Oecd Series On Testing And Assessment Guidance Document 116 On The Conduct And Design Of Chronic Toxicity And Carcinogenicity Studies Supporting Test Guidelines 451 452 And 453 Second Edition
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Oecd Series On Testing And Assessment Guidance Document 116 On The Conduct And Design Of Chronic Toxicity And Carcinogenicity Studies Supporting Test Guidelines 451 452 And 453 Second Edition
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Author : OECD
language : en
Publisher: OECD Publishing
Release Date : 2014-09-03
Oecd Series On Testing And Assessment Guidance Document 116 On The Conduct And Design Of Chronic Toxicity And Carcinogenicity Studies Supporting Test Guidelines 451 452 And 453 Second Edition written by OECD and has been published by OECD Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-09-03 with categories.
This guidance provides additional information on the conduct of studies performed using Test Guidelines 451, 452 and Test Guideline 453.
Haschek And Rousseaux S Handbook Of Toxicologic Pathology Volume 2 Safety Assessment And Toxicologic Pathology
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Author : Wanda M. Haschek
language : en
Publisher: Academic Press
Release Date : 2023-02-18
Haschek And Rousseaux S Handbook Of Toxicologic Pathology Volume 2 Safety Assessment And Toxicologic Pathology written by Wanda M. Haschek and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-02-18 with Medical categories.
Haschek and Rousseaux's Handbook of Toxicologic Pathology, recognized by many as the most authoritative single source of information in the field of toxicologic pathology, has been extensively updated to continue its comprehensive and timely coverage. The fourth edition has been expanded to five separate volumes due to an explosion of information in this field requiring new and updated chapters. Completely revised with a number of new chapters, Volume 2: Toxicologic Pathology in Safety Assessment is an essential part of the most authoritative reference on toxicologic pathology principles and techniques for assessing product safety and human risk. Volume 2 describes the integration of product-induced structural and functional changes in tissues and the interpretation of their biological implications. Completely revised with many new chapters, Volume 2 of the Fourth Edition covers product safety assessment from many angles including current and emerging issues in toxicologic pathology for many product classes. Volume 2 of the Handbook of Toxicologic Pathology is a key resource for pathologists, toxicologists, research scientists, and regulators who use toxicologic pathology methods to study and make decisions on product safety. - Previous chapters on such topics as drug discovery and development, toxicity and carcinogenicity testing, report preparation, and risk assessment and communication have undergone extensive revision that includes in-depth discussion of new developments in the field - New chapters consider fundamental attributes for additional product classes including protein therapeutics, nucleic acid pharmaceutical agents, gene therapy and gene editing, stem cell and other cell therapies, vaccines, agricultural and bulk chemicals, and assigning adversity - Chapters dealing with product-specific practices address pathology and regulatory issues - Chapters offer high-quality and up-to-date content in a trusted work written by the collaborative efforts of many leading international subject matter experts - Hundreds of full-color images and diagrams are featured in both the print and electronic versions of this book to illustrate classic examples and highlight difficult concepts
Reducing Animal Use In Carcinogenicity Testing
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Author : Joseph Manuppello
language : en
Publisher: Frontiers Media SA
Release Date : 2024-12-31
Reducing Animal Use In Carcinogenicity Testing written by Joseph Manuppello and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-12-31 with Medical categories.
Carcinogenicity to rats and mice is evaluated for substances to which humans are exposed, including pharmaceuticals, agrochemicals, and industrial chemicals. For pharmaceuticals, recent efforts to reduce animal use in long-term studies include an addendum to the International Council for Harmonisation (ICH) guideline S1B(R1) that prioritizes short-term studies in transgenic mice and recommends assessing the weight of evidence available to first determine whether a long-term study in rats would add value. For other sectors, an expert group of the Organisation for Economic Cooperation and Development (OECD) is developing an Integrated Approach to the Testing and Assessment (IATA) of non-genotoxic carcinogens based on common hallmarks of cancers and on key characteristics of carcinogens. Within current regulations, animal use could be reduced by evaluating toxicokinetics in main study animals with microsampling methods, by including only one negative control group, and by genotyping transgenic mice instead of using positive control groups in each study.
Oecd Series On Testing And Assessment Fish Toxicity Testing Framework
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Author : OECD
language : en
Publisher: OECD Publishing
Release Date : 2014-09-03
Oecd Series On Testing And Assessment Fish Toxicity Testing Framework written by OECD and has been published by OECD Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-09-03 with categories.
This document presents a review of fish toxicity testing for the regulatory purpose of chemical safety. The main focus is on fish toxicity, but fish bioaccumulation is also considered where relevant.
Protocols Of Actinomycetes
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Author : L Karthik
language : en
Publisher: CRC Press
Release Date : 2024-11-29
Protocols Of Actinomycetes written by L Karthik and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-11-29 with Medical categories.
Many of the natural products have been isolated and characterized from the actinobacteria, for example polyketides, phenazines, peptides, indolocarbarbazoles, and sterols. To explore new antibiotics from actinobacteria, several bioinformatics and synthetic biology tools were developed. This book covers basics to recent protocols for drug discovery from actinobacteria. Features: Discusses the benefits of production of antibiotics and enzymes from actinomycetes in a large scale Covers the synthetic biology approach Describes the strain improvement of actinobacteria Gives information on basic isolation of actinobacteria and modern techniques Covers the applications and metabolic engineering strategies of actinomycetes This book will be helpful for the pharmaceutical industries and researchers to develop new antibiotics from actinobacteria and can be used in support of future research in drug discovery.
Toxicogenomics In Predictive Carcinogenicity
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Author : Russell S Thomas
language : en
Publisher: Royal Society of Chemistry
Release Date : 2016-06-16
Toxicogenomics In Predictive Carcinogenicity written by Russell S Thomas and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-06-16 with Medical categories.
Research over the past decade has demonstrated that TGx methods of various types can be used to discriminate modes of mutagenesis as a function of dose. TGx can quickly inform safety evaluation regarding potential mechanisms of conventional outcomes and can provide essential dose-response information. This can then be used to ascertain the sequence of key events in a putative mode of action as may apply in quantitative cancer risk assessment. With the increasing complexity of research in mode of action investigations it is important to gain a better understand of approaches to data integration and health risk assessment. Furthermore, it is essential to consider how novel test systems and newer methods and approaches may be used in future to gain a better understanding of mechanisms. Toxicogenomics in Predictive Carcinogenicity describes toxicogenomics methods in predictive carcinogenicity testing, mode of action and safety evaluation, and cancer risk assessment. It illustrates these methods using case studies that have yielded significant new information on compounds and classes of compounds that have proven difficult to evaluate using conventional methods alone. This book additionally covers current and potential toxicogenomic research using stem cells as well as new bioinformatics methods for drug discovery and environmental toxicology. This publication is an indispensable tool for postgraduates, academics and industrialists working in biochemistry, genomics, carcinogenesis, pathology, pharmaceuticals, food technology, bioinformatics, risk assessment and environmental toxicology.
Oecd Series On Testing And Assessment Detailed Review Paper On The State Of The Science On Novel In Vitro And In Vivo Screening And Testing Methods And Endpoints For Evaluating Endocrine Disruptors
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Author : OECD
language : en
Publisher: OECD Publishing
Release Date : 2012-08-21
Oecd Series On Testing And Assessment Detailed Review Paper On The State Of The Science On Novel In Vitro And In Vivo Screening And Testing Methods And Endpoints For Evaluating Endocrine Disruptors written by OECD and has been published by OECD Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-08-21 with categories.
This paper provides methods for both the mechanistic evaluation of the action of Endocrine Disrupter Chemicals (EDCs).
Food Safety Assessment Of Pesticide Residues
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Author : Arpad Ambrus
language : en
Publisher: World Scientific
Release Date : 2017-01-05
Food Safety Assessment Of Pesticide Residues written by Arpad Ambrus and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-01-05 with Technology & Engineering categories.
Pesticides are now accepted as an integral part of modern agricultural production. This book provides analysis of the steps taken by national and international bodies working towards a cohesive global strategy for evaluating the safety of residues in food that result from approved pesticide uses. Also described is the role of the UN Food and Agriculture Organization (FAO), World Health Organization (WHO) and Codex Alimentarius in developing standards that protect the health of the consumers and ensure fair practices in the food trade. It goes on to look at the promotion of good agricultural practice in the use of pesticides and the need for control in their practical use. These include sampling, testing the compliance of marketed products against legal limits and verifying the effectiveness of the safety-based regulatory measures. This is a specialist book for those looking to go into the field of international food safety, for students and lecturers studying the topic, for policy makers working on public health and agricultural issues, and personnel responsible for taking samples and performing the analysis of pesticide formulations and residues.
Environmental Toxicants
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Author : Morton Lippmann
language : en
Publisher: John Wiley & Sons
Release Date : 2020-04-07
Environmental Toxicants written by Morton Lippmann and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-04-07 with Medical categories.
An Updated Reference on Human Exposure to Environmental Toxicants and A Study of Their Impact on Public Health With the 4th edition of Environmental Toxicants: Human Exposures and Their Health Effects, readers have access to up-to-date information on the study and science of environmental toxicology and public health worldwide. Practitioners and professionals can use this resource to understand newly discovered information on the adverse health effects of toxins and pollutants in air, water, and occupational and environmental environments on large human populations. The 4th edition of this book is updated to reflect new knowledge and research on: ● Performing risk assessments on exposed individuals ● Assessing the effects of toxicants and substances on large populations for health and medical professionals ● Patterns of human exposure to select chemical toxicants ● World Trade Center dust, agents for chemical terrorism, and nanoparticles For health professionals, including health authorities, public health officials, physicians, and industrial managers, who are seeking new research and techniques for managing environmental substances, this invaluable reference will guide you through in a thorough, easy- to-read manner.
Haschek And Rousseaux S Handbook Of Toxicologic Pathology Volume 1 Principles And Practice Of Toxicologic Pathology
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Author : Wanda M. Haschek
language : en
Publisher: Academic Press
Release Date : 2021-10-20
Haschek And Rousseaux S Handbook Of Toxicologic Pathology Volume 1 Principles And Practice Of Toxicologic Pathology written by Wanda M. Haschek and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-10-20 with Medical categories.
Haschek and Rousseaux's Handbook of Toxicologic Pathology, recognized by many as the most authoritative single source of information in the field of toxicologic pathology, has been extensively updated to continue its comprehensive and timely coverage. The fourth edition has been expanded to four separate volumes due to an explosion of information in this field requiring new and updated chapters. Completely revised with a number of new chapters, Volume 1, "Principles and the Practice of Toxicologic Pathology," covers the practice of toxicologic pathology in three parts: Principles of Toxicologic Pathology, Methods in Toxicologic Pathology, and the Practice of Toxicologic Pathology. Other volumes in this work round out the depth and breadth of coverage.Volume 2 encompasses "Toxicologic Pathology in Safety Assessment" and "Environmental Toxicologic Pathology". These two sections cover the application of toxicologic pathology in developing specific product classes, principles of data interpretation for safety assessment, and toxicologic pathology of major classes of environmental toxicants. Volumes 3 and 4 provide deep and broad treatment of "Target Organ Toxicity", emphasizing the comparative and correlative aspects of normal biology and toxicant-induced dysfunction, principal methods for toxicologic pathology evaluation, and major mechanisms of toxicity. These volumes comprise the most authoritative reference on toxicologic pathology for pathologists, toxicologists, research scientists, and regulators studying and making decisions on drugs, biologics, medical devices, and other chemicals, including agrochemicals and environmental contaminants. Each volume is being published separately. - Provides new chapters on digital pathology, juvenile pathology, in vitro/in vivo correlation, big data technologies and in-depth discussion of timely topics in the area of toxicologic pathology - Offers high-quality and trusted content in a multi-contributed work written by leading international authorities in all areas of toxicologic pathology - Features hundreds of full-color images in both the print and electronic versions of the book to highlight difficult concepts with clear illustrations