Phosphodiesterases Cns Functions And Diseases
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Phosphodiesterases Cns Functions And Diseases
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Author : Han-Ting Zhang
language : en
Publisher: Springer
Release Date : 2017-09-26
Phosphodiesterases Cns Functions And Diseases written by Han-Ting Zhang and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-09-26 with Medical categories.
PDEs are a family of enzymes that catalyze the hydrolysis of intracellular cyclic nucleotides. They are implicated in a number of disorders and dysfunctions and PDE inhibitors have already proven to be effective therapies for erectile dysfunction, COPD, and psoriatic arthritis. This family of enzymes also plays a role in diseases and disorders of the CNS such as depression, anxiety, schizophrenia, and Alzheimer's Disease. Unfortunately no effective PDE inhibitors have been developed for the treatment of these diseases. The proposed book will be a comprehensive overview of the current state of basic and translational research on PDE inhibitors written by internationally recognized experts. Authors will also discuss potential PDE subtypes and splice variants in the hopes that this will spur more creative approaches to PDE targeting drugs.
Phosphodiesterases
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Author :
language : en
Publisher:
Release Date : 2017
Phosphodiesterases written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with Nervous system categories.
PDEs are a family of enzymes that catalyze the hydrolysis of intracellular cyclic neucleotides. They are implicated in a number of disorders and dysfunctions and PDE inhibitors have already proven to be effective therapies for erectile dysfunction, COPD, and psoriatic arthiritis. This family of enzymes also plays a role in diseases and disorders of the CNS such as depression, anxiety, schizophrenia, and Alzheimer's Disease. Unfortunately no effective PDE inhibitors have been developed for the treatment of these diseases. The proposed book will be a comprehensive overview of the current state of basic and translational research on PDE inhibitors written by internationally recognized experts. Authors will also discuss potential PDE subtypes and splice variants in the hopes that this will spur more creative approaches to PDE targeting drugs.
Cyclic Nucleotide Phosphodiesterases In The Central Nervous System
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Author : Nicholas J. Brandon
language : en
Publisher: John Wiley & Sons
Release Date : 2014-03-07
Cyclic Nucleotide Phosphodiesterases In The Central Nervous System written by Nicholas J. Brandon and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-03-07 with Medical categories.
This book reviews advances in understanding phosphodiesteraseswithin the central nervous system and their therapeuticapplications. A range of expert authors from both academia andindustry describe these, then focus on the areas of greatestscientific and medical interest to provide more detailed coverage.Therapeutic and drug discovery applications are covered fordiseases including Alzheimer's, Parkinson's, schizophrenia,erectile dysfunction, and spinal cord injuries. There is also achapter on drug discovery tools such as in vitro assays and X-raystructures for medicinal chemistry studies.
Phosphodiesterases And Their Inhibitors
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Author : Spiros Liras
language : en
Publisher: John Wiley & Sons
Release Date : 2014-03-03
Phosphodiesterases And Their Inhibitors written by Spiros Liras and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-03-03 with Medical categories.
Written by the pioneers of Viagra, the first blockbuster PDE inhibitor drug. Beginning with a review of the first wave of phosphodiesterase (PDE) inhibitors, this book focuses on new and emerging PDE targets and their inhibitors. Drug development options for all major human PDE families are discussed and cover diverse therapeutic fields, such as neurological/psychiatric, cardiovascular/metabolic, pain, and allergy/respiratory diseases. Finally, emerging chemotherapeutic applications of PDE inhibitors against malaria and other tropical diseases are discussed.
Cgmp Generators Effectors And Therapeutic Implications
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Author : Harald H. H. W. Schmidt
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-12-17
Cgmp Generators Effectors And Therapeutic Implications written by Harald H. H. W. Schmidt and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-12-17 with Science categories.
After the discovery of endogenous NO formation in the late '80s and the 1998 Nobel Prize in Physiology or Medicine, many researchers and physicians again became interested in the NO/sGC interaction and cGMP-dependent signaling. This book is an enthusiastic celebration of cyclic guanosine monophosphate (cGMP) and amply illustrates the importance of this field of science to patients and the way in which the field has evolved. It is exclusively devoted to this exciting and important signaling molecule, addressing all recent advances in understanding guanylate cyclase regulation, NO/sGC interactions, cGMP effector mechanisms and their pathophysiological and pharmacological implications. Particular attention will also be given to clinical applications of the novel cGMP-elevating drugs which are on the horizon, thus spanning the continuum from basic science to clinic.
Cyclic Nucleotide Phosphodiesterases In Health And Disease
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Author : Joseph A. Beavo
language : en
Publisher: CRC Press
Release Date : 2006-12-05
Cyclic Nucleotide Phosphodiesterases In Health And Disease written by Joseph A. Beavo and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-12-05 with Medical categories.
Since the last major compendium dedicated to cyclic nucleotide phosphodiesterases (PDEs) was published over 15 years ago, an enormous amount of progress has occurred in the field. There is great need for a centralized source for key information in this burgeoning and therapeutically important area of medical research. Cyclic Nucleotide Phosph
Frontiers In Clinical Drug Research Cns And Neurological Disorders Volume 7
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Author : Zareen Amtul
language : en
Publisher: Bentham Science Publishers
Release Date : 2020-08-07
Frontiers In Clinical Drug Research Cns And Neurological Disorders Volume 7 written by Zareen Amtul and has been published by Bentham Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-08-07 with Science categories.
Frontiers in Clinical Drug Research - CNS and Neurological Disorders is a book series that brings updated reviews to readers interested in advances in the development of pharmaceutical agents for the treatment of central nervous system (CNS) and other nerve disorders. The scope of the book series covers a range of topics including the medicinal chemistry, pharmacology, molecular biology and biochemistry of contemporary molecular targets involved in neurological and CNS disorders. Reviews presented in the series are mainly focused on clinical and therapeutic aspects of novel drugs intended for these targets. Frontiers in Clinical Drug Research - CNS and Neurological Disorders is a valuable resource for pharmaceutical scientists and postgraduate students seeking updated and critical information for developing clinical trials and devising research plans in the field of neurology. The seventh volume of this series features reviews that cover the following topics related to the treatment of neurodegenerative diseases, epilepsy and stroke: -Fatty Acid Amides as a New Potential Therapeutic Agent in Multiple Sclerosis -Epileptic Seizures Detection Based on Non-Linear Characteristics Coupled with Machine Learning Techniques -Hampering Essential Tremor Neurodegeneration in Essential Tremor: Present and Future Directions -The Potential Therapeutic Role of the Melatoninergic System in Treatment of Epilepsy and Comorbid Depression -Modeling Neurodegenerative Diseases Using Transgenic Model of Drosophila -Genetic Basis in Stroke Treatment: Targets of Potent Inhibitors
Heart Failure A Companion To Braunwald S Heart Disease E Book
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Author : G. Michael Felker
language : en
Publisher: Elsevier Health Sciences
Release Date : 2019-02-06
Heart Failure A Companion To Braunwald S Heart Disease E Book written by G. Michael Felker and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-02-06 with Medical categories.
Up-to-date, authoritative and comprehensive, Heart Failure, 4th Edition, provides the clinically relevant information you need to effectively manage and treat patients with this complex cardiovascular problem. This fully revised companion to Braunwald’s Heart Disease helps you make the most of new drug therapies such as angiotensin receptor neprilysin inhibitors (ARNIs), recently improved implantable devices, and innovative patient management strategies. Led by internationally recognized heart failure experts Dr. G. Michael Felker and Dr. Douglas Mann, this outstanding reference gives health care providers the knowledge to improve clinical outcomes in heart failure patients. Focuses on a clinical approach to treating heart failure, resulting from a broad variety of cardiovascular problems. Covers the most recent guidelines and protocols, including significant new updates to ACC, AHA, and HFSA guidelines. Covers key topics such as biomarkers and precision medicine in heart failure and new data on angiotensin receptor neprilysin inhibitors (ARNIs). Contains four new chapters: Natriuretic Peptides in Heart Failure; Amyloidosis as a Cause of Heart Failure; HIV and Heart Failure; and Neuromodulation in Heart Failure. Covers the pathophysiological basis for the development and progression of heart failure. Serves as a definitive resource to prepare for the ABIM’s Heart Failure board exam. 2016 British Medical Association Award: First Prize, Cardiology (3rd Edition).
Mechanisms Of Neuroinflammation
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Author : Gonzalo Emiliano Aranda Abreu
language : en
Publisher: BoD – Books on Demand
Release Date : 2017-08-23
Mechanisms Of Neuroinflammation written by Gonzalo Emiliano Aranda Abreu and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-08-23 with Medical categories.
"Mechanisms of Neuroinflammation" book explains how the neuronal cells become swollen at the moment of the blood-brain barrier disruption and how they lose their immunological isolation. A cascade of cytokines and immune cells from the bloodstream enters the nervous system, inflaming neurons and activating the glia. This produces a neuroinflammatory process that can generate different neurodegenerative diseases. Better understanding of mechanisms that are activated at the time when the damage to the brain occurs could lead to the development of suitable therapies that revert the neuronal inflammation and thus prevent further damage to the nervous system.
Cyclic Nucleotide Signaling
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Author : XiaoDong Cheng
language : en
Publisher: CRC Press
Release Date : 2021-03-30
Cyclic Nucleotide Signaling written by XiaoDong Cheng and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-03-30 with Cellular signal transduction categories.
Showcasing the recent progresses of the field, Cyclic Nucleotide Signaling covers the major tools and methodologies used in various areas of research. The majority of the chapters are protocol oriented, with the goal of providing clear directions for laboratory use. Students and investigators new to the field will find this book particularly informative, as will scientists already actively researching nucleotide signaling.