Phasing In Crystallography
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Phasing In Crystallography
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Author : Carmelo Giacovazzo
language : en
Publisher: Oxford University Press
Release Date : 2014
Phasing In Crystallography written by Carmelo Giacovazzo and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014 with Science categories.
The book describes phasing techniques in modern crystallography. The main text is dedicated to their simple description, and further mathematical details are contained in the appendices. Practical aspects are described for each specific method, making it a useful tool for the daily work of practising crystallographers.
Direct Phasing In Crystallography
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Author : Carmelo Giacovazzo
language : en
Publisher: Oxford University Press on Demand
Release Date : 1998
Direct Phasing In Crystallography written by Carmelo Giacovazzo and has been published by Oxford University Press on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998 with Science categories.
Direct methods are, at present, applied to a large variety of cases: X-ray, neutron or electron data; single crystal and powder data; small molecules and macromolecules. While direct methods solved in practice the phase problem for small molecules, their application to macromolecules is recentand still undergoing strong development. The fundamentals of the methods are described: in particular it is shown how the methods can be optimized for powder, neutron or electron data, and how they can be integrated with isomorphous replacement, molecular replacement and anomalous dispersiontechniques. Maximum Entropy methods are also described and discussed. Sets of test structures are used to verify, throughout the various chapters, the mathematical techniques there described and to provide practical examples of applications. This book will appeal to a wide variety of readers -offering both a comprehensive description of direct methods in crystallography and an invaluable reference tool. The first three chapters can be considered as an introduction to the field, with sufficient material to constitute a university course and for allowing the expert use of most directmethods programs. Subsequent chapters are aimed at graduate students and working crystallographers. Basic results are described and discussed in the main body of the text, while the appendices compliment these with in depth mathematical details. The quoted literature is extremely wide and theinterested reader can find suggestions for future work and further reading throughout the book.
Principles Of Protein X Ray Crystallography
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Author : Jan Drenth
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-04-05
Principles Of Protein X Ray Crystallography written by Jan Drenth and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-04-05 with Science categories.
X-ray crystallography is an established method for studying the structure of proteins and other macromolecules. As the importance of proteins grows, researchers in many fields have found that a working knowledge of X-ray diffraction is an indispensable tool. In this new edition of his essential work, the internationally recognized researcher Dr. Jan Drenth offers an up-to-date and technically rigorous introduction to the subject, providing the theoretical background necessary to understand how the structure of proteins is determined at atomic resolution. New material in the 3rd edition includes a section on twinning, an additional chapter on crystal growth and a discussion of single-wavelength anomalous dispersion.
Phase Transitions In Ferroelastic And Co Elastic Crystals
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Author : E. K. Salje
language : en
Publisher: Cambridge University Press
Release Date : 1993-04-22
Phase Transitions In Ferroelastic And Co Elastic Crystals written by E. K. Salje and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993-04-22 with Science categories.
This textbook describes the fundamental principles of structural phase transitions in materials in an easily understandable form, suitable for both undergraduate and graduate students.
Protein Crystallography
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Author : Eaton E. Lattman
language : en
Publisher: JHU Press
Release Date : 2008-04-28
Protein Crystallography written by Eaton E. Lattman and has been published by JHU Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-04-28 with Science categories.
The proteome remains a mysterious realm. Researchers have determined the structures of only a small fraction of the proteins encoded by the human genome. Crystallography continues to be the primary method used to determine the structures of the remaining unknown proteins. This imaging technique uses the diffraction of X-rays to determine a protein’s three-dimensional molecular structure. Drawing on years of research and teaching experience, Eaton E. Lattman and Patrick J. Loll use clear examples and abundant illustrations to provide a concise and accessible primer on protein crystallography. Discussing the basics of diffraction, the behavior of two- and three-dimensional crystals, phase determination (including MIR and MAD phasing and molecular replacement), the Patterson function, and refinement, Lattman and Loll provide a complete overview of this important technique, illuminated by physical insights. The crisp writing style and simple illustrations will provide beginner crystallographers with a guide to the process of unraveling protein structure.
Outline Of Crystallography For Biologists
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Author : David Blow
language : en
Publisher: OUP Oxford
Release Date : 2002-04-11
Outline Of Crystallography For Biologists written by David Blow and has been published by OUP Oxford this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-04-11 with Science categories.
Outline of Crystallography for Biologists is intended for researchers and students in the biological sciences who require an insight into the methods of X-ray crystallography without needing to learn all the relevant theory. The main text is purely descriptive and is readable by those with minimal mathematical knowledge. Some mathematical detail is given throughout in boxes, but these can be ignored. Theory is limited to the essentials required to comprehend issues of quality. There is an extensive reference section and suggestions for further reading for those who wish to delve deeper. The first part 'Fundamentals' presents the underlying ideas which allow x-ray structure analysis to be carried out and provides an appropriate background to courses in structural determination. The second part 'Practice' gives more information about the procedures employed in the course of crystal structure determination. The emphasis is on the quality measures of X-ray diffraction analysis to give the reader a critical insight into the quality and accuracy of a structure determination and to enable the reader to appreciate which parts of a structure determination may have caused special difficulty. There is no pretence of completeness and many matters discussed in standard crystallography texts are deliberately omitted. However, issues not brought out in the standard texts are discussed, making it a useful resource for non-practising crystallographers as well.
Advancing Methods For Biomolecular Crystallography
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Author : Randy Read
language : en
Publisher: Springer
Release Date : 2013-04-03
Advancing Methods For Biomolecular Crystallography written by Randy Read and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-04-03 with Science categories.
This work presents a snapshot of the state of the art of modern biomolecular crystallography, from crystallisation through structure determination and even interactive presentation on the web. Methods driving the latest automated structure determination pipelines are explained, as well as how to deal with problems such as crystal pathologies that still demand expert analysis. These methods are illustrated through their application to problems of great biological interest, such as the molecular machinery underlying the complement pathway, the mechanism of action of monoamine oxidase inhibitors, and the structure of the eukaryotic ribosome. Complementary approaches, such as neutron diffraction, small angle X-ray scattering, coherent diffraction and computational modelling, are also explored.
X Ray Crystallography Of Biomacromolecules
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Author : Albrecht Messerschmidt
language : en
Publisher: John Wiley & Sons
Release Date : 2007-02-27
X Ray Crystallography Of Biomacromolecules written by Albrecht Messerschmidt and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-02-27 with Science categories.
Written by one of the most significant contributors to the progress of protein crystallography, this practical guide contains case studies, a troubleshooting section and pointers on data interpretation. It covers the theory, practice and latest achievements in x-ray crystallography, such that any researcher in structural biology will benefit from this extremely clearly written book. Part A covers the theoretical basis and such experimental techniques as principles of x-ray diffraction, solutions for the phase problem and time-resolved x-ray crystallography. Part B includes case studies for different kinds of x-ray crystal structure determination, such as the MIRAS and MAD techniques, molecular replacement, and the difference Fourier technique.
Phase Transitions In Ferroelastic And Co Elastic Crystals
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Author : Ekhard K. H. Salje
language : en
Publisher:
Release Date : 1990
Phase Transitions In Ferroelastic And Co Elastic Crystals written by Ekhard K. H. Salje and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1990 with Crystallography categories.
Principles Of Protein X Ray Crystallography
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Author : Jan Drenth
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-09
Principles Of Protein X Ray Crystallography written by Jan Drenth and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-09 with Science categories.
New textbooks at all levels of chemistry appear with great regularity. Some fields such as basic biochemistry, organic reaction mechanisms, and chemical thermodynamics are well represented by many excellent texts, and new or revised editions are published sufficiently often to keep up with progress in research. However, some areas of chemistry, especially many of those taught at the graduate level, suffer from a real lack of up to-date textbooks. The most serious needs occur in fields that are rapidly changing. Textbooks in these subjects usually have to be written by scientists actually involved in the research that is advancing the field. It is not often easy to persuade such individuals to set time aside to help spread the knowledge they have accumulated. Our goal, in this series, is to pinpoint areas of chemistry where recent progress has outpaced what is covered in any available textbooks, and then seek out and persuade experts in these fields to produce relatively concise but instructive intro ductions to their fields. These should serve the needs of one-semester or one-quarter graduate courses in chemistry and biochemistry. In some cases, the availability of texts in active research areas should help stimulate the creation of new courses. Charles R. Cantor v Preface to the Second Edition Since the publication of the previous edition in 1994, X-ray crystallography of proteins has advanced by improvements in existing techniques and by addition of new techniques.