Oecd Series On Testing And Assessment Detailed Review Paper On The State Of The Science On Novel In Vitro And In Vivo Screening And Testing Methods And Endpoints For Evaluating Endocrine Disruptors
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Oecd Series On Testing And Assessment Detailed Review Paper On The State Of The Science On Novel In Vitro And In Vivo Screening And Testing Methods And Endpoints For Evaluating Endocrine Disruptors
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Author : OECD
language : en
Publisher: OECD Publishing
Release Date : 2012-08-21
Oecd Series On Testing And Assessment Detailed Review Paper On The State Of The Science On Novel In Vitro And In Vivo Screening And Testing Methods And Endpoints For Evaluating Endocrine Disruptors written by OECD and has been published by OECD Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-08-21 with categories.
This paper provides methods for both the mechanistic evaluation of the action of Endocrine Disrupter Chemicals (EDCs).
Oecd Series On Testing And Assessment Revised Guidance Document 150 On Standardised Test Guidelines For Evaluating Chemicals For Endocrine Disruption
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Author : OECD
language : en
Publisher: OECD Publishing
Release Date : 2018-09-03
Oecd Series On Testing And Assessment Revised Guidance Document 150 On Standardised Test Guidelines For Evaluating Chemicals For Endocrine Disruption written by OECD and has been published by OECD Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-09-03 with categories.
This guidance document was originally published in 2012 and updated in 2018 to reflect new and updated OECD test guidelines, as well as reflect on scientific advances in the use of test methods and assessment of the endocrine activity of chemicals.
Oecd Series On Testing And Assessment Fish Toxicity Testing Framework
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Author : OECD
language : en
Publisher: OECD Publishing
Release Date : 2014-09-03
Oecd Series On Testing And Assessment Fish Toxicity Testing Framework written by OECD and has been published by OECD Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-09-03 with categories.
This document presents a review of fish toxicity testing for the regulatory purpose of chemical safety. The main focus is on fish toxicity, but fish bioaccumulation is also considered where relevant.
European Partnership On The Assessment Of Risks From Chemicals Parc Focus On New Approach Methodologies Nams In Risk Assessment
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Author : Terje Svingen
language : en
Publisher: Frontiers Media SA
Release Date : 2024-08-21
European Partnership On The Assessment Of Risks From Chemicals Parc Focus On New Approach Methodologies Nams In Risk Assessment written by Terje Svingen and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-08-21 with Medical categories.
The European Partnership on the Assessment of Risks from Chemicals (PARC) project was launched in 2022. The overarching aim of this partnership is to enhance our knowledge about chemical substances to better safeguard human health and the environment against harmful effects. The project will run for seven years under Horizon Europe. PARC is subdivided into several work packages (WPs). WP5 is focused on hazard assessment for human and environmental health and includes more than 80 partners across Europe. WP5 aims to fill data gaps for specified chemical substances of concern (e.g, bisphenol alternatives) and to develop or improve new approach methodologies (NAMs) for chemical hazard assessment. This is in order to progress towards a risk assessment paradigm relying less on animal toxicity data, both with respect to human health and environmental safety. As the PARC initiative will evolve over time with respect to both projects and activities, presenting early initiatives will foster an increased awareness of ongoing activities and potential incorporation of new activities going forward.
Toxicology And Risk Assessment
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Author : Helmut Greim
language : en
Publisher: John Wiley & Sons
Release Date : 2018-11-05
Toxicology And Risk Assessment written by Helmut Greim and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-11-05 with Science categories.
Provides a complete understanding of how our bodies respond to toxicants, and the principles used to assess the health risks of specific exposure scenarios Toxicology and Risk Assessment: A Comprehensive Introduction, Second Edition reflects recent advances in science and technology, and provides the scientific background and methodological issues to enable the reader to understand the basic principles in toxicology and to evaluate the health risks of specific exposure scenarios. Completely updated with the latest information, this book offers a concise introduction to the subject. It is divided into five sections: Principles in Toxicology, Organ Toxicology, Methods in Toxicology, Regulatory Toxicology, and Specific Toxicity. The 2nd Edition adds new chapters that cover recent scientific and technological advances and current topics including the endocrine system, alternatives to animal testing, risk assessment and thresholds for carcinogens, European and international regulation, nanomaterials, fuels, fragrances, and agrochemicals. Concentrates on the basic concepts of toxicology and provides sufficient information for the reader to become familiar with them in order to understand the principles and to evaluate the risks at given exposures 30% new chapters cover recent scientific and technological advances including alternatives to animal testing; genotoxic carcinogens; REACH regulations; nanomaterials; fuels; fragrances; PAHs; and agrochemicals Written by a team of international specialists, and edited by two outstanding scientists in the field Fully updated and expanded, Toxicology and Risk Assessment: A Comprehensive Introduction, Second Edition is an essential text for any student or researcher with an interest in toxicology and related risk assessments.
Comprehensive Toxicology
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Author :
language : en
Publisher: Elsevier
Release Date : 2017-12-01
Comprehensive Toxicology written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-12-01 with Science categories.
Comprehensive Toxicology, Third Edition, Fifteen Volume Set discusses chemical effects on biological systems, with a focus on understanding the mechanisms by which chemicals induce adverse health effects. Organized by organ system, this comprehensive reference work addresses the toxicological effects of chemicals on the immune system, the hematopoietic system, cardiovascular system, respiratory system, hepatic toxicology, renal toxicology, gastrointestinal toxicology, reproductive and endocrine toxicology, neuro and behavioral toxicology, developmental toxicology and carcinogenesis, also including critical sections that cover the general principles of toxicology, cellular and molecular toxicology, biotransformation and toxicology testing and evaluation. Each section is examined in state-of-the-art chapters written by domain experts, providing key information to support the investigations of researchers across the medical, veterinary, food, environment and chemical research industries, and national and international regulatory agencies. Thoroughly revised and expanded to 15 volumes that include the latest advances in research, and uniquely organized by organ system for ease of reference and diagnosis, this new edition is an essential reference for researchers of toxicology. Organized to cover both the fundamental principles of toxicology and unique aspects of major organ systems Thoroughly revised to include the latest advances in the toxicological effects of chemicals on the immune system Features additional coverage throughout and a new volume on toxicology of the hematopoietic system Presents in-depth, comprehensive coverage from an international author base of domain experts
Challenges In Endocrine Disruptor Toxicology And Risk Assessment
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Author : Alberto Mantovani
language : en
Publisher: Royal Society of Chemistry
Release Date : 2020-12-08
Challenges In Endocrine Disruptor Toxicology And Risk Assessment written by Alberto Mantovani and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-12-08 with Science categories.
Insight into the role of hormones, particularly estrogen and testosterone, in health and disease etiology – including interactions with other hormone pathways – has dramatically changed. Estrogen and androgen receptors, with their polymorphisms, are key molecules in all tissues and are involved in a number of homeostatic mechanisms but also pathological processes including carcinogenesis and the development of metabolic and neurological disorders such as diabetes and Alzheimer’s disease. Endocrine disrupting chemicals (EDCs) can interfere with the endocrine (hormone) systems at certain dosages and play a key role in the pathology of disease. Most known EDCs are manmade and are therefore an increasing concern given the number commonly found in household products and the environment. This book will cover the mechanisms of EDC pathology across the spectrum of disease, as well as risk assessment and government and legal regulation to provide a holistic view of the current issues and cutting-edge research in the topic. With contributions from global leaders in the field, this book will be an ideal reference for toxicologists, endocrinologists and researchers interested in developmental biology, regulatory toxicology and the interface between environment and human health.
Retinoids In Mammalian Reproduction With An Initial Scoping Effort To Identify Regulatory Methods
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Author : Nilsson, Charlotte
language : en
Publisher: Nordic Council of Ministers
Release Date : 2020-04-19
Retinoids In Mammalian Reproduction With An Initial Scoping Effort To Identify Regulatory Methods written by Nilsson, Charlotte and has been published by Nordic Council of Ministers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-04-19 with Political Science categories.
Available online: https://pub.norden.org/temanord2020-507/ Abstract [en] This Nordic report builds on ideas brought forward in the OECD Detailed Review Paper (DRP) 178 on screening and testing methods and endpoints for evaluating endocrine disruptors. It was identified that the retinoid system is not presently included in any OECD test guideline, and that it is urgent to cover this knowledge gap. The present TemaNord report is a contribution to an upcoming OECD DRP on retinoids. An overview of retinoid biology in female and male reproduction is presented. The report identifies that, in general, there is a lack of studies investigating effects of chemicals on reproduction, while simultaneously examining effects on retinoid related parameters. This is a major data gap. However, selected in vitro and/or in silico retinoid-related endpoints, presented in this report, could possibly be part of a broader screening test battery aimed at reproductive toxicity.
Treatment Of Type 2 Diabetes
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Author : Colleen Croniger
language : en
Publisher: BoD – Books on Demand
Release Date : 2015-04-01
Treatment Of Type 2 Diabetes written by Colleen Croniger and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-04-01 with Medical categories.
Obesity and type 2 diabetes are increasing worldwide problems. In this book we reviewed factors that contribute to glucose homeostasis and the pathogenesis of Type 2 diabetes. In addition the book addresses current strategies for treatment of Type 2 Diabetes.
Road To Regulation Of Endocrine Disruptors And Combination Effects
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Author : Karina Petersen
language : en
Publisher: Nordic Council of Ministers
Release Date : 2014-05-06
Road To Regulation Of Endocrine Disruptors And Combination Effects written by Karina Petersen and has been published by Nordic Council of Ministers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-05-06 with categories.
Discussions regarding regulation of endocrine disruptors (EDs) and combination effects are ongoing in Europe. Among the central topics of discussion are establishment of criteria for identification of EDs, whether there is a threshold for endocrine disrupting effects and how EDs should be handled within relevant EU regulations. In addition, a roadmap for further EU work regarding combination effects has been presented, but more detailed discussions are needed regarding scientific issues and regulatory intervention. Possible Member State initiatives to provide input to these EU processes were discussed in a Nordic workshop held in Oslo in November 2013. This report describes the workshop presentations, initiatives and thoughts from each of the Nordic countries, the plenary discussions, and the main workshop outcomes.