Phosphodiesterase Inhibitors
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Phosphodiesterase Inhibitors
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Author :
language : en
Publisher: Elsevier
Release Date : 1996-08-16
Phosphodiesterase Inhibitors written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996-08-16 with Science categories.
Non-selective inhibitors of cyclic nucleotide phosphodiesterase (PDE), such as theophylline, have been used extensively since 1958. In the decade of the '70s, various PDE isoenzymes were defined which led to the development of the second generation of PDE inhibitors. Currently a variety of these new inhibitors are under test as potential anti-inflammatory drugs. During the past five years, molecular biology has revealed a superfamily of these phosphodiesterase isoenzymes. This book summarizes the present state of knowledge, as well as giving a comprehensive description of the compounds available. It will be invaluable for everyone who wants to choose the most suitable PDE inhibitor for their research or who is dealing with such drugs in a clinical setting. Utilizes actual testing and research of new PDE inhibitors Valuable for researchers and students alike
Phosphodiesterases And Their Inhibitors
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Author : Spiros Liras
language : en
Publisher: John Wiley & Sons
Release Date : 2014-03-03
Phosphodiesterases And Their Inhibitors written by Spiros Liras and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-03-03 with Medical categories.
Written by the pioneers of Viagra, the first blockbuster PDE inhibitor drug. Beginning with a review of the first wave of phosphodiesterase (PDE) inhibitors, this book focuses on new and emerging PDE targets and their inhibitors. Drug development options for all major human PDE families are discussed and cover diverse therapeutic fields, such as neurological/psychiatric, cardiovascular/metabolic, pain, and allergy/respiratory diseases. Finally, emerging chemotherapeutic applications of PDE inhibitors against malaria and other tropical diseases are discussed.
Phosphodiesterases As Drug Targets
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Author : Sharron H. Francis
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-06-21
Phosphodiesterases As Drug Targets written by Sharron H. Francis and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-06-21 with Medical categories.
Cyclic nucleotide phosphodiesterases (PDEs) are promising targets for pharmacological intervention. Multiple PDE genes, isoform diversity, selective expression and compartmentation of the isoforms, and an array of conformations of PDE proteins are properties that challenge development of drugs that selectively target this class of enzymes. Novel characteristics of PDEs are viewed as unique opportunities to increase specificity and selectivity when designing novel compounds for certain therapeutic indications. This chapter provides a summary of the major concepts related to the design and use of PDE inhibitors.
Methylxanthines And Phosphodiesterase Inhibitors In The Treatment Of Airways Disease
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Author : J.F. Costello
language : en
Publisher: CRC Press
Release Date : 1994-10-15
Methylxanthines And Phosphodiesterase Inhibitors In The Treatment Of Airways Disease written by J.F. Costello and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994-10-15 with Medical categories.
This is a technically detailed state-of-the-art text on phosphodiesterase inhibition and the practical applications of theophylline and other phosphodiesterase inhibitors in asthma and chronic obstructive airways disease. It contains important new information on the mechanisms of drug action and on the inhibition of individual isoenzymes of the phosphodiesterase enzyme family as a potentially useful, safe, and non-toxic approach to asthma therapy.
Bipyridine Phosphodiesterase Inhibitors In Clinical Practice
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Author : Martin Goenen
language : en
Publisher:
Release Date : 1990-01-01
Bipyridine Phosphodiesterase Inhibitors In Clinical Practice written by Martin Goenen and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1990-01-01 with categories.
Phosphodiesterases Cns Functions And Diseases
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Author : Han-Ting Zhang
language : en
Publisher: Springer
Release Date : 2017-09-26
Phosphodiesterases Cns Functions And Diseases written by Han-Ting Zhang and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-09-26 with Medical categories.
PDEs are a family of enzymes that catalyze the hydrolysis of intracellular cyclic nucleotides. They are implicated in a number of disorders and dysfunctions and PDE inhibitors have already proven to be effective therapies for erectile dysfunction, COPD, and psoriatic arthritis. This family of enzymes also plays a role in diseases and disorders of the CNS such as depression, anxiety, schizophrenia, and Alzheimer's Disease. Unfortunately no effective PDE inhibitors have been developed for the treatment of these diseases. The proposed book will be a comprehensive overview of the current state of basic and translational research on PDE inhibitors written by internationally recognized experts. Authors will also discuss potential PDE subtypes and splice variants in the hopes that this will spur more creative approaches to PDE targeting drugs.
The Role Of Phosphodiesterase Inhibitors In Heart Failure
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Author : P. A. van Zwieten
language : en
Publisher:
Release Date : 1991
The Role Of Phosphodiesterase Inhibitors In Heart Failure written by P. A. van Zwieten and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991 with Heart categories.
Cyclic Nucleotide Phosphodiesterases In Health And Disease
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Author : Joseph A. Beavo
language : en
Publisher: CRC Press
Release Date : 2006-12-05
Cyclic Nucleotide Phosphodiesterases In Health And Disease written by Joseph A. Beavo and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-12-05 with Medical categories.
Since the last major compendium dedicated to cyclic nucleotide phosphodiesterases (PDEs) was published over 15 years ago, an enormous amount of progress has occurred in the field. There is great need for a centralized source for key information in this burgeoning and therapeutically important area of medical research. Cyclic Nucleotide Phosph
Phosphodiesterases As Drug Targets
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Author : Sharron H. Francis
language : en
Publisher: Springer
Release Date : 2011-08-02
Phosphodiesterases As Drug Targets written by Sharron H. Francis and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-08-02 with Medical categories.
Cyclic nucleotide phosphodiesterases (PDEs) are promising targets for pharmacological intervention. Multiple PDE genes, isoform diversity, selective expression and compartmentation of the isoforms, and an array of conformations of PDE proteins are properties that challenge development of drugs that selectively target this class of enzymes. Novel characteristics of PDEs are viewed as unique opportunities to increase specificity and selectivity when designing novel compounds for certain therapeutic indications. This chapter provides a summary of the major concepts related to the design and use of PDE inhibitors.
Cyclic Nucleotide Phosphodiesterases In The Central Nervous System
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Author : Nicholas J. Brandon
language : en
Publisher: John Wiley & Sons
Release Date : 2014-03-07
Cyclic Nucleotide Phosphodiesterases In The Central Nervous System written by Nicholas J. Brandon and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-03-07 with Medical categories.
This book reviews advances in understanding phosphodiesterases within the central nervous system and their therapeutic applications. A range of expert authors from both academia and industry describe these, then focus on the areas of greatest scientific and medical interest to provide more detailed coverage. Therapeutic and drug discovery applications are covered for diseases including Alzheimer's, Parkinson's, schizophrenia, erectile dysfunction, and spinal cord injuries. There is also a chapter on drug discovery tools such as in vitro assays and X-ray structures for medicinal chemistry studies.