysfunction in resting and task-active states. Additional chapters provide details on how these methods are (and can be) applied in the understanding of several neuropsychiatric disorders, including schizophrenia, mood disorders, autism, borderline personality disorder, and attention deficit hyperactivity disorder (ADHD). A final complement of chapters provides a collective overview of how this framework continues to provoke theoretical advances in our conception of the brain in psychiatry. This unique volume is designed to be a comprehensive resource for imaging researchers interested in psychiatry, and for psychiatrists interested in advanced imaging applications.
Synaptic Plasticity In Neurodegenerative Disorders
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Author : Sangeeta Singh
language : en
Publisher: CRC Press
Release Date : 2024-12-24
Synaptic Plasticity In Neurodegenerative Disorders written by Sangeeta Singh and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-12-24 with Science categories.
This book explores the pivotal role of synaptic plasticity in the pathogenesis, progression, and potential treatment of neurodegenerative disorders. The initial chapter provides an in-depth understanding of the complexity and impact of neurodegenerative conditions. It discusses the association of mitochondrial dysfunction, epigenetic influences, and neuroinflammation with synaptic plasticity in neurodegenerative diseases. The following chapters review the dynamic changes that occur at the cellular and synaptic levels in Parkinson's disease, Alzheimer's disease, and Huntington's disease, paving the way for innovative therapeutic strategies. Furthermore, the book presents various computational tools and methodologies essential for enhancing our understanding of synaptic plasticity. It examines the transformative role of artificial intelligence tools in addressing synaptic impairment across various neurodegenerative diseases. Discusses the role of synaptic plasticity in neurodegenerative diseases, shedding light on how dynamic changes occur at the cellular and synaptic levels Explores the transformative role of artificial intelligence tools in addressing synaptic impairment across various neurodegenerative diseases Provides a comprehensive overview of neurodegenerative disorders, including pathogenesis, etiology, and treatment strategies Presents tools and techniques used to simulate the complex system biology of synaptic plasticity Examines the role of computational neuroscience in understanding and potentially treating conditions such as multiple sclerosis and amyotrophic lateral sclerosis Toward the end, the book explores the role of synaptic impairment and computational neuroscience in understanding and potentially treating conditions such as multiple sclerosis and amyotrophic lateral sclerosis. With its multifaceted approach, this book serves as a useful resource for researchers, clinicians, and students in the fields of neuroscience, computational biology, and neurology.
The Aging Mind
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Author : National Research Council
language : en
Publisher: National Academies Press
Release Date : 2000-04-18
The Aging Mind written by National Research Council and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-04-18 with Social Science categories.
Possible new breakthroughs in understanding the aging mind that can be used to benefit older people are now emerging from research. This volume identifies the key scientific advances and the opportunities they bring. For example, science has learned that among older adults who do not suffer from Alzheimer's disease or other dementias, cognitive decline may depend less on loss of brain cells than on changes in the health of neurons and neural networks. Research on the processes that maintain neural health shows promise of revealing new ways to promote cognitive functioning in older people. Research is also showing how cognitive functioning depends on the conjunction of biology and culture. The ways older people adapt to changes in their nervous systems, and perhaps the changes themselves, are shaped by past life experiences, present living situations, changing motives, cultural expectations, and emerging technology, as well as by their physical health status and sensory-motor capabilities. Improved understanding of how physical and contextual factors interact can help explain why some cognitive functions are impaired in aging while others are spared and why cognitive capability is impaired in some older adults and spared in others. On the basis of these exciting findings, the report makes specific recommends that the U.S. government support three major new initiatives as the next steps for research.
Neurodegenerative Diseases
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Author : Jagan A Pillai PhD
language : en
Publisher: Oxford University Press
Release Date : 2016-10-17
Neurodegenerative Diseases written by Jagan A Pillai PhD and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-10-17 with Medical categories.
As the global population ages the impact of neurodegenerative diseases like Alzheimer's disease and Parkinson's disease are significant forces in shaping human health and quality of life in the 21st century. Insights into understanding these diseases, and knowing how to treat them are major frontiers of scientific research. Neurodegenerative Diseases: Unifying Principles is the result of a conceptual revolution over the last decade in our understanding of neurodegenerative diseases as sharing unifying features. There is an increasing appreciation of the common biological and pathological features across seemingly varied neurodegenerative diseases that entail protein misfolding dysfunction and its consequences over time. Providing an overview of this conceptual change is the main theme for the book. Conventional approach emphasize the differences among neurodegenerative disorders, here Drs. Cummings and Pillai compile the increasingly compelling evidence that these disorders share many features and that insights in one may be rapidly translated into advances in another. The goal is to accelerate understanding by showing linkages among biological, pathological, can clinical aspects of this class of diseases. This collection of 19, inter-related chapters, articulates and broadens our view of the unifying features that initiate and drive disease progression across a variety of neurodegenerative diseases over time. This book will serve as an outstanding sourcebook of insights from experts that have played key roles in this story.
Analyzing Neural Time Series Data
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Author : Mike X Cohen
language : en
Publisher: MIT Press
Release Date : 2014-01-17
Analyzing Neural Time Series Data written by Mike X Cohen and has been published by MIT Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-01-17 with Psychology categories.
A comprehensive guide to the conceptual, mathematical, and implementational aspects of analyzing electrical brain signals, including data from MEG, EEG, and LFP recordings. This book offers a comprehensive guide to the theory and practice of analyzing electrical brain signals. It explains the conceptual, mathematical, and implementational (via Matlab programming) aspects of time-, time-frequency- and synchronization-based analyses of magnetoencephalography (MEG), electroencephalography (EEG), and local field potential (LFP) recordings from humans and nonhuman animals. It is the only book on the topic that covers both the theoretical background and the implementation in language that can be understood by readers without extensive formal training in mathematics, including cognitive scientists, neuroscientists, and psychologists. Readers who go through the book chapter by chapter and implement the examples in Matlab will develop an understanding of why and how analyses are performed, how to interpret results, what the methodological issues are, and how to perform single-subject-level and group-level analyses. Researchers who are familiar with using automated programs to perform advanced analyses will learn what happens when they click the “analyze now” button. The book provides sample data and downloadable Matlab code. Each of the 38 chapters covers one analysis topic, and these topics progress from simple to advanced. Most chapters conclude with exercises that further develop the material covered in the chapter. Many of the methods presented (including convolution, the Fourier transform, and Euler's formula) are fundamental and form the groundwork for other advanced data analysis methods. Readers who master the methods in the book will be well prepared to learn other approaches.
The Bereitschaftspotential
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Author : Marjan Jahanshahi
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
The Bereitschaftspotential written by Marjan Jahanshahi and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
Kornhuber and Deecke first recorded and reported the Bereitschaftspotential in 1964. The aim of this book is to bring together in a single volume some of the important research on the Bereitschaftspotential and other movement-related cortical potentials and to highlight and address some of the pertinent questions relating to the Bereitschaftspotential and to identify the key issues for future investigation in this field. This book represents a unique compilation of information about the Bereitschaftspotential and related cortical potentials and techniques for measuring preparatory processes in the brain. The book will be of interest to motor physiologists, psychologists and neurologists working in clinical or research laboratories.
Addiction And Neurodegenerative Disorders
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Author : Samer El Hayek
language : en
Publisher: CRC Press
Release Date : 2026-01-22
Addiction And Neurodegenerative Disorders written by Samer El Hayek and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2026-01-22 with Medical categories.
The brain regions and neuronal processes that underlie addiction extensively overlap with those needed for cognitive functions, including learning, memory, and reasoning. Addiction negatively impacts cognitive functions, making it more challenging to maintain abstinence and potentially leading to progression into neurodegenerative disorders. Furthermore, individuals living with neurodegenerative disorders can engage in behaviors, such as self-medication, due to impaired judgment and impulsivity associated with their condition. Addressing either of these conditions becomes markedly more intricate when they co-occur. This book explores the intricate and often overlooked connection between neurodegenerative disorders and addiction. It delves into the complex interplay between the two areas, discussing preclinical to clinical findings that highlight commonalities, shared risk factors, causality, comorbidity, management, and evidence-based interventions. By examining all these factors, an international team of contributors offer a comprehensive understanding of this underexplored intersection and its profound implications on affected individuals and their families, the healthcare system, and treatment strategies.
Neurodegenerative Diseases
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Author : Sachchida Nand Rai
language : en
Publisher: CRC Press
Release Date : 2024-12-02
Neurodegenerative Diseases written by Sachchida Nand Rai and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-12-02 with Science categories.
This reference book provides a comprehensive overview of models and therapeutic approaches against neurodegenerative diseases, including Parkinson’s disease, Alzheimer’s disease, Huntington’s disease, and amyotrophic lateral sclerosis. It explores models based on the chemical, induced, cellular, genetic, transgenic, and 3D organoid approaches in neurodegenerative diseases. The book also reviews advantages and limitations of these models in designing the treatment strategies. Additionally, the book covers the emerging field of bioinformatics and its application in modeling various neurodegenerative diseases. Towards the end, the book highlights the role of holistic management, precision medicine, OMICS, and gene therapy against neurodegenerative disorders. It examines the implications and significance of stem cells therapy in translational models of neurodegenerative diseases. This book is an invaluable resource for researchers, neuroscientists, and neurosurgeons for getting in-depth information on the neurodegenerative models and therapeutic approaches. Key Features: Provides a comprehensive overview of neurodegenerative diseases and their models Examines the limitations associated with modeling neurodegenerative diseases Presents novel treatment strategies for Alzheimer's disease using cellular models Reviews importance of 3D organoid models for therapeutic approaches in Parkinson's disease Covers modeling techniques in understanding prion diseases Explores the role of genetic models in understanding Huntington's disease