Neuroprotective Signal Transduction
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Neuroprotective Signal Transduction
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Author : Mark P. Mattson
language : en
Publisher: Springer Science & Business Media
Release Date : 1997-10-10
Neuroprotective Signal Transduction written by Mark P. Mattson and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997-10-10 with Medical categories.
In Neuroprotective Signal Transduction prominent researchers and clinicians focus on how inter- and intracellular signaling mechanisms prevent the degeneration and death of neurons occurring in both acute and chronic neurodegenerative disorders. Authoritative contributions dissect the signaling pathways of an array of neuroprotective factors-ranging from neurotrophins (NGF, BDNF, NT-3, and NT-4/5), to growth factors (bFGF, IGF-1, GDNF), to cytokines (TNF, IL-1b, and TGFb), to secreted amyloid precursor proteins, to protease nexin-1. Also treated are cytoprotective signaling events that occur within injured neurons independently of intercellular signals. Neuroprotective Signal Transduction presents fundamental, cutting-edge treatment of the cellular and molecular signal transduction pathways found in human neurodegenerative conditions. The book's elucidation of the molecular cascades evolved by the nervous system to protect itself is now lead to effective strategies for preventing neuronal degeneration in such conditions as stroke, traumatic brain injury, Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis, and will form the basis for powerful new drug discovery and gene therapy strategies.
Neuroprotective Signal Transduction
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Author : Mark P. Mattson
language : en
Publisher:
Release Date : 2014-01-15
Neuroprotective Signal Transduction written by Mark P. Mattson and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-01-15 with categories.
Nicotinic Acetylcholine Receptor Signaling In Neuroprotection
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Author : Akinori Akaike
language : en
Publisher: Springer
Release Date : 2018-04-04
Nicotinic Acetylcholine Receptor Signaling In Neuroprotection written by Akinori Akaike and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-04-04 with Medical categories.
This open access book presents the roles and mechanisms of signal transduction triggered by nicotinic acetylcholine receptors (nAChRs) stimulation in neuroprotection against toxic effects of risk factors of neurodegenerative diseases. Accumulating evidence suggests that nAChRs in the CNS play important roles not only in excitatory neurotransmission but also in neuronal survival and related functions. Neuroprotection mediated by nAChRs in neurodegenerative diseases such as Alzheimer's disease is the major topic of this book. In response to rapidly evolving areas in clinical and laboratory neuropharmacology and neurochemistry, this volume provides in-depth coverage of neuroprotection in basic research and future developments in the clinical application of effective neuroprotective strategies in neurodegenerative diseases. This work appeals to both basic and clinical researchers in several fields, such as neuroscience, neurology, and pharmacology.
Nicotinic Acetylcholine Receptor Signaling In Neuroprotection
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Author : Shun Shimohama
language : en
Publisher:
Release Date : 2020-10-08
Nicotinic Acetylcholine Receptor Signaling In Neuroprotection written by Shun Shimohama and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-10-08 with Medical categories.
This open access book presents the roles and mechanisms of signal transduction triggered by nicotinic acetylcholine receptors (nAChRs) stimulation in neuroprotection against toxic effects of risk factors of neurodegenerative diseases. Accumulating evidence suggests that nAChRs in the CNS play important roles not only in excitatory neurotransmission but also in neuronal survival and related functions. Neuroprotection mediated by nAChRs in neurodegenerative diseases such as Alzheimer's disease is the major topic of this book. In response to rapidly evolving areas in clinical and laboratory neuropharmacology and neurochemistry, this volume provides in-depth coverage of neuroprotection in basic research and future developments in the clinical application of effective neuroprotective strategies in neurodegenerative diseases. This work appeals to both basic and clinical researchers in several fields, such as neuroscience, neurology, and pharmacology. This work was published by Saint Philip Street Press pursuant to a Creative Commons license permitting commercial use. All rights not granted by the work's license are retained by the author or authors.
Neuroprotection Methods And Protocols
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Author : Tiziana Borsello
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-08-08
Neuroprotection Methods And Protocols written by Tiziana Borsello and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-08-08 with Medical categories.
This book examines current research into the role of neuronal death in cell signaling pathways, and its role in neurodegenerative diseases, such as Alzheimer's and Parkinson's. After introducing neurodegenerative, traumatic, and ishemic disorders, the authors cover in vitro and animal systems, and cellular and molecular mechanisms.
Phytochemicals Signal Transduction And Neurological Disorders
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Author : Akhlaq A. Farooqui
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-07-10
Phytochemicals Signal Transduction And Neurological Disorders written by Akhlaq A. Farooqui and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-07-10 with Medical categories.
Phytochemicals Signal Transduction and Neurological Disorders Phytochemicals are heterogeneous group of bioactive compounds produced by plants, which are extensively researched by scientists for their health-promoting potentials in human diseases. Unlike vitamins and minerals, phytochemicals are not required for sustaining cell viability, but they play an important role in protecting tissues and cells from the harmful effects of oxidative stress and inflammation. Examples of phytochemicals include catechins, resveratrol, ginkgo biloba, curcumin, and sulfur compounds found in garlic. Although, the precise molecular mechanisms associated with beneficial effects of phytochemicals still remain the subject of intense investigations, but it is becoming increasingly evident that phytochemicals mediate their effects by counteracting, reducing, and repairing the damage caused by oxidative stress and neuroinflammation. In addition, phytochemicals also stimulate the synthesis of adaptive enzymes and proteins through the stimulation of a transcription factor called Nrf2 and induction of phase II detoxifying enzymes. Consumption of phytochemicals induces neurohormetic response that results in the expression of adaptive stress-resistance genes that are responsible for encoding antioxidant enzymes, protein chaperones, and neurotrophic factor (BDNF). Based on the stimulation of signal transduction network and adaptive stress-resistance genes, it is proposed that the use of phytochemicals from childhood to old age along with regular exercise is an important strategy for maintaining normal aging and delaying onset of age-related neurological disorders (stroke, Alzheimer disease, and Parkinson disease). Phytochemicals Signal Transduction and Neurological Disorders presents readers with cutting edge and comprehensive information not only on bioavailability, and mechanism of action of phytochemicals in the brain, but also provides the molecular mechanism associated with beneficial effects of phytochemicals in neurotraumatic (stroke, spinal cord trauma, and traumatic brain injury) and neurodegenerative (Alzheimers disease, Parkinson disease, Huntington disease, and amyotrophic lateral sclerosis) diseases.
Neuroinflammation Resolution And Neuroprotection In The Brain
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Author : Akhlaq A. Farooqui
language : en
Publisher: Academic Press
Release Date : 2021-09-15
Neuroinflammation Resolution And Neuroprotection In The Brain written by Akhlaq A. Farooqui and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-09-15 with Medical categories.
Neuroinflammation, Resolution, and Neuroprotection in the Brain discusses the molecular aspects of neuroinflammation in neurological disorders. The book examines the effect of diet and exercise on neuroinflammatory diseases. Chapters focus on bioactive lipids, cytokines and chemokines, as well as the involvement of neuroinflammation, resolution and neuroprotection in neurotraumatic diseases, neurodegenerative diseases and neuropsychiatric diseases. The comprehensive information in this monograph will help readers understand molecular cross-talk among mediators of phospholipid, sphingolipid and cholesterol metabolism. The book's goal is to jumpstart more studies on molecular mechanisms and the therapeutic aspects of neurological disorders in human subjects. Discusses the molecular aspects of neuroinflammation, resolution and neuroprotection Examines the role of diet and exercise on neuroinflammatory diseases Provides cutting-edge research on signal transduction processes Explores the treatment of neurological disorders caused by neuroinflammation
Neuroprotective Signaling Through Metabotropic Glutamate Receptor 1
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Author : Andrew Clayton Emery
language : en
Publisher:
Release Date : 2011
Neuroprotective Signaling Through Metabotropic Glutamate Receptor 1 written by Andrew Clayton Emery and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with categories.
Metabotropic glutamate receptor 1 (mGlu1) is a G protein-coupled receptor which enhances the hydrolysis of membrane phosphoinositides (PI). Additionally, mGlu1 receptors have been shown to stimulate cytoprotective signaling in the presence of the endogenous ligand glutamate. This goal of the experiments in the following thesis was to (1) characterize the signal transduction pathway through which mGlu1 receptors protect cells expressing these receptors from toxicity. Instead of the classical G protein-mediated (PI) signaling, the following experiments indicate that mGlu1a receptors cause a sustained phosphorylation of ERK that is {beta}-arrestin-1 dependent. This G protein-independent signaling pathway was necessary for protective signaling and was stimulated by glutamate, but not quisqualate, demonstrating ligand bias at this receptor. (2) Therefore, pharmacological and mutational studies were carried out to investigate the molecular basis of this ligand bias. Together, these studies indicate the existence of 3 classes of mGlu1a receptor agonists: (a) unbiased agonists, such as glutamate, which stimulate both signal transduction pathways, (b) biased agonists, such as quisqualate, which only stimulate PI hydrolysis, and (c) agonists which are biased toward sustained ERK phosphorylation and protective signaling. In these studies, glutaric and succinic acid were identified as protection-biased mGlu1a receptor agonists. Further pharmacological studies indicate that quisqualate does not inhibit glutamate-induced protection and glutaric acid fails to inhibit glutamate-induced PI hydrolysis, suggesting the existence of two distinct, non-overlapping agonist binding sites on mGlu1a receptors.
Molecular Aspects Of Neurodegeneration Neuroprotection And Regeneration In Neurological Disorders
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Author : Akhlaq A. Farooqui
language : en
Publisher: Academic Press
Release Date : 2020-09-24
Molecular Aspects Of Neurodegeneration Neuroprotection And Regeneration In Neurological Disorders written by Akhlaq A. Farooqui and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-09-24 with Medical categories.
Molecular Aspects of Neurodegeneration, Neuroprotection, and Regeneration in Neurological Disorders presents readers with comprehensive and cutting-edge information on the neurochemical mechanisms of various types of neurological disorders. The book covers information on signal transduction processes associated with neurochemistry of neurological disorders, including neurodegenerative, neurotraumatic, and neuropsychiatric disorders. The book also discusses risk factors, symptoms, pathogenesis, biomarkers, and the potential treatments of neurological disorders. The comprehensive information in this monograph may not only help in early detection of various neurological disorders, but will also promote the discovery of new drugs. Provides a comprehensive overview of the molecular aspects of neurodegeneration, neuroprotection, and neuro-regeneration, along with therapeutic strategies for various types of neurological disorders Provides cutting-edge research information on the signal transduction processes associated with the neurochemistry of neurological disorders Discusses risk factors, symptoms, pathogenesis, biomarkers, and the potential for treatments of neurological disorders
Signaling Pathways Neuroprot
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Author : Jianzhong Ji
language : en
Publisher: Open Dissertation Press
Release Date : 2017-01-27
Signaling Pathways Neuroprot written by Jianzhong Ji and has been published by Open Dissertation Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-01-27 with Medical categories.
This dissertation, "Signaling Pathways and Neuroprotection of Retinal Ganglion Cells in a Rat Glaucoma Model" by 紀建中, Jianzhong, Ji, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. DOI: 10.5353/th_b3124318 Subjects: Retinal ganglion cells Glaucoma Cellular signal transduction Neurophysiologic monitoring Rats - Physiology