Oecd Series On Testing And Assessment Guidance On Grouping Of Chemicals Second Edition
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Oecd Series On Testing And Assessment Guidance On Grouping Of Chemicals Second Edition
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Author : OECD
language : en
Publisher: OECD Publishing
Release Date : 2017-04-13
Oecd Series On Testing And Assessment Guidance On Grouping Of Chemicals Second Edition written by OECD and has been published by OECD Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-04-13 with categories.
This guidance document is part of the OECD effort to provide guidance for assessing the hazards of chemical substances while gaining efficiencies and improving animal welfare. The approach described in this guidance document is to consider closely related chemicals as a group, or category ...
Oecd Guidelines For The Testing Of Chemicals Oecd Series On Testing And Assessment Guidance Notes For Analysis And Evaluation Of Chronic Toxicity And Carcinogenicity Studies
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Author : OECD
language : en
Publisher: OECD Publishing
Release Date : 2002-12-12
Oecd Guidelines For The Testing Of Chemicals Oecd Series On Testing And Assessment Guidance Notes For Analysis And Evaluation Of Chronic Toxicity And Carcinogenicity Studies written by OECD and has been published by OECD Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-12-12 with categories.
These Guidance Notes outline core concepts in order to obviate the need to consult large numbers of text books, while still pointing the reader to sources of more detailed or specific information.
Oecd Series On Testing And Assessment Second Edition Guidance Document On Integrated Approaches To Testing And Assessment Iata For Serious Eye Damage And Eye Irritation
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Author : OECD
language : en
Publisher: OECD Publishing
Release Date : 2019-07-25
Oecd Series On Testing And Assessment Second Edition Guidance Document On Integrated Approaches To Testing And Assessment Iata For Serious Eye Damage And Eye Irritation written by OECD and has been published by OECD Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-07-25 with categories.
This document suggests an Integrated Approach on Testing and Assessment (IATA) for serious eye damage and eye irritation hazard identification. The document also provides key information characteristics of each of the individual information sources comprising the IATA. Furthermore it provides guidance on how and when to integrate existing and/or newly generated information for decision making, including decisions on the need for further testing or final decisions on classification and labelling regarding the potential eye hazard effects of test chemicals.
Oecd Series On Testing And Assessment Guidance Document 116 On The Conduct And Design Of Chronic Toxicity And Carcinogenicity Studies Supporting Test Guidelines 451 452 And 453 Second Edition
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Author : OECD
language : en
Publisher: OECD Publishing
Release Date : 2014-09-03
Oecd Series On Testing And Assessment Guidance Document 116 On The Conduct And Design Of Chronic Toxicity And Carcinogenicity Studies Supporting Test Guidelines 451 452 And 453 Second Edition written by OECD and has been published by OECD Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-09-03 with categories.
This guidance provides additional information on the conduct of studies performed using Test Guidelines 451, 452 and Test Guideline 453.
Chemical Testing Using New Approach Methodologies Nams
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Author : Amy J. Clippinger
language : en
Publisher: Frontiers Media SA
Release Date : 2022-12-16
Chemical Testing Using New Approach Methodologies Nams written by Amy J. Clippinger and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-12-16 with Science categories.
Comprehensive Medicinal Chemistry Iii
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Author :
language : en
Publisher: Elsevier
Release Date : 2017-06-03
Comprehensive Medicinal Chemistry Iii written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-06-03 with Technology & Engineering categories.
Comprehensive Medicinal Chemistry III, Eight Volume Set provides a contemporary and forward-looking critical analysis and summary of recent developments, emerging trends, and recently identified new areas where medicinal chemistry is having an impact. The discipline of medicinal chemistry continues to evolve as it adapts to new opportunities and strives to solve new challenges. These include drug targeting, biomolecular therapeutics, development of chemical biology tools, data collection and analysis, in silico models as predictors for biological properties, identification and validation of new targets, approaches to quantify target engagement, new methods for synthesis of drug candidates such as green chemistry, development of novel scaffolds for drug discovery, and the role of regulatory agencies in drug discovery. Reviews the strategies, technologies, principles, and applications of modern medicinal chemistry Provides a global and current perspective of today's drug discovery process and discusses the major therapeutic classes and targets Includes a unique collection of case studies and personal assays reviewing the discovery and development of key drugs
Oecd Principles Of Corporate Governance
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Author : OECD
language : en
Publisher: OECD Publishing
Release Date : 1999-10-06
Oecd Principles Of Corporate Governance written by OECD and has been published by OECD Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-10-06 with categories.
These principles of corporate governance, endorsed by the OECD Council at Ministerial level in 1999, provide guidelines and standards to insure inclusion, accountability and abilit to attract capital.
Application Of Modern Toxicology Approaches For Predicting Acute Toxicity For Chemical Defense
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Author : National Academies of Sciences, Engineering, and Medicine
language : en
Publisher: National Academies Press
Release Date : 2015-09-01
Application Of Modern Toxicology Approaches For Predicting Acute Toxicity For Chemical Defense written by National Academies of Sciences, Engineering, and Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-09-01 with Nature categories.
The US Department of Defense (DOD) is faced with an overwhelming task in evaluating chemicals that could potentially pose a threat to its deployed personnel. There are over 84,000 registered chemicals, and testing them with traditional toxicity-testing methods is not feasible in terms of time or money. In recent years, there has been a concerted effort to develop new approaches to toxicity testing that incorporate advances in systems biology, toxicogenomics, bioinformatics, and computational toxicology. Given the advances, DOD asked the National Research Council to determine how DOD could use modern approaches for predicting chemical toxicity in its efforts to prevent debilitating, acute exposures to deployed personnel. This report provides an overall conceptual approach that DOD could use to develop a predictive toxicology system. Application of Modern Toxicology Approaches for Predicting Acute Toxicity for Chemical Defense reviews the current state of computational and high-throughput approaches for predicting acute toxicity and suggests methods for integrating data and predictions. This report concludes with lessons learned from current high-throughput screening programs and suggests some initial steps for DOD investment.
Computational Nanotoxicology
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Author : Agnieszka Gajewicz
language : en
Publisher: CRC Press
Release Date : 2019-11-13
Computational Nanotoxicology written by Agnieszka Gajewicz and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-11-13 with Medical categories.
The development of computational methods that support human health and environmental risk assessment of engineered nanomaterials (ENMs) has attracted great interest because the application of these methods enables us to fill existing experimental data gaps. However, considering the high degree of complexity and multifunctionality of ENMs, computational methods originally developed for regular chemicals cannot always be applied explicitly in nanotoxicology. This book discusses the current state of the art and future needs in the development of computational modeling techniques for nanotoxicology. It focuses on (i) computational chemistry (quantum mechanics, semi-empirical methods, density functional theory, molecular mechanics, molecular dynamics), (ii) nanochemoinformatic methods (quantitative structure–activity relationship modeling, grouping, read-across), and (iii) nanobioinformatic methods (genomics, transcriptomics, proteomics, metabolomics). It reviews methods of calculating molecular descriptors sufficient to characterize the structure of nanoparticles, specifies recent trends in the validation of computational methods, and discusses ways to cope with the uncertainty of predictions. In addition, it highlights the status quo and further challenges in the application of computational methods in regulation (e.g., REACH, OECD) and in industry for product development and optimization and the future directions for increasing acceptance of computational modeling for nanotoxicology.
A Class Approach To Hazard Assessment Of Organohalogen Flame Retardants
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Author : National Academies of Sciences, Engineering, and Medicine
language : en
Publisher: National Academies Press
Release Date : 2019-07-19
A Class Approach To Hazard Assessment Of Organohalogen Flame Retardants written by National Academies of Sciences, Engineering, and Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-07-19 with Political Science categories.
In the 1970s, flame retardants began to be added to synthetic materials to meet strict flammability standards. Over the years, diverse flame retardants have been manufactured and used in various products. Some flame retardants have migrated out of the products, and this has led to widespread human exposure and environmental contamination. There also is mounting evidence that many flame retardants are associated with adverse human health effects. As a result, some flame retardants have been banned, restricted, or voluntarily phased out of production and use. This publication develops a scientifically based scoping plan to assess additive, nonpolymeric organohalogen flame retardants as a class for potential chronic health hazards under the Federal Hazardous Substances Act, including cancer, birth defects, and gene mutations.