Non Coding Rnas And Human Diseases Volume Ii Long Non Coding Rnas Lncrnas And Pathogenesis Of Human Disease
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Non Coding Rnas And Human Diseases Volume Ii Long Non Coding Rnas Lncrnas And Pathogenesis Of Human Disease
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Author : Yujing Li
language : en
Publisher: Frontiers Media SA
Release Date : 2024-11-06
Non Coding Rnas And Human Diseases Volume Ii Long Non Coding Rnas Lncrnas And Pathogenesis Of Human Disease written by Yujing Li and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-11-06 with Science categories.
Long non-coding RNAs (lncRNAs) are defined as transcripts longer than 200 nucleotides rarely translatable into protein, which distinguishes them from small non-coding RNAs (sncRNAs) such as miRNAs, siRNAs, piRNAs, snoRNAs exRNAs, (scaRNAs). Long intervening/intergenic noncoding RNAs (lincRNAs) refer to lncRNA non-overlapped to protein-coding genes. In terms of abundance and specificity, ~30,000 lncRNAs have been identified in human tissues with ~ 10- fold lower abundance than mRNA. Near 80% of lncRNAs show tissue-specific features, in contrast to only less than 20% of mRNAs. In addition to tissue specificity, lncRNAs are also characterized by having significantly higher developmental stage specificity. Of the identified lncRNAs, although only a very small proportion have been validated to be biologically relevant, the emerging evidence has confirmed important regulatory functions at levels of transcription, post transcription, and epigenetic control. Physiologically, lncRNAs are involved in growth, development, reproduction, aging, and pathogenesis of disease initiation and progression, such as neurological disorders and cancers.
Genetic Variants And Metabolic Diseases Volume Ii
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Author : Tarunveer Singh Ahluwalia
language : en
Publisher: Frontiers Media SA
Release Date : 2024-02-12
Genetic Variants And Metabolic Diseases Volume Ii written by Tarunveer Singh Ahluwalia and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-02-12 with Medical categories.
Metabolic syndrome (MetS) is a set of co-morbidities that collectively increase an individual’s risk of developing cardiovascular disease, stroke, and type 2 diabetes mellitus (T2D). Per the World Health Organization (WHO), MetS is typically characterized by obesity, insulin resistance, hypertension, and hyperlipidemia. Building on this point, some of the major risk factors for development of MetS include increased weight or an obese phenotype, lack of physical activity, and genetics. Interestingly, the last decade has witnessed a deluge of Genome-Wide Association Studies (GWAS) that have linked hundreds of genomic with both collective MetS traits, as well as individual metabolic disorders sitting within it. Currently, in the post-GWAS era, the focus has shifted to characterization of these novel genomic to establish causality and disease relevance. This is being pursued by way of functional validation such as gain- and loss-of-function studies, investigating resulting metabolic phenotypes, mechanisms and pathways underlying these phenotypes, their prevalence and potential for risk stratification across populations, and finally, identification of therapeutic targets for pharmacological intervention.
Non Coding Rnas And Human Diseases
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Author : Yujing Li
language : en
Publisher: Frontiers Media SA
Release Date : 2020-07-08
Non Coding Rnas And Human Diseases written by Yujing Li and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-07-08 with categories.
Evolutionary Mechanisms Of Infectious Diseases Volume Ii
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Author : Jianying Gu
language : en
Publisher: Frontiers Media SA
Release Date : 2023-04-28
Evolutionary Mechanisms Of Infectious Diseases Volume Ii written by Jianying Gu and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-04-28 with Science categories.
Th2 Associated Immunity In The Pathogenesis Of Systemic Lupus Erythematosus And Rheumatoid Arthritis
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Author : Qingjun Pan
language : en
Publisher: Frontiers Media SA
Release Date : 2022-08-04
Th2 Associated Immunity In The Pathogenesis Of Systemic Lupus Erythematosus And Rheumatoid Arthritis written by Qingjun Pan and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-08-04 with Medical categories.
Long Noncoding Rna
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Author : Susan Carpenter
language : en
Publisher: Springer Nature
Release Date : 2022-02-27
Long Noncoding Rna written by Susan Carpenter and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-02-27 with Science categories.
This book brings together what is currently known in terms of basic research in the field of long noncoding RNAs (lncRNAs) and builds on this to delve more deeply in the specific roles that lncRNAs are playing during inflammation. The book provides readers with basic knowledge on lncRNAs: from understanding the complexity of the transcriptome, conservation, structure and the tools used to investigate these aspects, to how we use this information to study lncRNAs in a specific biological context. The volume covers the emerging roles of lncRNAs in the initial stages of inflammation as well as their roles in specific inflammatory diseases including arthritis, lupus, diabetes and cardiovascular disease. The book also shows the emerging interest in using lncRNAs as a therapeutic target and how this could impact our ability to diagnose and treat inflammatory diseases in the future.
The Role Of Metabolic Syndrome And Disorders In Cardiovascular Disease Volume Ii
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Author : Carmine Izzo
language : en
Publisher: Frontiers Media SA
Release Date : 2025-08-12
The Role Of Metabolic Syndrome And Disorders In Cardiovascular Disease Volume Ii written by Carmine Izzo and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-08-12 with Medical categories.
Metabolic syndrome is a dangerous combination of cardiovascular risk factors that correlate with each other and can increase cardio and cerebrovascular events. The incidence of metabolic syndrome often parallels that of obesity and type 2 diabetes. It is widespread; in the United States, more than 40% of people over the age of 50 have metabolic syndrome. The diagnosis of metabolic syndrome is based on the coexistence of at least three risk factors including waist circumference greater than 102 cm in men or 88 cm in women, systolic blood pressure greater than 130 mmHg and diastolic greater than 85 mmHg, HDL cholesterol less than 40 mg/dl in men or 50 mg/dl in women, triglyceridemia higher than 150 mg/dl and finally fasting glycaemia higher than 110 mg/dl. The causes are to be found in a combination of lifestyle habits (diet and poor physical activity) and family predisposition (genetics). These causes lead to the accumulation of abdominal fat, which in turn plays a decisive role in favoring the combination of the various risk factors. Among these, insulin resistance is fundamental in the onset not only of hyperglycemia and diabetes, but also of dyslipidemia and hypertension. Metabolic syndrome does not manifest itself with specific symptoms, which is why attention should be paid to risk factors. With this in mind, we welcome researchers investigating this contemporary theme. This Research Topic welcomes original research articles, perspectives, and review articles.
Oncogene And Cancer
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Author : Yahwardiah Siregar
language : en
Publisher: Inst za onkologiju i radiol
Release Date : 2013-01-24
Oncogene And Cancer written by Yahwardiah Siregar and has been published by Inst za onkologiju i radiol this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-01-24 with Medical categories.
This book describes a course of cancer growth starting from normal cells to cancerous form and the genomic instability, the cancer treatment as well as its prevention in form of the invention of a vaccine. Some diseases are also discussed in detail, such as breast cancer, leucaemia, cervical cancer, and glioma. Understanding cancer through its molecular mechanism is needed to reduce the cancer incidence. How to treat cancer more effectively and the problems like drug resistance and metastasis are very clearly illustrated in this publication as well as some research result that could be used to treat the cancer patients in the very near future. The book was divided into six main sections: 1. HER2 Carcinogenesis: Etiology, Treatment and Prevention; 2. DNA Repair Mechanism and Cancer; 3. New Approach to Cancer Mechanism; 4. New Role of Oncogenes and Tumor Suppressor Genes; 5. Non Coding RNA and Micro RNA in Tumorigenesis; 6. Oncogenes for Transcription Factors
Non Coding Rnas In Cardiovascular Diseases
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Author : Junjie Xiao
language : en
Publisher: Springer Nature
Release Date : 2020-04-13
Non Coding Rnas In Cardiovascular Diseases written by Junjie Xiao and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-04-13 with Science categories.
This book presents the latest research on non-coding RNAs in cardiovascular disease, a major cause of death worldwide. Non-coding RNAs play a significant role in development, proliferation, differentiation and apoptosis. Since altered non-coding RNA expression is often associated with various diseases, their potential use in diagnostics, prognostics and therapeutics is an important current area of study. The book consists of six parts: 1) An overview of non-coding RNAs and cardiovascular system, 2) Bioinformatics and interactions, 3) Non-coding RNA regulation in cardiovascular system, 4) Non-coding RNAs and cardiovascular diseases, 5) Potential biomarkers and therapeutic implications, 6) Future prospects. It is particularly useful for researchers and students in the field of non-coding RNA and cardiovascular biology, as well as for cardiologists, pharmacologists and physiologists.
Single Cell Analysis On The Pathophysiology Of Autoimmune Diseases
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Author : Shiang-Jong Tzeng
language : en
Publisher: Frontiers Media SA
Release Date : 2024-07-11
Single Cell Analysis On The Pathophysiology Of Autoimmune Diseases written by Shiang-Jong Tzeng and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-07-11 with Medical categories.
Despite increasing research to facilitate the understanding of the pathophysiology of autoimmune disorders, the exact cause of the incident of autoimmunity is unknown. Current concepts on the occurrence of autoimmune diseases are thought to involve autoantigens, genetic predisposition, disease triggers, and the breakdown of immune tolerance. In addition to the breakdown of immunological tolerance, one key characteristic of autoimmune disease is that within a single disease there is considerable variability in the clinical manifestation and severity in patients. Single-cell omics have emerged as an effective means of unraveling the complexity and heterogeneity of chronic disease development and therapeutic responses. Recently, advances in cutting-edge spatial profiling of diverse cell types have increased our understanding of how distinct cells interact and orchestrate at specific locations across a tissue landscape in both physiological and pathological contexts at the single-cell level.